检索结果-南通市图书馆

乳腺癌患者HER2、CA153表达与声触诊组织成像定量技术参数的相关性分析

在线全文

学校读者我要写书评

暂无评论

中国医学装备 2024年第3期21卷 78-81,107页

作者：丁颖李家菊王国亮合肥市第三人民医院超声科合肥230022 合肥市第三人民医院放射科合肥230022

目的:分析乳腺癌患者人表皮生长因子受体2(HER2)、糖类抗原153(CA153)表达与声触诊组织成像定量(VTIQ)技术参数的相关性。方法:选取2018年5月至2020年5月合肥市第三人民医院收治的80例女性乳腺癌患者,其中世界卫生组织(WHO)分期Ⅰ期14... 详细信息

目的:分析乳腺癌患者人表皮生长因子受体2(HER2)、糖类抗原153(CA153)表达与声触诊组织成像定量(VTIQ)技术参数的相关性。方法:选取2018年5月至2020年5月合肥市第三人民医院收治的80例女性乳腺癌患者,其中世界卫生组织(WHO)分期Ⅰ期14例、Ⅱ期22例、Ⅲ期31例、Ⅳ期13例;另选取同时间段收治的53例女性乳腺良性疾病患者为对照。所有患者先行常规超声检查,随后进入超声VTIQ成像模式获得剪切波速度(SWV)均值参数;采用免疫组织化学法检测乳腺组织中HER2表达,采用罗氏E411电化学发光免疫分析仪检测血清CA153水平;采用Pearson法分析乳腺癌患者血清CA153水平与SWV均值的相关性。结果:与良性患者比较,乳腺癌患者VTIQ技术参数SWV均值、血清CA153水平及HRR2阳性表达率均显著升高,差异有统计学意义(F=39.107,78.353,P<0.05);与乳腺癌Ⅰ+Ⅱ期患者比较,乳腺癌Ⅲ、Ⅳ期患者VTIQ技术参数SWV均值、血清CA153水平、HRR2阳性表达率均显著升高,差异有统计学意义(t=2.685、3.556、8.326、10.455,P<0.05);与乳腺癌Ⅲ期比较,乳腺癌Ⅳ期患者VTIQ技术参数SWV均值、血清CA153水平、HRR2阳性表达率均显著升高,差异有统计学意义(t=4.632、8.659,P<0.05)。与HER2阴性表达乳腺癌患者SWV均值比较,HER2阳性表达乳腺癌患者SWV均值升高,差异有统计学意义(χ^(2)=59.751,P<0.05)。乳腺癌患者血清CA153水平与SWV均值呈正相关(r=0.501,P<0.05)。结论:乳腺癌患者VTIQ参数SWV均值与乳腺癌患者生物标志物HER2、CA153表达水平密切相关。

关键词：乳腺癌声触诊组织成像定量技术人表皮生长因子受体2(HER2) 糖类抗原153(CA153)

扶正解秽汤联合重组人干扰素治疗慢性宫颈炎合并高危型HPV感染临床研究

在线全文

学校读者我要写书评

暂无评论

陕西中医 2024年第5期45卷 605-609页

作者：何锋云欧琰丁莺韦笑桂林市中西医结合医院广西桂林541004 桂林生命与健康职业技术学院广西桂林541004

目的:观察扶正解秽汤联合重组人干扰素治疗慢性宫颈炎合并高危型人乳头瘤病毒(HPV)感染的临床疗效。方法:选择160例慢性宫颈炎合并高危型HPV感染患者,随机分为两组,对照组(80例)阴道内给予重组人干扰素α-2b凝胶栓治疗,观察组(80例)在... 详细信息

目的:观察扶正解秽汤联合重组人干扰素治疗慢性宫颈炎合并高危型人乳头瘤病毒(HPV)感染的临床疗效。方法:选择160例慢性宫颈炎合并高危型HPV感染患者,随机分为两组,对照组(80例)阴道内给予重组人干扰素α-2b凝胶栓治疗,观察组(80例)在其基础上联用扶正解秽汤治疗,疗程均为3个月。记录两组临床疗效,比较治疗前后两组中医症状积分、宫颈炎评分和HPV病毒载量的变化,记录阴道分泌物恢复正常时间、宫颈糜烂面愈合时间和HPV转阴率。比较两组细胞免疫指标与宫颈局部免疫微环境的变化。记录两组复发率与不良反应。结果:观察组与对照组临床总有效率分别为95.00%和76.25%,前者显著高于后者(P0.05)。结论:在重组人干扰素治疗基础上,加用扶正解秽汤能够显著改善慢性宫颈炎合并高危型HPV感染患者症状,提高治疗疗效,降低病毒载量,提高HPV转阴率,降低复发率,其机制可能与其调节机体细胞免疫,改善宫颈局部免疫微环境有关。

