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Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in Hep G2 cells

World Journal of Gastroenterology 2016年第25期22卷 5769-5779页

作者： ying-ying Li zheng-ming Shi Xiao-Yong Yu Ping Feng Xue-Jiang Wang Department of Physiology and Pathophysiology School of Basic Medical Sciences Capital Medical University Beijing 100069 China Beijing Key Laboratory for Cancer Invasion and Metastasis Research Capital Medical University Beijing 100069 China Department of General Surgery Beijing Jishuitan Hospital Beijing 100069 China

AIM: To investigated the effects of urotensin Ⅱ(UII) on hepatic insulin resistance in Hep G2 cells and the potential mechanisms ***: Human hepatoma Hep G2 cells were cultured with or without exogenous UII for 24 h, in the presence or absence of 100 nmol/L insulin for the last 30 min. Glucose levels were detected by the glucoseoxidase method and glycogen synthesis was analyzed by glycogen colorimetric/fluorometric assay. Reactive oxygen species(ROS) levels were detected with a multimode reader using a 2′,7′-dichlorofluorescein diacetate probe. The protein expression and phosphorylation levels of c-Jun N-terminal kinase(JNK), insulin signal essential molecules such as insulin receptor substrate-1(IRS-1), protein kinase B(Akt), glycogen synthase kinase-3β(GSK-3β), and glucose transporter-2(Glut 2), and NADPH oxidase subunits such as gp91 phox, p67 phox, p47 phox, p40 phox, and p22 phox were evaluated by Western ***: Exposure to 100 nmol/L UII reduced the insulin-induced glucose consumption(P < 0.05)and glycogen content(P < 0.01) in Hep G2 cells compared with cells without UII. UII also abolished insulin-stimulated protein expression(P < 0.01) and phosphorylation of IRS-1(P < 0.05), associated with down-regulation of Akt(P < 0.05) and GSK-3β(P < 0.05) phosphorylation levels, and the expression of Glut 2(P < 0.001), indicating an insulin-resistance state in Hep G2 cells. Furthermore, UII enhanced the phosphorylation of JNK(P < 0.05), while the activity of JNK, insulin signaling, such as total protein of IRS-1(P < 0.001), phosphorylation of IRS-1(P < 0.001) and GSK-3β(P < 0.05), and glycogen synthesis(P < 0.001) could be reversed by pretreatment with the JNK inhibitor SP600125. Besides, UII markedly improved ROS generation(P < 0.05) and NADPH oxidase subunit expression(P < 0.05). However, the antioxidant/NADPH oxidase inhibitor apocynin could decrease UII-induced ROS production(P < 0.05), JNK phosphorylation(P < 0.05), and insulin resistance(P < 0.05

关键词： Urotensin Ⅱ Insulin resistance NADPH oxidase Reactive oxygen species HepG 2 cells

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Fuzzy Topology Based on Residuated Lattice-Valued Logic

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Acta Mathematica Sinica,English Series 2001年第1期17卷 89-102页

作者： ming Sheng ying State Key Laboratory of Intelligent Technology and Systems Department of Computer Science and Technology Tsinghua University

We use a semantical method of complete residuated lattice-valued logic to give a general- ization of fuzzy topology as a partial answer to a problem by Rosser and Turquette.

关键词： Fuzzy topology Residuated lattice Many-valued logic Semantics

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Ruthenium Bisphosphine Catalyst on Functionalized Silica: Novel Efficient Catalyst for Carbon Dioxide Hydrogenation to Formic Acid

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Chinese Chemical Letters 2006年第2期17卷 261-264页

作者： Yi Ping ZHANG Jin Hua FEI ying Min YU Xiao ming zheng Institute of Catalysis Xixi Campus Zhejiang University Hangzhou 310028 Department of Chemistry Zhcjiang Education Institute Hangzhou 310012

A novel efficient catalyst for the hydrogenation of carbon dioxide to formic acid ruthenium bisphosphine on functionalized silica was in situ synthesized, affording turnover frequency （TOF） of 1190 h^-1 at 100% selectivity under 80℃ with total pressure of 16.0 MPa. The catalyst can be separated from the reaction mixture easily and reused with moderate loss of activity.

