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An Emergency Decision Making Method Based on Prospect Theory for Different Emergency Situations

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International Journal of Disaster Risk Science 2018年第3期9卷 407-420页

作者： Zi-Xin Zhang Liang wang ying-ming wang Decision Sciences Institute Fuzhou University Department of Computer Sciences University of Jaén

Emergency decision making(EDM) is an effective way to deal with emergency situations because of its prominent role in alleviating the losses of properties and lives caused by emergency events. It has drawn increasing attention from both governments and academia, and become an important research topic in recent years. Studies show that decision makers are usually guided by bounded rationality under risk and uncertainty conditions. Their psychological behavior plays an important role in the decision making process, and EDM problems are usually characterized by high risk and uncertainty. Thus, decision makers' psychological behavior has been considered in existing EDM approaches based on prospect theory. An emergency event might evolve into different situations due to its dynamic evolution, which is one of the distinctive features of emergency events. This important issue has been discussed in existing EDM approaches, in which different emergency situations are dealt with by devising different solutions. However, existing EDM approaches do not consider decision makers' psychological behavior together with the different emergency situations and the different solutions. Motivated by such limitation, this study proposed a novel approach based on prospect theory considering emergency situations, which considers not only decision makers' psychological behavior, but also different emergency situations in the EDM process. Two examples and related comparison are provided to illustrate the feasibility and validity of this approach.

关键词： Emergency situations Emergency decision making Prospect theory Psychological behavior

Review:Whole genome amplification in preimplantation genetic diagnosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 1-11页

作者： ying-ming ZHENG Ning wang Lei LI Fan JIN Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Preimplantation genetic diagnosis (PGD) refers to a procedure for genetically analyzing embryos prior to implantation,improving the chance of conception for patients at high risk of transmitting specific inherited *** method has been widely used for a large number of genetic disorders since the first successful application in the early *** chain reaction (PCR) and fluorescent in situ hybridization (FISH) are the two main methods in PGD,but there are some inevitable shortcomings limiting the scope of genetic ***,different whole genome amplification (WGA) techniques have been developed to overcome these *** DNA can be amplified and multiple tasks which need abundant DNA can be ***,WGA products can be analyzed as a template for multi-loci and multi-gene during the subsequent DNA *** this review,we will focus on the currently available WGA techniques and their applications,as well as the new technical trends from WGA products.

关键词： Whole genome amplification Multiple displacement amplification Primer extension preamplification Degenerate oligonucleotide primed-polymerase chain reaction Preimplantation genetic diagnosis

Effects of 530 nm monochromatic light on basic fibroblast growth factor and transforming growth factor-β1 expression in Müller cells

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 904-909页

作者： Xin-Yi Fu Xiao-Feng Zhang Wei Xia Lei Zhong ying-ming wang Zheng-Tai Sun Jing Xia Department of Ophthalmology the First Affiliated Hospital of Soochow University

AIMTo expose rat retinal Müller cells to 530 nm monochromatic light and investigate the influence of varying light illumination times on basic fibroblast growth factor (bFGF) and transforming growth factor-β1 (TGF-β1) *** groups of rat retinal Müller cells cultured in vitro under a 530 nm monochromatic light were divided into 6, 12 and 24h experimental groups, while cells incubated under dark conditions served as the control group. The bFGF and TGF-β1 mRNA expression, protein levels and fluorescence intensity of the Müller cells were *** bFGF mRNA expression and protein levels were significantly upregulated in Müller cells in all three experimental groups compared with the control group (P<0.05), while that of TGF-β1 was downregulated (P<0.05). Also, bFGF expression was positively correlated, but TGF-β1 expression was negatively correlated with illumination time. The largest changes for both cytokines were seen in the 24h group. The changes in bFGF and TGF-β1 fluorescence intensity were highest in the 24h group, and significant differences were observed among the experimental groups (P<0.05).CONCLUSIONThe expressions of bFGF and TGF-β1 changed in a time-dependent manner in Müller cells exposed to 530 nm monochromatic light with 250 lx illumination intensity. Müller cells might play a role in the development of myopia by increasing bFGF expression or decreasing TGF-β1 expression. Changes in cytokine expression in retinal Müller cells may affect monochromatic light-induced myopia.

