检索结果-南通市图书馆

CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis

International Journal of Ophthalmology(English edition) 2024年第4期17卷 616-624页

作者： Wen-Hao Shi Li-Mei Wang Hai-Jing Yan Shi-long Liu Xian Yang Xue-JiaoYang Cheng-ye Che Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Weifang Medical University Weifang 261053Shandong ProvinceChina Eye Hospital of Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Department of Medical Engineering the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus(***)keratitis in mice and the role of innate and adaptive immunity in ***:Mice models of *** keratitis were established by intra-stromal injection and corneal epithelial *** injections of natamycin,wedelolactone,LOX-1 inhibitor(poly I)or Dectin-1 inhibitor(laminarin)were used to treat mice with *** *** were pretreated by intraperitoneal injection of anti-mouse CD3ε.We observed the corneal infection of mice under the slit lamp microscope and made a clinical *** protein expression of CD3ε and interleukin-10(IL-10)was determined by Western ***:With the disease progresses,the degree of corneal opacity and edema *** the intrastromal injection models,CD3εprotein expression began to increase significantly on the 2^(nd) ***,in the scraping epithelial method models,CD3ε only began to increase on the 3^(rd) *** natamycin treatment,the degree of corneal inflammation in mice was significantly attenuated on the 3^(rd) *** wedelolactone treatment,the severity of keratitis *** the amount of CD3ε protein was also reduced,compared with the control *** inhibiting LOX-1 and Dectin-1,there was no significant difference in CD3ε production compared with the control *** inhibiting CD3ε,corneal ulcer area and clinical score increased,and IL-10 expression was ***:As a pan T cell marker,CD3ε participate in the adaptive immunity of *** keratitis in *** our mice models,the corneas will enter the adaptive immune stage *** regulating IL-10,CD3ε exerts antiinflammatory and repairs effects in the adaptive immune stage.

关键词： CD3ε adaptive immunity Aspergillus fumigatus keratitis interleukin-10

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sorely reducing emissions of non-methane short-lived climate forcers will worsen compound flood-heatwave extremes in the Northern Hemisphere

引用

Advances in Climate Change Research 2024年第4期15卷 737-750页

作者： ying-Fang LI Zhi-Li WANG Ya-Dong LEI Xiao-Chao YU Lin LIU Hui-Zheng CHE Xiao-ye ZHANG State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100190China

Non-methane short-lived climate forcer(SLCF)or near-term climate forcer(NTCF)emissions,as a significant driver of climate change,can be reduced to improve air *** reductions may contribute to additional warming of the climate system in the short term,thereby strongly affecting the likelihood of climate ***,there has been no quantitative assessment of the impact of non-methane SLCF mitigation on compound flood-heatwave extremes(CFHEs).This study quantitatively investigates the changes in future(2031-2050 versus 1995-2014)CFHEs and the resulting population exposure in the Northern Hemisphere(NH)due to non-methane SLCF *** used multi-model ensemble simulations under two future scenarios from the Aerosol and Chemistry Model Intercomparison Project(AerChemMIP)in the Coupled Model Intercomparison Project Phase 6(CMIP6).The two future scenarios share the same greenhouse gas(GHG)emissions but have weak(Shared Socioeconomic Pathway(SSP)3-7.0)versus strong(SSP3-7.0-lowNTCF)levels of air quality control *** results show that future non-methane SLCF reductions during 2031-2050 results in about a 7.3%±2.3%increase in grid exposure to CFHEs in the NH relative to the period *** frequency,intensity,and duration of CFHEs increase by varying *** the period 2031-2050,the frequency of CFHEs across the NH increases by 2.9±0.9 events per decade due to non-methane SLCF *** increases in CFHE frequency are more pronounced in East Asia,South Asia,Siberia,and northern and eastern North *** East and South Asia,the in-tensities of both heatwaves and floods corresponding to CFHEs increase markedly,where heatwave magnitude(HWM)increases by 0.3±0.2 K in East Asia and weighted average precipitation(WAP)increases by 18.3%±15.3%and 12.0%±4.5%in East Asia and South Asia,*** other regions,rising temperatures dominate the increase in *** regard to the duration of CFHEs,future reductions in non-methane SLC