关键词：人乳头瘤病毒扶正解秽汤重组人干扰素α-2b凝胶慢性宫颈炎免疫功能

在线全文

学校读者我要写书评

暂无评论

局部抗青光眼药物的研究及应用进展

中国新药与临床杂志 2024年第8期43卷 574-581页

作者：穆婉丁英卓席宇飞贲申煜陈彬葛玲上海市眼病防治中心/同济大学附属眼科医院药剂科上海200331 上海市眼病防治中心/同济大学附属眼科医院眼科上海200331

青光眼是导致全球不可逆性致盲性眼病的主要原因之一,病理性眼压升高是青光眼的主要危险因素,故其临床治疗宗旨是降低眼压至个体目标眼压水平。目前临床经典的局部抗青光眼药物主要有前列腺素类似物、肾上腺素β受体阻滞药、肾上腺素α... 详细信息

青光眼是导致全球不可逆性致盲性眼病的主要原因之一,病理性眼压升高是青光眼的主要危险因素,故其临床治疗宗旨是降低眼压至个体目标眼压水平。目前临床经典的局部抗青光眼药物主要有前列腺素类似物、肾上腺素β受体阻滞药、肾上腺素α2受体激动剂、碳酸酐酶抑制剂和胆碱能受体激动剂五类,作用机制包括减少房水产生,增加小梁网途径和经葡萄膜巩膜通路的房水外流,以及收缩瞳孔括约肌开放房角等。其中,前列腺素类似物因疗效和安全性较好,目前已成为临床上开角型青光眼患者控制眼压的首选药物。近年来,新型抗青光眼药物(包括Rho激酶抑制剂和一氧化氮供体抗青光眼药物等)的上市,以及相关药物缓释制剂(眼内及眼外药物递送系统)的研发,为青光眼的治疗提供了新的药物选择。

关键词：青光眼眼压前列腺素类似物 Rho激酶抑制剂一氧化氮供体缓释凝胶

Microstructure and properties of AgCu/2 wt%Ag-added Sn-Pb solder/CuBe joints fabricated by vapor phase soldering

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第6期41卷 1983-1988页

作者： Wei Liu Rong An ying ding Chun-Qing Wang Yan-Hong Tian Kun Shen State Key Laboratory of Welding and Joining Harbin Institute of TechnologyHarbin 150001China School of Engineering and Physical Sciences Heriot-Watt UniversityEdinburgh EH144ASUK Key Laboratory of Miero-systems and Micro-structures Manufacturing Ministry of Education.Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Control Engineering Beijing 100190China

The purpose of this paper is to investigate the effect of 2 wt%Ag addition in Sn-Pb eutectic solder on microstructure and mechanical properties of AgCu/solder/CuBe joint fabricated by vapor phase soldering.63Sn37Pb and 62Sn36Pb2Ag solder pastes were used to join Cu(1.7 wt%-2.5 wt%)Be and Ag(2 wt%-5 wt%)Cu *** fracture modes are observed in 62Sn36Pb2Ag and 63Sn37Pb joints after lateral shear tests at room temperature or 120℃,and shear forces of 62Sn36Pb2Ag joints are far higher than those of 63Sn37Pb *** obvious difference is observed in morphology and thickness of intermetallic compounds(IMCs)at interfaces of the 63Sn37Pb and 62Sn36Pb2Ag *** the two kinds of joints,for-mation of big blocky or plate-like Ag_(3)Sn is ***,many Ag_(3)Sn IMCs particles(1-3 μm in width)in isolated and dispersed distribution are observed within 62Sn36Pb2Ag *** Ag3Sn particles are responsible for the better mechanical properties of 62Sn36Pb2 Ag joints than those of 63Sn37Pb *** results present in this paper may provide a guide for restraining formation of big blocky or plate-like Ag_(3) Sn in joints with Ag pads or thick Ag surface finish on pads by utilizing vapor phase soldering process,and improving mechanical properties of Cu/SnPb/Ag joints by adding Ag in SnPb eutectic solder.

