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Food Science and Human Wellness 2024年第3期13卷 1672-1684页

作者： ling Zhang Wenyu Zou Yongyan Hu Honghua Wu ying Gao Junqing Zhang jia Zheng Department of Endocrinology Peking University First HospitalBeijing 100034China Laboratory Animal Facility Peking University First HospitalBeijing 100034China

Exercise training is critical for the early prevention and treatment of obesity and diabetes ***,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and *** showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism 16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia *** profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis *** conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose *** further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice.

关键词： High-fat diet Voluntary wheel running Gut microbiota Metabolomics Glucose metabolism

Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin linlin Tong jia Zhao Lan Zhang Na lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-ling Xiao Yue Gong ying-jia Qi Zhi-Ming Shao Yi-Zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

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Journal of Rare Earths 2024年第3期42卷 621-628,I0007页

作者： Dandan Zou Runlian lin Yu Han Juan jia Guoqiang Zhou Haisong Zhang Kun Ge Hebei Key Laboratory of Chronic Kidney Diseases and Bone Metabolism Affiliated Hospital of Hebei UniversityBaoding071000China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the body, especially in the bone, because of its similar structure to calcium. Moreover, La has a direct role in bone formation regulating osteoblasts and osteoclasts. Nevertheless, bone formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the bone microenvironment. It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of ***, some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO_(3))_(3)) on bone ***(NO_(3))_(3) has good biological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for bone marrow mesenchymal stem cells(BMMSC). In contrast, the differentiation,maturation, and bone erosion ability of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ability of human umbilical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, bone metabolism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system. These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment.

关键词： Lanthanum Bone microenvironment Osteogenic differentiation Angiogenesis Rare earths

Bimetallic CoNi single atoms supported on three-dimensionally ordered mesoporous chromia:highly active catalysts for n-hexane combustion

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Green Energy & Environment 2024年第7期9卷 1122-1137页

作者： Xiuqing Hao Yuxi Liu Jiguang Deng lin Jing jia Wang Wenbo Pei Hongxing Dai Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaLaboratory of Catalysis Chemistry and NanoscienceDepartment of Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing100124China

Developing the alternative supported noble metal catalysts with low cost,high catalytic efficiency,and good resistance toward carbon dioxide and water vapor is critically demanded for the oxidative removal of volatile organic compounds(VOCs).In this work,we prepared the mesoporous chromia-supported bimetallic Co and Ni single-atom(Co_(1)Ni_(1)/meso-Cr_(2)O_(3))and bimetallic Co and Ni nanoparticle(Co_(NP)Ni_(NP)/mesoCr_(2)O_(3))catalysts adopting the one-pot polyvinyl pyrrolidone(PVP)-and polyvinyl alcohol(PVA)-protecting approaches,*** results indicate that the Co_(1)Ni_(1)/meso-Cr_(2)O_(3)catalyst exhibited the best catalytic activity for n-hexane(C_(6)H_(14))combustion(T_(50%)and T_(90%)were 239 and 263℃ at a space velocity of 40,000 mL g^(-1)h^(-1);apparent activation energy and specific reaction rate at 260℃ were 54.7 kJ mol^(-1)and 4.3×10^(-7)mol g^(-1)_(cat)s^(-1),respectively),which was associated with its higher(Cr^(5+)+Cr^(6+))amount,large n-hexane adsorption capacity,and good lattice oxygen mobility that could enhance the deep oxidation of n-hexane,in which Ni_(1) was beneficial for the enhancements in surface lattice oxygen mobility and low-temperature reducibility,while Co_(1) preferred to generate higher contents of the high-valence states of chromium and surface oxygen species as well as adsorption and activation of n-hexane.n-Hexane combustion takes place via the Mars van Krevelen(MvK)mechanism,and its reaction pathways are as follows:n-hexane→olefins or 3-hexyl hydroperoxide→3-hexanone,2-hexanone or 2,5-dimethyltetrahydrofuran→2-methyloxirane or 2-ethyl-oxetane→acrylic acid→CO_x→CO_(2)and H_(2)O.

