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Strategies and prospects for melatonin to alleviate abiotic stress in horticultural plants

Horticultural Plant Journal 2024年第3期10卷 601-614页

作者： Xiaoyun Wang Meng Cao Hongxin Li ying liu Shuangxi Fan Na Zhang Yangdong Guo College of Horticulture China Agricultural UniversityBeijing100193China College of Plant Science and Technology Beijing University of AgricultureBeijing102206China Beijing Bei Nong Enterprise Management Co. Ltd.Beijing102206China Sanya Institute of China Agricultural University SanyaHainan572000China

Melatonin is a conserved pleiotropic molecule in animals and *** is involved in many development processes and stress responses;thus,exploring its function in plants,particularly in horticultural plants,has become a rapidly developing *** studies have revealed that phytomelatonin acts as a plant biostimulant and increase its tolerance to various abiotic stressors,including extreme temperature,drought,osmotic disturbance,heavy metals,and ultraviolet(UV).Melatonin appears to have roles in the scavenging of reactive oxygen species(ROS)and other free radicals,affecting the primary and secondary metabolism of plants,regulating the transcripts of stress-related enzymes and transcription factors,and crosstalk with other hormones under different environmental *** pleiotropy makes phytomelatonin an attractive regulator to improve resistance to abiotic stress in *** recent discovery of the potential phytomelatonin receptor CAND2/PMTR1 and the proposition of putative models related to the phytomelatonin signaling pathways makes phytomelatonin a new plant *** on relevant studies from our laboratory,this review summarizes the phytomelatonin biosynthetic and metabolic pathways in plants and the latest research progress on phytomelatonin in abiotic stress of horticultural *** study will provide a reference for elucidating the regulatory mechanism of phytomelatonin affecting the resistance to abiotic stress in plants.

关键词： Abiotic stress Biostimulant Horticultural plants Phytomelatonin

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Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency

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Current Medical Science 2024年第2期44卷 426-434页

作者： Bi-xin XI Si-ying liu Yu-ting XU De-dong ZHANG Qun HU Ai-guo liu Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Glucose-6-phosphate isomerase(GPI)deficiency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene *** disorder exhibits wide heterogeneity in its clinical manifestations and molecular characteristics,often posing challenges for precise diagnoses using conventional *** this end,this study aimed to identify the novel variants responsible for GPI deficiency in a Chinese ***:The clinical manifestations of the patient were summarized and analyzed for GPI deficiency phenotype *** compound heterozygous variants of the GPI gene,c.174C>A(***58Lys)and c.1538G>T(***513Leu),were identified using whole-exome and Sanger *** AlphaFold program and Chimera software were used to analyze the effects of compound heterozygous variants on GPI ***:By characterizing 53 GPI missense/nonsense variants from previous literature and two novel missense variants identified in this study,we found that most variants were located in exons 3,4,12,and 18,with a few localized in exons 8,9,and *** study identified novel compound heterozygous variants associated with GPI *** pathogenic variants disrupt hydrogen bonds formed by highly conserved GPI amino ***:Early family-based sequencing analyses,especially for patients with congenital anemia,can help increase diagnostic accuracy for GPI deficiency,improve child healthcare,and enable genetic counseling.

关键词： glucose-6-phosphate isomerase deficiency whole-exome sequencing compound heterozygous variants genetic characterization hydrogen bond

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Should Low-Frequency-High-Consumption Enterprises Add Online-to-Offline Platforms?An Empirical Study Using the VAR Model

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Journal of Systems Science and Information 2024年第1期12卷 81-95页

作者： Wei LI ying liu Haizhen YANG Sha ZHANG Binhong XU School of Economics and Management Univeristy of Chinese Academy of SciencesBeijing 100190China School of Business University of Chinese Academy of Social SciencesBeijing 102488China

This study investigates the impact of online-to-offline(O2O)platforms,such as *** and Meituan,on offline sales in low-frequency-high-consumption industries,specifically a mid-to-highend liquor distribution *** data from 77 offline stores in Beijing collected during 2019-2022,the study employs a VAR model to analyze the relationship between offline sales and the use of O2O *** results reveal a long-term equilibrium between the two,with most indicators showing a positive impact of O2O platforms on offline *** research provides valuable insights for lowfrequency-high-consumption enterprises in making multi-channel decisions and quantifies the impact of O2O platforms on offline sales.