关键词： Non-methane SLCFs CHFEs Cleaner air Population exposure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A wideband,high-resolution vector spectrum analyzer for integrated photonics

引用

Light(Science & Applications) 2024年第4期13卷 760-771页

作者： Yi-Han Luo Baoqi Shi Wei Sun Ruiyang Chen Sanli Huang Zhongkai Wang Jinbao long Chen Shen Zhichao ye Hairun Guo Junqiu Liu International Quantum Academy 518048 ShenzhenChina. Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology518055 ShenzhenChina. Department of Optics and Optical Engineering University of Science and Technology of China230026 HefeiChina. Hefei National Laboratory University of Science and Technology of China230088 HefeiChina. Qaleido Photonics 518048 ShenzhenChina. Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai University200444 ShanghaiChina

The analysis of optical spectra—emission or absorption—has been arguably the most powerful approach for discovering and understanding *** invention and development of many kinds of spectrometers have equipped us with versatile yet ultra-sensitive diagnostic tools for trace gas detection,isotope analysis,and resolving hyperfine structures of atoms and *** proliferating data and information,urgent and demanding requirements have been placed today on spectrum analysis with ever-increasing spectral bandwidth and frequency *** requirements are especially stringent for broadband laser sources that carry massive information and for dispersive devices used in information processing *** addition,spectrum analyzers are expected to probe the device’s phase response where extra information is *** we demonstrate a novel vector spectrum analyzer(VSA)that is capable of characterizing passive devices and active laser sources in one *** a dual-mode VSA can measure loss,phase response,and dispersion properties of passive *** also can coherently map a broadband laser spectrum into the RF *** VSA features a bandwidth of 55.1 THz(1260–1640 nm),a frequency resolution of 471 kHz,and a dynamic range of 56 ***,our fiber-based VSA is compact and *** requires neither high-speed modulators and photodetectors nor any active feedback ***,we employ our VSA for applications including characterization of integrated dispersive waveguides,mapping frequency comb spectra,and coherent light detection and ranging(LiDAR).Our VSA presents an innovative approach for device analysis and laser spectroscopy,and can play a critical role in future photonic systems and applications for sensing,communication,imaging,and quantum information processing.

关键词： spectrum resolution coherent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phanerozoic Tectonic Evolution,Metallogenesis and Formation of Mineral Systems in China

引用

Acta Geologica Sinica(English Edition) 2024年第4期98卷 819-842页

作者： CHEN Xuanhua HAN Lele DING Weicui XU Shenglin TONG ying ZHANG Yiping LI Bing ZHOU Qi WANG ye SinoProbe Laboratory Chinese Academy of Geological SciencesBeijing 100037China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The continental Asia is mainly composed of three major tectonic regimes,the Tethys,Paleo Asian Ocean,and West *** underwent multi-stage plate convergences,ocean-continent transformations,and subductions,collisions and/or collages,and post collisional(orogenic)extensions in *** evolution of the Asia brings up a unique fault system and tectonic geomorphological features in the China's ***,it provides a geodynamic background for the formation and evolution of metallogeneses and mineral systems,resulting in nonuniform distribution of tectono-metallogenic systems and metallogenic *** spatiotemporal distribution of mineral deposits in China and adjacent areas exhibits periodic variation under controlling of the full life Wilson cycle and tectonic evolution,forming the plate convergence-related mineral system in East *** Cu deposits are mainly related to compressional systems in Paleozoic and early Mesozoic,and more closely related to post-collision extensional settings in late Mesozoic and *** Au deposits mainly formed in post-orogeny extensional *** rock related rare earth element deposits formed mainly at margins of the North China and Yangtze ***-pegmatite Li and other rare metal deposits formed mainly in early Mesozoic,related to Indosinian post-orogeny ***-metallogenic systems provide important basis for the prospecting of mineral resources.

