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Redox-responsive diphenylalanine aggregate mediated by cyclodextrin

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Chinese Chemical Letters 2019年第1期30卷 120-122页

作者： Lu zhang ying-ming zhang Guoxing Liu Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University

The molecular assembling properties can be dramatically improved using redox-responsive nanoplatforms, which can bring quite different aggregation modes and binding behaviors in the redox states. In this work, we fabricated a redox-responsive system based on the host–guest complexation of b-cyclodextrin(b-CD) with ferrocene-modified diphenylalanine(Fc-FF). The morphological conversion of Fc-FF can be easily achieved from nanofibers to nanospheres in the presence of b-CD, and the supramolecular nanospheres can be reversibly assembled and disassembled by the chemical redox of ferrocenyl groups in the Fc-FF&b-CD nanoassemblies. These results demonstrate that the incorporation of stimuli-switchable components with macrocyclic receptors may become a promising approach to the construction of smart peptide-involved supramolecular assemblies.

关键词： Cyclodextrin Diphenylalanine Redox-responsiveness Morphological conversion Supramolecular assembly

Synergistic activation of photoswitchable supramolecular assembly based on sulfonated crown ether and dithienylethene derivative

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Chinese Chemical Letters 2022年第5期33卷 2447-2450页

作者： Conghui Wang ying-ming zhang Haoran Li Jin zhang Yu Zhou Guoxing Liu Xiufang Xu Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China College of Computer Science Nankai UniversityTianjin 300350China College of Sciences Henan Agricultural UniversityZhengzhou 450001China

Conformational regulation among two or more distant sites is not only one of the main pathways to accomplish multiple tasks in complex biological systems but also represents a powerful strategy to obtain stimuli-responsive supramolecular nanoconstructs with tailored physicochemical *** herein report the fabrication of a photochromic supramolecular assembly,which can be synergistically activated by the conformational regulation with bis(4,8-disulfonato-1,5-naphtho)-32-crown-8 and then reversibly switched by the through-space communication between restricted stilbazolium salt and photochromic *** work demonstrates that the synergistic conformational modulation via intra-and intermolecular interactions can be developed as a generalizable approach to construct more advanced biomimetic nanomaterials.

关键词： Supramolecular assembly Crown ether Photochromism Energy transfer Conformational regulation

Cucurbit[8]uril-mediated phosphorescent supramolecular foldamer for antibiotics sensing in water and cells

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Chinese Chemical Letters 2022年第2期33卷 851-854页

作者： De-Ao Xu Qing-Yang Zhou Xianyin Dai Xin-Kun Ma ying-ming zhang Xiufang Xu Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China

A phosphorescent supramolecular foldamer is conveniently constructed by the 1:1 host-guest complexation with cucurbit[8]uril and 1,2-diaminocyclohexane-bridged 4-(4-bromophenyl)-pyridinium salt. The tightly compact host-guest complexation in molecular foldamer can greatly suppress the fluorescence emissive channel and promote the intersystem crossing from singlet to triplet states, thus leading to the green phosphorescence at ambient temperature in aqueous solution. More intriguingly, the phosphorescence emission shows very rapid and sensitive responsiveness to different antibiotics in both inanimate milieu and living cells. Remarkably, the limit of detection of such binary inclusion complex toward sulfamethazine can reach as low as 1.86 × 10^(-7) mol/L. Thus, it is envisaged that this supramolecular nanoplatform featuring unique complexation-enhanced phosphorescence emission may hold great promise in sensing and detecting many other biological targets under physiological environment.

关键词： Supramolecular assembly Cucurbiturils Supramolecular foldamer Phosphorescence sensing Antibiotics detection

Optimization of Riboflavin Production from ccpA Mutant Bacillus subtilis 24A1/pMX45

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Transactions of Tianjin University 2006年第6期12卷 415-419页

作者：应明张帆班睿 School of Chemical Engineering and Technology Tianjin University

The nitrogen source requirements for riboflavin production by ccpA mutant Bacillus subtilis 24A1/pMX45 were optimized using linear regression. The optimal medium components considered included 8% glucose as carbon source, 2% yeast powder, 0.05% MgSO4 ·7H2O, and four types of nitrogen sources ： 0.1% yeast extract, 2% soybean powder, 1% corn plasm, and 0.2% （ NH4 ） 2 HPO4 in shake flask tests. Predictive ellipsoid was applied to determining the response values under the optimal levels for riboflavin production and glucose consumption. The optimal concentrations of the four types of nitrogen sources can remedy ammonium assimilative defection of ccpA mutant. Under the optimal conditions, the riboflavin yield increases to more than 5.0 g/L and 8%, glucose can be consumed completely after 60 h.

关键词： carbon catabolic repression ( CCR ) global regulator CcpA Bacillus subtilis orthogonal test linear regression

Reversing the Cytotoxicity of Bile Acids by Cyclodextrin-based Supramolecular Assembly

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Reversing the Cytotoxicity of Bile Acids by Cyclodextrin-bas...

