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World Journal of Clinical Cases 2021年第30期9卷 9038-9049页

作者： ying-chun zhu Yan-Xin Sun Xiao-Yue Shen Yue Jiang Jing-Yu Liu Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

BACKGROUND Treatment of thin endometrium with granular leukocyte-colony stimulating factor(G-CSF)remains *** To investigate the effect of G-CSF on the outcome of frozen embryo transfer in patients with thin *** A retrospective propensity score matching(PSM)study was performed to assess patients administered frozen embryo transfer at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School,in *** patients were divided into G-CSF intrauterine perfusion(G-CSF)and non-G-CSF groups,and clinical pregnancy,implantation,ectopic pregnancy,and early abortion rates between the two groups were *** Before PSM,372 cycles were enrolled,including 242 and 130 cycles in the G-CSF and non-G-CSF groups,***(34.23±5.76 vs 32.99±5.59 years;P=0.047)and the blastula/cleavage stage embryo ratio(0.68 vs 0.37;P=0.011)were significantly elevated in the G-CSF group compared with the non-G-CSF group;however,clinical pregnancy(46.28%vs 51.54%;P=0.371)and embryo implantation(35.21%vs 35.65%;P=0.910)rates were similar in both *** PSM by age and blastula/cleavage stage embryo ratio,244 cycles were included(122 cases each in the G-CSF and non-G-CSF groups).The clinical pregnancy(50.82%vs 48.36%;P=0.701)and embryo implantation(37.38%vs 34.11%;P=0.480)remained similar in both *** Intrauterine infusion of G-CSF does not improve the clinical outcome of frozen embryo transfer in patients with thin endometrium.

关键词： Thin endometrium Granular leukocyte-colony stimulating factor Intrauterine perfusion Frozen embryo transfer

基于模糊自适应PID控制的六旋翼飞行器稳定性控制（英文）

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机床与液压 2016年第24期44卷 39-46页

作者：朱瑛邹春喜赵建村沈阳航空航天大学机电工程学院沈阳110136

介绍了六旋翼飞行器的运动方式,根据牛顿-欧拉方程完成动力学模型的建立。依据模糊控制的相关理论以及模糊自整定PID控制器的设计过程,完成了基于模糊自适应PID算法的控制器的设计。通过对自适应模糊PID控制器进行Matlab/Simulink下的... 详细信息

介绍了六旋翼飞行器的运动方式,根据牛顿-欧拉方程完成动力学模型的建立。依据模糊控制的相关理论以及模糊自整定PID控制器的设计过程,完成了基于模糊自适应PID算法的控制器的设计。通过对自适应模糊PID控制器进行Matlab/Simulink下的系统仿真分析,得出所设计的控制器能够较好的完成悬停任务,实现对飞行器的稳定性控制。通过试验验证了六旋翼飞行器的控制稳定性。

关键词：六旋翼飞行器牛顿-欧拉方程模糊自适应PID控制

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： chun zhu Yifei Yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

血塞通、蝮蛇抗栓酶、降纤酶、尿激酶治疗脑梗死疗效比较

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中国新药与临床杂志 2003年第6期22卷 334-336页

作者：王春英朱虹孙淑芹泰安市中心医院山东泰安271000

目的 :比较血塞通、蝮蛇抗栓酶、降纤酶、尿激酶 4种药物治疗脑梗死的疗效。方法 :将 98例脑梗死病人 ,分为 4组。血塞通组 2 4例 ,男性 18例 ,女性 6例 ,年龄 (5 4±s 10 )a ,用血塞通 2 0 0～ 4 0 0mg ,iv ,gtt,qd× 15d ;蝮蛇抗栓酶... 详细信息

目的 :比较血塞通、蝮蛇抗栓酶、降纤酶、尿激酶 4种药物治疗脑梗死的疗效。方法 :将 98例脑梗死病人 ,分为 4组。血塞通组 2 4例 ,男性 18例 ,女性 6例 ,年龄 (5 4±s 10 )a ,用血塞通 2 0 0～ 4 0 0mg ,iv ,gtt,qd× 15d ;蝮蛇抗栓酶组 2 6例 ,男性 2 0例 ,女性 6例 ,年龄 (5 5± 10 )a ,用蝮蛇抗栓酶 2～ 3U ,iv ,gtt ,qd× 2 1d ;降纤酶组 30例 ,男性 2 2例 ,女性 8例 ,年龄 (5 2± 10 )a ,用降纤酶 10U ,iv ,gtt ,qd× 3d ,d 4降纤酶 5U ,iv ,gtt ,qd× 3～ 4d ;尿激酶组18例 ,男性 13例 ,女性 5例 ,年龄 (5 4± 10 )a ,给尿激酶首剂 10 0万U ,iv ,30min后用尿激酶 2 5～ 5 0万U ,iv ,gtt ,1h滴完 ,d 2用尿激酶 10 0万U ,iv ,gtt ,qd× 10d。结果 :治疗 1个疗程后 ,血塞通、蝮蛇抗栓酶、降纤酶、尿激酶 4组有效率分别为 92 % ,92% ,96 % ,94 % ,经F检验 ,差别无显著意义 (P >0 .0 5 )。结论

关键词：脑梗死溶栓药物血塞通蝮蛇抗栓酶降纤酶尿激酶疗效

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深层搅拌法在公路引桥软基加固中的应用

施工技术 2004年第1期33卷 55-56页

作者：庄迎春朱明双浙江大学浙江杭州310027

引桥是在建造大桥正桥的两端或立体交叉引道上,为避免高填土路堤所采用的一种结构.由于其建造位置的特殊性,下部的路基往往满足软土的特点.实践证明,引桥软基的处理不好将产生'跳桥'现象,严重影响公路交通的运营.本文结合工程实际,介绍... 详细信息

引桥是在建造大桥正桥的两端或立体交叉引道上,为避免高填土路堤所采用的一种结构.由于其建造位置的特殊性,下部的路基往往满足软土的特点.实践证明,引桥软基的处理不好将产生'跳桥'现象,严重影响公路交通的运营.本文结合工程实际,介绍了深层搅拌法在引桥路基处理中的应用.