关键词： tectonic evolution geodynamic system post-orogenic extension metallogenesis tectono-metallogenic system East Asia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

引用

National Science Review 2024年第2期11卷 145-154页

作者： Farong ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng Tianlei ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Path-Dependent Progressive Failure Analysis for 3D-Printed Continuous Carbon Fibre Reinforced Composites

引用

Chinese Journal of Mechanical Engineering 2024年第4期37卷 84-93页

作者： Yuan Chen Lin ye School of System Design and Intelligent Manufacturing(SDIM) Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Intelligent Manufacturing for Continuous Carbon Fibre Reinforced Composites Southern University of Science and TechnologyShenzhen 518055China

In order to predict the damage behaviours of 3D-printed continuous carbon fibre(CCF)reinforced composites,when additional short carbon fibre(SCF)composite components are employed for continuous printing or special functionality,a novel path-dependent progressive failure(PDPF)numerical approach is ***,a progressive failure model using Hashin failure criteria with continuum damage mechanics to account for the damage initiation and evaluation of 3D-printed CCF reinforced polyamide(PA)composites is developed,based on actual fibre placement trajectories with physical measurements of 3D-printed CCF/PA ***,an elastic-plastic model is employed to predict the plastic damage behaviours of SCF/PA ***,the accuracy of the PDPF model was validated so as to study 3D-printed CCF/PA composites with either negative Poisson's ratio or high *** results demonstrate that the proposed PDPF model can achieve higher prediction accuracies in mechanical properties of these 3D-printed CCF/PA *** analyses show that the stress distribution is generally aggregated in the CCF areas along the fibre placement paths,and the shear damage and matrix tensile/compressive damage are the key damage *** study provides a new approach with valuable information for characterising complex 3D-printed continuous fibre-matrix composites with variable mechanical properties and multiple constituents.

关键词： 3D printing Continuous carbon fibre Modelling Energy absorption Negative Poisson's ratio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the role of transition metal single-atom electronic structure in oxysulfur radical-mediated oxidative degradation

引用

Environmental Science and Ecotechnology 2024年第4期20卷 247-258页

作者： Guanshu Zhao Jing Ding Jiayi Ren Qingliang Zhao Chengliang Mao Kun Wang Jessica ye Xueqi Chen Xianjie Wang Mingce long State Key Laboratory of Urban Water Resources and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Solar Fuels Group Department of ChemistryUniversity of Toronto80 St.George StreetTorontoOntarioM5S 3H6Canada School of Physics Harbin Institute of TechnologyHarbin150001China School of Environmental Science and Engineering Key Laboratory of Thin Film and Microfabrication Technology(Ministry of Education)Shanghai Jiao Tong University800 Dongchuan RoadShanghai200240China

The ubiquity of refractory organic matter in aquatic environments necessitates innovative removal *** radical-based advanced oxidation has emerged as an attractive solution,offering high selectivity,enduring efficacy,and anti-interference *** many technologies,sulfite activation,leveraging its cost-effectiveness and lower toxicity compared to conventional persulfates,stands ***,the activation process often relies on transition metals,suffering from low atom *** we introduce a series of single-atom catalysts(SACs)employing transition metals on g-C_(3)N_(4)substrates,effectively activating sulfite for acetaminophen *** highlight the superior performance of Fe/CN,which demonstrates a degradation rate constant significantly surpassing those of Ni/CN and Cu/*** investigation into the electronic and spin polarization characteristics of these catalysts reveals their critical role in catalytic efficiency,with oxysulfur radical-mediated reactions ***,under visible light,the catalytic activity is enhanced,attributed to an increased generation of oxysulfur radicals and a strengthened electron donation-back donation *** proximity of Fe/CN's d-band center to the Fermi level,alongside its high spin polarization,is shown to improve sulfite adsorption and reduce the HOMO-LUMO gap,thereby accelerating photo-assisted sulfite *** work advances the understanding of SACs in environmental applications and lays the groundwork for future water treatment technologies.