关键词： Microstructure Mechanical property 62Sn36Pb2Ag solder Ag,Sn Vapor phase soldering

国医大师丁樱临证治疗过敏性紫癜(皮肤型)思路管窥

在线全文

学校读者我要写书评

暂无评论

中华中医药杂志 2024年第8期39卷 4091-4094页

作者：陈文霞丁樱闫永彬李向峰刘晓李芳琳河南中医药大学儿科医学院郑州450046 河南中医药大学第一附属医院郑州450045 上海市中医药研究院中医儿科研究所上海201203

过敏性紫癜以皮肤型多见,且易反复发作,治疗较为棘手。国医大师丁樱教授认为,对于本病而言,所见部位既是皮肤,则属脾肺;所见疾患既是斑、点,则属血分,即与卫气营血及心肝肾相关,今以丁教授临证三则验案,揣其思路,认为过敏性紫癜(皮肤型... 详细信息

过敏性紫癜以皮肤型多见,且易反复发作,治疗较为棘手。国医大师丁樱教授认为,对于本病而言,所见部位既是皮肤,则属脾肺;所见疾患既是斑、点,则属血分,即与卫气营血及心肝肾相关,今以丁教授临证三则验案,揣其思路,认为过敏性紫癜(皮肤型)主要有3种证候,临证从以下3个阶段论治,初发而见风热伤络者,以银翘散加凉血化瘀止血之品;猝发而见血热妄行者,以犀角地黄汤加化瘀养血之药;久发或反复发作而见阴虚血热者,创清热止血颗粒,三方虽证候不同,亦有相兼者,随证变法,可合而用之。

关键词：国医大师丁樱过敏性紫癜(皮肤型) 临证思路验案

A Journal for Human and Machine

在线全文

学校读者我要写书评

暂无评论

Data Intelligence 2019年第1期1卷 1-5页

作者： James Hendler ying ding Barend Mons Rensselaer Institute for Data Exploration and Applications Rensselaer Polytechnic InstituteTroyNY12180USA School of Informatics Computingand EngineeringIndiana UniversityBloomingtonIN 47408USA Leiden University Medical Centre The NetherlandsPoortgebouw N-01Rijnsburgerweg 102333 AA LeidenThe Netherlands

It is with great pride to bring you this new journal of Data *** journal has at least two major purposes that we hope ***,it will embrace the traditional role of a journal in helping to facilitate the communication of research and best practices in scientific data sharing,especially across disciplines,an area that is continually growing in importance for the modern practice of ***,we will be experimenting with new methods of enhancing the sharing of this communication,and examples of the field,by utilizing the increasing power of intelligent computing systems to further facilitate the growth of the *** journal’s title,combining“data,”the field we will support,and“intelligence,”a means to that end,is meant to connote this growing interaction.

关键词： interaction. journal utilizing

Research on Integration of Coal Mine Moni-toring and Control System with Field Bus Control System

在线全文

学校读者我要写书评

暂无评论

Journal of China University of Mining and Technology 2006年第1期16卷 82-85页

作者： WU Jian-xin ding ying JIANG Xiu-zhu School of Information and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

According to the construction of current coal mine monitoring and control systems in China, the paper proposes three kinds of applicable schemes of integrating PLC and DCS systems with field bus technology to digitize the system and to improve the flexibility and extent of the system. Essentially, the paper introduces the integration of FCS on I/O layers. Based on a real coal mine safety-monitoring and control system applied with a CAN field bus, the major technology of system relays and extensions is discussed. We believe that one of the most applicable methods is currently replacing the connection between function-stations and field-sensors with a CAN bus on I/0 layers for system integration.

