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Effects of bilateral subthalamic nucleus deep brain stimulation on motor symptoms in Parkinson’s disease: a retrospective cohort study

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Neural Regeneration Research 2021年第5期16卷 905-909页

作者： Guo-Xiong Cheng Shu-Bin Yin ying-hao yang Yuan-Hu Hu Chih-yang Huang Qian-Ming Yao Wei-Jen Ting Deparment of Neurosurgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Deparment of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong ProvinceChina Graduate Institute of Basic Medical Science China Medical UniversityTaichungTaiwanChina Department of Health and Nutrition Biotechnology Asia UniversityTaichungTaiwanChina College of Medicine Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi UniversityHualienTaiwanChina Medical Research Center for Exosome and Mitochondria Related Diseases China Medical University and HospitalTaichungTaiwanChina

Deep brain stimulation of the bilateral subthalamic nucleus(STN)is a therapeutic option for patients with Parkinson’s disease(PD)in whom medical therapies have been *** retrospective cohort study analyzed the motor function of 27 patients with advanced PD,from the First Affiliated Hospital of Guangzhou Medical University,China,who received deep brain stimulation of the bilateral subthalamic nucleus and evaluated its therapeutic *** 10-year follow-up data of patients was analyzed in Qingyuan People’s Hospital,Sixth Affiliated Hospital of Guangzhou Medical University,*** follow-up data were divided into two categories based on patients during levodopa treatment(on-medication)and without levodopa treatment(off-medication).Compared with baseline,the motor function of onmedication PD patients improved after deep brain stimulation of the bilateral subthalamic *** 2 years later,the motor function of off-medication PD patients had ***-medication PD patients exhibited better therapeutic effects over the 5 years than offmedication PD ***-medication patients’akinesia,speech,postural stability,gait,and cognitive function worsened only after 5 *** results suggest that the motor function of patients with advanced PD benefitted from treatment with deep brain stimulation of the bilateral subthalamic nucleus over a period up to 5 *** overall therapeutic effects were more pronounced when levodopa treatment was combined with deep brain stimulation of the bilateral subthalamic *** study was approved by Institutional Review Board of Qingyuan People’s Hospital,The Sixth Affiliated Hospital of Guangzhou Medical University,China(approval ***-IRB-A0140)on January 11,2018.

关键词： clinical trial deep brain stimulation dopamine dyskinesia levodopa long-term follow-up neurological function Parkinson’s disease thalamus UPDRS

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A 27 GHz,simple 2-bit 1×8 phased array

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Journal of Electronic Science and Technology 2024年第3期22卷 26-34页

作者： Jun-Xian Liu Yun-ying Man hao yang Peng yang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

This study demonstrates a simple 2-bit phased array operating at 27 GHz that supports one-dimensional beam scanning with left-handed circular polarization(LHCP).The antenna is constructed using a compact four-layer printed circuit board(PCB)structure,consisting of a 90°phase shifter layer with microstrip structures,a ground(GND)layer,a direct current(DC)control layer,and a circularly polarized annular radiation patch layer with 1-bit phase *** on the proposed unit structure,a 1×8 array with half-wavelength inter-element spacing was designed and *** results show that the array achieves a peak gain of 10.23 dBi and is capable of beam scanning within±50°.

关键词： 27 GHz 2-bit P-i-n diodes Phased array Reconfigurable antennas

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Colon signet-ring cell carcinoma with chylous ascites caused by immunosuppressants following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2343-2350页

作者： ying Li yang Tai hao Wu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chylous ascites is caused by disruption of the lymphatic system,which is characterized by the accumulation of a turbid fluid containing high levels of triglycerides within the abdominal *** two most common causes are cirrhosis and tuberculosis,and colon signer ring cell carcinoma(SRCC)due to the use of immunosuppressants is extremely rare in cirrhotic patients after liver transplantation,making it prone to misdiagnosis and missed *** SUMMARY A 52-year-old man who underwent liver transplantation and was administered with immunosuppressants for 8 months was admitted with a 3-month history of progressive abdominal ***,based on lymphoscintigraphy and lymphangiography,lymphatic obstruction was considered,and cystellar chyli decompression with band lysis and external membrane stripping of the lymphatic duct was ***,his abdominal distention was persistent without *** paracentesis revealed allogenic cells in the ascites,and immunohistochemistry analysis revealed adenocarcinoma cells with phenotypic features suggestive of a gastrointestinal *** endoscopy was performed,and biopsy showed atypical signet ring cells in the ileocecal *** patient eventually died after a three-month follow-up due to progression of the *** Colon SRCC,caused by immunosuppressants,is an unusual but un-neglected cause of chylous ascites.

关键词： Colonic signer ring cell carcinoma Immunosuppressant Chylous ascites Cirrhosis Liver transplantation Case report

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Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun hao Lin Yuheng Liao Hui yang ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

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Endowing low fatigue for elastocaloric effect by refined hierarchical microcomposite in additive manufactured NiTiCuCo alloy

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International Journal of Extreme Manufacturing 2024年第4期6卷 307-322页

作者： Bo Feng Helong Liu ying yang Hui Shen yang Ren Yinong Liu Lishan Cui Bingmin Huang Shijie hao College of New Energy and Materials China University of PetroleumBeijing 102249People's Republic of China College of Chemical Engineering and Environment China University of PetroleumBeijing 102249People's Republic of China Department of Physics City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong Special Administrative Region of ChinaPeople's Republic of China Department of Mechanical Engineering The University of Western AustraliaPerthWA 6009Australia Jiangsu Smart Advanced Material Tech Co. LtdXuzhou 221000People's Republic of China

NiTiCu-based shape memory alloys have been considered as ideal materials for solid-state refrigeration due to their superb cycling stability for elastocaloric ***,the embrittlement and deterioration caused by secondary phase and coarse grains restrict their applications,and it is still challenging since the geometric components are ***,bulk NiTiCuCo parts with excellent forming quality were fabricated by laser powder bed fusion(LPBF)*** as-fabricated alloy exhibits refined three-phases hierarchical microcomposite formed based on the rapid cooling mode of LPBF,composed of intricate dendritic Ti2Ni–NiTi composite and nano Ti2Cu embedded inside the *** configuration endows far superior elastocaloric stability compared to the as-cast *** low fatigue stems from the strong elastic coupling between the interphases with reversible martensite transformation,revealed by in-situ synchrotron high-energy x-ray *** fabrication of NiTiCuCo alloy via LPBF fills the bill of complex geometric structures for elastocaloric NiTiCu *** understanding of interphase micro-coupling could provide the guide for designing LPBF fabricated shape memory-based composites,enabling their applications for special demands on other functionalities.

关键词： NiTiCuCo shape memoryalloy microcomposite high-energyx-raydiffraction laser powderbedfusion

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Possibilities for the synthesis of superheavy element Z=121 in fusion reactions

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Nuclear Science and Techniques 2024年第6期35卷 90-100页

作者： Ming-hao Zhang Yu-Hai Zhang ying Zou Xiu-Xiu yang Gen Zhang Feng-Shou Zhang The Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China School of Physical Science and Technology Guangxi UniversityNanning 530004China National Laboratory of Heavy Ion Accelerator of Lanzhou Center of Theoretical Nuclear PhysicsLanzhou 730000China

Based on the dinuclear system model,the calculated evaporation residue cross sections matched well with the current experimental *** synthesis of superheavy elements Z=121 was systematically studied through combinations of stable projectiles with Z=21-30 and targets with half-lives exceeding 50 *** influence of mass asymmetry and isotopic dependence on the projectile and target nuclei was investigated in *** reactions^(254)Es(^(46)Ti,3n)^(297)121 and^(252)Es(^(46)Ti,3n)^(295)121 were found to be experimentally feasible for synthesizing superheavy element Z=121,with maximal evaporation residue cross sections of 6.619 and 4.123 fb at 219.9 and 223.9 MeV,respectively.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Evaporation residue cross section

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Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： yang Hong ying-Peng Song Lu-Ping Zhou Jing-Yu Tang Zhi-hao Zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

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LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

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Oncology Research 2024年第8期32卷 1335-1346页

作者： HAIQING HU hao yang SHUAISHUAI FAN XUE JIA ying Zhao HONGRUI LI Department of Endoscopic Center Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHuhhot010020China Department of Radiation Oncology Peking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityKey Laboratory of Radiation Physics and Biology of Inner Mongolia Medical UniversityPeking University Cancer Hospital(Inner Mongolia Campus)&Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHuhhot010020China Graduate School Inner Mongolia Medical UniversityHuhhot010020China

