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Near-infrared light(NIR)-responsive nanoliposomes combining photodynamic therapy and chemotherapy for breast tumor control

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Chinese Chemical Letters 2022年第4期33卷 1923-1926页

作者： Guangzhao Lu Xiqing Gao he Zhang Yeye Zhang Yuan Yu Zhiguo Sun Wei Li Wei Wu ying Lu hao Zou Department of Pharmaceutical Sciences School of PharmacyNaval Medical UniversityShanghai 200433China Department of Pharmacy Zhongshan HospitalFudan UniversityShanghai 200032China Laboratory of Nano Biomedicine&International Joint Cancer Institute Naval Medical UniversityShanghai 200433China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 200032China

Light-responsive carriers have been used for the controlled release of antitumor drugs in recent ***, most light-responsive vectors require high-energy ultraviolet or visible light to achieve local drug release, and ultraviolet light would cause cellular damage. Near-infrared light has a deeper tissuepenetration depths and minimal harm to tissues, but it is difficult to cleave the chemical bond *** aim of this study is to develop a novel near-infrared light-responsive carrier for local release of antitumor drugs. Unsaturated phospholipids can be oxidized by singlet oxygen to achieve liposomal drug release, and singlet oxygen can be produced by photosensitizer under light irradiation. A new near-infrared light-responsive nanoliposome was designed that imparts light-triggered local drug release. Nanoliposomes, which were composed of matrix phospholipids and unsaturated phospholipids, were prepared by ammonium sulfate gradient method, and loaded with antitumor drug doxorubicin(DOX) and photosensitizer 1,4,8,11,15,18,22,25-octabutoxypalladium phthalocyanine. Under near-infrared light, photosensitizers could produce singlet oxygen and damage tumor cells by photodynamic therapy. Simultaneously, the unsaturated phospholipids were oxidized by singlet oxygen and result in DOX release, causing sustained cell damage by chemotherapy. Near-infrared light-responsive nanoliposomes exhibit enhanced anticancer activity owing to combined treatment of photodynamic therapy and chemotherapy. A new platform is thus offered for designing effective intracellular drug-release systems, holding great promise for future cancer therapy.

关键词： Near-infrared light Unsaturated phospholipids Nanoliposomes Photosensitizer Singlet oxygen

Prostate cancer risk prediction models in Eastern Asian populations:current status,racial difference,and future directions

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Asian Journal of Andrology 2020年第2期22卷 158-161页

作者： Bi-Ming he Rui Chen Tian-Qi Sun Yue Yang Chun-Lei Zhang Shan-Cheng Ren Xu Gao ying-hao Sun Department of Urology Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Prostate cancer(PCa)risk calculators(RCs)with prostate-specific antigen(PSA)and other risk factors can greatly improve the accurate prediction of potential risk of PCa compared to *** European Randomized Study of Screening for PCa Risk Calculator(ERSPC-RC)and the Prostate Cancer Prevention Trial Risk Calculator(PCPT-RC)are developed on the Western ***,the Western RCs showed limited diagnostic efficacy in the Eastern Asian population,mainly due to racial differences between the two *** aimed to review the application of Western RCs and Eastern Asian RCs in Eastern Asian cohorts and to identify the characteristics and efficacy of these RCs.

关键词： Asians nomogram prediction models prostate cancer risk prediction

The roles and mechanisms of SREBP1 in cancer development and drug response

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Genes & Diseases 2024年第4期11卷 258-269页

作者： ying he Shasha Qi Lu Chen Jinyu Zhu Linda Liang Xudong Chen hao Zhang Lvjia Zhuo Shujuan Zhao Shuiping Liu Tian Xie School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer Centre SingaporeSingapore 169610Singapore

Cancer occurrence and development are closely related to increased lipid produc-tion and glucose *** are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and *** regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid *** addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly ***,no review of sREBP1 in cancer biology has yet been ***,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ***-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.

