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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： Yuxun Lu Weisi Wang Le Yu Yuqiang Zhao ying Chen Yunhai Guo Bingrong Luo Yuhua Liu Shizhu Li Liping Duan ying zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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SymPas:Symbolic Program Slicing

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Journal of Computer Science & Technology 2021年第2期36卷 397-418页

作者： ying-zhou Zhang College of Computer Science and Technology Nanjing University of Posts and TelecommunicationsNanjing 210023China

Program slicing is a technique for simplifying programs by focusing on selected aspects of their *** mainstream static slicing methods operate on dependence graph PDG(program dependence graph)or SDG(system dependence graph),but these friendly graph representations may be a bit expensive for some *** this paper we attempt to study a light-weight approach of static program slicing,called Symbolic Program Slicing(SymPas),which works as a dataflow analysis on LLVM(low-level virtual machine).In our SymPas approach,slices are stored in symbolic forms,not in procedures being re-analyzed(*** summaries).Instead of re-analyzing a procedure multiple times to find its slices for each callling context,we calculate a single symbolic slice which can be instantiated at call sites avoiding re-analysis;SymPas is implemented with LLVM to perform slicing on LLVM intermediate representation(IR).For comparison,we systematically adapt IFDS(interprocedural finite distributive subset)analysis and the SDG-based slicing method(SDGIFDS)to statically slice IR *** on open-source and benchmark programs,our backward SymPas shows a factor-of-6 reduction in time cost and a factor-of-4 reduction in space cost,compared with backward SDG-IFDS,thus being more *** addition,the result shows that after studying slices from 66 programs,ranging up to 336800 IR instructions in size,SymPas is highly size-scalable.

关键词： data flow analysis instruction dependency table low-level virtual machine(LLVM) procedure symbolic slice program slicing

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Photometry of δ Sct-type and Related Stars: Results of AD Ari, IP Vir and YZ Boo

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Chinese Journal of Astronomy and Astrophysics 2002年第1期2卷 43-50页

作者： Ai-ying zhou National Astronomical Observatories Chinese Academy of SciencesBeijing 100012

Photometric results of three δ Scuti stars, AD Ari, IP Vir and YZ Boo from new observations obtained at the:Xinglong Station of the Beijing Astronom- ical Observatory (BAO) during 2000 aELd 2001 are reported. We present here the preliminary analyses. Detailed studies of these stars based on additional data will be published separately.

关键词： stars:variables:δ Scuti - stars: individual:AD Ari IP Vir YZ Boo - techniques:photometric

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An alternative practical design method for structures with viscoelastic dampers

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 459-473页

作者： Joaquim Mimusse Tchamo zhou ying State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University

Viscoelastic dampers（VEDs） are one of the most common passive control devices used in new and retrofit building projects which reduce the structure responses and dissipate seismic energy during an *** methods to design this kind of dampers have been proposed based on the desired level of additional damping,eigenvalue assignment,modal strain energy,linear quadratic regulator control theories,and other *** the current engineering practice,the popular method is the one based on the modal strain energy that uses the inter-story lateral stiffness as one of the main variables for damper ***,depending on the configuration of the structure,in some cases the resulting interstory lateral stiffness can be very ***,the dampers size would also be large producing much more damping than that effectively necessary,resulting in an increase of the overall cost of the supplemental damping system and causing excessive stress on the structural elements connected to the *** this paper an alternative practical design method for structures with VEDs is *** method uses the inter-story shear forces as one of the main variables to accomplish the damper design compared to what was done in previous *** time-history analyses were conducted on a 7-story reinforced concrete（RC） structure to check the reliability and effectiveness of the proposed *** on the seismic performance between the structure without dampers and that equipped with VEDs were carried *** is concluded that the proposed method results in a very suitable size of dampers,which are able to improve the performance of the structure at all levels of earthquake ground motions and satisfying the drift requirement prescribed in the codes.

关键词： viscoelastic dampers passive control seismic design method inter-story shear forces earthquake engineering

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Seismic design and analysis of a high-rise self-centering wallbuilding:Case study

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Frontiers of Structural and Civil Engineering 2023年第11期17卷 1690-1706页

作者： ying zhou Rui WANG Yiqiu LU State Key Laboratory of Disaster Reduction in Civil Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

Post-tensioning self-centering walls are a well-developed and resilient ***,despite extensive research,the application of this technology has previously been limited to low-rise buildings.A ten-story selfcentering wall building has now been designed and constructed using the state-of-art design methodologies and construction detailing,as described in this *** building is designed in accordance with direct displacement-based design methodology,with modification of seismic demand due to relevant issues including higher-mode effects,second order effects,torsional effects,and flexural deformation of wall *** sections are designed with external energydissipating devices of steel dampers,and seismic performance of such designed self-centering walls is evaluated through numerical *** is the first engineering project that uses self-centering walls in a high-rise *** seismic design procedure of such a high-rise building,using self-centering wall structures,is comprehensively reviewed in this work,and additional proposals are put *** of construction detailing,including slotted beams,flexible wall-to-floor connections,embedded beams,and damper installation,is *** demonstration project promotes the concept of seismic resilient structures and contributes to the most appealing city planning strategy of resilient cities at *** paper could be a reference for industry engineers to promote the self-centering wall systems worldwide.

