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Comparison of 24×20 mm^(2) swept-source OCTA and fluorescein angiography for the evaluation of lesions in diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1798-1805页

作者： Qiao-Zhu Zeng si-ying li Yu-Ou Yao En-Zhong Jin Jin-Feng Qu Ming-Wei Zhao Department of Ophthalmology Eye Diseases and Optometry InstitutePeking University People's HospitalBeijing 100044China Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases College of OptometryPeking University Health Science CenterBeijing 100044China

AIM: To compare ultra-widefield(24×20 mm^(2)) sweptsource optical coherence tomography angiography(SSOCTA) and fluorescein angiography(FA) in the evaluation of diabetic retinopathy(DR) lesions. METHODS: Forty-six eyes of 23 patients with treatmentna?ve DR were included at Peking University People’s Hospital from September 1, 2021, until December 31, 2021, as well as 23 age and gender matched healthy controls. Quantitative assessments of DR lesions on FA and SS-OCTA(superficial capillary plexus, SCP, 24×20 mm^(2)) were ***: Area of fovea avascular zone(FAZ) was larger in DR cases than controls(0.34±0.069 mm^(2) vs 0.287±0.108 mm^(2), P=0.006). In DR eyes, the mean FAZ area was 0.34±0.069 and 0.334±0.087 mm^(2) on SS-OCTA and FA, respectively(P=0.428), while the median FAZ perimeter was 2.382(IQR, 2.201-2.59) and 2.333(IQR, 2.138-2.6) mm on SS-OCTA and FA images(P=0.733). There was no significant difference in the size of the non-perfusion area(NPA) between the images on SS-OCTA and FA(12.389, IQR 4.96-28.3 and 11.125, IQR 5-28.31 mm^(2), P=0.197). The median total microaneurysm(MA) count was 35(IQR, 19-46) and 73(IQR, 43-93) on SS-OCTA and FA(Psignificant difference in intra-retinal microvascular abnormality(IRMA) and neovascularization (NV) count was found between the two techniques. The intraclass coefficient(ICCs) of all the parameters above indicated stable ***: Ultra-widefield SS-OCTA represents a reliable, noninvasive, and quantitative imaging technique in the assessment of microvasculature in DR, which offers a potential substitute for FA in DR evaluation.

关键词： ultra-widefield swept-source optical coherence tomography angiography fluorescein angiography comparison diabetic retinopathy

Efficacy of indirect intense pulsed light irradiation on meibomian gland dysfunction: a randomized controlled study

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 2014-2022页

作者： Yu Cheng Wen-Jing Song Mei-Ting Huang Yuan Gao Luo-ying Xie ying-si li Song-lin Yang Xiao-Ming Yan Department of Ophthalmology Peking University First HospitalBeijing 100034China

AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled *** were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,*** groups received three times treatment with 3-week *** gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every ***:After three IPL treatments,both groups had significant improvement in MGYSS(both Plids showed significant improvement in *** of SPEED questionnaire in both groups declined significantly(both Psity of central corneal subepithelial nerves and TBUTs showed no statistically significant *** 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had ***:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment *** may primarily act on the functional improvement of the meibomian glands and corneal nerves.

关键词： meibomian gland disfunction dry eye intense pulsed light ocular surface

Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian li Deng-xing Lun Ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang li Ji-wu Song Kewei Hu Lala li si-ying li Wenbo liu Wanping Zhu Yunlong Zhang Jikai li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu lin liu Hongguang Zhu Yuyun Wu Bin liu Weifang People's Hospital WeifangShandong261000China School of life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

Modification of ricin and its hepatotoxicity and activity against hepatocellular cancer in mice

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World Journal of Gastroenterology 1998年第4期4卷 35-38页

作者： WANG WenXue, DONG Juying, ZHOU siYuan, li Wenli and ZHAO yingKeywords ricin/chemistry ricin/toxicity liver/drug effects liver neoplasms carcinoma, hepatocellular glutathione transferase

AIM To observe the effects of ricin (RT) with and without chemical modification on both hepatotoxicity of mice and activity against hepatocellular cancer (HCC), and evaluate the possibility to improve RT anticancer activity via chemical *** RT was modified with N-succinimidyl3-(2-pyridyldithio) propionate (SPDP), a heterobifunctional cross-linker, and SPDP derivative of RT (PDP-R) was obtained. The serum glutathione-s-transferase (SGST) activity, as an index of liver damage, was determined in mice intoxicated with RT and PDP-R, at various doses and time. The tissue damage of HCC in the nude mice ip injected with PDP-R was compared with that with RT at the same dose by immunohistochemical method, the relative content of both RT and PDP-R in the HCC tissues was measured by computerized *** The SGST activities increased with doses or/and time intoxicated with both RT and PDP-R, and the increase in the value of RT group was more significant than that in the PDP-R group; the SGST activity of RT group was 2.8-fold (P＜0.01) of PDP-R group at a dose of 12.5μg/kg for 42h, showing the much lower toxicity of R-PDP than that of RT. Under an optical microscope, hemolysis and necrosis of massive cells in the HCC tissues of PDP-R group were observed and the ratio of necrosis mounted to 90.5% while the corresponding value of RT group only to 62.5%. With computerized image-analysis, the average relative content of RT and PDP-R in the HCC tissues, represented as greyness, was 140.06±3.43 and 169.10±2.74, respectively. There was significant difference between the two (P＜0.05), indicating the higher content of PDP-R in the HCC tissue than that of *** The hepatotoxicity of PDP-R to mice may be reduced by chemical modification with SPDP, but both the affinity of PDP-R to the HCC tissues and ability to kill it may be stronger than that of RT. So this might be a valuable attempt to improve the anticancer activity of RT.