关键词： Cancer Drug Lipid metabolism reprogramming Resistance SREBP1

Invasion biology of the cotton mealybug, Phenacoccus solenopsis Tinsley: Current knowledge and future directions

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Journal of Integrative Agriculture 2019年第4期18卷 758-770页

作者： TONG hao-jie AO Yan LI Zi-hao WANG ying JIANG Ming-xing Institute of Insect Sciences Zhejiang University

The cotton mealybug Phenacoccus solenopsis Tinsley(hemiptera: Pseudococcidae), which is native to North America, emerged as a major invasive insect pest of multiple crops in Asia at the beginning of the 21 st century. Considering the economic significance of this insect and its rapid worldwide spread, we examined the possible factors driving its invasions. In this paper, we summarize the life history traits of P. solenopsis conceivably related to population development in invaded regions; these traits include its use of diverse host plants, reproductive capacity and mode, adaptation to temperature, response to food shortage, and insecticidal resistance. Then, focusing on the multiple trophic interactions that may promote or hinder invasion, we review the mutualistic relationship of this mealybug with ants and predation and parasitism by natural enemies. Finally, we suggest topics for future research and provide our perspective on the biological invasions of this mealybug. We speculate that specific biological factors associated with this mealybug, particularly its wide host range, high reproductive potential, evolved changes in life history traits, and mutualism with ants have played important roles in its invasions, allowing this pest to become established and rapidly increase its population upon its introduction into new regions.

关键词： cotton mealybug biological invasion reproduction mutualism natural enemies adaptation

Multiple analyses indicate the specific association of NR1I3,C6 and TNN with low hip BMD risk

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Journal of Genetics and Genomics 2017年第6期44卷 327-330页

作者： ying-ying Han Lan-Juan Zhao Yong Lin hao he Qing Tian Wei Zhu Hui Shen Xiang-Ding Chen Hong-Wen Deng Center of System Biomedical Sciences University of Shanghai for Science and Technology Center for Bioinformatics and Genomics Department of Global Biostatistics and Data ScienceSchool of Public Health and Tropical MedicineTulane University Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education College of Life SciencesHunan Normal University

Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are

关键词： BMD ERE is in Multiple analyses indicate the specific association of NR1I3,C6 and TNN with low hip BMD risk of GWAS BRCA NR with

Manipulating metal-sulfur interactions for achieving high-performance S cathodes for room temperature Li/Na-sulfur batteries

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Carbon Energy 2021年第2期3卷 253-270页

作者： ying-ying Dai Chun-Mei Xu Xiao-hao Liu Xiang-Xi he Zhuo Yang Wei-Hong Lai Li Li Yun Qiao Shu-Lei Chou School of Environmental and Chemical Engineering Shanghai UniversityShanghaiChina Institute for Superconducting&Electronic Materials Innovation CampusUniversity of WollongongWollongongNew South WalesAustralia

Rechargeable lithium/sodium-sulfur batteries working at room temperature(RT-Li/S,RT-Na/S)appear to be a promising energy storage system in terms of high theoretical energy density,low cost,and abundant resources in *** are,thus,considered as highly attractive candidates for future application in energy storage ***,the solubility of sulfur species,sluggish kinetics of lithium/sodium sulfide compounds,and high reactivity of metallic anodes render these cells *** a consequence,metal-sulfur batteries present low reversible capacity and quick capacity loss,which hinder their practical *** to address these issues regarding S cathodes are critical to the increase of their performance and our fundamental understanding of RT-Li/S and RT-Na/S battery ***-sulfur interactions,recently,have attracted considerable attention,and there have been new insights on pathways to high‐performance RT-Li/Na sulfur batteries,due to the following factors:(1)deliberate construction of metal-sulfur interactions can enable a leap in capacity;(2)metal-sulfur interactions can confine S species,as well as sodium sulfide compounds,to stop shuttle effects;(3)traces of metal species can help to encapsulate a high loading mass of sulfur with high‐cost efficiency;and(4)metal components make electrodes more *** this review,we highlight the latest progress in sulfide immobilization via constructing metal bonding between various metals and S ***,we summarize the storage mechanisms of Li/Na as well as the metal-sulfur interaction ***,the current challenges and future remedies in terms of intact confinement and optimization of the electrochemical performance of RT-Li/Na sulfur systems are discussed in this review.

