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Birth Defects in Assisted Reproductive Technology and Spontaneously Conceived Children:A Meta-analysis

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Journal of Reproduction and Contraception 2013年第4期24卷 237-252页

作者： Yan JIA Li-hong GENG ying zhong Reproductive Centre Jinjiang Maternal and Child Health Hospital

Objective To evaluate the risk of birth defects in children born following assisted reproductive technology （ART） and spontaneous conceptions. Methods This study carried out an updated systematic review to identify papers published by August 2013 with data relating to birth defects of children conceived using ART （IVF and for ICSI） compared with those spontaneously conceived and also compared birth defects between subgroups of lVF and ICSI. Results Totally 76 studies were identified for review. The individual relative risk （RR） estimated for these studies ranged from 0.44 to 5.51, a signifieantly increased risk of birth defects was observed （RR=l.36, 95%CI=1.25-1.47） in ART compared with the spontaneously conceived group, which was also evident in the subgroup analysis. Among these studies, 16 studies simultaneously gave data of birth defects comparing IVF and ICSI children, which showed no difference in risk of combined effects （RR=0.90, 95%CI=0.80 1.02）, but ICSI had a higher risk in subgroups of clinical research （RR=O. 76, 95%CI=0.65-0.89） and crude RR value （RR=O. 78, 95%CI=0.67 0.91）. Conclusion Pooled results from all suitable published studies suggested that children born following ART were at increased risk of birth defects compared with spontaneous conceptions. There is no difference in birth defect risk between children conceived by IVF or 1CS1 using a summative analysis, however, 1CS1 had a significant higher risk in birth defect risk comparing with 1VF when using subgroup analyses of sample size and RR value.

关键词： birth defects assisted reproductive technology (ART) IVF ICSI Meta-analysis

On behavior of two-dimensional cellular automata with an exceptional rule under periodic boundary condition

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The Journal of China Universities of Posts and Telecommunications 2010年第1期17卷 67-72页

作者： ZHAI ying,YI zhong,DENG Pei-min Department of Mathematics,Guangxi Normal University,Guilin 541004,China Department of Mathematics Guangxi Normal University Guilin 541004 China

This article deals with the behavior of two-dimensional （2-D） cellular automata （CA） with a special rule under periodic boundary condition by using matrix algebra. The important characteristics of CA have been studied, such as Garden of Eden （GOE）, maximal transient length, maximal cycle length and so forth. Several necessary and sufficient conditions are provided, which guarantee a given configuration of being a GOE in different cases. Besides, algorithms are proposed to obtain the number of GOEs, the maximal transient length, and the maximal cycle length in such a CA with the rule mentioned above under periodic condition.

关键词： cellular automata GOE maximal transient length maximal cycle length

Bioinformatic analysis and functional characterization of the cfem proteins in maize anthracnose fungus Colletotrichum graminicola

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Journal of Integrative Agriculture 2020年第2期19卷 541-550页

作者： GONG An-dong JING zhong-ying ZHANG Kai TAN Qing-qun WANG Guo-liang LIU Wen-de State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China College of Life Science Xinyang Normal UniversityXinyang 464000P.R.China Department of Plant Pathology The Ohio State UniversityColumbusOhio 43210USA

Fungal secreted proteins that contain the Common in Fungal Extracellular Membrane(CFEM)domain are important for *** hemibiotrophic fungus Colletotrichum graminicola causes the serious anthracnose disease of *** this study,we identified 24 CgCFEM proteins in the genome of *** analysis revealed that these 24 proteins(CgCFEM1–24)can be divided into 2 clades based on the presence of the trans-membrane *** alignment analysis indicated that the amino acids of the CFEM domain are highly conserved and contain 8 spaced cysteines,with the exception that CgCFEM1 and CgCFEM24 lack 1 and 2 cysteines,*** CgCFEM proteins with a signal peptide and without the trans-membrane domain were considered as candidate effectors and,thus were selected for structural prediction and functional *** CFEM domain in the candidate effectors can form a helical-basket structure homologous to the Csa2 protein in Candida albicans,which is responsible for haem acquisition and *** localization analysis revealed that these effectors accumulate in the cell membrane,nucleus,and cytosolic ***,5 effectors,CgCFEM6,7,8,9 and 15,can suppress the BAX-induced programmed cell death in Nicotiana benthamiana with or without the signal *** results demonstrate that these 10 CgCFEM candidate effectors with different structures and subcellular localizations in host cells may play important roles during the pathogenic processes on maize plants.

