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Distributions and risk assessment of heavy metals in solid waste in lead-zinc mining areas and across the soil, water body, sediment and agricultural product ecosystem in their surrounding areas

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China Geology 2025年第1期8卷 92-106页

作者： Zhi-qiang Wu Hai-ying Li Liu-yan Lü Guo-jun Liang Ting-ting Wu Jiang-xia zhu No.117 Geological Team Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550023China Ecological Environment Monitoring Center of Guizhou Province Guiyang 550023China Guizhou Institute of Geological Survey Guiyang 550081China Environmental Engineering Assessment Center of Anshun City Anshun 561000China Environmental Emergency Center of Anshun City Anshun 561000China

To identify the root causes of heavy metal contamination in soils as well as prevent and control such contamination from its sources,this study explored the accumulation patterns and ecological risks of heavy metals like Cd and Pb in solid waste in mining areas and across the water body,sediment,soil and agricultural product ecosystem surrounding the mining *** on the residual solid waste samples in lead-zinc deposits in a certain area of Guizhou Province,along with samples of topsoils,irrigation water,river sediments,and crops from surrounding *** study analyzed the distributions of eight heavy metals,i.e.,Cd,As,Cr,Hg,Pb,Zn,Cu,and Ni,in the samples through field surveys and sample ***,this study assessed the contamination levels and ecological risks of heavy metals in soils,sediments,and agricultural products using methods such as the single-factor index,Nemerow composite index,and potential ecological risk *** results indicate that heavy metals in the solid waste samples all exhibited concentrations exceeding their risk screening values,with 60%greater than their risk intervention *** soils and sediments demonstrate slight and moderate comprehensive ecological risks of heavy *** single-factor potential ecological risks of heavy metals in both the soil and sediment samples decreased in the order of Hg,Cd,Pb,As,Cu,Zn,Cr,and Ni,suggesting the same sources of heavy metals in the soils and *** of the agricultural product samples exhibited over-limit concentrations of heavy metals dominated by Cd,Pb,Ni,and Cr,excluding Hg and *** agricultural product assessment using the Nemerow composite index reveals that 35%of the agricultural product samples reached the heavy metal contamination level,implying that the agricultural products from farmland around the solid waste dumps have been contaminated with heavy *** eight heavy metals in the soil,sediment,and agricultural product samples manifested hig

关键词： Lead-zinc mining area Solid waste Soil Water body Sediment Agricultural product Nemerow composite index Cd,Pb,Ni,Cr elements Heavy metal contamination Ecological risk assessment Coefficients of variation(CVs) Environmental restoration engineering

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运用PDCA提高烧结机产量

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冶金标准化与质量 2005年第5期43卷 57-59页

作者：翟文利孙盈竹河南安钢水冶钢铁公司河南安阳455133

主要介绍在提高烧结矿产量中,PDCA循环的具体应用。

关键词：质量改进 PDCA 烧结机高产

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KDM2A and KDM2B protect a subset of CpG islands from DNA methylation

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Journal of Genetics and Genomics 2025年第1期52卷 39-50页

作者： Yuan Liu ying Liu Yunji zhu Di Hu Hu Nie Yali Xie Rongrong Sun Jin He Honglian Zhang Falong Lu State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Biochemistry&Molecular Biology College of Natural ScienceMichigan State UniversityEast LansingMI 48824US State Key Laboratory of Animal Nutrition and Feeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

In the mammalian genome,most CpGs are ***,CpGs within the CpG islands(CGIs)are largely unmethylated,which are important for gene expression *** mechanism underlying the low methylation levels at CGIs remains largely ***2 proteins(KDM2A and KDM2B)are H3K36me2 demethylases known to bind specifically at ***,we report that depletion of each or both KDM2 proteins,or mutation of all their JmjC domains that harbor the H3K36me2 demethylation activity,leads to an increase in DNA methylation at selective *** Kdm2a/2b double knockout shows a stronger increase in DNA methylation compared with the single mutant of Kdm2a or Kdm2b,indicating that KDM2A and KDM2B redundantly regulate DNA methylation at *** addition,the increase of CGI DNA methylation upon mutations of KDM2 proteins is associated with the chromatin *** findings reveal that KDM2A and KDM2B function redundantly in regulating DNA methylation at a subset of CGIs in an H3K36me2 demethylation-dependent manner.