关键词： electrochemical mechanism metal-sulfur interactions room temperature Li/Na sulfur batteries S-confinement strategy

Isolation of Trichoderma reesei pyrG Negative Mutant by UV Mutagenesis and Its Application in Transformation

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Chemical Research in Chinese Universities 2008年第5期24卷 565-569页

作者： LONG hao WANG Tian-hong ZHANG ying-kuan State Key Laboratory of Microbial Technology Shandong University Jinan 250100 P. R. China

Two uridine auxotrophic mutants of Trichoderma reesei were isolated by resistance to 5-fluoroorotic acid after UV mutagenesis. One mutant, called M23, was complemented with the Aspergillus niger pyrG gene carried by plasmid pAB4-1. A mutated pyrG gene of M23 was cloned and DNA sequencing analysis indicated that a cytosine was inserted into the 934―939 oligo dC position of the pyrG coding region, resulted in a frameshift mutation. Transformation efficiency was approximately 200―300 transformants per microgram of DNA with plasmid pAB4-1. Stable transformants were obtained by monosporic culture and showed to be prototroph after successive propagation. Vitreoscilla hemoglobin expression plasmid pUCVHb was cotransformed with plasmid pAB4-1 and attained a transformation efficiency of 71.8% or of 26.1% with pAN7-1. Southern blot analysis of the transformants demonstrated that plasmid pUCVHb was integrated into the chromosomal DNA. The experimental results demonstrated that the pyrG-based system was more efficient and timesaving than the conventional hygromycin B resistance-based transformation system.

关键词： Trichoderma reesei UV mutagenesis pyrG negative strain pyrG-based transformation system

Prostate cancer research in China

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Asian Journal of Andrology 2013年第3期15卷 350-353页

作者： Shan-Cheng Ren Rui Chen ying-hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China

Prostate cancer （PCa） research in China has been on a rocketing trend in recent years. The first genome-wide association study （GWAS） in China identified two new PCa risk associated single nucleotide polymorphisms （SNPs）. Next generation sequencing is beginning to be used, yielding novel findings： gene fusions, long non-coding RNAs and other variations. Mechanisms of PCa progression have been illustrated while various diagnosis biomarkers have been investigated extensively. Personalized therapy based on genetic factors, nano-medicine and traditional Chinese medicine has been the focus of experimental therapeutic research for PCa. This review intends to shed light upon the recent progress in PCa research in China and points out the possible breakthroughs in the future.

关键词： prostate cancer (PCa) genome-wide association study (GWAS) single nucleotide polymorphisms (SNPs) China

Carboxylatopillarene-Modified Reduced Graphene Oxides with High Water Dispersibility for Fluorescent Dye Sensing

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Chinese Journal of Chemistry 2015年第1期33卷 125-130页

作者： Ting Zhou hao Yu Mingqiang Liu ying-Wei Yang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012China

Carboxylated pillar[5]arene(CP5)macrocycles were modified onto the surface of reduced graphene oxide(RGO)via covalent bonds to form new pillarene-functionalized RGO nanosheets,i.e.,*** obtained RGO-CP5 nanosheets capable of molecular recognition exhibited much better water-dispersibility and enhanced fluorescence-quenching property as compared with native *** new sensing platform holds great potentials in the sensing and detection of analytes,such as organic dye molecules and pesticides,in aqueous solutions.

关键词： dye molecule fluorescence quenching nanosheets pillarene reduced graphene oxide