关键词： self-centering wall post-tensioned precast concrete wall seismic resilient structure high-rise building seismic design engineering practice

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Study on the effect of the infill walls on the seismic performance of a reinforced concrete frame

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 507-517页

作者： Zhang Cuiqiang zhou ying zhou Deyuan Lu Xilin Research Institute of Structural Engineering and Disaster Reduction Tongji University Shanghai 200092 China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China

Motivated by the seismic damage observed to reinforced concrete （RC） frame structures during the Wenchuan earthquake, the effect of infill walls on the seismic performance of a RC frame is studied in this paper. Infill walls, especially those made of masonry, offer some amount of stiffness and strength. Therefore, the effect of infill walls should be considered during the design of RC frames. In this study, an analysis of the recorded ground motion in the Wenehuan earthquake is performed. Then, a numerical model is developed to simulate the infill walls. Finally, nonlinear dynamic analysis is carried out on a RC frame with and without infill walls, respectively, by using CANNY software. Through a comparative analysis, the following conclusions can be drawn. The failure mode of the frame with infill walls is in accordance with the seismic damage failure pattern, which is strong beam and weak column mode. This indicates that the infill walls change the failure pattern of the frame, and it is necessary to consider them in the seismic design of the RC frame. The numerical model presented in this paper can effectively simulate the effect of infill walls on the RC frame.

关键词： infill walls RC frame structure strong column and weak beam strong beam and weak column nonlinear time history analysis

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Numerical Simulation of a New 3D Isolation System Designed for a Facility with Large Aspect Ratio

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 759-777页

作者： ying zhou Peng Chen State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai200092China

This paper proposes a novel three-dimensional(3D)isolation system for facilities and presents the numerical simulation approach for the isolated system under earthquake excitations and impact effect using the OpenSees(Open System for Earthquake Engineering Simulation)software frame *** 3D isolators combine the quasi-zero stiffness(QZS)system in the vertical direction and lead rubber bearing in the horizontal *** the large aspect ratio of the isolated facility,linear viscous dampers are designed in the vertical direction to diminish the overturning *** vertical QZS isolation system is characterized by a cubic force-displacement relation,thus,no elements or materials can model this mechanic behavior in the existing finite element *** study takes advantage of the open source feature of the OpenSees to create a new material to represent the mechanic properties of the QZS *** the user-defined material is combined with the rubber isolator element to model the 3D *** different soil types and input magnitudes,six sets of natural seismic records and artificial waves and half sine pulses are selected as the input excitations.A finite element model for the 3D isolated facility is established based on the combined element and the simulation is performed to calculate the time history *** numerical simulation reveals the flexibility of the OpenSees to deal with new engineering problems,and the results prove that the new 3D isolation system can have an optimal isolation effect in both horizontal and vertical *** maximum acceleration response at the top of the facility is below the target limit,and the maximum deformation and the overturning motion of the isolation system can be controlled in a safe range.

关键词： 3D isolation quasi-zero stiffness OpenSees facility large aspect ratio

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Output feedback adaptive control of multivariable nonlinear systems using Nussbaum gain method

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Journal of Systems Engineering and Electronics 2006年第4期17卷 829-835页

作者： zhou ying Wu Yuqiang Research Inst. of Automation Southeast Univ. Nanjing 210096 P. R. China Inst. of Automation Qufu Normal Univ. Qufu 273165 P. R. China

A new output feedback adaptive control scheme for multi-input and multi-output nonlinear systems with parametric uncertainty is presented based on the Nussbaum gain method and the backstepping approach. The high frequency gain matrix of the linear part of the system is not necessarily positive definite, but can be transformed into a lower or upper triangular matrix whose signs of diagonal dements are unknown. The new required condition for the high fi＇equency gain matrix can be easily checked for certain plants so that the proposed method is widely applicable. The global stability of the closed loop systems is guaranteed through this control scheme, at the same time the tracking error converges to zero.

关键词： backstepping method nussbaum gain global stability MIMO nonlincar systems.

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Gravitational waves from the axial oscillation of neutron star considering non-Newtonian gravity

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Nuclear Science and Techniques 2013年第5期24卷 38-43页

作者： WEN Dehua zhou ying Department of Physics South China University of Technology

The eigen-frequencies of the axial w-modes of neutron star described by a super-soft equation of state(EOS) are investigated,by considering the non-Newtonian *** results show that at the same stellar mass,the frequencies of wI and wI2 for our model are lower than that of the typical EOSs(such as APR); and the frequencies increase with the stellar masses,which is contrary to that of the typical *** characters may provide a probe to testify the super soft symmetry energy and the non-Newtonian gravity in the ***,our model also has the universal behavior of the mass-scaled eigen-frequencies as a function of the compactness.

关键词：非牛顿引力中子星轴向引力波摆动本征频率恒星质量 EOS

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New heuristic method for data discretization based on rough set theory

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 113-120页

作者： ZHAO Jun zhou ying-hua Institute of Computer Science and Tcchnology Chongqing University of Posts and Telecommunications Chongqing 400065 China

Data discretization contributes much to the induction of classification rules or trees by machine learning *** rough set theory is a valid tool for discretizing continuous information ***,a new method is proposed to improve those typical rough set based heuristic algorithms for data discretization,by utilizing decision information to reduce the scales of candidate cuts,and by more reasonably measuring cut significance with a new conception of cut selection *** demonstrate that compared with other typical discretization algorithms based on the rough set theory,the proposed method is more capable and valid to discretize continuous information *** can effectively improve the predictive accuracies of information systems while still conceptually keeping their consistency.

关键词： data discretization rough set theory cut cut significance selection probability

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