关键词： Immobilized ruthenium silica bis(1,2-diphenylphosphino)ethane (dppe) formic acid.

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磁场下碳化物析出的热力学机制

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原子与分子物理学报 2025年第4期42卷 121-130页

作者：廖已莹侯廷平杨雨豪郑一航于涛刘伍明吴开明武汉科技大学理学院武汉430081 冶金工业过程系统科学湖北省重点实验室武汉430081 省部共建耐火材料与冶金国家重点实验室武汉430081 江汉大学光电材料与技术学院光电化学材料与器件教育部重点实验室武汉430056 中国科学院物理研究所北京100190

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(... 详细信息

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(2)C、Fe_(3)C、Fe_(2)Mo_(4)C、Fe_(3)Mo_(3)C-Ⅰ、Fe_(3)Mo_(3)C-Ⅱ和Fe_(4)Mo_(2)C等合金碳化物的磁矩,计算结果表明其中Fe_(4)Mo_(2)C的磁矩最大,达到了7.04μB.磁矩不仅由碳化物晶胞中Fe原子个数有关,还与Fe Wyckoff占位紧密相关.通过模拟计算碳化物的磁致磁热熔、磁熵、磁焓和磁自由能,从热力学角度对各碳化物进行分析,结果表明磁场会使碳化物的磁致磁热熔和磁熵增加;强磁场会降低M_(6)C的磁自由能进而提高其稳定性.此工作为研究核聚变材料磁性能提供理论基础和技术参考.

关键词：磁场碳化物析出相热力学机制

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Immobilized Ruthenium Catalyst for Carbon Dioxide Hydrogenation

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Chinese Chemical Letters 2006年第8期17卷 1097-1100页

作者： ying Min YU Jin Hua FEI Yi Ping ZHANG Xiao ming zheng Institute of Catalysis Zhejiang University Hangzhou 310028 Department of Chemistry Zhejiang Education Institute Hangzhou 310012

Three kinds of cross linked polystyrene resin （PS） supported ruthenium complexes were developed as catalysts for the synthesis of formic acid from carbon dioxide hydrogenation. Many factors, such as the functionalized supports, solvents and ligands, could influence their activities and reuse performances greatly. These immobilized catalysts also offer the industrial advantages such as easy separation.

关键词： Immobilization resin supported Ru catalyst hydrogenation CO2-expanded solvent.

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Breast cancer screening and early diagnosis in Chinese women

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Cancer Biology & Medicine 2022年第4期19卷 450-467页

作者： Rui Ding Yi Xiao Miao Mo ying zheng Yi-Zhou Jiang Zhi-ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Cancer Prevention Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Precision Cancer Medicine Center Fudan University Shanghai Cancer CenterShanghai 200032China

Breast cancer is the most common malignant tumor in Chinese women,and its incidence is *** screening is an effective method for early tumor detection and improving patient *** this review,we analyze the epidemiological changes and risk factors associated with breast cancer in China and describe the establishment of a screening strategy suitable for Chinese *** patients with breast cancer tend to be younger than Western patients and to have denser ***,the age of initial screening in Chinese women should be earlier,and the importance of screening with a combination of ultrasound and mammography is ***,Chinese patients with breast cancers have several ancestry-specific genetic features,and aiding in the determination of genetic screening strategies for identifying high-risk *** the basis of current studies,we summarize the development of risk-stratified breast cancer screening guidelines for Chinese women and describe the significant improvement in the prognosis of patients with breast cancer in China.

关键词： Breast cancer screening Chinese imaging screening genetic test

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The feasibility of leadless pacemaker implantation in nonagenarians:case report and literature review

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Journal of Geriatric Cardiology 2022年第8期19卷 626-630页

作者： Chun-Ling zheng Li ZHAO Yu CHEN zheng-ming XU Ling LIU Li-Li WANG ying-ming LIU Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina

In the aging populations of China,there is an increasing prevalence of various types of bradycardias that require pacing *** 1958,the first transvenous pacemaker(TVPM)was implanted at Karolinska Hospital in Sweden,which unveiled the era of cardiac pacing therapy.[1]A TVPM includes transvenous electrodes and a pulse gener-ator that is implanted *** its obvious benefits,the complication rate associated with TVPM could be as high as 10%.

