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Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer:A single center experience

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3457-3470页

作者： Zhao Gao Xuan Jin ying-chao wu Shi-Jie Zhang Shi-Kai wu Xin Wang Department of Medical Oncology Peking University First HospitalBeijing 10000China Department of General Surgery Peking University First HospitalBeijing 10000China Department of Thoracic Surgery Peking University First HospitalBeijing 10000China

BACKGROUND Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer(CRC)and resectable pulmonary metastases(PM).However,the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains *** hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from *** To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from *** We retrospectively collected demographic,clinical,and pathologic data on patients who underwent radical surgery for isolated PM from *** survival(CSS)and disease-free survival were calculated using Kaplan-Meier ***-group differences were compared using the log-rank *** multivariate analysis,Cox regression was utilized when *** This study included 120 patients with a median age of 61.6 *** 5-year CSS rate was 78.2%,with 36.7% experiencing *** resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second *** chemotherapy(P=0.079)did not enhance survival *** associated with improved survival included fewer metastatic lesions[hazard ratio(HR):2.51,P=0.045],longer disease-free intervals(HR:0.35,P=0.016),and wedge lung resections(HR:0.42,P=0.035).Multiple PM predicted higher recurrence risk(HR:2.22,P=0.022).The log-rank test showed no significant difference in CSS between single and repeated metastasectomy(P=0.92).CONCLUSION Perioperative chemotherapy shows no survival benefit post-PM resection in ***-free intervals and fewer metastatic lesions predict better *** metastasectomy is warranted for eligible patients.

关键词： Pulmonary metastasis Colorectal cancer Perioperative chemotherapy Survival Repeated pulmonary metastasectomy

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Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3171-3184页

作者： Zhao Gao Shi-Kai wu Shi-Jie Zhang Xin Wang ying-chao wu Xuan Jin Department of Medical Oncology Peking University First HospitalBeijing 100034China Department of Thoracic Surgery Peking University First HospitalBeijing 100034China Department of Gastrointestinal Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The benefit of adjuvant chemotherapy(ACT)for patients with no evidence of disease after pulmonary metastasis resection(PM)from colorectal cancer(CRC)remains *** To assess the efficacy of ACT in patients after PM resection for *** This study included 96 patients who underwent pulmonary metastasectomy for CRC at a single institution between April 2008 and July *** primary end-point was overall survival(OS);secondary endpoints included cancer-specific survival(CSS)and disease-free survival(DFS).An inverse probability of treat-ment-weighting(IPTW)analysis was conducted to address indication ***-vival outcomes compared using Kaplan-Meier curves,log-rank test,Cox regre-ssion and confirmed by propensity score-matching(PSM).RESULTS With a median follow-up of 27.5 months(range,18.3-50.4 months),the 5-year OS,CSS and DFS were 72.0%,74.4%and 51.3%,*** had no significant effect on OS after PM resection from CRC[original cohort:P=0.08;IPTW:P=0.15].No differences were observed for CSS(P=0.12)and DFS(P=0.68)between the ACT and non-ACT *** analysis showed no association of ACT with better survival,while sublobar resection(HR=0.45;95%CI:0.20-1.00,P=0.049)and longer disease-free interval(HR=0.45;95%CI:0.20-0.98,P=0.044)were associated with improved *** ACT does not improve survival after PM resection for *** well-designed randomized controlled trials are needed to determine the optimal ACT regimen and duration.

关键词： Colorectal cancer Resection of pulmonary metastasis Adjuvant chemotherapy Inverse probability treatment weighting Prognosis

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Vacuum Black Hole Mass Formula Is a Vanishing Noether Charge

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Communications in Theoretical Physics 2002年第3期38卷 309-312页

作者： wu Xiao-Ning GUO Han-ying HUANG chao-Guang wu Ke Institute of Theoretical Physics the Chinese Academy of Sciences P.O. Box 2735 Beijing 100080 China Institute of Theoretical Physics the Chinese Academy of Sciences P.O. Box 2735 Beijing 100080 China Institute of High Energy Physics the Chinese Academy of Sciences P.O. Box 9184 Beijing 100039 China Institute of Theoretical Physics the Chinese Academy of Sciences P.O. Box 2735 Beijing 100080 China Institute of Theoretical Physics the Chinese Academy of Sciences P.O. Box 2735 Beijing 100080 China Departrnent of Mathematics Capital Normal University Beijing 100037 China