关键词： CFEM domain candidate effector anthracnose disease maize Colletotrichum graminicola

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支护桩破坏类型及机理分析研究

工程勘察 2025年第1期53卷 26-32页

作者：唐秋元王桂林钟盈陈超丁于哲中煤科工重庆设计研究(集团)有限公司重庆400016 重庆大学土木工程学院重庆400045 重庆建筑科学研究院有限公司重庆400016

支护桩是边坡及基坑的重要支护形式,随着工程建设大规模开展,支护桩的使用越来越多,但边坡工程事故也随之增多,其中不乏有支护桩产生破坏。然而,目前国内外对支护桩破坏方面的研究还较为匮乏。因此,本文基于对实际工程中支护桩破坏现象... 详细信息

支护桩是边坡及基坑的重要支护形式,随着工程建设大规模开展,支护桩的使用越来越多,但边坡工程事故也随之增多,其中不乏有支护桩产生破坏。然而,目前国内外对支护桩破坏方面的研究还较为匮乏。因此,本文基于对实际工程中支护桩破坏现象的分析,结合支护桩破坏受力概化模型和数值模拟,对支护桩破坏类型及机理进行研究。研究结果表明:按支护桩的破坏特征可将支护桩破坏类型分为受推倾斜、受剪剪断和受弯折断三类,分别由其特定的地质环境和支护结构形式孕育,最后基于破坏机理分析提出应对措施建议。论文的结论及建议对指导边坡事故原因判断、边坡应急抢险、边坡工程安全评价及边坡加固工程的勘察、设计、施工具有重要的价值。

关键词：支护桩受推倾斜受剪剪断受弯折断边坡事故

Antioxidant lignans sesamin and sesamolin in sesame(Sesamum indicum L.):a comprehensive review and future prospects

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Journal of Integrative Agriculture 2023年第1期22卷 14-30页

作者： Senouwa Segla Koffi DOSSOU XU Fang-tao Komivi DOSSA ZHOU Rong ZHAO ying-zhong WANG Lin-hai Oil Crops Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhan 430062P.R.China Laboratory of Plant Biotechnology and Physiology University of LoméLome 01 BP 1515Togo French Agricultural Research Center for International Development(CIRAD) Genetic Improvement and Adaptation of Mediterranean and Tropical Plants-UMR AGAP InstituteMontpellier F-34398France UMR AGAP Institute University of MontpellierCIRADFrench National Research Institute for AgricultureFood and Environment(INRAE)Montpellier F-34398France

Sesame(Sesamum indicum L.)is a significantly lucrative cash crop for millions of small-holder *** seeds are an important source of a highly appreciated vegetable oil globally and two clinically essential antioxidant lignans,sesamin and ***,many countries import millions of tons of sesame seed every *** demand for lignan-rich sesame seeds has been increasing in recent years due to the continuous discovery of several pharmacological attributes of sesamin and *** meet this demand,the sesame breeder’s primary objective is to release sesame cultivars that are enriched in oil and ***,it is necessary to summarize the information related to the sesamin and sesamolin contents in sesame in order to promote the joint efforts of specialized research teams on this important oilseed *** this article,we present the current knowledge on the sesamin and sesamolin contents in *** *** respect to the updated biosynthesis pathway,associated markers,governing loci,available variability in sesame germplasm,the in planta potential roles of these compounds in sesame,and the newly discovered pharmacological *** addition,we propose and discuss some required studies that might facilitate genomics-assisted breeding of high lignan content sesame varieties.

关键词： Sesamum indicum lignan biosynthesis antioxidants molecular breeding sesamin and sesamolin

Construction of a Normalized Full-Length cDNA Library of Sesame Developing Seed by DSN and SMART^(TM)

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Agricultural Sciences in China 2011年第7期10卷 1004-1009页

作者： KE Tao DONG Cai-hua MAO Han ZHAO ying-zhong LIU Hong-yan LIU Sheng-yi Key Laboratory for Oil Crops Biology Ministry of Agriculture/Oil Crops Research Institute Chinese Academy of Agricultural Sciences Wuhan 430062 P.R.China Department of Life Science and Technology Nanyang Normal University Nanyang 473061 P.R.China

