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Effect of alloying elements on magnesium alloy damping capacities at room temperature

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International Journal of Minerals,Metallurgy and Materials 2019年第6期26卷 760-765页

作者： Di-qing Wan ying-lin Hu Shu-ting Ye Zhu-min Li Li-li Li Yi Huang School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China Materials Research Group Faculty of Engineering and the EnvironmentUniversity of SouthamptonSouthampton SO17 1 BJUK

Alloying is a good approach to increasing its strength but leads to a reduction of damping to pure *** the alloying characteristics of various alloying elements in magnesium alloys and their combined effects on the damping and mechanical properties of magnesium alloys is *** this paper,the properties of the Mg-0.6wt%X binary alloys were analyzed through strength measurements and dynamic mechanical *** effects of foreign atoms on solid-solution strengthening and dislocation damping were studied *** effect of solid solubility on damping capacity can be considered from two perspectives:the effect of single solid-solution atoms on the damping capacities of the alloy,and the effect of solubility on the damping capacities of the *** results provide significant information that is useful in developing high-strength,high-damping magnesium *** study will provide scientific guidance regarding the development of new types of damping magnesium alloys.

关键词： magnesium alloys high-damping high-strength alloying

川芎嗪激活Nrf2/HO-1/CXCR4通路调控神经干细胞迁移干预缺血再灌注大鼠的作用机制

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中国中药杂志 2024年第9期49卷 2308-2315页

作者：李卓航王栋王艳秋戚明珠黄荷兰林娜苏晓慧孔祥英中国中医科学院中药研究所北京100700

以核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)/血红素加氧酶1(heme oxygenase 1,HO-1)/趋化因子C-X-C-基元受体4(C-X-C motif chemokine receptor 4,CXCR4)通路为切入点,探讨川芎嗪(tetramethylpyrazine,TMP)干预大脑中动脉阻塞(middle cerebral artery occlusion,MCAO)模型大鼠脑内神经干细胞(neural stem cells,NSCs)迁移的作用机制。SD大鼠分为假手术组、模型组、TMP 20 mg·kg^(-1)组和TMP 40 mg·kg^(-1)组;通过神经功能缺失评分评价神经功能损伤;免疫荧光法检测脑组织5-溴脱氧尿苷(5-bromodeoxyuridine,BrdU)/双皮质素(doublecortin,DCX)双标细胞;观察TMP对C17.2细胞迁移的影响;蛋白免疫印迹法检测脑组织和C17.2细胞中Nrf2、HO-1、p62、醌氧化还原酶1[NAD(P)H quinone oxidoreductase 1,NQO1]、基质细胞衍生因子1(stromal cell-derived factor 1,SDF-1)、CXCR4蛋白表达。结果显示,大鼠脑缺血7、21 d后,神经功能损伤评分及BrdU+/DCX+细胞显著升高,脑组织中Nrf2及CXCR4表达均显著升高;与模型组相比,TMP 40 mg·kg-1可显著降低神经功能评分,进一步升高BrdU+/DCX+细胞数量及Nrf2、CXCR4及SDF-1表达;此外TMP可以显著促进C17.2细胞迁移,且时间以及剂量依赖性提高p62、Nrf2、HO-1、NQO1表达,TMP 50μg·mL^(-1)给药12 h表达量最高(P<0.01)。综上,TMP可通过活化Nrf2/HO-1/CXCR4通路,促进NSCs迁移从而发挥抗缺血再灌注损伤作用。该研究为TMP在缺血性脑卒中疾病中的应用提供了实验支持。

关键词：大脑中动脉阻塞川芎嗪神经干细胞迁移 Nrf2/HO-1/CXCR4通路

微絮凝-超滤工艺处理电镀废水的工艺参数研究

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当代化工研究 2024年第9期 151-153页

作者：徐丽杉任晓龙林立兴孙月徐佳中国海洋大学化学化工学院山东266100

絮凝和膜分离在水处理领域中日趋成熟,这为工业废水的深度处理提供了技术支撑。鉴于此,本文主要研究了微絮凝在超滤处理电镀废水过程中的影响,重点考察了PAC絮凝剂的投加量对膜通量、浊度去除率、UV_(254)去除率等影响,结果表明,PAC最... 详细信息

絮凝和膜分离在水处理领域中日趋成熟,这为工业废水的深度处理提供了技术支撑。鉴于此,本文主要研究了微絮凝在超滤处理电镀废水过程中的影响,重点考察了PAC絮凝剂的投加量对膜通量、浊度去除率、UV_(254)去除率等影响,结果表明,PAC最佳投入量50 mg/L及与PAM复配质量比50:1时,超滤性能最佳。结合SDI、COD_(Cr)、pH等指标,验证了微絮凝-超滤耦合作为反渗透深度处理电镀废水预处理工艺的可行性。