The Noether current and its variation relation with respect to diffeomorphism invariance of gravitationaltheories have been derived from the horizontal variation and vertical-horizontal bi-variation of the Lagrangian, respec-tively. For Einstein's GR in the stationary, axisymmetric black holes, the mass formula in vacuum can be derived fromthis Noether current although it definitely vanishes. This indicates that the mass formula of black holes is a vanishingNoether charge in this case. The first law of black hole thermodynamics can also be derived from the variation relationof this vanishing Noether current.

关键词： black hole, mass formula, Noether charge, diffeomorphism invariance

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Appendico-vesicocolonic fistula:A case report and review of literature

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World Journal of Clinical Cases 2022年第10期10卷 3241-3250页

作者： Han Yan ying-chao wu Xin Wang Yu-Cun Liu Shuai Zuo Peng-Yuan Wang Department of General Surgery Peking University First HospitalBeijing 100032China

BACKGROUND Appendico-vesicocolonic fistulas and appendiceal-colonic fistulas are two kinds of intestinal and bladder diseases that are rarely seen in the *** our knowledge,no more than 4 cases of appendico-vesicocolonic fistulas have been publicly reported throughout the world,and no more than 100 cases of appendiceal-colonic fistulas have been *** the overall incidence is low,an early diagnosis is difficult due to their atypical initial symptoms,but these diseases still require our *** SUMMARY Here,we report a case of a 77-year-old male patient diagnosed with an appendico-vesicocolonic fistula combined with an appendiceal-colonic *** main manifestations were diarrhea and urine that contained fecal *** diagnosis was confirmed by multiple laboratory and imaging examinations.A routine urinalysis showed red blood cells and white blood *** and pelvic computed tomography scans showed close adhesions between the bowels and the bladder,and fistulas could be *** and cystoscopy and some other imaging examinations clearly showed *** preoperative diagnoses were a colovesical fistula and an appendiceal-colonic *** fistulas were repaired by laparoscopic surgical *** diseased bowel and part of the bladder wall were removed,followed by a protective *** postoperative diagnosis was an appendico-vesicocolonic fistula combined with an appendiceal-colonic fistula,and the pathology suggested inflammatory *** patient recovered well after surgery,and all his symptoms *** The final diagnosis in this case was a double fistula consisting of an appendicovesicocolonic fistula combined with an appendiceal-colonic fistula.

关键词： Appendico-vesicocolonic Appendiceal-colonic Enterovesical Fistula Laparoscopic surgery Case report

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

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Frontiers of Medicine 2010年第2期4卷 235-240页

作者： Ge-Qing XIA Yu HU Ze-Hua WANG Li ZOU chao-ying wu Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

This study was aimed to detect maternal serum levels of thromboxane B2(TXB2)in different durations of pregnancy and explore the predictive value of TXB2 for *** employing a prospective and double-blind study method,180 pregnant women with previously normal blood pressures during their progestation were included in the *** venous blood samples were obtained during 10+0–14+6(period I),20+0–24+6(period II)and 30+0–34+6(period III)weeks of *** serum levels of TXB2 were measured by enzyme-linked *** pathogenetic condition and pregnancy outcomes of these cases were observed.(1)Among the 180 previously normotensive women,ten developed preeclampsia(case group;four severe and six mild preeclampsia).One hundred and seventy remained normal till the end of pregnancy(control group).(2)With development of pregnancy,the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen through the Wilcoxon Signed Ranks *** was a statistical signiﬁcance in maternal TXB2 levels between two different gestational stages(P0.05);the levels of TXB2 were signiﬁcantly higher in the case group than in the control group during periods II and III of gestation(both P<0.05).(3)The best cutoff points of maternal TXB2 were 3750 and 4400 ng/mL during periods II and III of gestation by receiver operator characteristic(ROC)curve;and the sensitivity,speciﬁcity,positive predictive value,negative predictive value and odds radio of TXB2 in predicting preeclampsia were 80%,69.5%,13.3%,98.33%,9.11 and 90%,68.82%,13.84%,99.13,19.86,*** levels of maternal serum TXB2 were detected a long time before clinical symptoms *** maternal serum TXB2 after 20 weeks of gestation had predictive value,and the index after 30 weeks was superior

关键词： thromboxane B2 preeclampsia

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Highly Aligned Graphene Aerogels for Multifunctional Composites

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Nano-Micro Letters 2024年第6期16卷 276-342页

作者： ying wu chao An Yaru Guo Yangyang Zong Naisheng Jiang Qingbin Zheng Zhong‑Zhen Yu Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004People’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhenGuangdong 518172People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Stemming from the unique in-plane honeycomb lattice structure and the sp^(2)hybridized carbon atoms bonded by exceptionally strong carbon–carbon bonds,graphene exhibits remarkable anisotropic electrical,mechanical,and thermal *** maximize the utilization of graphene’s in-plane properties,pre-constructed and aligned structures,such as oriented aerogels,films,and fibers,have been *** unique combination of aligned structure,high surface area,excellent electrical conductivity,mechanical stability,thermal conductivity,and porous nature of highly aligned graphene aerogels allows for tailored and enhanced performance in specific directions,enabling advancements in diverse *** review provides a comprehensive overview of recent advances in highly aligned graphene aerogels and their *** highlights the fabrication methods of aligned graphene aerogels and the optimization of alignment which can be estimated both qualitatively and *** oriented scaffolds endow graphene aerogels and their composites with anisotropic properties,showing enhanced electrical,mechanical,and thermal properties along the alignment at the sacrifice of the perpendicular *** review showcases remarkable properties and applications of aligned graphene aerogels and their composites,such as their suitability for electronics,environmental applications,thermal management,and energy *** and potential opportunities are proposed to offer new insights into prospects of this material.

关键词： Highly aligned graphene aerogels Quantitative characterization of alignment Multifunctional composites Anisotropic properties Multifunctional applications

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Micro-aluminum powder with bi-or tri-component alloy coating as a promising catalyst:Boosting pyrolysis and combustion of ammonium perchlorate

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Defence Technology（防务技术） 2024年第3期33卷 100-113页

作者： chao Wang ying Liu Mingze wu Jia Li ying Feng Xianjin Ning Hong Li Ningfei Wang Baolu Shi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

A novel design of micro-aluminum(μAl)powder coated with bi-/tri-component alloy layer,such as:Ni-P and Ni-P-Cu(namely,Al@Ni-P,Al@Ni-P-Cu,respectively),as combustion catalysts,were introduced to release its huge energy inside Al-core and promote rapid pyrolysis of ammonium perchlorate(AP)at a lower temperature in aluminized *** microstructure of Al@Ni-P-Cu demonstrates that a three-layer Ni-P-Cu shell,with the thickness of~100 nm,is uniformly supported byμAl carrier(fuel unit),which has an amorphous surface with a thickness of~2.3 nm(catalytic unit).The peak temperature of AP with the addition of Al@Ni-P-Cu(3.5%)could significantly drop to 316.2℃ at high-temperature thermal decomposition,reduced by 124.3℃,in comparison to that of pure AP with 440.5℃.It illustrated that the introduction of Al@Ni-P-Cu could weaken or even eliminate the obstacle of AP pyrolysis due to its reduction of activation energy with 118.28 kJ/*** laser ignition results showed that the ignition delay time of Al@Ni-P-Cu/AP mixture with 78 ms in air is shorter than that of Al@Ni-P/AP(118 ms),decreased by 33.90%.Those astonishing breakthroughs were attributed to the synergistic effects of adequate active sites on amorphous surface and oxidation exothermic reactions(7597.7 J/g)of Al@Ni-P-Cu,resulting in accelerated mass and/or heat transfer rate to catalyze AP pyrolysis and ***,it is believed to provide an alternative Al-based combustion catalyst for propellant designer,to promote the development the propellants toward a higher energy.

