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Characterization of astrocytes and microglial cells in the hippocampal CA1 region after transient focal cerebral ischemia in rats treated with Ilexonin A

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Neural Regeneration Research 2020年第1期15卷 78-85页

作者： Ai-Ling Xu Guan-Yi Zheng hui-ying ye Xiao-Dong Chen Qiong Jiang Department of Traditional Chinese Medicine Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Department of Neonatology People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Neurology People’s Hospital of NanpingNanpingFujian ProvinceChina Burns Institute of Fujian Medical University Union Hospital FuzhouFujian ProvinceChina

Ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese *** A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ***,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain *** cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in *** A(20,40 or 80 mg/kg)was administered immediately after ischemia/*** astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot *** levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 *** were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/*** number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin *** cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin *** A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/*** results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory *** study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China.

关键词： astrocytes hippocampal CA1 region ilexonin A microglia middle cerebral artery occlusion neural stem cell neuroprotection transient focal cerebral ischemia

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Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 649-655页

作者： Yu-li QIAN ying-hui ye Chen-ming XU Fan JIN He-feng HUANG Department of Reproductive Endocrinology Women＇s Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Objective:To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment. Methods: In a study group, 117 consecutive IVF or intracytoplasmic sperm injection (ICSI) cycles with embryo transfer were carried out and 312 embryos were scored using a combined scoring system (CSS) of zygote and embryo morphology before transplantation. In a control group, a total of 420 IVF or ICSI cycles were carried out and 1176 embryos were scored using a cumulative embryo score (CES). The effects of the combined scoring system on the embryo implantation rate and pregnancy rate per cycle were analyzed. Results: Using the combined scoring system, the embryo implan-tation rate (27.6%) and the clinical pregnancy rate (48.7%) were significantly higher than those in the control group (20.8% and 38.6%, respectively). Also, the implantation rate of embryos scoring ≥70 (38.5%: 82 sacs/213 embryos) was significantly higher (P<0.001) than that of embryos scoring <70 (4%: 4 sacs/99 embryos). The pregnancy rate of patients with embryos scoring ≥70 using the combined scoring system (66.7%) was significantly higher (P<0.001) than that of patients with embryos scoring ≥20 using the cumulative embryo score (59.0%). Conclusion: The results suggest that selecting embryos with a high score (≥70) using the combined scoring system could increase the implantation rate and pregnancy rate, and that using a scoring system combining assessments of human zygotes and pre-implantation embryos might predict IVF outcomes more accurately than using a cumula-tive embryo score.

关键词： Embryo score Combined scoring system (CSS) Implantation In vitro fertilization (IVF) Pregnancy

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Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 1-10页

作者： Yue-hong LU1,2, hui-juan GAO1, Bai-jia LI1, ying-ming ZHENG1, ying-hui ye1, Yu-li QIAN1, Chen-ming XU1, He-feng HUANG1, Fan JIN1 (1Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, and Key Laboratory of Women’s Reproductive Health of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China) (2Department of Reproductive Health, Shaoxing Women and Children Hospital, Shaoxing 312000, China) Department of Reproductive Endocrinology Key Laboratory of Reproductive Genetics Ministry of Education and Key Laboratory of Women's Reproductive Health of Zhejiang Province Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. Group 6 was composed of 250 cycles using testicular or epididymal sperm, and Group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from Groups 1 to 6, and reached statistical difference in Groups 5 and 6 (P0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring mal-formation will require further study using a larger sample size.

关键词： Intracytoplasmic sperm injection (ICSI)i Sperm Sperm source Sperm parameters Malformation

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Evaluation of Human Sperm Function After Being Cryopreserved Within Zona Pellucida

Evaluation of Human Sperm Function After Being Cryopreserved...

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2008年全国生物化学与分子生物学学术大会

作者： ying-hui ye (Department of Reproductive Endocrinology,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou,310006)

Empty human zona pellucida has been suggested to be an ideal vehicle to cryopreserve a small number of *** high post-thaw sperm recovery rate was reported,the function of spermatozoa after being cryopreserved within z...

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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FGF2 bind to FGFR2 in trophectoderm cells is indispensable for expanded blastocyst formation and is activated via PKC-p38 signalling pathway

FGF2 bind to FGFR2 in trophectoderm cells is indispensable f...

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中国中西医结合学会生殖医学分会首届学术年会暨生殖医学专业委员会成立大会

作者： Jing Yang Yong-Chao Lu Xian-Hua Lin ying Yu ying-hui ye Liang Jin Dan Zhang Jian-Zhong Sheng He-Feng Huang International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine The Key Laboratory of Reproductive Genetics Ministry of Education(Zhejiang University) Department of Pathology and Pathophysiology School of MedicineZhejiang University

BACKGROUND:The fibroblast growth factors(FGFs) binding to fibroblast growth factor receptors(FGFRs) plays important roles in the formation of the inner cell mass(ICM) lineages in mouse embryo ***,its role in trophectoderm(TE) remains ***:In the present study,we investigated which and how FGFs/FGFRs in trophectoderm cells(TEs) acted in expanded blastocyst formation using embryo culture,quantitative real-time PCR,immunofluorescence labeling,confocal microscopy,embryo culture,siRNA transfection and ***:The FGF2/FGFR2 in TEs was required for expanded blastocyst ***2 or FGFR2 knockdown in blastocyst suppressed the expression and altered the distribution of E-cadherin,ZO-1,Na-K ATPase,epithelial Na channel(ENaC),aquaporin(AQP) 3 and AQP 9 in *** with protein kinase C(PKC) inhibitor,G66983,suppressed expanded blastocyst formation,p-p38 translocation and the above proteins ***,p38 MAPK inhibitor,SB202190,also blocked p-p38 translocation and the above proteins ***:The present results suggest that FGF2/FGFR2 may act in an autocrine fashion and activate downstream PKC/p38 pathway in TEs in expanded blastocyst formation.

关键词： fibroblast growth factor 2 fibroblast growth factor receptor 2 expanded blastocyst formation protein kinase C p38 MAPK

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu Xi Xu Tianyi Huang ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 381-381页

作者： Yue-hong LU hui-juan GAO Bai-jia LI ying-ming ZHENG ying-hui ye Yu-li QIAN Chen-ming XU He-feng HUANG Fan JIN

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. Group 6 was composed of 250 cycles using testicular or epididymal sperm, and Group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from Groups 1 to 6, and reached statistical difference in Groups 5 and 6 (P0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring malformation will require further study using a larger sample size.

关键词：胚胎植入显微注射精子低出生体重胞浆 ICSI 畸形率循环使用

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai Li-hui Cao Xu-Yong Chen Jia-Yu Wang Zi-ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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