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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke zhao Dong Fu Meina Wang chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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New magnetic nano Fe304 gene vector improve adenovirus vector＇s efficiency for salivary tumor cell lines

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中国口腔颌面外科杂志 2008年第B5期6卷 123-123页

作者： Hong Chen Sun Lei ying Miao chao Liu zhao Qiang Li Kai Zhang Oral Pathology Department Hospital of Stomatolosoy JilinUniversity Changchun 130041China

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Preliminary Design of a System for Picking up Audio-Signals From Bubble Detectors GAO Si-ze1,NI Bang-fa,ZHANG Gui-ying,XIAO Cai-jin,LIU Cun-xiong, CHEN Zhe1,NIE Peng,LIU chao1,zhao Chang-jun (*** of Physics Science and Engineering Technology,Guang

Preliminary Design of a System for Picking up Audio-Signals ...

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作者： GAO Si-ze NI Bang-fa ZHANG Gui-ying XIAO Cai-jin LIU Cun-xiong CHEN Zhe NIE Peng LIU chao zhao Chang-jun College of Physics Science and Engineering Technology Guangxi University

This system is designed to pick up sound signals from large volume,low-threshold energy, low-background superheated droplets bubble detectors.A sound-sensitive bubble detector is composed of a container filled with a mixture of superheated droplets and gel,a temperature and pressure control system,and an audio acquisition system attached on the outer surface of the *** superheated droplets are in a metastable and superheated state at ambient temperature and *** the outside

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不同类型学业压力对不同年级高中生执行功能子成分的影响

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心理学报 2025年第1期57卷 18-35页

作者：马超汪彦云付军军赵鑫甘肃省行为与心理健康重点实验室西北师范大学心理学院兰州730070

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交... 详细信息

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交压力对各执行功能成分的负向预测作用逐渐减弱。相比之下,自我压力对高中生的干扰抑制、反应抑制和注意转换能力均显示出了正向预测作用,并随年级的升高而增强。这表明,不同类型学业压力对各执行功能成分的预测作用存在差异,并将随高中生年级的升高而发生变化。本研究所产生的结论对于教育工作者有效制定高中生学业压力应对策略具有重要的启示意义。

关键词：执行功能学业压力高中生结构方程模型

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang zhao-Xian Li Wei-Qi Zhang Yu-ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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A novel alkaloid from the fruiting bodies of Ganoderma sinense zhao,Xu et Zhang

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Chinese Chemical Letters 2010年第2期21卷 197-199页

作者： Liu, chao zhao, Fen Chen, RuoYun Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Minist Educ Key Lab Bioact Substances & Resources Utilizat Ch Beijing 100050 Peoples R China

A new alkaloid,sinensine(1),had been isolated from the fruiting bodies of Ganoderma sinense zhao,Xu et *** structure was elucidated on the basis of 1D and 2D spectral *** alkaloid exhibited activity in protecting the ... 详细信息

关键词： Alkaloid Ganoderma sinense Sinensine

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Effect of Nanoclay on the Phase Separation Behavior of Poly(methyl methacrylate)/Poly(vinyl acetate) Binary Polymer Blends

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Chinese Journal of Polymer Science 2014年第11期32卷 1419-1419,1420-1430页

作者： Ji-shi zhao 左敏 chao-ying Lin Qiang Zheng Key Laboratory of Macromolecule Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and EngineeringZhejiang University

The effect of nanoclay on the phase-separation behavior of poly（methyl methacrylate）/poly（vinyl acetate）（PMMA/PVAc） blends has been mainly investigated by small-angle laser light scattering. It is found that the effect of clay on the thermodynamics and kinetics of phase-separation for PMMA/PVAc blends seems inconsistent. The kinetics phaseseparation rate decreases, while the thermodynamics parameters, cloud points Tc and delay time tD of isothermal phaseseparation also decrease, and the variation amplitude depends on the matrix composition. The affinity of clay to PMMA results in the composition difference between the border layer and the polymer matrix and further causes the concentration fluctuation at the early stage of phase separation to reduce Tc and tD. On the other hand, the decrease of phase-separation rate is caused by the mechanical barrier effect of clay on the macromolecular diffusion of blend matrix. Hence, such seemingly counterintuitive results on the thermodynamics and kinetics of phase-separation are attributed to different dominant factors.

关键词： Nanocomposites PMMA/PVAc blend Clay Phase separation behavior Morphology.

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Derivative Formula and Coupling Property for Linear SDEs Driven by Lévy Processes

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 708-721页

作者： zhao DONG Yu-lin SONG ying-chao XIE Institute of Applied Mathematics Academy of Mathematics and Systems Sciences Chinese Academy of Sci- ences Beijing 100190 China School of Mathematical Sciences Beijing Normal University Beijing 100875 China School of Mathematics and Statistics Jiangsu Normal University Jiangsu Province Xuzhou 221116 China

In this paper we investigate an integration by parts formula for Lévy processes by using lower bound conditions of the corresponding Lévy measure. As applications, derivative formula and coupling property are derive... 详细信息

关键词： Lévy processes integration by parts formula derivative formula coupling property

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Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao zhao Xuelin Wang Hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

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