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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2321-2326页

作者： Hong-Zhe Li Fu-man Yang Ze-Hui Zhu Yin-ying Zhao Ping-jun Chang Yun-E Zhao School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To present a technique of transcapsular scleral fixation of the standard capsular tension ring(CTR)through equatorial capsulotomy and in-the-bag intraocular lens(IOL)implantation in subluxated ***:This retrospective consecutive case series included patients with subluxated lenses by more than 180 degrees who underwent lens extraction,transcapsular scleral fixation of the standard CTR through equatorial capsulotomy,in-the-bag IOL implantation and with at least 6mo *** and postoperative best corrected visual acuity(BCVA),intraocular pressure(IOP),complications,and postoperative IOL tilt and decentration were ***:Nine eyes of 7 patients with a mean followup of 11.0±3.7mo were included in this *** BCVA was significantly improved from 0.64±0.22 logmaR preoperatively to 0.21±0.19 logmaR postoperatively(Pmal range *** mean tilt of the IOL was 4.30°±2.31°(range,1.0°to 8.9°)and the mean decentration of the IOL was 0.37±0.12 mm(range,0.14 to 0.50 mm).No visually threatened intraoperative and postoperative complications were detected during the follow-up ***:This is a safe and effective surgical technique for managing patients with severely subluxated *** has achieved favorable outcomes with fewer surgical manipulations and less need for advanced capsular support devices.

关键词： lens subluxation surgical technique capsular tension ring transcapsular scleral fixation in-thebag IOL implantation

Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1154-1167页

作者： Cuidan Li Xiaoyuan Jiang Tingting Yang yingjiao Ju Zhe Yin Liya Yue Guannan ma Xuebing Wang ying Jing Xinhua Luo Shuangshuang Li Xue Yang Fei Chen Dongsheng Zhou CAS Key Laboratory of Genome Sciences&Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830011China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still *** conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read *** results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant *** analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP ***,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring ***,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 ***,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after *** then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP ***,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations.

关键词： Klebsiella pneumoniae Drug resistance Carbapenemase Plasmid Genomic epidemiology

Surgical management of patients with bowel obstructions secondary to gastric cancer

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World Journal of Gastroenterology 2013年第28期19卷 4559-4567页

作者： Wen-Guang Wu Ping Dong Xiang-Song Wu mao-Lan Li Qi-Chen Ding Lin Zhang Jia-Hua Yang Hao Weng Qian Ding Zhu-jun Tan Jian-Hua Lu jun Gu ying-Bin Liu Laboratory of General Surgery Department of General Surgery Xinhua Hospital Affiliated to School of Medicine Shanghai Jiaotong University

AIM: To assess whole-body fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the management of small bowel obstructions (SBOs) secondary to gastric cancer and its role in treatment strategies. METHODS: The medical records of all of the patients who were admitted for an intestinal obstruction after curative resection for gastric cancer were retrospectively reviewed. PET/CT was performed before a clinical treatment strategy was established for each patient. The patients were divided into 2 groups: patients with no evidence of a tumor recurrence and patients with evidence of a tumor recurrence. Tumor recurrences included a local recurrence, peritoneal carcinomatosis or distant metastases. The primary endpoint was the 1-year survival rate, and other variables included patient demographics, the length of hospital stay, complications, and mortality. RESULTS: The median time between a diagnosis of gastric cancer and the detection of a SBO was 1.4 years. Overall, 31 of 65 patients (47.7%) had evidence of a tumor recurrence on the PET/CT scan, which was the only factor that was associated with poor survival. Open and close surgery was the main type of surgical procedure reported for the patients with tumor recurrences. R0 resections were performed in 2 patients, including 1 who underwent combined adjacent organ resection. In the group with no evidence of a tumor recurrence on PET/CT, bowel resections were performed in 7 patients, adhesiolysis was performed in 7 patients, and a bypass was performed in 1 patient. The 1-year survival curves according to PET/CT evidence of a tumor recurrence vs no PET/CT evidence of a tumor recurrence were significantly different, and the 1-year survival rates were 8.8% vs 93.5%, respectively. There were no significant differences (P = 0.71) in the 1-year survival rates based on surgical vs nonsurgical management (0% with nonoperative treatment vs 20% after exploratory laparotomy). CONCLUSION: 18 F-FDG PET/CT c