The significance of tumor markers in pulmonary alveolar proteinosis

全国第十九届大环化学暨第十一届超分子化学学术讨论会

作者： ying-ming zhang Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)

＜正＞In this talk, our recent endeavors on the construction of some cyclodextrin-based bioactive supramolecular systems will be introduced, with the aim of reversing the cytotoxicity of bile acids by supramolecular *** biocompatible β-cyclodextrin derivatives possessing ammonium sites were synthesized, which showed enhanced binding affinity with bile acids,especially with the hepatotoxic deoxycholic and chenodeoxycholic *** assessments at cellular level and in animal mode jointly demonstrate that the inclusion complexation of bile acids can facilitate the clearance of bile acids, thus leading to the dramatic recovery of cell viability and liver ***, it is believed that the supramolecular complexation with modified cyclodextrins can be developed as a promising therapy in the treatment of bile acid-related diseases.

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The significance of tumor markers in pulmonary alveolar prot...

Biosorption Characteristics of Ectomycorrhizal Fungal Mycelium for Anthracene

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： shen cun fang ying ming zhang Nan jing chest hospital

Background the role of tumor markers in pulmonary alveolar proteinosis(PAP) remains *** study investigated the tumor markers in serum and bronchoalveolar lavage fluid(BALF) in PAP patients and explored the relationships between tumor markers and the severity of PAP. Methods and Results We retrospectively reviewed 38 patients with *** CEA and CYFRA levels were

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Biomedical and Environmental Sciences 2010年第5期23卷 378-383页

作者： YI HUANG,SHU-ying zhang,ming-JI LV,AND SHU-GUANG XIE College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China [a] College of Environmental Sciences Engineering Peking University Beijing 100871 China

Objective To investigate the potential of Gomphidius viscidus,a kind of ectomycorrhizal fungi,for phytoremediation of anthracene in *** Absorptioe changes of micro-habitat were studied in *** Ectomycorrhizal plants have a strong potential for remediation of polycyclic aromatic hydrocarn characteristics of both active and inactivated *** A high calculated adsorption capacity of 1 886.79 mg/g and 1 515.15 mg/g at 25 ℃,pH 6.0 for active and inactivated mycelia respectively,was obtained based on Langmuir *** ANT biosorption was more ideally characterized by the Langmuir model than by the Freundlich *** biosorption of anthracene to biomass was extremely fast and could be modeled with pseudo-second order adsorption ***,ectomycorrhizal mycelia demonstrated a strong ability to adjust the physiological process to get adapted to the change of micro-habitat.

关键词： Biosorption Phytoremediation Anthrocene Ectomycorrhizal fungi

飞机大部件调姿机构磨损预测模型的构建与仿真

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浙江大学学报（工学版） 2013年第2期47卷 209-215页

作者：应征章明王青柯映林浙江大学流体传动及控制国家重点实验室浙江杭州310027

针对飞机大部件调姿机构球铰磨损量预测问题,提出一种含间隙的球铰磨损模型.根据球铰的几何结构构建运动学模型;采用含迟滞阻尼系数的连续接触力模型与改进Coulomb摩擦力模型建立球铰的动力学模型;结合Archard方程建立球铰的磨损模型.... 详细信息

针对飞机大部件调姿机构球铰磨损量预测问题,提出一种含间隙的球铰磨损模型.根据球铰的几何结构构建运动学模型;采用含迟滞阻尼系数的连续接触力模型与改进Coulomb摩擦力模型建立球铰的动力学模型;结合Archard方程建立球铰的磨损模型.为了能够获得接触表面的磨损分布情况,将磨损表面离散,借助Hertz接触理论计算接触力的分布,并以离散后的单张曲面为单元分别计算与保存单张曲面磨损量.针对一种四定位器的调姿机构,模拟调姿过程进行仿真计算,结果显示:单个球头表面磨损分布并不均衡,4个球头之间的磨损分布情况类似,但是磨损量存在一定的差异.该磨损模型能够用于调姿机构寿命的预测,并对调姿机构的机械设计提供参考.

关键词：调姿机构球铰动力学建模磨损

磺酸化β-环糊精与吉西他滨药物分子键合及组装

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中国科学：化学 2016年第6期46卷 593-598页

作者：赵金张瀛溟刘育元素有机化学国家重点实验室南开大学化学系天津300071 天津化学化工协同创新中心天津300071

基于环糊精的主-客体键合及其组装行为是超分子化学领域的研究重点.本文利用核磁共振、圆二色光谱、分子模拟以及微量热滴定等方法探究了磺酸化?-环糊精(1)和吉西他滨(2)的键合模式、键合常数以及热力学参数.核磁等实验说明,吉西他滨客... 详细信息

基于环糊精的主-客体键合及其组装行为是超分子化学领域的研究重点.本文利用核磁共振、圆二色光谱、分子模拟以及微量热滴定等方法探究了磺酸化?-环糊精(1)和吉西他滨(2)的键合模式、键合常数以及热力学参数.核磁等实验说明,吉西他滨客体分子中的嘧啶碱基环从大口端进入到环糊精的空腔.微量热滴定数据表明该键合过程是焓驱动过程,并且伴随着不利的熵损失,说明键合过程的驱动力主要来自于疏水、氢键以及范德华相互作用.进而通过丁达尔、光散射以及电镜实验,表明环糊精与药物分子形成的包合物1·2能够有效诱导十六烷基三甲基溴化铵(CTAB)聚集形成球形纳米超分子组装体.该三元超分子组装体在设计和制备新型药物传输载体方面具有潜在的应用价值.

关键词：磺酸化环糊精吉西他滨包合物主客体相互作用超分子组装体