Long non-coding RNAs(lncRNAs)have been implicated in cancer progression and drug resistance ***,there is evidence that lncRNA HOX transcript antisense intergenic RNA(HOTAIR)is involved in colorectal cancer(CRC)*** present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells,as well as the underlying *** relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues,as well as in radiosensitive and radioresistant *** correlations between HOTAIR expression levels and clinical features of patients with CRC were assessed using the Chi-square *** assays such as cell proliferation,colony formation and apoptosis assays were conducted to determine the radiosensitivity in CRC cells with HOTAIR silencing after treatment with different doses of *** pull-down assay andﬂuorescence in situ hybridization(FISH)were used to determine the interaction between HOTAIR and DNA damage response mediator ataxia-telangiectasia mutated-and Rad3-related(ATR).HOTAIR was signiﬁcantly upregulated in CRC tumor tissues,especially in radioresistant tumor *** elevated expression of HOTAIR was correlated with more advanced histological grades,distance metastasis and the poor prognosis in patients with *** HOTAIR suppressed the proliferation and promoted apoptosis and radiosensitivity in CRC *** knockdown also inhibited the tumorigenesis of CRC cells and enhanced the sensitivity to radiotherapy in a mouse xenograft ***,the data showed that HOTAIR could interact with ATR to regulate the DNA damage repair signaling *** HOTAIR impaired the ATR-ATR interacting protein(ATRIP)complex and signaling in cell cycle ***,the present results indicate that lncRNA HOTAIR facilitates the DNA damage response pathway and promotes radioresistance in CRC cells by targeting ATR.

关键词： LncRNA HOTAIR CRC radioresistance DNA damage repair ATR

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Fractionation of Heavy Metals in Sediments from Dianchi Lake,China

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Pedosphere 2007年第2期17卷 265-272页

作者： LI Ren-ying yang hao ZHOU Zhi-Gao Lü Jun-Jie Shao Xiao-Hua JIN Feng State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China）. College of Geography Science Nanjing Normal University Nanjing 210097 （China） Department of Applied Meteorology Nanjing University of Information Science ＆ Technology Nanjing 210044 （China）

Fractionation of heavy metals in sediments can help in understanding potential hazards of heavy metals. The present study analyzed total concentrations and fractions of selected heavy metals （Cd, Cr, Cu, Pb, and Zn） in surface sediments from Dianchi Lake, Yunnan Province, China, as well as factors that may affect distributions of the various heavy metal fractions. Total concentrations of the heavy metals decreased in the order Zn 〉 Cu 〉 Pb 〉 Cr 〉 Cd. These heavy metals, except Cr, were much higher than their background levels, indicating that Dianchi Lake was polluted by Cd, Zn, Pb, and Cu. Cadmium occurred mainly as the non-residual fraction （sum of the HOAc-soluble, reducible, and oxidizable fractions）（97.6%）, and Zn （55.7%） was also predominantly found in the non-residual fraction. In contrast, most of the Cr （88.5%）, Pb （81.8%）, and Cu （59.2%） occurred in the residual fraction. Correlation analysis showed that total heavy metal concentrations, organic matter and reducible Fe were the main factors affecting the distributions of the various heavy metal fractions. In the Walhai section of Dianchi Lake （comprising 97% of the lake area）, the concentrations of Cd, Zn, Pb, and Cu in the non-residual fraction were significantly lower （P ≤ 0.01 or 0.05） than those of the Caohal section （3% of the lake area）. This indicated that potential heavy metal hazards in the Caohai section were greater than the Waihai section.

关键词： Dianchi Lake heavy metal fractions lake sediment organic matter reducible Fe

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Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 956-964页

作者： Li-ying hao Gege Dong Tieshan Li Zhouhua Peng the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731the Navigation CollegeDalian Maritime UniversityDalian 116026 the yangtze Delta Region Institute(Huzhou) Huzhou 313001China

This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external *** surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to *** reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency *** nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external *** using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of *** with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance ***,the comparison results through simulations are given to verify the effectiveness of the proposed method.

关键词： Actuator faults autonomous surface vehicle(ASVs) improved artificial potential function nonlinear state observer obstacle avoidance

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