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Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Neural Regeneration Research 2018年第12期13卷 2119-2128页

作者： Hai-ying cui Xiang-Jian Zhang Yi Yang Cong Zhang chun-Hua Zhu Jiang-Yong Miao Rong Chen Department of Neurology Second Hospital of hebei Medical university Shijiazhuang Hebei Province China Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardiocerebrovascular Disease ShijiazhuangHebei Province China

Rosmarinic acid（RA） can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice（Beijing Vital River Laboratory Animal Technology, Beijing, China） by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits were evaluated using modified Longa scores. Subsequently, cerebral infarct volume was measured using TTC staining and ischemic brain tissue was examined for cell apoptosis with TUNEL staining. Superoxide dismutase activity and malondialdehyde levels were measured by spectrophometry. Expression of heme oxygenase-1（HO-1）, nuclear factor erythroid 2-related factor 2（Nrf2）, Bcl-2, Bax, Akt, and phospho-Ser473 Akt proteins in ischemic brain tissue was detected by western blot, while mRNA levels of Nrf2, HO-1, Bcl-2, and Bax were analyzed using real time quantitative PCR. In addition, HO-1 enzyme activity was measured spectrophotometrically. RA（20 and 40 mg/kg） greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated Bcl-2 protein and mRNA expression, downregulated Bax protein and mRNA expression, increased HO-1 and Nrf2 protein and mRNA expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice. However, intraperitoneal injection of a HO-1 inhibitor（10 mg/kg zinc protoporphyrin IX） reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression. The PI3 K/Akt signaling pathway inhibitor LY294002（10 mM） inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. Our findings suggest that RA has anti-oxidative and anti-apoptotic properties that protect against ischemic stroke by a mechanism involving upregulation of Nrf2 and HO

关键词： cerebral ischemia/reperfusion rosmarinic acid cellular apoptosis oxidative injury neuroprotection Bcl-2 Bax Nrf2 heme oxygenase 1 PI3K/Akt signal pathway neural regeneration

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基底动脉尖综合征42例临床分析

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实用医技杂志 2008年第14期15卷 1774-1776页

作者：刘颖刘春红崔立海杨延芳张文英张士喜聊城市第二人民医院山东临清252601

目的:研究基底动脉尖综合征的病因、临床特征、影像学表现及治疗预后,提高对该疾病的认识。方法:对2001年至2007年收治的42例TOBS患者的临床表现及影像学资料等原始资料进行回顾性分析。结果:TOBS患者以中老年为主,主要危险因素是高血压... 详细信息

目的:研究基底动脉尖综合征的病因、临床特征、影像学表现及治疗预后,提高对该疾病的认识。方法:对2001年至2007年收治的42例TOBS患者的临床表现及影像学资料等原始资料进行回顾性分析。结果:TOBS患者以中老年为主,主要危险因素是高血压,其次是高脂血症,脑栓塞是其主要病因,临床主要症状是意识障碍、眼球运动障碍和瞳孔改变。结论:CT和MRI是诊断TOBS的主要检查手段,MRI在早期诊断方面优于CT,TOBS预后较差,致残率较高,早期全面综合治疗可提高生存率。

关键词：基底动脉尖综合征脑梗死磁共振成像

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Two Cases of Multi-antibiotic Resistant Cronobacter spp. Infections of Infants in China＊

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Biomedical and Environmental Sciences 2017年第8期30卷 601-605页

作者： cui Jing Hua YU Bo XIANG Yun ZHANG Zhen ZHANG Ting ZENG ying chun cui Zhi Gang HUO Xi Xiang State Key Laboratory for infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Hubei provincial center for disease control and prevention Wuhan 430079 Hubei China Department of Laboratory Medicine Wuhan Medical and Health Center for Women and Children Tongji Medical College Huazhong University of Science and Technology Wuhan 430015 Hubei China

Infections by Cronobacter spp. are hazardous to infants since they can lead to neonatal meningitis, bacteremia, and necrotizing enterocolitis. Cronobacter spp. are frequently resistant to 13-1actam derivatives, macrolides, and aminoglycosides. In addition, multi-resistant strains have also been detected. In China, the isolation rate of Cronobacter spp. from commercial powdered infant formula （PIF） or follow-up formula （FUF） is relatively high. Nevertheless, clinical cases of Cronobacter infection have been ignored to date. Here we describe two cases of Cronobacter infection detected at the Wuhan Women and Children Medical Care Center Hospital （Wuhan City, China）. We provide the genomic analysis of the isolates and the antibiotic-resistance profiles of the two strains. The Cronobacter strains identified in this study were not susceptible to third-generation cephalosporins, aminoglycoside, and/or trimethoprim-sulfamethoxazole. Whole genome sequencing revealed various genes known to encode antibiotic resistance. Future studies are needed to determine whether the genes predicted in this study are functional. As with Enterobocter spp., the antibiotic resistance of Cronobocter is a serious issue that requires more attention.