关键词： Three-dimensional ordered mesoporous chromium oxide Supported bimetallic single-atom catalyst Cobalt-nickel single atoms n-Hexane combustion Catalytic reaction mechanism

Progress,challenges,and prospects of spent lithium-ion batteries recycling:A review

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Journal of Energy Chemistry 2024年第2期89卷 144-171,I0005页

作者： Pengwei Li Shaohua Luo lin Zhang Qiuyue Liu Yikai Wang Yicheng lin Can Xu jia Guo Peam Cheali Xiaoning Xia School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004HebeiChina Department of Chemistry and Bioscience Aalborg UniversityAalborg 9220Denmark Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004HebeiChina Department of Materials and Production Aalborg UniversityAalborg 9220Denmark School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The recycling and reutilization of spent lithium-ion batteries(LIBs)have become an important measure to alleviate problems like resource scarcity and environmental *** some progress has been made,battery recycling technology still faces challenges in terms of efficiency,effectiveness and environmental *** review aims to systematically review and analyze the current status of spent LIB recycling,and conduct a detailed comparison and evaluation of different recycling *** addition,this review introduces emerging recycling techniques,including deep eutectic solvents,molten salt roasting,and direct regeneration,with the intent of enhancing recycling efficiency and diminishing environmental ***,to increase the added value of recycled materials,this review proposes the concept of upgrading recycled materials into high value-added functional materials,such as catalysts,adsorbents,and *** life cycle assessment,the paper also explores the economic and environmental impacts of current battery recycling and highlights the importance that future recycling technologies should achieve a balance between recycling efficiency,economics and environmental ***,this review outlines the opportunities and challenges of recycling key materials for next-generation batteries,and proposes relevant policy recommendations to promote the green and sustainable development of batteries,circular economy,and ecological civilization.

关键词： Spent li-ion batteries Recycle Direct regeneration High-value conversion Functional materials

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality

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Zoological Research 2024年第5期45卷 1037-1047页

作者： Chun-Xue Niu jia-Wei Li Xiao-Li Li lin-lin Zhang Yan Lang Zhen-Bo Song Chun-Lei Yu Xiao-Guang Yang Hai-Feng Zhao jia-ling Sun Li-Hua Zheng Xue Wang ying Sun Xiao-Hong Han Guan-Nan Wang Yong-Li Bao National Engineering Laboratory for Druggable Gene and Protein Screening Northeast Normal UniversityChangchunJilin 130117China China International Joint Research Center for Human Stem Cell Bank Northeast Normal UniversityChangchunJilin 130117China Jilin Institute for Drug Control ChangchunJilin 130022China

Serine protease 50(PRSS50/TSP50)is highly expressed in *** study investigated its role in testicular development and ***,PRSS50 knockdown was observed to impair DNA synthesis in *** further explore this,we generated PRSS50 knockout(Prss50^(−/−))mice(Mus musculus),which exhibited abnormal spermatid nuclear compression and reduced male ***,dysplastic seminiferous tubules and decreased sex hormones were observed in 4-week-old Prss50^(−/−)mice,accompanied by meiotic progression defects and increased apoptosis of spermatogenic *** analysis indicated that PRSS50 deletion resulted in increased phosphorylation of extracellular signal-regulated protein kinases 1 and 2(ERK1/2)and elevated levels of MAP kinase phosphatase 3(MKP3),a specific ERK antagonist,potentially accounting for testicular dysplasia in adolescent Prss50−/−*** together,these findings suggest that PRSS50 plays an important role in testicular development and spermatogenesis,with the MKP3/ERK signaling pathway playing a significant role in this process.

关键词： PRSS50(TSP50) Meiotic progression Sperm quality MKP3 ERK

Islet transplantation for diabetic rats through the spleen

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 203-206页

作者： ying Cheng, jia-lin Zhang, Yong-Feng Liu, Tie-Min Li and Ning Zhao Shenyang, China Organ Transplant Unit, First Affiliated Hospital of China Medical University, Shenyang 110001, China Organ Transplant Unit First Affiliated Hospital of China Medical University Shenyang 110001 China. chengying75@***