关键词：微絮凝超滤预处理电镀废水

影响合作社分异演化的管理因素研究——基于广西38家农民合作社跟踪分析

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农业现代化研究 2024年第4期45卷 636-648页

作者：赵迎冬潘新潮植子伦汤传勇党洁白琨琳南宁师范大学地理科学与规划学院广西南宁530001 南宁师范大学初等教育学院广西南宁530001 南宁师范大学党委统战部广西南宁530001

分析合作社的发展特征与类型演化,并剖析其合作分异演化的管理因素可引导农民专业合作社健康有序发展,为合作社发展与改进找到新路径。本研究采用绩效跟踪评价法,对世界银行项目广西片区38家农民合作社进行动态详尽评估,提炼不同阶段和... 详细信息

分析合作社的发展特征与类型演化,并剖析其合作分异演化的管理因素可引导农民专业合作社健康有序发展,为合作社发展与改进找到新路径。本研究采用绩效跟踪评价法,对世界银行项目广西片区38家农民合作社进行动态详尽评估,提炼不同阶段和不同类型的合作社画像特征,揭示其发展状态和演变轨迹。结果表明,其一,广西片区38家农民合作社在建成1年后的初始阶段会演化为4种类型;而在发展3年后进入成熟阶段,合作社演化为5种类型。其二,经营计划、改进计划、管理培训投入、市场信息、财务计划、资金投入、调查研究等管理因素对合作社分异演化发挥关键作用,并决定了合作社不同阶段的演化方向。因此,在合作社发展过程中应强化政府支持,为农民合作社高质量发展提供管理保障;提升合作社运营能力,为农民合作社成熟发展提供计划支持;持续开展调查研究,为农业农村项目发展提供规划支撑。

关键词：农民专业合作社分异演化管理因素画像绩效评价

Effect of 1,8-Diiodooctane Content on the Performance of P_(3)HT:PC_(61)BM Bulk Heterojunction Photodetectors

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Chinese Journal of Polymer Science 2021年第7期39卷 831-837页

作者： Xin Wang Shi-jia Gao Jin-Feng Han Yu-lin Zhang Sai Zhang Wen-Qiang Qiao Zhi-Yuan Wang StateKey Laboratory of Fine Chemicals Department of Polymer Science&MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Department of Materials Science and Engineering and Department of Chemistry Johns Hopkins UniversityBaltimoreMD 21218USA Department of Chemistry Carleton UniversityOntario K1S 5B6Canada

A series of polymer photodetectors with device configuration of ITO/PEDOT:PSS/P_(3)HT:PC_(61)BM/C_(60)/AI were prepared by using P3HT as the donor material and PC61BM as the acceptor *** regulating the content of 1,8-diiodooctane(DIO)(V/V:1%,3%,5%)as a processing additive,the morphology of the active layer can be greatly improved With Ceo as the hole blocking layer,the dark current density of the device can be reduced by about an order of *** employing 3%DIO(V/V)in the active layer processing,the photodetetcors present the best performance,and the detectivity of the device is 1.52×10^(12)Jones at 540 nm under a bias of-0.1 ***,it also has a wider linear dynamic range of 60 dB as well as faster response speed(T1/T2=0.53/0.71μs)than those of devices with other content of DIO additives.

关键词： Polymer photodeteaor Configuration 1,8-Diiodooctane Morphology

Genetic spectrum and clinical features in a cohort of Chinese patients with autosomal recessive cerebellar ataxias

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Translational Neurodegeneration 2021年第4期10卷 536-550页

作者： Hao-ling Cheng Ya-Ru Shao Yi Dong Hai-lin Dong Lu Yang Yin Ma ying Shen Zhi-ying Wu Department of Neurology and Research Center of Neurology in Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310000China Department of Neurology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200000China Institute of Neuroscience Zhejiang University School of MedicineHangzhou 310000China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200000China

Background:Although many causative genes have been uncovered in recent years,genetic diagnosis is still missing for approximately 50%of autosomal recessive cerebellar ataxia(ARCA)*** studies have been performed to determine the genetic spectrum and clinical profile of ARCA patients in the Chinese ***:Fifty-four Chinese index patients with unexplained autosomal recessive or sporadic ataxia were investigated by whole-exome sequencing(WES)and copy number variation(CNV)calling with *** causal CNV predictions were validated by ***:Thirty-eight mutations including 29 novel ones were identified in 25 out of the 54 patients,providing a 46.3%positive molecular diagnostic *** different genes were involved,of which four most common genes were SACS,SYNE1,ADCK3 and SETX,which accounted for 76.0%(19/25)of the positive *** de novo microdeletion in SACS was reported for the first time in China and the uniparental disomy of ADCK3 was reported for the first time *** features of the patients carrying SACS,SYNE1 and ADCK3 mutations were ***:Our results expand the genetic spectrum and clinical profiles of ARCA patients,demonstrate the high efficiency and reliability of WES combined with CNV analysis in the diagnosis of suspected ARCA,and emphasize the importance of complete bioinformatics analysis of WES data for accurate diagnosis.

