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Empirical Likelihood-Based Subset Selection for Partially Linear Autoregressive Models

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Acta Mathematicae Applicatae Sinica 2013年第4期29卷 793-808页

作者： Yu HAN ying-hua jin Min CHEN College of Mathematics Jilin University College of Science Northeast Dianli University Academy of Mathematics and Systems Science Chinese Academy of Sciences

Based on the empirical likelihood method, the subset selection and hypothesis test for parameters in a partially linear autoregressive model are investigated. We show that the empirical log-likelihood ratio at the true parameters converges to the standard chi-square distribution. We then present the definitions of the empirical likelihood-based Bayes information criteria （EBIC） and Akaike information criteria （EAIC）. The results show that EBIC is consistent at selecting subset variables while EAIC is not. Simulation studies demonstrate that the proposed empirical likelihood confidence regions have better coverage probabilities than the least square method, while EBIC has a higher chance to select the true model than EAIC.

关键词： subset selection empirical likelihood partial linear autoregressive model

Euclidean distance harmonic method for establishing theoretical MAPK/Erk signaling pathway in treated breast cancer line MCF-7

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 80-84页

作者： ZHANG Hong-xin LU ying-hua ZHANG jin-ling School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Hierarchical clustering algorithms, such as Pearson＇s correlation, Euclidean distance, Euclidean distance harmonic, Spearman rank correlation, Kendall＇s tau, and City-block distance, were used to find the best way to establish theoretical MAPK/Erk signaling pathway on the basis of breast cancer line MCF-7 gene expressions. The algorithm constructs a hierarchy from top to bottom on the basis of a self-organizing tree. It dynamically finds the number of clusters at each level. It was found that only Euclidean distance harmonic is fit for the analysis of the cascade composed from a RAF1 （c-Raf）, a MKNK1, a MAPKK （MEK1/2） to MAPK （Erk） in breast cancer line MCF-7. The result is consistent with the biological experimental MAP/Erk signaling pathway, and the theoretical MAPK/Erk signaling pathway on breast cancer line MCF-7 is set up.

关键词： hierarchical clustering signaling pathway,Euclidean distance harmonic

Identification of natural compounds targeting Annexin A2 with an anti-cancer effect

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Protein & Cell 2018年第6期9卷 568-579页

作者： Yu-Shi Wang He Li Yang Li Hongyan Zhu ying-hua jin Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education College of Life Science Jilin University Changchun 130012 China

Annexin A2, a multifunctional tumor associated protein, promotes nuclear factor-kappa B （NF-κB） activation by interacting with NF-κB p50 subunit and facilitating its nuclear translocation. Here we demonstrated that two ginsenosides Rg5 （G-Rg5） and Rkl （G-Rkl）, with similar structure, directly bound to Annexin A2 by molecular docking and cellular thermal shift assay. Both Rg5 and Rkl inhibited the interaction between Annexin A2 and NF-κB p50 subunit, their translocation to nuclear and NF-κB activation. Inhibition of NF-κB by these two gin- senosides decreased the expression of inhibitor of apoptosis proteins （lAPs）, leading to caspase activation and apoptosis. Over expression of K302A Annexin A2, a mutant version of Annexin A2, which fails to interact with G-Rg5 and G-Rkl, effectively reduced the NF-κB inhibitory effect and apoptosis induced by G-Rg5 and G-Rkl. In addition, the knockdown of Annexin A2 largely enhanced NF-κB activation and apoptosis induced by the two molecules, indicating that the effects of G-Rg5 and G-Rkl on NF-κB were mainly mediated by Annexin A2. Taken together, this study for the first time demon- strated that G-Rg5 and G-Rkl inhibit tumor cell growth by targeting Annexin A2 and NF-κB pathway, and G-Rg5 and G-Rkl might be promising natural compounds for targeted cancer therapy.