BACKGROUND: Islet transplantation is considered a po- tentially curative treatment for diabetic mellitus. The aim of this study was to assess the feasibility of islet transplant through the spleen. METHODS: Both donor and recipient Wistar rats (BW150± 20 g) were provided by the Animal Center of China Medi- cal University, Shenyang, China. Islets were isolated and purified with the modified Minnesota program. 600-800IE graft islets were handpicked and transplanted through the spleen of diabetic recipients. Blood glucose and insulin were evaluated after operation every other day. IVGTT was performed 10 days after transplantation. RESULTS: 300-400IE islet was procured from one donor rat. Secretion index (SI) of the glucose stress was 5.59± 0.62, showing the graft functioning well. The diabetic rats restored normal blood glucose levels of 3.4-5.4 mmol/L (mean 4.8 mmol/L). Their insulin levels were as normal as 8.5-12.2 μIU/ml. The K value of IVGTT in the rats after transplantation was similar to the normal one. CONCLUSIONS: The islets can be transplanted successfully through the spleen, while avoiding the complications caused by traditional transplantation through the portal vein, such as bleeding and portal vein hypertension. The graft islets loss can be reduced because of less centrifugation and mechanic pressure. In conclusion, transplantation through the spleen is a simple and feasible method.

关键词： islet transplantation spleen diabetes mellitus

Mechanisms of Sophora flavescens in the treatment of cervical squamous cell carcinoma based on comprehensive biological analysis,network pharmacology,and experimental verification

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Cancer Advances 2024年第10期7卷 1-8页

作者： Ning-jia Song Yuan Wang Ya-ying lin Department of Obstetrics and Gynecology Affiliated Hospital of Jiangnan UniversityWuxi 214000China Wuxi Medical School Jiangnan UniversityWuxi 214000China

Objective:This study used comprehensive bioinformatics analysis and network pharmacology analysis to investigate the potentially relevant mechanisms of Sophora flavescens against cervical squamous cell ***:Consistently altered genes involved in cervical squamous cell cancerization were analyzed in the GEO *** chemical ingredients and target genes of Sophora flavescens were explored using the TCMSP *** obtained the potential therapeutic targets of Sophora flavescens by intersecting the above genesets and validated them in the GEPIA *** interaction between Sophora flavescens and target genes was predicted by molecular ***-qPCR was used to verify the changes of target genes in HeLa cells treated with Sophora ***-gene GSEA functional analysis were performed to determine the molecular ***:Fifteen genes related to the transformation of cervical squamous cell carcinoma were identified,among which AR and ESR1 were confirmed as targets for kaempferol,wighteone,formononetin,and *** compounds are the active ingredients in Sophora *** expressions of AR and ESR1 correlate with a poor prognosis,while Sophora flavescens treatment increases the expression of AR and ESR1 in *** analysis showed that AR and ESR1 mainly participate in the epithelial-mesenchymal transition in cervical squamous cell ***:Sophora flavescens exert anti-tumor effects by targeting AR and ESR1,which may regulate cancer metastasis.

关键词： cervical squamous cell carcinoma biological analysis network pharmacology Sophora flavescens

Low-viscosity oligoether esters(OEEs)as high-efficiency lubricating oils:Insight on their structure‒lubricity relationship

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Friction 2024年第6期12卷 1133-1153页

作者： Hanwen WANG ying WANG Ping WEN lin MA Mingjin FAN Rui DONG Chunhua ZHANG Shaanxi Key Laboratory of Phytochemistry College of Chemistry&Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Key Laboratory of Shaanxi Province for Development and Application of New Transportation Energy Chang’an UniversityXi’an 710064China

Development of energy-efficient lubricants is a way to reduce energy consumption for transportation,with the tendency to design molecules that are beneficial in reducing the viscosity of synthetic *** esters(OEEs),as a low-viscosity ester base oil,have characteristics such as simple synthesis and excellent lubrication effect;however,the application of OEEs in tribology field has rarely been *** objective of the present study is to investigate the effect of structure on the lubricating performance of OEEs and to develop a predictive model for OEEs based on quantitative structure‒property relationship(QSPR)through a combination of experiment and statistical *** showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of *** to branched-chain OEEs,straight-chain OEEs exhibited reduced wear,which was mainly due to the thicker adsorption film formed by the straight-chain ***,carbon films were detected on lightly worn surfaces,indicating that OEEs underwent oxidation during the friction *** on the results of principal component analysis(PCA)and partial least squares(PLS),it could be found that the predictive models of viscosity‒temperature performance,thermal stability performance,coefficient of friction(COF),and wear volume(WV)performed well and *** them,COF and WV can be best predicted with an R^(2) of about 0.90.

关键词： oligoether esters(OEEs) low-viscosity ester friction wear quantitative structure-property relationship(QSPR)