关键词： KDM2A KDM2B CpG island DNA methylation H3K36me2 Demethylation Embryonic stemcell

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Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： Zhong-Sheng Nong Hao-Fan Qian ying-Chun Chen Pu-Sheng Wang Liu-zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries:a propensity score matched analysis

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 409-414页

作者： Li-Li zhu Bing-Xue zhu Yue Han Yong-Yan Tang ying-ying Wen Xu-Hong Zhang Li-Yue Zhang Ri-Lei zhu Dong-Yu Guo Department of Ophthalmology First Affiliated Hospital of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology People’s Hospital of Haixi Autonomous Prefecture of Qinghai ProvinceDelingha 817000Qinghai ProvinceChina

AIM:To compare analysis of the impact of high altitude on corneal endothelial cells,and the prognosis in patients with cataract ***:Totally 265 plateau patients with cataract surgeries performed between January 2019 and July 2022(average altitude=3000 m),and 524 plain patients with cataract surgeries performed between January 2020 and July 2022 were *** propensity score matching(PSM)method was applied to match the basic information of patients in both regions on a 1:1 *** endothelial cell density(ECD),coefficient of variation(CV),hexagonal cell ratio(HEX),duration of surgery,and pre-and postoperative visual acuity(VA)were compared retrospectively,and correlation tests were ***:Totally 223 pairs have been matched *** HEX in the plateau group was higher than that in the plain group(61.95%±6.191%vs 44.91%±6.829%,P0.1).The pre-and postoperative VA of patients with cataract surgeries in the plateau group were lower(1.40±0.610 vs 0.71±0.514,P0.05),while the post-operative VA was significantly related to the pre-operative VA and the duration of surgery(P<0.05).CONCLUSION:The relative hypoxic environment of the plateau does not promote the apoptosis of corneal endothelial cells,but may lead to the compensatory increase of their *** plateau patients,no significant associations are found between the poor VA and the corneal endothelial functions early after cataract surgeries.

关键词： cataract surgery corneal endothelial cells hypoxia plateau propensity score matching

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao ying Peng Jianyong zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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脱离监护之侵权的认定及责任

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北京理工大学学报（社会科学版） 2025年第1期27卷 56-65页

作者：朱虎王滢中国人民大学民商事法律科学研究中心北京100872

将监护定位于职责或权利,监护关系的外部效力都具有绝对性,对其侵犯需适用《民法典》侵权责任编规则。侵权人包括令被监护人从监护状态中脱离的行为人,以及延续其脱离状态的收买人等在后行为人。即便其他行为也可能延续被监护人脱离监... 详细信息

将监护定位于职责或权利,监护关系的外部效力都具有绝对性,对其侵犯需适用《民法典》侵权责任编规则。侵权人包括令被监护人从监护状态中脱离的行为人,以及延续其脱离状态的收买人等在后行为人。即便其他行为也可能延续被监护人脱离监护的状态,这一假设原因也不减免在后行为人的损害赔偿责任。无过失的受托监护人并非侵权人。除监护人的身份利益之外,脱离监护关系同时有损被监护人的人格利益,因此被亲生父母出卖的子女可主张侵害人格权的损害赔偿。脱离监护型侵权的损害赔偿范围包括被监护人成年后持续产生的损害,损害赔偿请求权适用普通诉讼时效。精神损害赔偿请求权的主体不应限于父母和其他近亲属,非近亲属监护人等也可主张。