关键词： Annexin A2 G-Rg5 G-Rkl HCC NF-κB

p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells

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Protein & Cell 2014年第3期5卷 224-234页

作者： Xiao-Xi Guo Yang Li Chao Sun Dan Jiang ying-Jia Lin Feng-Xie jin Seung-Ki Lee ying-hua jin Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education College of Life Science Jilin University Changchun 130012 China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650500 China College of Bio and Food Technology Dalian Polytechnic University Dalian 116034 China College of Pharmacy and the Research Institute for Pharmaceutical Science Seoul National University Seoul 157-742Republic of Korea

We have recently reported that Ginsenoside Rh2 （G- Rh2） induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. How- ever, the molecular mechanism of its death-inducing function remains unclear. Here we show that G-Rh2 stimulated the activation of both caspase-8 and cas- pase-9 simultaneously in HeLa cells. Under G-Rh2 treatment, membrane death receptors Fas and TNFR1 are remarkably upregulated. However, the induced expression of Fas but not TNFR1 was contributed to the apoptosis process, Moreover, significant increases in Fas expression and caspase-8 activity temporally coin- cided with an increase in p53 expression in p53-non- mutated HeLa and SK-HEP-1 cells upon G-Rh2 treat- ment. In contrast, Fas expression and caspase-8 activity remained constant with G-Rh2 treatment in p53-mutated SW480 and PC-3 cells. In addition, siRNA-mediated knockdown of p53 diminished G-Rh2-induced Fas expression and caspase-8 activation, These results indicated that G-Rh2-triggered extrinsic apoptosis relies on p53-mediated Fas over-expression. In the intrinsic apoptotic pathway, G-Rh2 induced strong and immedi- ate translocation of cytosolic BAK and BAX to the mitochondria, mitochondrial cytochrome c release, and subsequent caspase-9 activation both in HeLa and in SW480 ceils, p53-mediated Fas expression and sub- sequent downstream caspase-8 activation as well as p53-independent caspase-9 activation all contribute to the activation of the downstream effector caspase-3/-7, leading to tumor cell death. Taken together, we suggest that G-Rh2 induces cancer cell apoptosis in a multi-path manner and is therefore a promising candidate for anti- tumor drug development.

关键词： G-Rh2 Fas p53 apoptosis

Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis

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Protein & Cell 2011年第7期2卷 543-553页

作者： Xiao-Xi Guo Hanna Kim Yang Li Hyungshin Yim Seung Ki Lee ying-hua jin Key Laboratory for Molecular Enzymology&Engineering of the Ministry of Education Jilin UniversityChangchun 130012China Division of Pharmaceutical Biosciences Research Institute for Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 151-742Korea

Sequential activation of cyclin-dependent kinases(Cdks)controls mammalian cell *** we demonstrate that the upregulation of cyclin-dependent kinase 2(Cdk2)activity coincides with the loss of mitochondrial membrane potential(MMP)in paclitaxel-induced *** expression of the dominant negative Cdk2(Cdk2-dn)and a specific Cdk2 inhibitor,p21WAF1/CIP1,effectively suppresses the loss of MMP,the release of cytochrome c,and subsequent activation of caspase-3 in paclitaxel-treated *** forced activation of Cdk2 by overexpression of cyclin A dramatically promotes these *** further show that Cdk2 activation status does not interfere with a procedure that lies downstream of cytochrome c release induced by Bax *** findings suggest that Cdk2 kinase can regulate apoptosis at earlier stages than mitochondrial permeability transition and cytochrome c release.