关键词： Multi-antibiotic resistant Cronobacter spp. Infant Case report

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Modifying agent selection for Al-7Si alloy by Miedema model

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International Journal of Minerals,Metallurgy and Materials 2012年第2期19卷 131-135页

作者： Zhong-wei Chen cui-ying Ma Pei Chen State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

To determine the modifying agents for Al-7Si alloys, microstructure observation and mixing enthalpy analysis using Miedema model for Al-7Si alloy with additions of different rare earth elements were performed, and the effects of rare earth elements on the modifica-tion of eutectic silicon morphology were investigated. The results of mixing enthalpy analysis show that these four rare earth elements, La, Sm, Pr, and Ce, which have the large negative mixing enthalpies with Si, can be selected as modifying agents for eutectic silicon morphology. The element with the largest negative mixing enthalpy is Ce. Furthermore, the microstructures indicate that these four elements can effec-tively modify the eutectic （α）Al-Si crystals in Al-7Si alloy, and the most effective one is also Ce. Differential scanning calorimetry （DSC） results show that the eutectic temperature depressions due to the additions of modifying agents are the important reasons for the modification of eutectic （α）Al-Si crystals.

关键词： aluminum alloys silicon alloys modifying agents rare earth elements microstructure enthalpy

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DESIGN AND ANALYSIS OF THE GREEN CLIMATE FUND

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Journal of Systems Science and Systems Engineering 2014年第3期23卷 266-299页

作者： Lian-biao cui Lei ZHU Marco SPRINGMANN ying FAN Center for Energy and Environmental Policy Research Institute of Policy and ManagementChinese Academy of Sciences Department of Economics University of Oldenburg

The Green Climate Fund （GCF） has been one of the core issues of the world climate summits under the United Nations Framework Convention on Climate Change （UNFCCC） in recent years. However, the GCF has not progressed smoothly, and currently there are no satisfactory schemes for raising and distributing the fund. This paper first discusses how to finance the GCF among Annex II countries. It introduces the ＇preference score compromises＇（PSC） approach which is based on environmental responsibility and economic capacity, with historical emissions as an indicator for environmental responsibility and GDP as indicator for economic capacity. The results show that the United States and the European Union are the two largest contributors to the GCF, sponsoring more than 80% of the funds. Second, we discuss how to allocate the funds among non-Annex II parties. The ＇adaptation needs＇（AN） approach, which takes account of economic strength and climate damages, is proposed to achieve the adaptation purpose of the GCF, and the results reveal that African countries with high levels of climate vulnerability could get most funds, with a share of almost 30%. Regarding the mitigation purpose of the GCF, this research introduces two approaches： the ＇carbon reduction contribution＇（CC） approach and the ＇incremental cost＇（IC） approach. Both approaches could achieve significant reductions in carbon emissions in non-Annex II parties, whereas the latter may provide limited adaptation finance but result in more mitigation effects. This paper also develops a method to combine abatement efficiency and adaptation fairness of the GCF, and we find that with an equal split between the AN and CC （or AN and IC） approaches, the amount of USD 100 billion could finance an emissions reduction of 1613 MtCO2 （2477 MtCO2）, while allocating USD 16 （or USD 9） per capita for adaptation in non-Annex II parties. The schemes proposed may be useful for promoting the development of the GCF in the future.

关键词： Climate change green climate fund preference score compromises carbon reductioncontribution mitigation and adaptation

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Water quality forecast through application of BP neural network at Yuqiao reservoir

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1482-1487页

作者： ZHAO ying NAN Jun cui Fu-yi GUO Liang School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China

This paper deals with the study of a water quality forecast model through application of BP neural network technique and GUI (Graphical User Interfaces) function of MATLAB at Yuqiao reservoir in Tianjin. To overcome the shortcomings of traditional BP algorithm as being slow to converge and easy to reach extreme minimum value,the model adopts LM (Leven-berg-Marquardt) algorithm to achieve a higher speed and a lower error rate. When factors affecting the study object are identified,the reservoir's 2005 measured values are used as sample data to test the model. The number of neurons and the type of transfer functions in the hidden layer of the neural network are changed from time to time to achieve the best forecast results. Through simulation testing the model shows high efficiency in forecasting the water quality of the reservoir.

关键词： Water quality forecast BP neural network MATLAB Graphical User Interfaces (GUI)

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Numerical Simulation of Flow in Centrifugal Pump with Complex Impeller

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Journal of Thermal Science 2011年第1期20卷 47-52页

作者： Bao-ling cui Yong-gang Lin ying-zi Jin The Laboratory of Fluid Transmission and Application Zhejiang Sci-Tech University Hangzhou 310018China State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

Based on the Navier-Stokes equations and the Spalart-Allmaras turbulence model,three dimensional turbulent flow fields in centrifugal pump with long-mid-short blade complex impeller are calculated and analyzed *** relative velocity and pressure distributions in the flowpart are *** is found that the flow in the passage of the complex impeller is unsymmetrical due to the joint action between volute and *** back-flow region is at inlet of long-blade suction side,near middle part of long-blade pressure side and outlet of short-blade suction *** flow near volute throat is affected greatly by *** relative velocity is large and it is easy to bring back flow at outlet of the complex impeller near volute *** static and total pressure rise uniformly from inlet to outlet in the *** impeller outlet,the pressure periodically decreases from pressure side to suction side,and then the static pressure sharply rise near the *** experimental results show that the back flow in the impeller has an important influence on the performance of pump.

关键词： Complex impeller Centrifugal pump Numerical simulation Experiment

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Enhanced photocataly tic activity of TiO_2 by surface fluorination in degradation of organic cationic compound

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Journal of Environmental Sciences 2007年第1期19卷 86-89页

作者： YANG Shi-ying CHEN You-yuan ZHENG Jian-guo cui ying-jie Key Lab of Maline Environmental Science and Ecology Ministry of Education Ocean University of China Qingdao 266100 China College of Environmental Science and Engineering Ocean University of China Qingdao 266100 China

Experiments were carried out to investigate the influence of TiO2 surface fluorination on the photodegradation of a representative organic cationic compound, Methylene Blue （MB）. The eleetropositive MB shows poor adsorption on TiO2 surface; its degradation performs a HO. radical-mediated mechanism. In the F-modified system, the kinetic reaction rate enlarged more than 2.5 fold that was attributed mainly to the accumulating adsorption of MB and the increased photogenerated hole available on the F-modified TiO2 surface.

关键词： photocatalysis mechanism adsorption surface fluorination photogenerated hole Methylene Blue(MB)

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Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis

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Biomedical and Environmental Sciences 2021年第6期34卷 465-477页

作者： LI Min DONG Xu Dong LYU Qiu Bo ZHANG Wei HUANG Shuai YANG chun Xue cui Di LAI Hui ying Department of Obstetrics and Gynecology Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Obstetrics the First People's Hospital of Yunnan ProvinceKunming 650032YunnanChina Department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking University Health Science Center Beijing 100069China Clinical Laboratory Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective To investigate the molecular mechanism of high phosphorylation levels of cofilin-1(p-CFL-1)associated with paclitaxel resistance in epithelial ovarian cancer(EOC)*** Cells displaying varying levels of p-CFL-1 and CFL-1 were created by plasmid transfection and shRNA *** inhibition rate indicating paclitaxel efficacy was assessed by Cell Counting Kit-8(CCK-8)*** was assessed by flow cytometry and protein levels were detected by western *** real-time polymerase chain reaction(qRT-PCR)was used to measure the expression levels of phosphokinases and phosphatases of *** analysis evaluated the correlation between the prognosis of EOC patients and the levels of p-CFL-1 and slingshot-1(SSH-1).Results High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of ***3 cell mutants with upregulated p-CFL-1 showed impaired paclitaxel efficacy,as well as decreased apoptosis rates and pro-survival patterns of apoptosis-specific protein *** accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial ***-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 ***,the high level of p-CFL-1 and the low level of SSH-1 in EOC tissues were closely related to chemotherapy resistance and poor prognosis in EOC *** The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor.

关键词： Cofilin-1 Slingshot-1 Epithelial ovarian cancer Chemo-resistance Apoptosis

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Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress,NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2021年第1期10卷 87-93页

作者： Huan Xiang Dongxiao Sun-Waterhouse chun cui School of Food Science and Engineering South China University of TechnologyGuangzhou510640GuangdongChina Guangdong Weiwei Biotechnology Co. LTDGuangzhou510640GuangdongChina School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

Auricularia auricula(AA)and Auricularia polytricha(AP)are popular edible *** study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving(through a 10-mesh sieve)AA and AP(termed as AAP/AAP-10 and APP/APP-10)via scalable processes(water extraction,ethanolic precipitation and deproteinization).This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice(body weight,fasting blood glucose,serum insulin,proinflammatory mediator and cytokines,oxidative stress-related products,antioxidant enzymes).APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose(100 mg/kg/day)likely working *** the same dose,APP generally performed more effective than AAP,and AAP-10/APP-10 seemed slightly more beneficial than AAP/*** mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling *** is cheaper than AA,thereby representing a favorable source of functional polysaccharides.

关键词： Polysaccharides Auricularia auricula Auricularia polytricha Hypoglycemic effect Oxidative stress

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