关键词： Positron emission tomography/computed tomography Small bowel obstructions Gastric cancer Clinical treatment strategy

激光波长对纳米光纤俘获和输送聚苯乙烯微球的影响

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物理学报 2014年第4期63卷 395-399页

作者：李英胡艳军广东医学院信息工程学院东莞523808

研究激光波长对纳米光纤俘获和输送聚苯乙烯微球能力的影响.理论分析结果表明,当光纤直径和激光功率一定时,随着激光波长的增大,光纤外面倏逝波的分布范围和强度都变大,微球所受到的光梯度力和散射力也随之增大,这意味着纳米光纤俘获和... 详细信息

研究激光波长对纳米光纤俘获和输送聚苯乙烯微球能力的影响.理论分析结果表明,当光纤直径和激光功率一定时,随着激光波长的增大,光纤外面倏逝波的分布范围和强度都变大,微球所受到的光梯度力和散射力也随之增大,这意味着纳米光纤俘获和输送微球的能力随着激光波长的增大而增强.实验现象和理论预测完全符合.将三种波长的激光分别导入直径为600 nm的光纤中,通过实验观察发现,随着激光波长的增大,俘获微球所需要的临界功率变小,意味着光纤俘获微球的能力增强;而当激光功率一定时,随着激光波长的增大,微球的运动速度也增大,说明光纤输送微球的能力增强.

关键词：激光波长纳米光纤倏逝波俘获和输送

Demonstration of safety characteristics and effects on gut microbiota of Lactobacillus gasseri HMV18

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Food Science and Human Wellness 2024年第2期13卷 611-620页

作者： Xianxian Jia Miaomiao Jia Xiang Gao Xiang Li Mengyuan Wang Shengqiang Du Rui Huang Xiaotong Li jun Zhang Shujin Li Chunling ma Yan Zhang Bin Cong Department of Pathogen Biology Institute of basic MedicineHebei Medical UniversityShijiazhuang 050017China Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology Chinese Academy of Medical SciencesShijiazhuang 050017China Institute of Basic Medicine Hebei Medical UniversityShijiazhuang 050017China College of Forensic Medicine Hebei Key Laboratory of Forensic MedicineCollaborative Innovation Center of Forensic Medical Molecular IdentificationHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050227China

Human normal flora is a source of *** safety characteristics of a specific isolate determine its application in foods or *** food-borne-pathogen antagonist strain Lactobacillus gasseri HMV18 is one of the isolates from normal human *** this work,we assessed the in vitro pH tolerance,bile tolerance,biogenic amine production,mucin utilization,and safety of in vivo administration to mice to evaluate general health,organ-body weight index,organ histopathological change,whether *** HMV18 can colonize in the gut or modulate the gut microbiota after oral *** results suggest that *** HMV18 can tolerate pH 3 for 2 h,3%bile for 3 h,biogenic amine negative,mucin usage negative,does not encode verified toxins,and cause no visible change in mice's *** HMV18 might not colonize in mice's gut,but can significantly affect the structure of gut microbiota.A bibliographical survey suggested that there were as few as 8 opportunistic infection cases from 1984 to 2022 and that the possibility for *** to cause infection is relatively ***,this work provides a basis for the foods or drugs application of *** HMV18 and gives a map of experiments for the safety assessment of probiotics.

关键词： Probiotics Lactobacillus gasseri Safety assessment Gut microbiota

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A NEW TRITERPENE SAPONIN FROM THE STEMS AND LEAVES OF PANAX GINSENG

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Chinese Chemical Letters 1992年第11期3卷 887-888页

作者： Yu Qing ZHAO Li jun WU Chang Lu YUAN Xian LI ying Jie CHEN Department of Traditional Chinese materia Medica Liaoning College of Traditional Chinese MedicineShenyang 110032 Shenyang College of Pharmacy Shenyang 110015

a new triterpene compound was isolated from the stems and leaves of Panax ginseng C. A. Meyer and established as 3β, 6α, 12β-trihydroxy-dammar-20(21), 24-diene-6-0-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside o... 详细信息

关键词： Chen In A NEW TRITERPENE SAPONIN FROM THE STEMS AND LEAVES OF PANAX GINSENG

Improving job satisfaction of Chinese nurses: the positive effects of structural empowerment and psychological capital

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TMR Integrative Nursing 2018年第4期2卷 169-177页

作者： Xin Dan Qiao-Mei Zhang jun-Jie Shi Su-Huan Xu Jing-ying Liu Yan-Hui Liu Hong-Wen ma School of Nursing Tianjin University of Traditional Chinese Medicine Tianjin China Chief Superintendent nurse TianjinUnion Medical Center Tianjin China

Objectives:This study examined the influence of Chinese nurses’personal resources(psychological capital)and access to workplace resources(structural empowerment)on their job ***:A cross-sectional study was designed during the period of January to April *** anonymous questionnaire containing demographic characteristics sheet,Minnesota Satisfaction Questionnaire,Conditions for Work Effectiveness Questionnaire-II and psychological capital(PsyCap)was issued to 480 registered nurses in Tianjin,China.A total of 462 respondents became our *** regression was performed to explore the factors associated with job ***:The average Minnesota Satisfaction Questionnaire score was 65.68±12.35 in our study *** regression analysis showed that structural empowerment(β=0.421,P<0.01),PsyCap(β=0.227,P<0.01) and educational level(β=0.061,P<0.05) were positively associated with job ***:The job satisfaction of Chinese nurses was at a moderate *** empowerment was the most crucial predictor of job satisfaction,followed by ***,nursing administrators should take measures such as building an authorized work environment and improving nurses’PsyCap in order to promote job satisfaction among Chinese nurses.

关键词： Empowerment Job satisfaction Nursing Psychological capital

Endostatin promotes the anabolic program of rabbit chondrocyte

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Cell Research 2005年第3期15卷 201-206页

作者： Yi FENG,Yi Pin WU,Xu Dong ZHU,Yan Hong ZHANG,Qing jun ma* Department of Molecule Genetics,Beijing Institute of Biotechnology,27 Taiping Road,Beijing 100850,China Department of Molecule Genetics Beijing Institute of Biotechnology Beijing China

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism.

关键词： endostatin angiogenesis chondrocyte matrix metalloproteinase.

A new flavonoid from Selaginella tamariscina

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Chinese Chemical Letters 2009年第5期20卷 595-597页

作者： Jian Feng Liu Kang Ping Xu De Jian Jiang Fu Shuang Li Jian Shen ying jun Zhou Ping Sheng Xu Bin Tan Gui Shan Tan School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 China Xiangya Hospital of Central South University Changsha Hunan 410008 China Xiangnan University Chenzhou Itunan 423000 China

6-（2-Hydroxy-5-acetylphenyl）-apigenin （1）, a new flavonoid with a phenyl substituent, was first isolated from Selaginella tamariscina. Its structure was elucidated on the basis of 1D and 2D NMR as well as ESI-HR-M... 详细信息

关键词： Selaginella tamariscina Flavonoids 6-(2-Hydroxy-5-acetylphenyl)-apigenin

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基于运行线可调的动车组周转计划优化研究

中国铁道科学 2012年第4期33卷 112-119页

作者：王莹刘军苗建瑞北京交通大学交通运输学院北京100044

针对高速铁路动车组周转计划的优化问题,在列车运行图可作微调的前提下,用时间窗描述运行线的可行平移范围,构建接续网络,刻画运行线间的接续关系,考虑接续弧互斥约束和动车组交路平移累加约束,以可行动车组交路为决策变量建立求解问题... 详细信息

针对高速铁路动车组周转计划的优化问题,在列车运行图可作微调的前提下,用时间窗描述运行线的可行平移范围,构建接续网络,刻画运行线间的接续关系,考虑接续弧互斥约束和动车组交路平移累加约束,以可行动车组交路为决策变量建立求解问题的优化模型,并设计基于改进广义标号法的分枝定价算法求解。实例验证表明,通过对运行图进行微调,可以在一定程度上减少需要的动车组数量,从而达到动车组运用优化与运行图优化编制的相互协调。

关键词：动车组周转运用优化运行图调整时间窗分枝定价算法高速铁路