关键词： monochromatic light myopia Mü ller cells basic fibroblast growth factor transforming growth factor-β 1

Valproic acid alters differential protein expression in SH-SY5Y cells

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Neural Regeneration Research 2011年第27期6卷 2134-2139页

作者： Zhong Dong ying wang ming Chang Guoyi Li Linsen Hu Department of Neurology the First Affiliated Hospital Jilin University Changchun 130021 Jilin Province China

This study sought to identify differentially expressed proteins in SH-SY5Y cells treated with valproic acid, using two-dimensional difference gel electrophoresis analysis. Three proteins were unambi-guously identified： the eukaryotic translation initiation factor 4A isoform 1 and ATP6V1B2 protein were downregulated, while the heterogeneous nuclear ribonucleoprotein K was upregulated. Moreover, all three proteins are associated with altered expression due to oxidative stress. Ma-trix-assisted laser desorption/ionization-time of flight mass spectrometry and protein immunoblotting assay confirmed the differential expression of eukaryotic translation initiation factor 4A isoform 1. The results indicate that valproic acid exerts an antioxidation effect by regulating the expression of eukaryotic translation initiation factor 4A isoform 1.

关键词： valproic acid two-dimensional difference gel electrophoresis matrix-assisted laser desorption-ionization SH-SY5Y cells proteomics neural regeneration

Glycobiological study of acutobin（defibrase） and its HEK-293T recombinant

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Glycobiological study of acutobin（defibrase） and its HEK-2...

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

第十一届中国生物毒素研究及医药应用年会

作者： Inn-Ho Tsai ying-ming wang Institute of Biological Chemistry Academia SinicaTaiwan Institute of Biochemical Sciences National Taiwan University

＜正＞Acutobin has been isolated from Deinagkistrodon acutus venom and used to prevent or treat stroke for Chinese patients over the last three *** 38 kDaα-fibrinogenase contains disialyl-capped complex type glycans at four Asn *** functional roles of these glycans remain to be ***（DS-） acutobin,prepared by sialidase treatment,cleaved fibrinogen Act chains as efficiently as native acutobin in vitro. However,the fibrinogen degradation product levels in DS-acutobin treated mice（i.p.） were significantly lower than those in native acutobin treated mice in 4 h,indicating that the disialyl moieties may facilitate vascular homing and prolong the half-life of acutobin in vivo. We prepared recombinant acutobins（designated as HEK-ATB and SW-ATB,respectively） from HEK293T and SW1353 cells and activated and purified *** profiling showed that the glycans of HEK-ATB were smaller and less sialylated,while those of SW-ATB were larger than acutobin’s *** spite of the fact that both recombinants showed similar reactivities toward chromogenic substrate as the native acutobin,HEK-ATB effectively cleaved the Aα,Bβandγchains,while SW-ATB had lowerα-fibrinogenolytic and clotting *** deglycosylation by PNGase F under non-denaturing condition did not affect the activities of native or recombinant acutobins toward chromogenic substrate,but reduced their fibrinogenolytic activity,clotting activity and their thermal *** of site directed mutagenesis of HEK-ATB further showed that only the Asn glycosylation site at the C-terminal region was dispensable,as mutation of the other three Asn-glycosylation sites prevented normal folding and secretion of the *** together,our results revealed that the terminal disialyl-capped glycans of acutobin are important for its stability, fibrinogen specificity and pharmacokinetics,and that the glycosylation pathway of venom gland tissue appears to be important for the evolutio

关键词： Snake venom defibrinogenating agent sialidase or PNGase F treatment HEK293T and SW1353 recombinants N-glycan site mutagenesis

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

飞机大部件调姿机构磨损预测模型的构建与仿真

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浙江大学学报（工学版） 2013年第2期47卷 209-215页

作者：应征章明王青柯映林浙江大学流体传动及控制国家重点实验室浙江杭州310027

针对飞机大部件调姿机构球铰磨损量预测问题,提出一种含间隙的球铰磨损模型.根据球铰的几何结构构建运动学模型;采用含迟滞阻尼系数的连续接触力模型与改进Coulomb摩擦力模型建立球铰的动力学模型;结合Archard方程建立球铰的磨损模型.... 详细信息

针对飞机大部件调姿机构球铰磨损量预测问题,提出一种含间隙的球铰磨损模型.根据球铰的几何结构构建运动学模型;采用含迟滞阻尼系数的连续接触力模型与改进Coulomb摩擦力模型建立球铰的动力学模型;结合Archard方程建立球铰的磨损模型.为了能够获得接触表面的磨损分布情况,将磨损表面离散,借助Hertz接触理论计算接触力的分布,并以离散后的单张曲面为单元分别计算与保存单张曲面磨损量.针对一种四定位器的调姿机构,模拟调姿过程进行仿真计算,结果显示:单个球头表面磨损分布并不均衡,4个球头之间的磨损分布情况类似,但是磨损量存在一定的差异.该磨损模型能够用于调姿机构寿命的预测,并对调姿机构的机械设计提供参考.

关键词：调姿机构球铰动力学建模磨损

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong wang Pengyang wang Yali Liu Shanshan Qi Biao Shi ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Perovskite solar cells

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang ying wang Siyuan Xu Yiting wang Wencong wang Zhiping wang Hongkui wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection