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A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

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Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo yingpeng Wan chun‑sing Lee Shengliang Li xiao‑Hong Zhang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

Influence of Freezing Layer on the Crystallization Kinetics of PCL on Oriented PE Film

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Chinese Journal of Polymer Science 2023年第5期41卷 778-786,I0010页

作者： Hao Zhang ying-xiao Song Na Li Shao-Juan Wang Jian Hu Rui Xin Jie Zhang chun-Feng Song Shou-Ke Yan Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science&TechnologyQingdao 266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

The effect of freezing layer on the crystallization kinetics of poly(ε-caprolactone)(PCL)thin and ultrathin films was investigated by monitor the growth process of it on oriented polyethylene(PE)and CaF_(2)with and without freezing layer,*** was found that the PCL films with similar thicknesses crystallize much faster on oriented PE than on CaF_(2)*** example,the crystallization rate constant of a 102 nm thick PCL film decreases tremendously by 3 orders of magnitude from 1.1×10^(-1) on PE substrate at 50℃to 7×10^(-4)on CaF_(2)surface at 40℃.Moreover,the crystallization of PCL accelerates on CaF_(2)surface while slows down at PE surface with increasing film *** ultrathin films of PCL with thickness less than 14 nm exhibits the fastest crystallization rate on oriented PE with a rate constant of about 3.5×10^(-1),which is 3 times higher than that of a ca.50 nm thick *** illustrates the great influence of freezing layer on the crystallization process of *** freezing layer thickness of PCL on PE is estimated to be in the range of 14-17 *** the radius of gyration(R_(g)~15.6 nm)of the used PCL material into account,the obtained results may imply the existence of a correlation between the R_(g)of PCL and its freezing layer thickness at PE substrate.

关键词： Poly(ε-caprolactone) Polyethylene Interface Freezing layer Crystallization kinetics

Human endostatin gene transfer,either naked or with liposome,has the same inhibitory effect on growth of mouse liver tumor cells in vivo

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World Journal of Gastroenterology 2004年第19期10卷 2874-2877页

作者： chun-HongMa YanZhang xiao-YanWang Li-FenGao HuaLiu chunGuo Su-XiaLiu ying-Lincao Li-NingZhang Wen-ShengSun InstituteofImmunology MedicalCollegeofShandongUniversityJinan250012ShandongProvinceChina

AIM: To explore a safe and efficient strategy of tumortherapy using anti-angiogenetic ***: Endostatin gene with a signal sequence ofhuman IgG y chain was amplified by PCR and cloned intopVAXl plasmid which was the only vector authorized byFDA in clinical trial to construct a recombinant plasmidnamed as pVAX-sEN. The recombinant plasmid wasdetected with EcoRI/KpnI and DNA sequencing. BALB/c micebearing hepatocarcinoma cell line H22 were treated withnaked pVAX-sEN or liposome-DNA complex in which thedose of DNA and the ratio of DNA and liposome weredifferent from each other. To compare the efficiency ofgene transfection, expression of endostatin at the treatedtumor site was assayed with ELISA. To investigate the effectof pVAXI-sEN on hepatocellular carcinoma, pVAX-sENeither naked or in liposome-DNA complex was injectedinto BALB/c mice bearing H22, then the diameter of tumorswas measured, microvessel density was detected byimmunohistochemistry, endostatin expression in vivo wasassayed at different time ***: DNA sequencing showed the endostatin genewith the signal peptide was correctly cloned. In situ geneexpression assay indicated that both the ratio of DNAand liposome and the dose of DNA could affect the genetransfection efficiency. Interestingly, naked pVAX-sEN hada similar in situ endostatin expression to pVAX-sEN withliposome. Animal experiments showed that pVAX-sENtogether with pVAX-sEN-liposome complex could efficientlysuppress the growth of mouse hepatoma ***: Naked endostatin plasmid intratumoralinjection can get a similar gene transfection efficiency toliposome-DNA complex when used in situ.

关键词：人类基因转移脂质体裸露的抑制作用生长繁殖老鼠肝脏癌癌细胞体内肿瘤

Highly active iridium catalyst for hydrogen production from formic acid

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Chinese Chemical Letters 2017年第8期28卷 1746-1750页

作者： ying Du Yang-Bin Shen Yu-Lu Zhan Fan-Di Ning Liu-Ming Yan xiao-chun Zhou Department of Chemistry Shanghai UniversityShanghai 200444China Division of Advanced Nanomaterials Suzhou Institute of Nano-tech and Nano-bionicsChinese Academy of SciencesSuzhou 215125China University of Chinese Academy of Sciences Beijing 100049China University of Science and Technology of China Hefei 230026China

Formic acid（FA） dehydrogenation has attracted a lot of attentions since it is a convenient method for H_2 production. In this work, we designed a self-supporting fuel cell system, in which H_2 from FA is supplied into the fuel cell, and the exhaust heat from the fuel cell supported the FA dehydrogenation. In order to realize the system, we synthesized a highly active and selective homogeneous catalyst Ir Cp＊Cl_2 bpym for FA dehydrogenation. The turnover frequency（TOF） of the catalyst for FA dehydrogenation is as high as7150 h^（-1）at 50°C, and is up to 144,000 h^（-1）at 90°C. The catalyst also shows excellent catalytic stability for FA dehydrogenation after several cycles of test. The conversion ratio of FA can achieve 93.2%, and no carbon monoxide is detected in the evolved gas. Therefore, the evolved gas could be applied in the proton exchange membrane fuel cell（PEMFC） directly. This is a potential technology for hydrogen storage and generation. The power density of the PEMFC driven by the evolved gas could approximate to that using pure hydrogen.

关键词： Formic acid Hydrogen generation Homogeneous catalyst Catalytic performance Proton exchange membrane fuel cell

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang Lu Qiu xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Electroacupuncture reduces apoptotic index and inhibits p38 mitogen-activated protein kinase signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2017年第3期12卷 409-416页

作者： xiao Lan Xin Zhang Guo-ping Zhou chun-xiao Wu chun Li Xiu-hong Xu School of Traditional Chinese Medicine Southern Medical University College of Acupuncture Moxibustion and TuinaHunan University of Chinese Medicine

Electroacupuncture attenuates cerebral hypoxia and neuronal apoptosis induced by cerebral ischemia/reperfusion *** further identify the involved mechanisms,we assumed that electroacupuncture used to treat cerebral ischemia/reperfusion injury was associated with the p38 mitogen-activated protein kinase（MAPK） signaling *** established rat models of cerebral ischemia/reperfusion injury using the modified Zea-Longa＇s *** 30 minutes before model establishment,p38 MAPK blocker SB20358 was injected into the left lateral *** 1.5 hours after model establishment,electroacupuncture was administered at acupoints of Chize（LU5）,Hegu（LI4）,Zusanli（ST36）,and Sanyinjiao（SP6） for 20 minutes in the affected *** showed that the combination of EA and SB20358 injection significantly decreased neurologic impairment scores,but no significant differences were determined among different interventional ***-eosin staining also showed reduced brain tissue *** with the SB20358 group,the cells were regularly arranged,the structures were complete,and the number of viable neurons was higher in the SB20358 ＋ electroacupuncture *** deoxynucleotidyl transferase（Td T）-mediated d UTP nick-end labeling assay showed a decreased apoptotic index in each group,with a significant decrease in the SB20358 ＋ electroacupuncture *** revealed reduced phosphorylated p38 expression at 3 days in the electroacupuncture group and SB20358 ＋ electroacupuncture group compared with the ischemia/reperfusion *** was no significant difference in phosphorylated p38 expression between the ischemia/reperfusion group and SB20358 *** findings confirmed that the electroacupuncture effects on mitigating cerebral ischemia/reperfusion injury are possibly associated with the p38 MAPK signaling pathway.A time period of 3 days could promote the repair of ischemic cerebral nerves.

关键词： nerve regeneration brain injury electroacupuncture cell apoptosis cerebral ischemia/reperfusion injury neurological impairment score morphological changes immunohistoehemical assay p38 mitogen-activated protein kinases phosphorylated p38 hippocampus neural regeneration

Free Completely J^(e)-simple Semigroups

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Acta Mathematica Sinica,English Series 2015年第7期31卷 1086-1096页

作者： Jun ying GUO xiao Jiang GUO Juan ying DING Department of Mathematics Jiangxi Normal University

A semigroup is called completely J（e）-simple if it is isomorphic to some Rees matrix semi- group over a left cancellative monoid and each entry of whose sandwich matrix is in the group of units of the left cancellative monoid. It is proved that completely J（e）-simple semigroups form a quasivarity. Moreover, the construction of free completely J（e）simple semigroups is given. It is found that a free completely J（e）-simple semigroup is just a free completely J＊-simple semigroup and also a full subsemigroup of some completely simple semigroups.

关键词： Strongly rpp semigroup free semigroup completely J(e)-simple semigroup quasivariety

Persistent Currents in the Double Aharonov-Bohm Ring Connected to Electron Reservoirs

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Communications in Theoretical Physics 2007年第3期47卷 573-576页

作者： ZHANG ying xiao Jing-Lin Department of Mathematics and Physics Hebei Normal University of Science and Technology Qinhuangdao 066004 China College of Physics and Electromechanics Inner Mongolia National University Tongliao 028043 China

We study persistent currents in the double Aharonov-Bohm ring connected to two electron reservoirs by quantum waveguide theory. It is found that the persistent currents in the double Aharonov-Bohm ring depend .on the direction of the current flow from one reservoir to another. When the direction of the current flow reverses, tl2e persistent current in each ring of the double Aharonov-Bohm ring changes. If the two rings are of the same size, the persistent currents in the left and the right rings exchange at the reversal of the current flow direction.

关键词： quantum waveguide theory mesoscopic structure persistent currents

Stable expression of human cytochrome P450 2D6*10 in HepG2 cells

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World Journal of Gastroenterology 2004年第2期10卷 234-237页

作者： JianZhuge ying-NianYu xiao-DanWu DepartmentofPathologyandPathophysiology SchoolofMedicineZhejiangUniversityHangzhou310031ZhejiangProvinceChina CenterofAnalysis ZhejiangUniversityHangzhou310031ZhejiangProvinceChina

AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver *** most important enzymes are CYPIA2, 3A4,2C9/19,2D6 and *** CYP2D6 accounts for<2% of the total CYP liver enzyme content,it mediates metabolism in almost 25% of *** order to study its enzymatic activity for drug metabolism, its cDNA was cloned and a HepG2 cell line stably expressing CYP2D6 was ***:Human CYP2D6 cDNA was amplified with reverse transcription-polymerase chain reaction (RT-PCR) from total RNA extracted from human liver tissue and cloned into pGEM-T vector,cDNA segment was identified by DNA sequencing and subcloned into a mammalian expression vector pREP9.A cell line was established by transfecting the recombinant plasmid of pREP9-CYP2D6 to hepatoma HepG2 *** of mRNA was validated by *** activity of catalyzing dextromethorphan Odemethylation in postmitochondrial supernant (S9) fraction of the cells was determined by high performance liquid chromatography (HPLC).RESULTS:The cloned cDNA had 4 base differences, e.g.100 C→T, 336 T→C,408 C→G and 1 457 G→C,which resulted in P34S,and S486T amino acid substitutions, and two samesense mutations were 112F and 136V compared with that reported by Kimura et al (GenBank accession number: M33388).P34S and S486T amino acid substitutions were the characteristics of CYP2D6*10 *** relative activity of S9 fraction of HepG2-CYP2D6*10 metabolized detromethorphan O-demethylation was found to be 2.31±0.19nmol·min^-1·mg^-1 S9 protein (n=3),but was undetectable in parental HepG2 ***:cDNA of human CYP2D6*IOcan be successfully doned.A cell line,HepG2-CYP2D6*10,expressing CYP2D6*10 mRNA and having metabolic activity,has been established.

关键词： P-450细胞色素 HepG2细胞逆转录聚合酶链反应高效液相色谱法肝脏同功酶 DNA序列