检索结果-南通市图书馆

Multivariate time delay analysis based local KPCA fault prognosis approach for nonlinear processes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2016年第10期24卷 1413-1422页

作者： Yuan Xu ying Liu Qunxiong zhu College of Information Science and Technology Beijing University of Chemical Technology

Currently, some fault prognosis technology occasionally has relatively unsatisfied performance especially for in- cipient faults in nonlinear processes duo to their large time delay and complex internal connection. To overcome this deficiency, multivariate time delay analysis is incorporated into the high sensitive local kernel principal component analysis. In this approach, mutual information estimation and Bayesian information criterion （BIC） are separately used to acquire the correlation degree and time delay of the process variables. Moreover, in order to achieve prediction, time series prediction by back propagation （BP） network is applied whose input is multivar- iate correlated time series other than the original time series. Then the multivariate time delayed series and future values obtained by time series prediction are combined to construct the input of local kernel principal component analysis （LKPCA） model for incipient fault prognosis. The new method has been exemplified in a sim- ple nonlinear process and the complicated Tennessee Eastman （TE） benchmark process. The results indicate that the new method has suoerioritv in the fault prognosis sensitivity over other traditional fault prognosis methods.

关键词： Fault prognosis Time delay estimation Local kernel principal component analysis

Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

Arsenate and phosphate interaction in Saccharomyces cerevisiae

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2006年第1期18卷 96-100页

作者： GENG chun-nu zhu Yong-guan Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Shanghai Academy of Environmental Sciences Shanghai 200233 China

In the present study, arsenate（As（V）） and phosphate（P（V）） interactions were investigated in growth, uptake and RNA content in yeast（Saccharomyces cerevisiae）. Yeast grew slowly with As（V） concentrations increasing in the medium. However, the maximal population density was almost the same among different As（V） treatments. It was in the late log phase that yeast growth was aug- mented by low As（V）, which was maybe due to the fact that methionine metabolism was stressed by vitamin B6 deprivation, so As（V） treatments did not affect maximal population density. However, with P （V） concentrations increasing, the maximal population density increased. Therefore, the maximal population density was determined by P （V） concentrations in the medium but not by As （V） concentrations in the medium. Ycflp（a tonoplast transpor） transports As（GS）3 into the vacuole, but arsenic（As） remaining in the thalli was 1.27% with As（V） exposure for 60 h, from which it can be speculated that the percentage of As transported into vacuole should be lower than 1.27%. However, the percentage of As pumped out of cell was 71.49% with As （V） exposure for 68 h. Although two pathways （extrusion and sequestration） were involved in As detoxification in yeast, the extrusion pathway played a major role in As detoxification. RNA content was the highest in the early-log phase and was reduced by As（V）.

关键词： yeast maximal population density arsenic essentiality arsenic speciation

Synthesis of Ti_3AlC_2 by SHS and thermodynamic calculation based on first principles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2015年第2期34卷 107-110页

作者： chun-Cheng zhu Jia zhu Hua Wu Hong Lin College of Chemistry and Chemical Engineering Harbin Normal University

In this paper, a self-propagating high-temperature combustion synthesis with the pseudo-hot isostatic pressing process（SHS/PHIP） was employed to fabricate high-pure Ti_3AlC_2（φ 240 mm）. In addition, the first principle with quasi-harmonic approximation was applied for the thermodynamic properties＇ investigation of Ti_2AlC and Ti_3AlC_2, including Gibbs free energy, enthalpy, and *** temperature increasing, Gibbs free energy increases,but enthalpy and entropy decrease. The present work provides the theoretical proof for the synthesis mechanism of Ti_3AlC_2 by SHS/PHIP.

关键词： Ti_3AlC_2 Combustion synthesis Thermodynamics

卷曲螺旋结构域蛋白2通过促进线粒体自噬抑制帕金森病SH-SY5Y细胞凋亡

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第25期29卷 5403-5413页

作者：祝柳慧张歆悦朱洲海杨兴隆管莹刘彬昆明医科大学第一附属医院神经内科云南省昆明市650032 烟草与健康联合研究院云南省昆明市650106

背景:卷曲螺旋结构域蛋白2(coiled-coil-helix-coiled-coil-helix domain-containing 2,CHCHD2)能否调控PINK1/Parkin介导的线粒体自噬在帕金森病中发挥神经保护作用尚未可知。目的:探讨CHCHD2在6-羟基多巴胺诱导的帕金森病细胞模型中对PINK1/Parkin信号通路介导的线粒体自噬发挥的作用及机制。方法:利用重组质粒转染技术过表达或敲低CHCHD2,用6-羟基多巴胺构建SH-SY5Y细胞帕金森病模型后分对照组、模型组、过表达阴性对照+6-羟基多巴胺组、敲低阴性对照+6-羟基多巴胺组、过表达CHCHD2+6-羟基多巴胺组和敲低CHCHD2+6-羟基多巴胺组。Western blot及RT-qPCR检测CHCHD2的表达;Western blot检测LC3Ⅰ/Ⅱ、p62、MFN1、COXⅣ、DRP1、PINK1、Parkin、TIM23、Bax、Bcl-2及cleavedcaspase3蛋白表达;CCK-8、JC-1和活性氧试剂盒检测细胞活性、线粒体膜电位和活性氧水平,单丹磺酰尸胺染色观察细胞自噬情况,透射电镜观察自噬溶酶体。结果与结论:①与对照组相比,模型组细胞活性、线粒体膜电位及CHCHD2、PINK1、Parkin蛋白表达降低,活性氧水平、凋亡水平及LC3Ⅰ/Ⅱ、p62蛋白表达升高(P<0.05),并观察到自噬溶酶体的存在;②与模型组相比,过表达CHCHD2能降低细胞活性氧水平,升高线粒体膜电位及PINK1、Parkin和MFN1蛋白表达水平,并观察到线粒体自噬溶酶体增多,而敲低CHCHD2后有与上述相反的作用,并伴有COXⅣ、TIM23和p-DRP1蛋白表达的升高(P<0.05);③与模型组相比,过表达CHCHD2能减少细胞凋亡,上调Bcl-2并下调Bax及cleavedcaspase3蛋白的表达,而敲低CHCHD2后有与上述相反的作用(P<0.05);④结果提示,CHCHD2在6-羟基多巴胺诱导的帕金森病细胞模型中可以通过促进PINK1/Parkin介导的线粒体自噬改善线粒体功能从而减轻细胞凋亡发挥神经保护作用。

关键词：帕金森病卷曲螺旋结构域蛋白2 PINK1 Parkin 线粒体自噬线粒体功能细胞凋亡 6-羟基多巴胺 SH-SY5Y细胞

Algebra-Geometry of Piecewise Algebraic Varieties

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2012年第10期28卷 1973-1980页

作者： chun Gang zhu Ren Hong WANG School of Mathematical Sciences Dalian University of Technology

Algebraic variety is the most important subject in classical algebraic geometry. As the zero set of multivariate splines, the piecewise algebraic variety is a kind generalization of the classical algebraic variety. This paper studies the correspondence between spline ideals and piecewise algebraic varieties based on the knowledge of algebraic geometry and multivariate splines.

关键词： Piecewise algebraic varieties multivariate splines partitions algebraic geometry

A NON-LINEAR MODEL FOR ESTIMATING THE COST OF ACHIEVING EMISSION REDUCTION TARGETS:THE CASE OF THE U.S.,CHINA AND INDIA

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2012年第3期21卷 297-315页

作者： Lei zhu Xiao-Bing ZHANG ying FAN Center for Energy & Environmental Policy Research Institute of Policy and Management Chinese Academy of Sciences Beijing 100190 China Department of Economics University of Gothenburg SE 40530 G teborg Sweden

With the world talking about climate change, the United States （U.S.）, China and India have announced their carbon emission reduction targets. For these three countries to achieve their targets, significant questions arise, shch as what will be the annual emission reduction efforts to achieve those targets, how much it would cost and what would be the economic effects. This paper puts the carbon intensity reduction targets of China and India together with the absolute emission reduction target of the U.S. into the same non-linear model to quantitatively study the optimal emission control strategies and associated total cost for achieving those targets by the year 2020, and estimate and compare the minimized total costs of the three countries to reach their targets. Our results show that the total cost for the U.S. to achieve its emission reduction target is greater than those of China and India in terms of absolute amount. However, in terms of proportion of total cost to GDP, China and India＇s ratios are significantly greater than that of the U.S., indicating that for the developing countries such as China and India, the achievement of emission reduction targets needs relatively greater effort.

关键词： Emission reduction cost analysis emission reduction strategy optimization model

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang zhu Chen Heng Xiao Hai-Yang Hu Xing-Yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2023年第8期29卷 750-760页

作者： SUN Hao-xian zhu ying Department of Gastroenterology the First Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410007)China Hunan University of Chinese Medicine Changsha(410208)China

Ulcerative colitis(UC)is a chronic,non-specific intestinal disease that not only affects the quality of life of patients and their families but also increases the risk of colorectal *** nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome is an important component of inflammatory response system,and its activation induces an inflammatory cascade response that is involved in the development and progression of UC by releasing inflammatory cytokines,damaging intestinal epithelial cells,and disrupting the intestinal mucosal *** medicine(CM)plays a vital role in the prevention and treatment of UC and is able to regulate NLRP3 *** experimental studies on the regulation of NLRP3 inflammasome mediated by CM have been carried out,demonstrating that CM formulae with main effects of clearing heat,detoxifying toxicity,drying dampness,and activating blood *** and phenylpropanoids can effectively regulate NLRP3 *** active components of CM can interfere with the process of NLRP3 inflammasome assembly and activation,leading to a reduction in inflammation and UC ***,the reports are relatively scattered and lack systematic *** paper reviews the latest findings regarding the NLRP3 inflammasome activation-related pathways associated with UC and the potential of CM in treating UC through modulation of NLRP3 *** purpose of this review is to explore the possible pathological mechanisms of UC and suggest new directions for development of therapeutic tools.

关键词： NLRP3 inflammasome ulcerative colitis Chinese medicine mechanism of action review