关键词： Autosomal recessive cerebellar ataxias Chinese Genetic spectrum Structural variation Clinical features

兔豆状囊尾蚴Ⅰ型胱抑素对脂多糖诱导小鼠脓毒症防治机制的研究

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中国预防兽医学报 2024年第8期46卷 837-846页

作者：车亮王由森石正发李甲羊倩倩肖琴孙晓林甘肃农业大学动物医学院寄生虫实验室甘肃兰州730070 中牧实业股份有限公司兰州生物药厂甘肃兰州730070

为深入探究兔豆状囊尾蚴半胱氨酸蛋白酶抑制剂(CPI)超家族成员I型胱抑素(Stefin)对脂多糖(LPS)诱导的小鼠脓毒症的治疗效果,本研究将重组菌pGEX-4T-CpStefin/BL21经IPTG诱导表达重组Stefin蛋白(r-Stefin),采用GST试剂盒纯化上述蛋白,并... 详细信息

为深入探究兔豆状囊尾蚴半胱氨酸蛋白酶抑制剂(CPI)超家族成员I型胱抑素(Stefin)对脂多糖(LPS)诱导的小鼠脓毒症的治疗效果,本研究将重组菌pGEX-4T-CpStefin/BL21经IPTG诱导表达重组Stefin蛋白(r-Stefin),采用GST试剂盒纯化上述蛋白,并去除内毒素后,采用SDS-PAGE检测r-Stefin的纯化效果。结果显示,r-Stefin在大肠杆菌中获得了表达且纯化效果较好。将雄性BALB/c小鼠随机分为6组,每组16只,分别为A组(生理盐水100μL/只,阴性对照组)、B组:GST蛋白对照组(25μg/只)、C组:r-Stefin组(25μg/只)、D组:脓毒症组(0.2 mg/100μL LPS/只)、E组:GST蛋白干预组(0.2 mg/100μL/只LPS+GST蛋白25μg/只)、F组:r-Stefin干预组(0.2 mg/100μL LPS/只+r-Stefin 25μg/只)。经腹腔注射后观察各组小鼠的临床症状、绘制各组小鼠在LPS诱导后不同时间的生存率曲线。在LPS诱导后12 h和24 h对各组小鼠采血,采用ELISA检测各组小鼠血清中各炎性细胞因子的含量,通过全自动生化仪测定各组小鼠血清中肝、肾功能指标。结果显示,D、E组小鼠经LPS诱导后很快出现被毛发凌乱、活动量减少、精神沉郁等症状。F组小鼠上述症状在一定程度上得到改善。A、B、C组小鼠均健活。生存率曲线显示,D组小鼠在36 h内全部死亡,E组小鼠在48 h~60 h时的生存率由75%快速降至72 h时的37.5%,F组小鼠的生存率在72 h时达75%。A~C组小鼠生存率均达100%。ELISA结果显示,LPS诱导12 h时,D组、E组和F组小鼠血清中促炎细胞因子(IL-6、TNF-α和TNF-β)及抑炎细胞因子(IL-10)的含量与A组相比均极显著升高;D组小鼠血清中IL-10含量显著低于F组。TNF-α及TNF-β含量分别极显著和显著高于F组。LPS诱导24 h时,D组小鼠血清中IL-6、TNF-α和TNF-β含量极显著高于F组,IL-10含量极显著低于F组。经LPS诱导后12 h,D组、E组、F组小鼠血清中肝脏指标ALB的含量与A组相比均极显著下降(P<0.001),ALT含量均极显著升高。D组小鼠血清中ALB和ALT含量显著或极显著高于F组;LPS诱导24 h时,D组小鼠血清中ALB的含量极显著低于F组,ALT的含量极显著高于F组。LPS诱导12 h时,D组、E组、F组小鼠血清中肾脏指标BUN和CREA的含量与A组相比均极显著升高,D组小鼠血清中BUN和CREA的含量均显著高于F组。LPS诱导24 h时,D组小鼠血清中BUN和CREA的含量均极显著高于F组。病变观察结果显示,LPS诱导后12 h,各组小鼠各脏器组织病变均无差别;LPS诱导后24 h,D组和E组小鼠肺、肝、肾组织均出现较严重的病理改变,而F组小鼠上述各组织病变均得到了改善。A、B、C组小鼠各组织均无明显病变。上述结果表明,r-Stefin干预可减轻脓毒症小鼠的炎症反应,使其肝肾功能明显好转,各组织病变明显减轻。综上所述,本研究首次证实Stefin蛋白对LPS诱导的小鼠脓毒症有明显的治疗作用,具有成为治疗脓毒症候选药物的潜力,为深入探究脓毒症的发病机制及开发新的治疗药物提供实验依据。