关键词： cardiac venous implantation

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The Contribution of United States Aircraft Reconnaissance Data to the China Meteorological Administration Tropical Cyclone Intensity Data:An Evaluation of Homogeneity

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Advances in Atmospheric Sciences 2024年第4期41卷 639-654页

作者： ming ying Xiaoqin LU Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

This paper investigates the homogeneity of United States aircraft reconnaissance data and the impact of these data on the homogeneity of the tropical cyclone(TC)best track data for the seasons 1949-1987 generated by the China Meteorological Administration(CMA).The evaluation of the reconnaissance data shows that the minimum central sea level pressure(MCP)data are relatively homogeneous,whereas the maximum sustained wind(MSW)data show both overestimations and spurious abrupt *** comparisons suggest that both the reconnaissance MCP and MSW were well incorporated into the CMA TC best track *** no spurious abrupt changes were evident in the reconnaissance-related best track MCP data,two spurious changepoints were identified in the remainder of the best-track MCP ***,the influence of the reconnaissance MSWs seems to extend to the best track MSWs unrelated to reconnaissance,which might reflect the optimistic confidence in making higher estimates due to the overestimated extreme wind“observations”.In addition,the overestimation of either the reconnaissance MSWs or the best track MSWs was greater during the early decades compared to later decades,which reflects the important influence of reconnaissance data on the CMA TC best track *** wind-pressure relationship(WPR)used in the CMA TC best track dataset is also evaluated and is found to overestimate the MSW,which may lead to inhomogeneity within the dataset between the aircraft reconnaissance era and the satellite era.

关键词： tropical cyclone intensity homogeneity best track aircraft reconnaissance

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Magnetoelectroelastic fields in rotating multiferroic composite cylindrical structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 319-326页

作者： Ji ying Hui-ming WANG Department of Mechanical Engineering Zhejiang University Hangzhou 310027 China Department of Mechanics Zhejiang University Hangzhou 310027 China

An analytical solution is obtained for a rotating multiferroic composite hollow cylinder made of radially polarized piezoelectric and piezomagnetic materials. Both the number of layers and the stacking sequence of the composite cylinder can be arbitrary. General mechanical, electric and magnetic boundary conditions can be applied at both the inner and outer cylindrical surfaces. The state space method is employed so that only a 2×2 matrix is involved in the whole solving procedure. In the nu-merical experiments, the distributions of elastic, electric as well as magnetic fields in an internally pressurized rotating BaTiO3/CoFe2O4 composite hollow cylinder subjected to different boundary conditions are presented graphically. The results clearly show that the stress fields in a multiferroic composite cylinder are controllable.

关键词： Analytical solution Multiferroic composite Rotating hollow cylinder State space method

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Machine learning-aided scoring of synthesis difficulties for designer chromosomes

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Science China(Life Sciences) 2023年第7期66卷 1615-1625页

作者： Yan zheng Kai Song Ze-Xiong Xie ming-Zhe Han Fei Guo ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin300072China School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China School of Computer Science and Engineering Central South UniversityChangsha410083China

Designer chromosomes are artificially synthesized ***,these chromosomes have numerous applications ranging from medical research to the development of ***,some chromosome fragments can interfere with the chemical synthesis of designer chromosomes and eventually limit the widespread use of this *** address this issue,this study aimed to develop an interpretable machine learning framework to predict and quantify the synthesis difficulties of designer chromosomes in *** the use of this framework,six key sequence features leading to synthesis difficulties were identified,and an e Xtreme Gradient Boosting model was established to integrate these *** predictive model achieved high-quality performance with an AUC of 0.895 in cross-validation and an AUC of 0.885 on an independent test *** on these results,the synthesis difficulty index(S-index)was proposed as a means of scoring and interpreting synthesis difficulties of chromosomes from prokaryotes to *** findings of this study emphasize the significant variability in synthesis difficulties between chromosomes and demonstrate the potential of the proposed model to predict and mitigate these difficulties through the optimization of the synthesis process and genome rewriting.

关键词： synthetic biology machine learning artificial chromosome chemical synthesis

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