关键词： O2O platform low-frequency-high-consumption liquor distribution chain enterprise store sales VAR model

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Graphene binding on black phosphorus enables high on/off ratios and mobility

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National Science Review 2024年第2期11卷 188-195页

作者： Fanrong Lin Zhonghan Cao Feiping Xiao Jiawei liu Jiabin Qiao Minmin Xue Zhili Hu ying liu Huan Lu Zhuhua Zhang Jens Martin Qingjun Tong Wanlin Guo Yanpeng liu Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics Centre for Advanced 2D Materials National University of Singapore School of Physics and Electronics Hunan University Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and MeasurementSchool of PhysicsBeijing Institute of Technology Leibniz Institute für Kristallzüchtung

Graphene is one of the most promising candidates for integrated circuits due to its robustness against short-channel effects, inherent high carrier mobility and desired gapless nature for Ohmic contact, but it is difficult to achieve satisfactory on/off ratios even at the expense of its carrier mobility, limiting its device applications. Here, we present a strategy to realize high back-gate switching ratios in a graphene monolayer with well-maintained high mobility by forming a vertical heterostructure with a black phosphorus multi-layer. By local current annealing, strain is introduced within an established area of the graphene, which forms a reflective interface with the rest of the strain-free area and thus generates a robust off-state via local current depletion. Applying a positive back-gate voltage to the heterostructure can keep the black phosphorus insulating, while a negative back-gate voltage changes the black phosphorus to be conductive because of hole accumulation. Then, a parallel channel is activated within the strain-free graphene area by edge-contacted electrodes, thereby largely inheriting the intrinsic carrier mobility of graphene in the on-state. As a result, the device can provide an on/off voltage ratio of >10～3 as well as a mobility of ～8000 cm2V-1s-1at room temperature, meeting the low-power criterion suggested by the International Roadmap for Devices and Systems.

关键词： graphene on/off ratio mobility black phosphorus reflective interface

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The current situation of semen analysis in China,based on a survey of 296 laboratories

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Asian Journal of Andrology 2024年第2期26卷 220-221页

作者： Long-Long Fu ying liu Xiao-Wei Wang Fang Zhou ying Guo Wen-Hong Lu Yi-Qun Gu National Health Commission Key Laboratory of Male Reproductive Health Reproductive Health Research CenterNational Research Institute for Family PlanningBeijing 100081China Institute of Pediatric Research Children's Hospitalof Soochow UniversitySuzhou 215025China

Dear Editor,Semen analysis is a basic test to assess male fertility and is a fundamental test in assisted reproductive *** the first publication of World Health Organization(WHO)Laboratory Manual of Human Semen and Sperm-Cervical Mucus Interaction in 1980,to the publication of the WHO Manual,6th edition in 2021,these 40 years have been recognized as providing a global standard that is widely used in research and clinical laboratories *** WHO Manual,6th edition in Chinese,which we have been authorized by the WHO to translate,will be published soon.

关键词： technology. analysis translate

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A novel copper metabolism-related signature model for predicting the prognosis,target drugs,and immunotherapy in stomach adenocarcinoma

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Genes & Diseases 2024年第5期11卷 21-24页

作者： Kai Zhuang Siqi Tang Haixin Feng Jinying Zhang ying liu Yong liu Yongjian Su Jiaqi Yu Zunnan Huang Key Laboratory of Computer-Aided Drug Design of Dongguan City The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523710China Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguanGuangdong 523808China School of Public Health Guangdong Medical UniversityDongguanGuangdong 523808China Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdong 524203China

Stomach adenocarcinoma(STAD)is one of the most common gastric neoplasms with a high death ***,there is an urgent need to propose an efficient therapy for *** plays key roles in regulating the distribution of immune cells and affecting the tumor immune escape,and may be a novel indicator of immunotherapy in ***,the specific impact of copper metabolism-related genes(CMRGs)on the patient’s prognosis,tumor microenvironment,and immunotherapeutic response remains unelucidated.