关键词： monitor and control field bus control system CAN integration

Tetrandrine inhibits activation of rat hepatic stellate cells in vitro via transforming growth factor-β signaling

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第19期11卷 2922-2926页

作者： Yuan-WenChen Jian-XinWu ying-WeiChen ding-GuoLi Han-MingLu DigestiveDiseaseLaboratory XinhuaHospitalShanghaiSecondMedicalUniversityShanghai200092China

AIM: To investigate the effect of various concentrations of tetrandrine on activation of quiescent rat hepatic stellate cells (HSCs) and transforming growth factor-β (TGF-β) signaling in ***: HSCs were isolated from rats by in situperfusion of liver and 18% Nycodenz gradient centrifugation, and primarily cultured on uncoated plastic plates for 24 hwith DMEM containing 20% fetal bovine serum (FBS/DMEM) before the culture medium was substituted with 2% FBS/DMEM for another 24 h. Then, the HSCs were cultured in 2% FBS/DMEM with tetrandrine (0.25, 0.5, 1,2 mg/L, respectively). Cell morphological features were observed under an inverted microscope, smooth muscleα-actin (α-SMA) was detected by immunocytochemistry and image analysis system, laminin (LN) and type Ⅲprocollagen (PCⅢ) in supernatants were determined byradioimmunoassay. TGF-β1 mRNA, Smad 7 mRNA and Smad 7 protein were analyzed with RT-PCR and Western blotting, ***: Tetrandrine at the concentrations of 0.25-2 mg/L prevented morphological transformation of HSC from the quiescent state to the activated one, while α-SMA, LN and PCⅢ expressions were inhibited. As estimated by gray values, the expression of α-SMA in tetrandrine groups (0.25, 0.5, 1, 2 mg/L) was reduced from 21.3% to 42.2%(control: 0.67, tetrandrine groups: 0.82, 0.85, 0.96, or 0.96, respectively, which were statistically different from the control, P＜0.01), and the difference was more significant in tetrandrine at 1 and 2 mg/L. The content of LN in supernatants was significantly decreased in tetrandrine groups to 58.5%, 69.1%, 65.8% or 60.0% that of the control respectively, and that of PCⅢ to 84.6%, 81.5%,75.7% or 80.7% respectively (P＜0.05 vs control), with no significant difference among tetrandrine groups. RTPCR showed that TGF-β1 mRNA expression was reduced by tetrandrine treatments from 56.56% to 87.90% in comparison with the control, while Smad 7 mRNA was increased 1.4-4.8 times. The TGF-β1 mRNA and Smad 7 mRNA expre

关键词： Tetrandrine Hepatic stellate cell Transforming growth factor-β Smad 7 Liver fibrosis Signal transduction

The association between demodex infestation and ocular surface manifestations in meibomian gland dysfunction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第4期11卷 589-592页

作者： Xiao-Bo Zhang ying-Hui ding Wei He Shenyang He Eye Hospital Liaoning He UniversityShenyang 110034Liaoning ProvinceChina Eye Institute of Xiamen University Xiamen 361005FujianProvinceChina Department of Ophthalmology the People's Hospital ofBozhouBozhou 236800Anhui ProvinceChina

AIM： To investigate the association between ocular demodex folliculorum infestation and ocular surface manifestations in meibomian gland dysfunction（MGD）.METHODS： Eight-six patients with MGD were enrolled. All enrolled subjects were tested in the following sequence： ocular surface disease index（OSDI）, slit-lamp biomicroscope examination, corneal surface regularity index（SRI） and surface asymmetry index（SAI）, tear fluid collection, fluorescein tear film break-up time（F-BUT）, corneal fluorescein staining（CFS）, Schirmer I test（SIT） and demodex folliculorum counting. Tear matrix metalloproteinase（MMP）-9 activity was assessed using MMP-9 activity assay ***： Among 86 MGD patients, 40 were positive for demodex. The ocular demodex-positive group showed significantly increased scores of OSDI（25.96±13.74 vs 18.07±11.55, P=0.01）, lid margin abnormality（2.38±0.87 vs 1.98±0.91, P=0.04） and CFS（1.28±2.00 vs 0.94±1.36, P=0.01） compared to the ocular demodex-free group. The tear MMP-9 activity was higher in the ocular demodex-positive group（102.9±32.4 ng/mL） than the ocular demodex-free group（46.2±19.2 ng/mL, P=0.03）. There was no significant difference in meibum quality and expressibility, SRI, SAI, F-BUT and SIT between the two groups（P〉0.05 for each）. No significant correlation was noted between the number of demodex and ocular surface parameters in demodexpositive MGD group（P〉0.05 for each）.CONCLUSION： Ocular demodex folliculorum infestation may be associated with ocular discomfort and ocular surface damage in MGD.

关键词： demodex meibomian gland dysfunction ocular surface