关键词： Single-atom catalysts(SACs) Oxysulfur radical Sulfite activation Spin polarization Electronic structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of electron “zebra stripes” in the South Atlantic Anomaly: Initial observations from Macao Science Satellite-1

引用

Science China Technological Sciences 2024年第11期67卷 3344-3353页

作者： LIU ying ZONG QiuGang ZOU Hong ye YuGuang SUN Yi Xin Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology

“Zebra stripes” denote banded structures characterized by periodic peaks and valleys in the spectrograms of energetic electrons in the Earth's inner radiation belt and slot region. In contrast to previous investigations primarily grounded in equatorial observations,this study presents two events exhibiting the evolution of electron zebra stripes within the South Atlantic Anomaly, as observed from the Macao Scientific Satellite-1 in low Earth orbit. Our findings affirm that the structural and evolutionary features of zebra stripes in both events accord with the drift echo hypothesis. The start time extrapolated from the electron spectrograms correlates with substorm onsets, consistent with prior conclusions. Notably, the duration of zebra stripe evolution during the event of June 5–6, 2023, reaches an impressive 34.7 h, a markedly longer interval than findings from the Van Allen Probes. This discrepancy suggests that the observed lifetime of electron zebra stripes may not inherently reflect natural limitations but could be constrained by instrumental capabilities. The results implicate that high-energy-resolution detectors have the potential to significantly enhance our capacity to scrutinize the dynamics of the radiation belt.

关键词： zebra stripe inner radiation belt energetic electron South Atlantic Anomaly Macao Science Satellite large-scale electric field

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Simultaneous control of ferromagnetism and ferroelasticity by oxygen octahedral backbone stretching

引用

Chinese Physics B 2024年第9期33卷 186-192页

作者： Genhao Liang Hui Cao long Cheng Junkun Zha Mingrui Bao Fei ye Hua Zhou Aidi Zhao Xiaofang Zhai Department of Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Materials Science Division Argonne National LaboratoryLemontIL 60439USA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontIL 60439USA

Coexistence of ferromagnetism and ferroelasticity in a single material is an intriguing phenomenon,but has been rarely *** we studied both the ferromagnetism and ferroelasticity in a group of LaCoO3 films with systematically tuned atomic *** found that all films exhibit ferroelastic domains with four-fold symmetry and the larger domain size(higher elasticity)is always accompanied by stronger *** performed synchrotron x-ray diffraction studies to investigate the backbone structure of the CoO6 octahedra,and found that both the ferromagnetism and the elasticity are simultaneously enhanced when the in-plane Co–O–Co bond angles are *** the study demonstrates the inextricable correlation between the ferromagnetism and ferroelasticity mediated through the octahedral backbone structure,which may open up new possibilities to develop multifunctional materials.

关键词： perovskite oxide film ferromagnetism ferroelasticity twin domain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PSRDP:A Parallel Processing Method for Pulsar Baseband Data

引用

Research in Astronomy and Astrophysics 2024年第1期24卷 300-310页

作者： Ya-Zhou Zhang Hai-long Zhang Jie Wang Xin-Chen ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang Shao-Cong Guo Meng Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

To address the problem of real-time processing of ultra-wide bandwidth pulsar baseband data,we designed and implemented a pulsar baseband data processing algorithm(PSRDP)based on GPU parallel computing *** can perform operations such as baseband data unpacking,channel separation,coherent dedispersion,Stokes detection,phase and folding period prediction,and folding integration in GPU *** tested the algorithm using the J0437-4715 pulsar baseband data generated by the CASPSR and Medusa backends of the Parkes,and the J0332+5434 pulsar baseband data generated by the self-developed backend of the Nan Shan Radio *** obtained the pulse profiles of each baseband *** experimental analysis,we have found that the pulse profiles generated by the PSRDP algorithm in this paper are essentially consistent with the processing results of Digital Signal Processing Software for Pulsar Astronomy(DSPSR),which verified the effectiveness of the PSRDP ***,using the same baseband data,we compared the processing speed of PSRDP with DSPSR,and the results showed that PSRDP was not slower than DSPSR in terms of *** theoretical and technical experience gained from the PSRDP algorithm research in this article lays a technical foundation for the real-time processing of QTT(Qi Tai radio Telescope)ultra-wide bandwidth pulsar baseband data.

关键词： (stars:)pulsars:general methods:data analysis techniques:miscellaneous

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：