关键词： metabolism stomach adenocarcinoma

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Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 67-78页

作者： ying liu Qiushi Wang Yidi liu ying Wang Haixia Qiu Dan Zhu ying Gu Defu Chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853P.R.China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics A duanced Biomedical Imaging FacilityWuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiP.R.China Precision Laser Medical Diagnosis and Treatment Innovation Unit Chinese A cademy of Medical SciencesBeijing 100000P.R.China

Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS *** optical clearing technique can increase light penetration in depth by reducing light *** study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber *** responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the *** further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin *** combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood *** results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS.

关键词： Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains

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Current trends and hotspots of depressive disorders with colorectal cancer:A bibliometric and visual study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3687-3704页

作者： Zi-Wei Yan ying-Nan liu Qian Xu Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Laboratory of GI Cancer Etiology and Prevention in Liaoning Province The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Depression is strongly associated with colorectal cancer(CRC).Few bibliometric analyses have systematically summarized the research focus and recent progress in this *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and *** Articles on depression in CRC patients were collected from the Web of Science Core *** and VOSviewer software were used to visualize bibliometric *** From 2001 to 2022,Supportive Care in Cancer,the United States,Tilburg University,and Mols were the most productive and influential journal,country,institution,and author ***-occurrence cluster analysis of keywords placed quality of life,anxiety,and psychological stress in the center of the visual network *** clustering was performed for the clusters with studies of the relevant mechanism of action,which showed that:(1)Cytokines have a role essential for the occurrence and development of depressive disorders in CRC;(2)MicroRNAs have a role essential for the development of depressive disorders in CRC;(3)Some anticancer drugs have pro-depressant activity;and(4)Selective serotonin reuptake inhibitors have both antitumor and antidepressant *** Life quality and psychological nursing of the cancer population were key *** roles of cytokines and microRNAs,the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

关键词： Depression Colorectal cancer Bibliometric analysis Cytokines Drugs Mechanism

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Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1008-1016页

作者： ying liu Ding-Quan Yang Jun-Nan Jiang Yan Jiao Department of General Surgery The Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Gastrointestinal and Colorectal Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Helicobacter pylori(***)plays an important role in the development of gastric cancer,although its association to colorectal polyp(CP)or colorectal cancer(CRC)is *** this issue of World Journal of Gastrointestinal Surgery,Zhang et al investigated the risk factors for *** infection after colon polyp ***,the researchers used R software to create a prediction model for *** infection based on their *** editorial gives an overview of the association between *** and CP/CRC,including the clinical significance of *** as an independent risk factor for CP/CRC,the underlying processes of ***-associated carcinogenesis,and the possible risk factors and identification of ***.

关键词： Helicobacter pylori Colorectal polyp Colorectal cancer Risk factor

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Interfacial mechanism of hydrogel with controllable thickness for stable drag reduction

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Friction 2024年第2期12卷 231-244页

作者： Xiaotong WU ying liu Yunlei ZHANG Xingwei WANG Wufang YANG Lang JIANG Shuanhong MA Meirong CAI Feng ZHOU School of Advanced Manufacturing Nanchang UniversityNanchang 330031China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Yantai Advanced Materials and Green ManufactureYantai 264006China

Surface wettability plays a significant role in reducing solid–liquid frictional resistance,especially the superhydrophilic/hydrophilic interface because of its excellent thermodynamic *** this work,poly(acrylic acid)-poly(acrylamide)(PAA–PAM)hydrogel coatings with different thicknesses were prepared in situ by polydopamine(PDA)-UV assisted surface catalytically initiated radical *** drag reduction performance of hydrogel surface was measured using a rotational rheometer by the plate–plate *** experimental results showed that the average drag reduction of hydrogel surface could reach up to about 56%in Couette flow,which was mainly due to the interfacial polymerization phenomenon that enhanced the ability of hydration layer to delay the momentum dissipation between fluid layers and the diffusion behavior of *** proposed drag reduction mechanism of hydrogel surface was expected to shed new light on hydrogel–liquid interface interaction and provide a new way for the development of steady-state drag reduction methods.

关键词： steady state drag reduction hydrogel interface hydration hydrophilic

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