Sesame （Sesamue indicum L.） is one of the most important oilseed crops with high oil yield. Here, we described a simple and efficient method for constructing a normalized cDNA library from a high oil content cultivar of sesame zhongzhi 14, during its oil accumulation stages. It combined switching mechanism at 5？end of RNA transcript （SMART） technique and duplex-specific nuclease （DSN） normalization methods. Double-stranded cDNAs were synthesized from mRNAs, processed by normalization and Sfi I restriction endonuclease, and finally the cDNAs were ligated to pDNR-LIB vector. The ligation mixture was transformed into Escherichia coli DH10B by electroporation. The capacity of the library was 1.0？06 clones in this library. Gel electrophoresis results indicated the fragments ranged from 700 to 2 000 bp, with the average size of 1 800 bp. Random picking clones showed that the recombination rate was 100%. The results showed that the cDNA library constructed successfully was a full-length library with high quality, and could be used to screen the genes related to development of oil synthesis.

关键词： DSN full-length library normalization oil accumulation Sesamue indicum zhongzhi 14 cDNA library switching mechanism SMARTTM

Metabolic Regulation of Mammary Gland Epithelial Cells of Dairy Cow by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： TONG Hui-li GAO Xue-jun LI Qing-zhang LIU Jie LI Nan WAN zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

Protective effect of inducible nitric oxide synthase inhibitor on pancreas transplantation in rats

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World Journal of Gastroenterology 2007年第45期13卷 6066-6071页

作者： Bai-Feng Li Yong-Feng Liu ying Cheng Ke-zhong Zhang Tie-Min Li Ning Zhao Department of Surgery and OrganTransplant Unit The First Affiliated Hospital China MedicalUniversity Shenyang 110001 Liaoning Province China

AIM: To investigate the effect of inducible nitric oxide synthase inhibitor, aminoguanidine, on pancreas transplantation in rats. METHODS: A model of pancreas transplantation was established in rats. Streptozotocin-induced diabetic male Wistar rats were randomly assigned to sham-operation control group (n= 6), transplant control group (n= 6), and aminoguanidine (AG) treatment group (n=18). In the AG group, aminoguanidine was added to intravascular infusion as the onset of reperfusion at the dose of 60 mg/kg, 80 mg/kg, 100 mg/kg body weight, respectively. Serum nitric oxide (NO) level, blood sugar and amylase activity were detected. Nitric oxide synthase (NOS) test kit was used to detect the pancreas cNOS and inducible NOS (iNOS) activity. Pancreas sections stained with HE and immunohistochemistry were evaluated under a light microscope. RESULTS: As compared with the transplant control group, the serum NO level and amylase activity decreased obviously and the evidence for pancreas injury was much less in the AG group. The AG (80 mg/kg body weight) group showed the most signifi cant difference in NO and amylase (NO: 66.0 ± 16.6 vs 192.3 ± 60.0, P < 0.01 and amylase: 1426 ± 177 vs 4477 ± 630, P < 0.01). The expression and activity of tissue iNOS, and blood sugar in the AG (80 mg/kg body weight) group were much lower than those in the transplant control group (iNOS: 2.01 ± 0.23 vs 26.59 ± 5.78, P < 0.01 and blood sugar: 14.2 ± 0.9 vs 16.8 ± 1.1, P < 0.01). CONCLUSION: Selective iNOS inhibitor, aminoguanidine as a free radical, has a protective effect on pancreas transplantation in rats by inhibiting NO and reducing its toxicity.

关键词： Pancreas Transplantation Inducible nitricoxide synthase Aminoguanidine Rat

Electrical Characteristics of High Mobility Si/Si_(0.5)Ge_(0.5)/SOI Quantum-Well p-MOSFETs with a Gate Length of 100 nm and an Equivalent Oxide Thickness of 1.1 nm

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Chinese Physics Letters 2013年第10期30卷 214-216页

作者： MU Zhi-Qiang YU Wen-Jie ZHANG Bo XUE zhong-ying CHEN Ming State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050

Short-channel high-mobility Si/Si_(0.5)Ge_(0.5)/silicon-on-insulator(SOI)quantum-well p-type metal-oxide-semiconductor field effect transistors(p-MOSFETs)were fabricated and electrically *** transistors show good transfer and output characteristics with Ion/Ioff ratio up to 105 and sub-threshold slope down to 100 mV/***_(2)/TiN gate stack is employed and the equivalent oxide thickness of 1.1 nm is *** effective hole mobility of the transistors reaches 200 cm^(2)/V·s,which is 2.12 times the Si universal hole mobility.

关键词： Si/Si SOI MOSFETs