关键词： Micro-aluminum powder(μAl) Nano-sized alloy coating Combustion catalyst Ammonium perchlorate Pyrolysis behavior Ignition and combustion

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Dynamical switchable quantum nonreciprocity induced by off-resonant chiral two-photon driving

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 31-37页

作者： Da-Wei Liu Zi-Hao Li Shi-Lei chao ying wu Liu-Gang Si School of Physics and Institute for Quantum Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Optical nonreciprocity,which refers to the direction-dependent emission,scattering and absorption of photons,plays a very important role in quantum engineering and quantum information ***,we propose an all-optical approach to achieve the optical dynamical switchable quantum nonreciprocity by an off-resonant chiral two-photon driving in a single microring cavity,which differs from the conventional nonreciprocal *** is shown that the optical field with time-dependent statistical properties can be generated and the nonreciprocity flips periodically,with switchable photon blockade and photon-induced tunneling *** find that the dynamical system is robust and immune to the parameter variations,which loosens the parameter range of ***,the time window for one-way quantum information is sufficiently wide and *** work opens a new idea for the current quantum nonreciprocal research,which can facilitate a memory functionality and be used for future inmemory superconducting quantum *** other nonreciprocal quantum devices,i.e.,dynamical switchable nonreciprocal squeezing and entanglement,may be inspired by our method,which is expected to have important applications in future quantum technology.

关键词： dynamical switchable nonreciprocity single-photon source chiral two-photon driving

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Active flutter suppression of nonlinear fin-actuator system via inverse system and immersion and invariance method

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Chinese Journal of Aeronautics 2024年第4期37卷 343-362页

作者： Jin LU Zhigang wu chao YANG Chinese Aeronautical Establishment Beijing 100029China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

Structural nonlinearities such as freeplay will affect the stability and even flight safety of the fin-actuator *** is a lack of a practical method for designing Active Flutter Suppression (AFS) control laws for nonlinear fin-actuator systems.A design method for the AFS controller of the nonlinear all-movable fin-electromechanical actuator system is established by combining the inverse system and the Immersion and Invariance (I&I) ***,the composite control law combining the inverse system principle and internal model control is used to offset the nonlinearity and dynamics of the actuator,so that its driving torque can follow the ideal ***,the ideal torque of the actuator is designed employing the I&I *** unfavorable oscillation of the fin is suppressed by making the output torque of the actuator track the ideal *** simulation results reveal that the proposed AFS method can increase the flutter speed of the nonlinear finactuator system with freeplay,and a set of controller parameters is also applicable for wider freeplay within a certain *** power required for the actuator does not exceed the power that can be provided by the commonly used aviation *** method can also resist a certain level of noise and external disturbance.

关键词： Aeroelasticity Active flutter suppression Fin-actuator system Freeplay Inverse system Immersion and invariance

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Intelligent feedforward gust alleviation based on neural network

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Chinese Journal of Aeronautics 2024年第3期37卷 116-132页

作者： Yitao ZHOU Zhigang wu chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

This paper proposes a neural network-based intelligent feedforward gust alleviation framework,which includes a neural network identification model and a neural network controller.A neural network training dataset is formed by collecting flight data and the gust data encountered during the aircraft flight.A neural network identification model is first trained to accurately predict the aircraft’s ***,based on the output of the identification model and the collected flight data,the parameters of the time-delay neural network controller are obtained through a learning *** simulation results show that the designed intelligent controller has good gust alleviation effects for both continuous turbulence excitation and discrete gust *** example,when the aircraft is 40000 kg and the flight speed is 0.81Ma,the controller achieves a 67.82%reduction in wingtip acceleration and a 35.90%reduction in center of mass acceleration under continuous turbulence *** considering the measurement uncertainties,such as noise existing in the collected data,the trained controller can still achieve an acceptable gust alleviation ***,considering a flight in which the aircraft mass is constantly changing,the intelligent controller,which continuously learns from new flight data,maintains a good gust alleviation effect throughout the flight.

关键词： Gust alleviation Intelligent control Feedforward control Neural networks Time-varying aircraft

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