关键词：半胱氨酸蛋白酶抑制剂小鼠脓毒症脂多糖

Group VB transition metal dichalcogenides for oxygen reduction reaction and strain-enhanced activity governed by p-orbital electrons of chalcogen

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Nano Research 2019年第4期12卷 925-930页

作者： Shuyang Zhao Ke Wang Xiaolong Zou lin Gan Hongda Du Chengjun Xu Feiyu Kang Wenhui Duan jia Li Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China Shenzhen Geim Graphene Center Division of Energy and Environment Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China Tsinghua-Berkeley Shenzhen Institute (TBSI) Tsinghua University Shenzhen 518055 China Department of Physics and State Key Laboratory of Low-Dimensional Quantum Physics Tsinghua University Beijing 100084 China

Developi ng alter native oxyge n reducti on reactio n (ORR) catalysts to replace precious Pt-based metals with abundant materials is the key challe nge of commercial application of fuel cells. Owing to their various compositi ons and tun able electronic properties, transition metal dichalcogenides (TMDs) have the great potential to realize high-efficiency catalysts for ORR. Here, various 3R-phase dichalcogenides of group VB and VIB transition metals (MX2, M = Nb, Ta, Mo, W;X = S, Se, Te) are investigated for ORR catalysts by using density functional theory calculations. The computed over-potentials of group VB TMDs are much less than those of group VIB TMDs. For group VB TMDs, a volcano-type plot of ORR catalytic activity is established on the adsorption energies of *OH, and NbS2 and TaTe2 exhibit best ORR activity with an oveepotential of 0.54 V. To achieve even better activity, strain engineering is performed to tune ORR catalytic activity, and the minimum over-potential of 0.43 V can be realized. We further dem on strate that the shift of p orbital center of surface chalcoge n elements under strain is responsible for tuning the catalytic activity of TMDs.

关键词： transition metal dichalcogenides fuel cells oxygen reduction reaction strain density functional theory (DFT) calculations

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羟基镓咔咯光动力抗肝癌的体内外活性

应用化学 2024年第8期41卷 1184-1192页

作者：钟永辉欧晓倩黄岳卿郑佩莎黄慧琳郑嘉琪史蕾张召佛山市第四人民医院结核科佛山528041 广东第二师范学院化学与材料科学学院广州510800 广东医科大学基础医学院湛江524023

制备了10-(4-羟基苯基)-5,15-二(五氟苯基)咔咯(1)及其金属镓配合物(1-Ga),并用分子生物技术对肝癌细胞的光动力活性进行了研究。结果表明,咔咯金属配合物的光动力活性在很大程度上取决于中心金属,镓的引入可以提高光动力抗肿瘤活性在... 详细信息

制备了10-(4-羟基苯基)-5,15-二(五氟苯基)咔咯(1)及其金属镓配合物(1-Ga),并用分子生物技术对肝癌细胞的光动力活性进行了研究。结果表明,咔咯金属配合物的光动力活性在很大程度上取决于中心金属,镓的引入可以提高光动力抗肿瘤活性在肝癌细胞中,1-Ga在光照射下触发细胞内活性氧物种(ROS)的显著产生以及线粒体膜电位的变化,最终导致癌细胞坏死和凋亡。1-Ga对人肝癌细胞MHCC97H细胞(MHCC97H)与人肝癌细胞HepG2细胞(HepG2)的光动力半数抑制浓度在2~4μmol/L之间,而1的浓度大于4μmol/L。此类咔咯化合物表现出较高的生物相容性和光动力抗癌效率,在小鼠体内癌症模型中表现明显,与对照组相比,治疗组肿瘤组织质量下降超过70%。其作用机制可能与ROS产生后对线粒体功能影响有关。1-Ga的光动力活性明显优于1,可能是金属镓光动力产生更多ROS的结果。

关键词：光动力活性咔咯镓肝癌