关键词： apoptosis cyclin-dependent kinase 2 cytochrome c release mitochondrial membrane potential paclitaxel

Poly(imine-amide)Hybrid Covalent Adaptable Networks via in situ Oxidation Polymerization

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高分子科学:英文版 2023年第10期41卷 1577-1583页

作者： Hong-Xuan Chen Ze-Peng Lei Shao-Feng huang huan Jiang Kai Yu ying-hua jin Wei Zhang Department of Chemistry University of Colorado BoulderBoulderColorado80309USA RockyTech Ltd. BoulderColorado80309USA Department of Mechanical Engineering University of Colorado DenverDenverColorado80217USA

Polyimine represents a rapidly emerging class of readily accessible and affordable covalent adaptable networks(CANs)that have been extensively studied in the past few *** being highly malleable and recyclable,the pioneering polyimine materials are relatively soft and not suitable for certain applications that require high mechanical *** studies have demonstrated the possibility of significantly improving polyimine properties by varying its monomer building blocks,but such component variations are usually not straightforward and can be potentially challenging and ***,we report an in situ oxidation polymerization strategy for preparation of mechanically strong poly(imine-amide)(PIA)hybrid CANs from simple amine and aldehyde *** converting a portion of reversible imine bonds into high-strength amide linkages in situ,the obtained hybrid materials exhibit gradually improved Young’s modulus and ultimate tensile strength as the oxidation level ***,the PIAs remain reprocessable and can be depolymerized into small molecules and oligomers similar as *** work demonstrates the great potential of the in situ transformation strategy as a new approach for development of various mechanically tunable CANs from the same starting building blocks.

关键词： Covalent adaptable networks Polyimine Polyamide In situ oxidation polymerization

Alleviation of Al Toxicity in Barley by Addition of Calcium

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Agricultural Sciences in China 2006年第11期5卷 828-833页

作者： GUO Tian-rong CHEN ying ZHANG Yan-hua jin Ye-fei Life Science Campus Shaoxing Univeristy Shaoxing 312000 P.R.China

The potential mechanism by which Ca alleviates Al toxicity was investigated in barley seedlings. It was found that 100 Al-alone treatment inhibited barley plant growth and thereby reduced shoot height and root length, and dry weights of root, shoot and leaf; promoted Al accumulation but inhibited Ca absorption in plant tissues; and induced an increase in the activities of superoxide dismutase （SOD）, catalase （CAT）, and peroxidase （POD） and in the level of lipid peroxidation （MDA content） in leaves. Except for the increase in Ca concentration in plant tissues, treatment with 0.5 mM Ca in the absence of Al had less effect on the above-mentioned parameters, compared with the control. Addition of Ca efficiently reduced Al toxicity, which is reflected by the promotion of plant growth, reduction in Al concentration and MDA content, increase in Ca concentration and in SOD, POD, and CAT activities compared with the Al-alone-treatment; with increase in Ca level （3.0 raM）, the ameliorative effect became more dominant. This indicated that the alleviation of aluminum toxicity in barley seedlings with Ca supplementation could be associated with less absorption of Al and the enhancement of the protective ability of the cell because of increased activity of the antioxidative enzyme.

关键词： barley (Hordeum vulgare L.) aluminum toxicity calcium anti-oxidative enzyme

A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate

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Chinese Chemical Letters 2006年第1期17卷 9-11页

作者： Wei Ge ZHANG ying hua jin Ping QI Kai BAO jin Guang LIN Nai Li WANG Xin Shen YAO School of Pharmaceudcal Engineering Shenyang Pharmaceutical University Shenyang 110016 The Research Center of Traditional Chinese Medicines and Natural Products Research Institute of Tsinghua University Shenzhen 518057 Department of Pharmacy General Hospital of Beijing Military Command Beijing 100003

Reaction of 12-membered macrolide 1 with lead tetraacetate in dichloromethane afforded an unexpected, novel oxidative N-demethyl product 3.

关键词： Oxidative N-demethylation 12-membered macrolide lead tetraacetate.

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2024年第4期21卷 421-430页

作者： jing TAN jin SI Ke-Ling XIAO ying-hua ZHANG Qi hua jing LI Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are *** We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(< 170 mg/L) and those with the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% CI: 0.651–0.754, P< 0.001;sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction