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Efficacy and safety of short duration radiotherapy combined with chemotherapy for advanced rectal cancer

World Journal of Clinical Cases 2021年第7期9卷 1524-1531页

作者： Shu-Quan Gao ying-chun zhang Chao zhang Sheng-Jie Wang Wei Ren Na Yuan Jun-Ye Wen Department of Hepatobiliary Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina Department of Interventional Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina The First Affiliated Hospital of Hebei North University Zhangjiakou 075061Hebei ProvinceChina Department of Radiotherapy The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina Department of General Surgery Hebei Provincial People’s HospitalShijiazhuang 050003Hebei ProvinceChina

BACKGROUND Radiotherapy or chemoradiotherapy is widely used for the treatment of rectal cancer *** the combination of radiotherapy and chemotherapy as an established preoperative neoadjuvant therapy shows high efficacy in the treatment of rectal cancer,some patients experience a response of poor tolerance and outcomes due to the long duration *** study compared short duration radiotherapy plus chemotherapy vs long duration radiotherapy plus chemotherapy for rectal cancer to determine whether short duration radiation treatment should be considered to diminish complications,reduce risk of recurrence and improve survival in patients with rectal *** To evaluate the efficacy and safety of short duration radiotherapy combined with chemotherapy for the treatment of advanced rectal *** One hundred patients with stage IIIB or higher severe rectal cancer were selected as the study subjects at The First Affiliated Hospital of Hebei North University between December 2018 and December *** patients were assigned to different groups based on the treatment *** patients who received preoperative short durations of radiotherapy plus chemotherapy were enrolled in an observation group and fifty patients who received conventional radiotherapy and chemotherapy were enrolled in a control *** biopsy was performed for all patients with pathological diagnosis of rectal *** expression of tumor-related factors such as RUNX3 and Ki-67 was quantitatively analyzed using immunohistochemistry in the tissues of the patients before and after ***,the duration of procedure,the amount of bleeding during the operation,the anus-conserving rate,the incidence of postoperative complications(wound infection,anastomotic leakage,postoperative intestinal obstruction,etc.)and postoperative pathology were compared between the two *** overall survival rate,recurrence rate and distant metastasis rate were a

关键词： Short course radiotherapy Chemotherapy Advanced rectal cancer Runx3 Ki-67

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Fuzzy Adaptive Control of Stochastic Nonlinear Systems with Unknown Virtual Control Gain Function

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自动化学报 2006年第2期32卷 170-178页

作者： WANG ying-chun zhang Hua-Guang WANG Yi-Zhong Institute of Electrical Automation Northeastern University Shenyang 110004

The problem of track control is studied for a class of strict-feedback stochastic nonlinear systems in which unknown virtual control gain function is the main feature. First, the so-called stochastic LaSalle theory is extended to some extent, and accordingly, the results of global ultimate boundedness for stochastic nonlinear systems are developed. Next, a new design scheme of fuzzy adaptive control is proposed. The advantage of it is that it does not require priori knowledge of virtual control gain function sign, which is usually demanded in many designs. At the same time, the track performance of closed-loop systems is improved by adaptive modifying the estimated error upper bound. By theoretical analysis, the signals of closed-loop systems are globally ultimately bounded in probability and the track error converges to a small residual set around the origin in 4th-power expectation.

关键词：随机非线性系统模糊自适应控制虚拟控制增益函数

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Transcranial Sonographic Alterations of Substantia Nigra and Third Ventricle in Parkinson＆#39;s Disease with or without Dementia

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Chinese Medical Journal 2017年第19期130卷 2291-2295页

作者： Zhi-Fen Dong Cai-Shan Wang ying-chun zhang ying zhang Yu-Jing Sheng Hua Hu Wei-Feng Luo chun-Feng Liu Department of Ultrasound The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Psychiatry The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Neurology The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China

Background： Numerous studies have demonstrated that patients with Parkinson＆#39;s disease （PD） have a higher prevalence of substantia nigra （SN） hyperechogenicity compared with controls. Our aim was to explore the neuroimaging characteristics of transcranial sonography （TCS） of patients with PD and those with PD with dementia （PDD）. The correlation between the echogenicity of the SN and clinical symptoms in Chinese patients with PDD was also assessed. Methods： The ratios of SN hyperechogenicity （SN＋）, maximum sizes of SN＋, and widths of third ventricle （TV） were measured using TCS for all the recruited patients. Data were analyzed using one-way analysis of variance, rank-sum test, Chi-square test, and receiver-operating characteristic （ROC） curve analysis. Results： The final statistical analysis included 46 PDD patients, 52 PD patients, and 40 controls. There were no significant differences in ratios of SN＋ and maximum sizes of SN＋ between PDD and PD groups （P 〉 0.05）. TV widths were significantly larger in PDD group （7.1± 1.9 mm） than in PD group （6.0± 2.0 mm） and controls （5.9 ± 1.5 mm, P 〈 0.05）; however, the ratios of enlarged TV did not differ among the three groups （P = 0.059）. When cutoff value was set at 6.8 mm, the TV width had a relatively high sensitivity and specificity in discriminating between PDD and PD groups （P = 0.030） and between PDD group and controls （P = 0.003）, based on ROC curve analysis. In PDD patients, SN＋ was more frequently detected in akinetic-rigid subgroup, and patients with SN＋ showed significantly higher Hoehn and Yahr stage and Nonmotor Symptoms Questionnaire scores （P 〈 0.05）. Conclusions： Compared to Chinese patients with PD, patients with PDD had a wider TV, altered SN sonographic features, and more severe clinical symptoms. Our findings suggest that TCS can be used to assess brain atrophy in PD and may be useful in discriminating between PD with and without dementia.

关键词： Dementia Parkinson's Disease Substantia Nigra Third Ventricle Transcranial Sonography

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Melatonin attenuatesβ-amyloid-induced inhibition of neurofilament expression

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Acta Pharmacologica Sinica 2004年第4期25卷 49-53页

作者： ying-chun zhang, Ze-fen WANG, Qun WANG, Yi-pengWANG, Jian-zhi WANG2 Department of Pathophysiology, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan 430030, China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology

AIM: To explore the effect of β-amyloid (Aβ) on metabolism of cytoskeletal protein neurofilament, and search for effective cure to the lesion. METHODS: Wild type murine neuroblastoma N2a (N2awt) and N2a stably transfected with wild type amyloid precursor protein (N2aAPP) were cultured. Sandwich ELISA, immunocytochemistry, and Western blot were used respectively to measure the level of Aβ, the expression and phosphorylation of neurofilament proteins. RESULTS: The immunoreactivity of neurofilament protein was almost abolished in N2aAPP, which beard a significantly higher level of Aβ. Melatonin effectively decreased the level of Aβ, and restored partially the level of phosphorylated and non-phosphorylated neurofilament in N2aAPP. CONCLUSION: Overproduction of Aβ inhibits neurofilament expression, and melatonin attenuates the Aβ-induced lesion in cytoskeletal protein.

关键词： Alzheimer disease amyloid beta-protein neurofilament proteins melatonin

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Effect of amyloid peptides on serum withdrawal-induced cell differentiation and cell viability

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Cell Research 2004年第6期14卷 467-472页

作者： Yi Peng WANG, Ze Fen WANG, ying chun zhang, Qing TIAN, Jian Zhi WANG Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China Department of Pathophyiiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Abnormal deposition of amyloid-p(Ap) peptides and formation of neuritic plaques are recognized as pathological processes in Alzheimer’s disease (AD) brain. By using amyloid precursor protein (APP) transfected cells, this study aims to investigate the effect of overproduction of Aβ on cell differentiation and cell viability. It was shown that after serum withdrawal, untransfected cell (N2a/Wt) and vector transfected cells (N2a/vector) extended long and branched cell processes, whereas no neurites was induced in wild type APP (N2a/APP695) and Swedish mutant APP (N2a/ APPswe) transfected N2a cells. After differentiation by serum withdrawal, the localization of APP/AP and neurofilament was extended to neurites, whereas those of APP-transfected cells were stillrestricted within the cell body. Levels of both APP and Aβ were significantly higher in N2a/APP695 and N2a/APPswe than in N2a/Wt, as determined by Western blot and Sandwich ELISA, respectively. To further investigate the effect of A0 on the inhibition

关键词： Alzheimer’s disease amyloid β cell differentiation.

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Chronic Myelomonocytic Leukemia with t （3; 9）（p21; p13） as a Sole Abnormal Appearance： One Case Report

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Clinical oncology and cancer researeh 2010年第5期7卷 326-329页

作者： Ji-hong zhang Li-jun GUAN Yun-xiu WANG ying-chun ZHENG Nan zhang Hai-xia TONG Hematology Laboratory Hematology Malignancy Treatment Center Shengjing Hospital China Medical University Shenyang 110004 Liaoning Province China.

Chronic myelomonocytic leukemia, （CMML） is a clinically rare chronic myeloid leukemia, with an incidence rate of about 1-2/ 100,000/year, and the age of the predominant cases is over 60 years. The median age of onset is 65-70 years, and the ratio of the incidence between male and female is about 1.5 ： 3.1. Specific etiological factors of the disease are not clear, but may be associated with the exposure to ionizing radiation,

关键词： chronic myelomonocytic leukemia genetics pathogenesis.

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Correlation of serum PDCD5 and Bax contents with the pathological features of tumor lesions in patients with lung cancer

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Journal of Hainan Medical University 2018年第8期24卷 44-47页

作者： Qian Huang chun-ying zhang Jun Su Department of Laboratory Medicine West China HospitalSichuan UniversityChengduSichuan Province610041

Objective:To study the correlation of serum PDCD5 and Bax contents with the pathological features of tumor lesions in patients with lung ***:Patients with lung cancer who underwent surgical treatment in West China Hospital between June 2014 and March 2017 were selected as the lung cancer group for the study, the serum specimens were collected before surgery, and the lung cancer lesion and adjacent lesion were taken after surgery;the healthy subjects who underwent physical examination in West China Hospital during the same period were selected as the control group, and the serum samples were taken during the physical examination;the contents of PDCD5 and Bax in serum as well as the contents of PDCD5 and Bax, and the expression of proliferation genes and invasion genes in the lung cancer lesion and adjacent lesion were ***: PDCD5 and Bax contents in serum of lung cancer group were significantly lower than those of control group, PDCD5 and Bax contents in lung cancer lesion were significantly lower than those in adjacent lesion, and the PDCD5 and Bax contents in serum of patients with lung cancer were positively correlated with the PDCD5 and Bax contents in lung cancer lesion;C-myc, RACK1, CatL, MMP2 and N-cadherin mRNA expression in lung cancer lesion were significantly higher than those in adjacent lesion and negatively correlated with PDCD5 and Bax contents in serum whereas LAST1, PAQR3, TCF21, E-cadherin, TIMP1 and TIMP2 mRNA expression were significantly lower than those in adjacent lesion and positively correlated with PDCD5 and Bax contents in serum. Conclusion:The decrease of PDCD5 and Bax in serum of patients with lung cancer is closely related to the aggravation of cancer cell proliferation and invasion in tumor lesions.

关键词： Lung cancer Programmed cell death 5 Bcl-2 associated X protein Proliferation Invasion

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Follow-up of children born after intracytoplasmic sperm injection with epididymal and testicular spermatozoa

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Chinese Medical Journal 2013年第11期126卷 2129-2133页

作者： GUO Yi-hong DONG Rui-na SU ying-chun LI Jing zhang Ya-jie SUN ying-pu Reproductive Medicine Center First Affiliated Hospital ofZhengzhou University Zhengzhou Henan 450052 China

Background To evaluate the safety of intracytoplasmic sperm injection （ICSI） with epididymal or testicular sperm, this study compared children born after ICSI treatment with epididymal or testicular sperm with children conceived after ICSI with ejaculated sperm. Methods This retrospective study included 317 children born after ICSI with percutaneous epididymal sperm aspiration （PESA）, 103 children born after ICSI with testicular sperm aspiration （TESA）, and a control group of 1008 children born after ICSI with ejaculated sperm. All of the patients received their assisted reproductive treatment in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2004 to December 2011. Data, such as the rate of stillbirths, perinatal mortality, gestational age, birth weight, and the rate of congenital malformations of the three groups, were compared. Results PESA and TESA children were not different from ICSI children in the rate of stillbirths, perinatal mortality, infant mortality rate, gestational age, the rate of prematurity, and the rate of malformations （P〉0.05）. A slight increase in birth defects was reported in the TESA group compared with those in the control group, but there was no significant difference between the groups （P〉0.05）. Conclusion ICSI with epididymal or testicutar sperm does not lead to more stillbirths or congenital malformations compared with ICSI using ejaculated sperm.

关键词： intracytoplasmic sperm injection epididymal spermatozoa testicular spermatozoa birth defects

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Sonographic Alteration of Basal Ganglia in Different Forms of Primary Focal Dystonia： A Cross-sectional Study

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Chinese Medical Journal 2016年第8期129卷 942-945页

作者： ying zhang ying-chun zhang Yu-Jing Sheng Xiao-Fang Chen Cai-Shan Wang Qi Ma Han-Bing Chen Li-Fang Yu Cheng-Jie Mao Kang-Ping Xiong Wei-Feng Luo chun-Feng Liu Department of Ultrasound The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Neurology The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China

Background：Few studies have addressed whether abnormalities in the lenticular nucleus （LN） are characteristic transcranial sonography （TCS） echo features in patients with primary *** study aimed to explore alterations in the basal ganglia in different forms of primary focal ***：A cross-sectional observational study was performed between December 2013 and December 20 1 4 in 80 patients with different forms of primary focal dystonia and 55 neurologically normal control *** was performed in patients and control *** comparisons of multiple rates were used to compare LN hyperechogenicity ratios between control and patient ***：Thirteen individuals were excluded due to poor temporal bone windows,and two subjects were excluded due to disagreement in evaluation by ***,70 patients （cervical dystonia,n =30;blepharospasm,n =30;oromandibular dystonia,n =10） and 50 normal controls were included in the final *** hyperechogenicity was observed in 51% （36/70） of patients with primary focal dystonia,compared with 12% （6/50） of controls （P 〈 0.001）.Substantia nigra hyperechogenicity did not differ between the two *** hyperechogenicity was observed in 73% （22/30） of patients with cervical dystonia,a greater prevalence than in patients withblepharospasm （33%,10/30,P =0.002） and oromandibular dystonia （40%,4/10,P =0.126）.LN hyperechogenicity was more frequently observed in patients with cervical dystonia compared with controls （73% vs.12%,P 〈 0.001）;however,no significant difference was detected in patients with blepharospasm （33% vs.12%,P =0.021） or oromandibular dystonia （40% vs.12%,P =0.088）.Conclusions：LN hyperechogenicity is more frequently observed in patients with primary focal dystonia than in *** does not appear to be a characteristic TCS echo feature in patients with blepharospasm or oromandibular dystonia.

关键词： Basal Ganglia Lenticular Nucleus Primary Focal Dystonia Transcranial Sonography

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Study on the Temperature of the Bridge Wire in the Initiator Used in Nuclear Explosion Valve

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American Journal of Analytical Chemistry 2016年第12期7卷 908-917页

作者： Lan Shi An-Min Yang ying-chun zhang Yuan-He Wang Zhanying Li Shaanxi Applied Physics-Chemistry Research Institute Xi’an China

This paper established the mathematical model of bridge wire temperature rise under direct current condition and gave the solution. It computed bridge wire temperature by using the thermal-electric coupling method provided by ANSYS-Workbench finite element analysis software. In the end, the temperature bridge wire applied to different electric current was measured by the infrared thermal imaging temperature measurement method. The result shows that the ANSYS simulation results are in agreement with the theoretical calculation and the experimental results. It is feasible to compute bridge wire temperature of initiator by using ANSYS-Workbench software, and it is an important method to analyze complex structure of pyrotechnics.

关键词： Bridge Wire Temperature ANSYS-Workbench Thermal-Electric Coupling Infrared Thermal Imaging

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