关键词：监护权脱离监护身份关系精神损害赔偿

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Viscous Flow Activation Energy and Short-Term Aging Resistance of SBS-Modified Asphalt Enhanced by PPA Oil-Grinding Activated MoS_(2)

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Fluid Dynamics & Materials Processing 2025年第2期21卷 387-404页

作者： shun Chen yingjie Wang Xingyang He ying Su yingyuan Pan Yimin Cao Wentian Wang Chao Yang Bo Jiang Shaolin Zhang School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China Building Waterproof Engineering and Technology Research Center of Hubei Province Hubei University of TechnologyWuhan430068China Key Laboratory of Intelligent Health Perception and Ecological Restoration of Rivers and Lakes Ministry of EducationHubei University of TechnologyWuhan430068China China Construction Third Bureau First Engineering Co. Ltd.China

Styrene-butadiene-styrene(SBS)modified asphalt(SA)has long found effective applications in road construction *** combined with fillers,SBS-modified asphalt has demonstrated promising resistance to fatigue cracking caused by temperature fluctuations and *** this study,molybdenum disulfide(MoS_(2))and polyphosphoric acid(PPA)were ground in naphthenic oil(NO)and subjected to mechanical activation to create PPAmodified MoS_(2),referred to as *** blending various ratios of OMS-PPA with SBS-modified asphalt,composite-modified asphalts were successfully developed to enhance their overall *** assess the mechanical characteristics and stability of these modified asphalts,various methods were employed,including penetration factor,flow activation energy,fluorescence microscopy,and dynamic shear ***,the short-term aging performance was evaluated using Fourier transform infrared(FTIR)spectroscopy and nanoindentation *** results revealed a 3.7%decrease in the penetration-temperature coefficient for SAOMS compared to SA,while 1-SA-OMS-PPA showed an even greater reduction of 7.1%.Furthermore,after short-term aging,carboxyl group generation in SA increased by 5.93%,while SA-OMS exhibited a smaller rise of 1.36%,and 1-SA-OMS-PPA saw an increase of just 0.93%.The study also highlighted significant improvements in the hardness of these *** hardness change ratio for SA-OMS decreased by 43.08%,while the ratio for 1-SA-OMS-PPA saw a notable reduction of 65.16% compared to unmodified *** findings suggest that OMS-PPA contributed to improvements in temperature sensitivity,particle dispersibility,and resistance to shortterm aging in *** results hold significant promise for the future development of advanced asphalt-based materials with potential high-value applications in flexible pavements for highways.

关键词： Composite-modified asphalt grinding viscous flow activation energy short-term aging collaborated

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边疆学的学科边界与理论自觉

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云南社会科学 2025年第1期 94-103页

作者：朱金春张颖四川大学国际关系学院

在边疆学学科建构的探讨中,学术界普遍强调跨学科与学科交叉的重要性。然而,强调跨学科交叉可能导致“跨学科悖论”,使得边疆学的学科建构有可能面临学科离散与学科殖民等困境,在“学科之间的边界交汇区”划定自身领地并确立边疆学的学... 详细信息

在边疆学学科建构的探讨中,学术界普遍强调跨学科与学科交叉的重要性。然而,强调跨学科交叉可能导致“跨学科悖论”,使得边疆学的学科建构有可能面临学科离散与学科殖民等困境,在“学科之间的边界交汇区”划定自身领地并确立边疆学的学科边界是应对这一困境的有效方式。但学科边界并非武断划定的,而是学科知识体系化与结构化的外在呈现,在根本上是由学科的理论“硬核”所决定的。因此应对边疆学的“硬核”展开探讨并实现理论创新,而这需要推动形成基于建立范畴体系的概念自觉、基于发展命题与原理的学术自觉,以及基于展开规范与批判的学科自觉,从而实现边疆学的有机建构。

关键词：边疆学学科建构学科边界概念自觉学术自觉学科自觉

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