关键词： ricin Modification

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling li Xiaoyao Yu yingjie Zhou Yao lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou ying Xiaoli si Naijia Xue Yi liu Ran Zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Urine proteomics for profiling of mouse toxoplasmosis using liquid chromatography tandem mass spectrometry analysis

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Urine proteomics for profiling of mouse toxoplasmosis using ...

UPLC-MS/MS同时测定静脉注射荭草花提取物大鼠血浆中3种成分及其药代动力学研究

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Yi Zhang lin-lin Cui Chun-Xue Zhou Bing Han si-ying li Dong-Hui Zhou Key Laboratory of Fujian-Taiwan Animal Pathogen Biology College of Animal Sciences(College of Bee Science)Fujian Agriculture and Forestry University Department of Pathogen Biology School of Basic Medical SciencesCheeloo College of MedicineShandong University

Toxoplasma gondii is an obligate intracellular parasite that causes *** is an easily obtained clinical sample that has been widely applied for diagnostic ***,changes in the urinary proteome during *** infection have never been *** four-hour urine samples were obtained from BALB/c mice with acute infection [11 days post infection(DPI)],mice with chronic infection(35 DPI) and healthy controls,and were analyzed using a label-free liquid chromatography tandem mass spectrometry *** identified a total of 13,414 peptides on 1802 proteins,of which169 and 47 proteins were significantly differentially expressed at acute and chronic infection phases,*** analysis revealed obvious differences in proteome profiles among all *** ontology analysis showed that a large number of differentially expressed proteins(DEPs) detected in acute infection were associated with biological binding activity and single-organism *** pathway enrichment analysis showed that the majority of these DEPs were involved in disease-related and metabolic *** findings revealed global reprogramming of the urine proteome following *** infection,and data obtained in this study will enhance our understanding of the host responses to *** infection and lead to the identification of new diagnostic biomarkers.

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中药材 2016年第7期39卷 1574-1577页

作者：郑林杨武向文英孙佳陈思颖李勇军贵州医科大学贵州省药物制剂重点实验室贵州贵阳550004 贵州医科大学药学院贵州贵阳550004 贵州医科大学民族药与中药开发应用教育部工程研究中心贵州贵阳550004

目的:建立UPLC-MS/MS测定大鼠尾静脉注射荭草花提取物后的大鼠血浆中3种成分(原儿茶酸、山柰素-葡萄糖苷、檞皮苷)含量的分析方法,并研究这3种成分在大鼠体内药代动力学特征。方法:采用Waters BEH C18(50 mm×2.1 mm,1.7μm)色谱柱;流... 详细信息

目的:建立UPLC-MS/MS测定大鼠尾静脉注射荭草花提取物后的大鼠血浆中3种成分(原儿茶酸、山柰素-葡萄糖苷、檞皮苷)含量的分析方法,并研究这3种成分在大鼠体内药代动力学特征。方法:采用Waters BEH C18(50 mm×2.1 mm,1.7μm)色谱柱;流动相为0.1%甲酸乙腈-0.1%甲酸溶液,梯度洗脱;质谱采用电喷雾电离源(Esi);扫描方式为多反应离子监测(MRM)。结果:静脉注射荭草花提取物后原儿茶酸、山柰素-葡萄糖苷、槲皮苷在大鼠体内的半衰期分别为(41.9±12.3)min、(71.3±56.8)min和(90.3±74.8)min,达峰浓度(1.7±0.7)μg/m L、(2.1±0.9)μg/m L和(8.7±3.7)μg/m L。结论:实验结果表明建立的方法快速、准确、灵敏,精密度回收率均符合生物样品的测定要求,适用于原儿茶酸、山柰素-葡萄糖苷、檞皮苷3个成分在大鼠血浆中浓度的测定,3个成分在大鼠体内的药动学特征均符合二室模型。

关键词： UPLC-MS/MS 药动学荭草花提取物

黑龙江省黑河地区森林地上生物量和NPP估测及时空格局

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应用生态学报 2016年第10期27卷 3070-3080页

作者：赵颖慧李思琪甄贞李凤日魏庆彬东北林业大学林学院哈尔滨150040 黑龙江省环境监测中心站哈尔滨150056

根据黑龙江省黑河地区2005和2010年1390块固定样地数据和东北地区树种生物量异速模型,估算各样地单位面积森林地上生物量(AGB)和净初级生产力(NPP).结合该地区2005和2010年两期ETM+遥感图像,运用地统计克里格与协同克里格法对AGB和NPP... 详细信息

根据黑龙江省黑河地区2005和2010年1390块固定样地数据和东北地区树种生物量异速模型,估算各样地单位面积森林地上生物量(AGB)和净初级生产力(NPP).结合该地区2005和2010年两期ETM+遥感图像,运用地统计克里格与协同克里格法对AGB和NPP进行插值,比较多种方差函数的拟合效果,并用最佳插值方法得出该地区AGB和NPP的分布图;通过两期分布图的对比,分析该区域AGB和NPP随时间和空间的动态变化趋势,及其与地形因子(坡向、坡度、海拔)和不同林分类型的时空变化规律.结果表明:2005—2010年,黑河地区AGB呈现增加趋势,高于40 t·hm^(-2)的生物量面积明显增加;NPP有所下降,出现高NPP地区向低NPP地区转变的现象.AGB和NPP与各地形因子均有一定的相关性,其中,与海拔的相关性明显,说明AGB和NPP的分布受海拔影响显著.研究期间,AGB在各个坡向均有所提高,NPP则降低;AGB和NPP随着坡度增大、海拔增高有增加趋势;常绿针叶林AGB和NPP增长最多,针阔混交林AGB增长最少,落叶阔叶林NPP增长最少.

关键词：地上生物量净初级生产力空间格局