关键词：公路引桥软基加固深层搅拌法路基

乳腺X线与自动乳腺容积超声检查对病变检出效能的比较

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中国肿瘤临床 2017年第19期44卷 969-972页

作者：郝玉娟苏月颖朱鹰青春刘佩芳天津医科大学肿瘤医院乳腺影像诊断科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室天津市300060

目的:探讨乳腺X线(mammography)与自动乳腺容积超声(automated breast ultrasound system,ABUS)检查对病变的检出效能。方法:收集2016年7月至2016年9月142例天津医科大学肿瘤医院经术后病理证实的乳腺良恶性病变患者的临床资料,共149个... 详细信息

目的:探讨乳腺X线(mammography)与自动乳腺容积超声(automated breast ultrasound system,ABUS)检查对病变的检出效能。方法:收集2016年7月至2016年9月142例天津医科大学肿瘤医院经术后病理证实的乳腺良恶性病变患者的临床资料,共149个病变纳入研究,比较术前患者乳腺X线和ABUS检查对病变的检出率。结果:乳腺X线和ABUS检查对病变总检出率分别为87.2%(130/149)和98.0%(146/149),两者之间差异具有统计学意义(P0.05);乳腺X线和ABUS检查对良性病变的检出率分别为79.2%(38/48)和100.0%(48/48),两者之间差异具有统计学意义(P<0.05)。ABUS在致密型乳腺中的病变总检出率及乳腺癌、良性病变检出率分别为97.7%(126/129)及96.5%(82/85)、100.0%(44/44),乳腺X线检查分别为86.0%(111/129)及90.6%(77/85)、77.3%(34/44),差异均具有统计学意义(P<0.05)。乳腺X线检查漏诊的为乳腺致密组织和腺体深面的病变,ABUS检查漏诊的多为钙化型病变。结论:ABUS检查对病变总检出效能及致密型乳腺中的病变检出效能均高于乳腺X线检查,漏诊的病变以钙化为主要影像学表现,乳腺X线检查对钙化型病变的检出具有独特优势。乳腺X线与ABUS检查在乳腺癌筛查中具有一定的互补作用。

关键词：乳腺X线检查自动乳腺容积超声乳腺病变检出

Serum neuropeptide Y level in hypertensive patients with obstructive sleep apnea syndrome

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Serum neuropeptide Y level in hypertensive patients with obs...

第十三次全国心血管病学术会议

作者： YAO Xiao-guang,Li Nan-fang,WANG ying-chun,LI Tao,zhu Jia Hypertension Institute of Xinjiang,Hypertension Center of People’s Hospital Of Xinjiang Uygur Autonomous Region,Xinjiang 830001, China

Objective To explore the potential role of neuropeptide Y(NPY) in the pathphysiological process of hypertension caused by obstructive sleep apnea sydrome(OSAS).Methods The concentration of serum NPY were measured with radioimmunoassay in 417 subjects(97 cases of normotensive without OSAS,113 cases of normotensive with OSAS,73 cases of

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幽门螺杆菌感染与2型糖尿病并发症的关系

世界华人消化杂志 2016年第26期24卷 3799-3803页

作者：朱春英张英福马静静杨茜郭淑芹李志红保定市第一中心医院内分泌二科河北省保定市071000 保定市第一中心医院内镜室河北省保定市071000 保定市第一中心医院内分泌科河北省保定市071000

目的探讨幽门螺杆菌(Helicobacter pylori,***)感染与2型糖尿病并发症之间的关系,为防治并发症提供依据.方法于我科住院的131例2型糖尿病患者,均行胃黏膜组织切片染色确定***感染,分为***阳性组62例,***阴性组69例,通过血管彩超确定糖... 详细信息

目的探讨幽门螺杆菌(Helicobacter pylori,***)感染与2型糖尿病并发症之间的关系,为防治并发症提供依据.方法于我科住院的131例2型糖尿病患者,均行胃黏膜组织切片染色确定***感染,分为***阳性组62例,***阴性组69例,通过血管彩超确定糖尿病性血管病变、尿微量白蛋白(the urine trace albumin,ALB)及24 h尿蛋白定量确定糖尿病性肾病、依据眼科眼底检查确定糖尿病性视网膜病变以及肌电图或临床神经病变症状确定糖尿病性周围神经病变.观察***与糖尿病并发症的关系.结果***阳性组中糖尿病性血管病变、糖尿病性肾病、糖尿病性周围神经病变发病率依次为62.9%、27.4%、56.4%,与***阴性组比较差异有统计学意义(P<0.05).H.p y l o r i阳性组中A L B及24 h尿蛋白明显高于***阴性组,差异具有统计学意义(P<0.05).结论***与糖尿病性血管病变、糖尿病性肾病及糖尿病性周围神经病变关系密切,积极抗***治疗,辅助降低糖尿病并发症的发生、发展具有十分重要的意义.

关键词： 2型糖尿病并发症幽门螺杆菌

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui zhu Li Mu Xi Xu Tianyi Huang ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection