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Developing and validating a predictive model of delivering large-forgestational-age infants among women with gestational diabetes mellitus

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World Journal of Diabetes 2024年第6期15卷 1242-1253页

作者： Yi-Tian Zhu Lan-Lan Xiang Ya-Jun Chen Tian-ying zhong Jun-Jun Wang Yu Zeng Department of Clinical Laboratory Jinling Clinical Medical College of Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Department of Clinical Laboratory Women’s Hospital of Nanjing Medical UniversityNanjing Women and Children’s Healthcare HospitalNanjing 210003Jiangsu ProvinceChina

BACKGROUND The birth of large-for-gestational-age(LGA)infants is associated with many shortterm adverse pregnancy *** has been observed that the proportion of LGA infants born to pregnant women with gestational diabetes mellitus(GDM)is significantly higher than that born to healthy pregnant ***,traditional methods for the diagnosis of LGA have ***,this study aims to establish a predictive model that can effectively identify women with GDM who are at risk of delivering LGA *** To develop and validate a nomogram prediction model of delivering LGA infants among pregnant women with GDM,and provide strategies for the effective prevention and timely intervention of *** The multivariable prediction model was developed by carrying out the following ***,the variables that were associated with LGA risk in pregnant women with GDM were screened by univariate analyses,for which the P value was<***,Least Absolute Shrinkage and Selection Operator regression was fit using ten cross-validations,and the optimal combination factors were se-lected by choosing lambda 1se as the *** final predictors were deter-mined by multiple backward stepwise logistic regression analysis,in which only the independent variables were associated with LGA risk,with a P value<***,a risk prediction model was established and subsequently evaluated by using area under the receiver operating characteristic curve,calibration curve and decision curve *** After using a multistep screening method,we establish a predictive *** risk factors for delivering an LGA infant were identified(P<0.01),including weight gain during pregnancy,parity,triglyceride-glucose index,free tetraiodothyronine level,abdominal circumference,alanine transaminase-aspartate aminotransferase ratio and weight at 24 gestational *** nomogram’s prediction ability was supported by the area under the curve(0.703,0.709,and 0.699 f

关键词： Large-for-gestational-age Gestational diabetes mellitus Predictive model Nomogram Triglyceride-glucose index

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自驱动杆状粒子在半柔性弹性环中的集体行为

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物理学报 2020年第8期69卷 112-119页

作者：仲颖施夏清苏州大学物理科学与技术学院软凝聚态物理及交叉研究中心苏州215006

在生物体系的活性系统中,杆状粒子在弹性半柔性边界中的受限行为极为常见.本文研究了二维情况下,自驱动杆状粒子受限在半柔性弹性环中的集体行为.改变系统的粒子数及噪声强度,系统显示明显的自驱吸附有序态、无序态及中间的过渡态.通过... 详细信息

在生物体系的活性系统中,杆状粒子在弹性半柔性边界中的受限行为极为常见.本文研究了二维情况下,自驱动杆状粒子受限在半柔性弹性环中的集体行为.改变系统的粒子数及噪声强度,系统显示明显的自驱吸附有序态、无序态及中间的过渡态.通过表征弹性环内部粒子的径向极性大小和空间分布的非球度性对这些状态进行了刻画.进一步对弹性环中心附近粒子密度的分析,发现环中心气态粒子分布存在一个与边界高密度区域共存的饱和平台,出现类似吸附转变的粒子分布.在过渡区间,体系内存在较大的涨落会导致弹性环出现异常形变.非对称的粒子分布对弹性环整体的迁移具有重要贡献,系统在过渡区间能获得相对较强的定向迁移.

关键词：活性物质自驱动杆状粒子吸附相分离饱和密度

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Influence of Ca addition on microstructure,mechanical properties and corrosion behavior of Mg-2Zn alloy

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China Foundry 2018年第5期15卷 363-371页

作者： Hong-xiang Li Shi-kai Qin Chang-lin Yang ying-zhong Ma Jian Wang Yun-jin Liu Ji-shan Zhang State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology.BeijingBeijing 100083China State Key Laboratory qf Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

The microstructure,mechanical properties and corrosion behaviors of as-cast ternary Mg-2Zn-x Ca(x=0,0.2,0.4,0.8)alloys have been investigated in this *** indicate that the microstructure of Mg-Zn-Ca alloys can be significantly refined with increasing Ca ***,the alloys with different contents of Ca exhibit the different phases formation behaviors,i.e.α-Mg+Ca_2Mg_6Zn_3 phases for Mg-2Zn-0.2Ca and Mg-2Zn-0.4Ca alloys,andα-Mg+Ca_2Mg_6Zn_3+Mg_2Ca phases for Mg-2Zn-0.8Ca alloy,*** all the alloys,the maximum ultimate tensile strength and elongation(161 MPa and 9.1%)can be attained for the Mg-2Zn-0.2Ca *** tests in Hanks’balanced salt solution indicated that Ca addition is detrimental to corrosion resistance of Mg-2Zn *** relationship between as-cast microstructure and properties for different Ca-containing alloys is also discussed in detail.

关键词： magnesium alloys Mg-Zn-Ca microstructure mechanical properties corrosion behaviors

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Variations in Carbohydrate and Protein Accumulation among Spikelets at Different Positions Within a Panicle During Rice Grain Filling

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Rice science 2012年第3期19卷 223-232页

作者： DONG Ming-hui CHEN Pei-feng XIE Yu-lin QIAO zhong-ying YANG Jian-chang Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou UniversityYangzhou 225009China Suzhou City Academic of Agriculture sciences Suzhou 215155China

The accumulation dynamics of kernel components for spikelets at different positions within a rice panicle were investigated during grain filling to understand the physiological reasons for the variation of grain *** rice cultivars,Yangdao 6 （indica） and Yangjing 9538 （japonica）,were field-grown,and the grain filling characters and contents of starch,soluble sugar,and protein of the spikelets at different positions were *** were significant differences in matter accumulation among spikelets at different positions during grain *** early-flowering spikelets presented dominance over the late-flowering spikelets in initial time and initial rate of *** the initial and mid filling stages,the contents and the rates of starch and amylose accumulation in spikelets decreased with the flowering sequence,but soluble sugar content （SSC） exhibited the opposite *** difference in SSC among the spikelets of Yangjing 9538 was greater than that of Yangdao 6,but amylose content in mature spikelets showed no obvious relationship to their flowering *** crude protein content （CPC） of early-flowering spikelets decreased more rapidly than that of late-flowering ones at the initial filling stage,and CPC in the spikelets on the secondary branch was higher than that on the primary branch,but CPC in early-flowering ones was lower than that in late-flowering across the whole grain filling *** water content （GWC） of early-flowering spikelets decreased more rapidly than that of late-flowering spikelets on the same branch at the initial and mid filling stages,especially for the top grain on each primary *** results suggested that poor grain filling of late-flowering spikelets may be attributed to their low biological activity rather than carbohydrate supply limitation.

关键词： spikelet position starch protein accumulation dynamic variation rice grain filling

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一种腐蚀疲劳损伤的非线性累加演化模型（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第6期15卷 447-453页

作者： zhong-ying HAN Xiao-guang HUANG Yu-guang CAO Jin-quan XU College of Petroleum Engineering China University of Petroleum Qingdao College of Pipeline and Civil Engineering China University of Petroleum School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University

研究目的:提出一种新的腐蚀疲劳损伤演化模型,建立基于损伤演化的腐蚀疲劳寿命预测模型。创新要点:将应力腐蚀损伤与疲劳损伤非线性耦合,建立腐蚀疲劳损伤演化律,依托实验确定腐蚀疲劳损伤演化参数,形成基于损伤演化律的腐蚀疲劳寿命预... 详细信息

研究目的:提出一种新的腐蚀疲劳损伤演化模型,建立基于损伤演化的腐蚀疲劳寿命预测模型。创新要点:将应力腐蚀损伤与疲劳损伤非线性耦合,建立腐蚀疲劳损伤演化律,依托实验确定腐蚀疲劳损伤演化参数,形成基于损伤演化律的腐蚀疲劳寿命预测模型。研究方法:采用理论研究与实验验证相结合的研究方法。选取特定材料设计应力腐蚀实验,回归应力腐蚀门槛值应力和损伤参数(图2);查阅疲劳实验数据建立变幅疲劳损伤模型,将应力腐蚀损伤与变幅疲劳损伤非线性累加形成腐蚀疲劳损伤非线性演化模型。根据腐蚀疲劳实验结果,验证腐蚀疲劳损伤演化模型并确定非线性损伤累加参数(图5和6),形成基于损伤演化律的腐蚀疲劳寿命预测模型。重要结论:从损伤力学角度,将材料的腐蚀疲劳损伤处理成应力腐蚀损伤与疲劳损伤的非线性累加,形成腐蚀疲劳损伤演化模型。结合LY12CZ铝合金的试验结果,验证了损伤演化模型的可行性。该方法可以为材料腐蚀疲劳的寿命评价研究提供新的思路。

关键词：腐蚀疲劳应力腐蚀非线性累加损伤演化

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Isolation, Culture and Induced Differentiation of Fetal Porcine Islet Derived Pancreatic Stem Cell

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Agricultural Sciences in China 2007年第6期6卷 742-748页

作者： FENG Ruo-peng ZHANG Hui-ru WANG Yun QIAO Hai ZHAO Ting SHEN Wen-zheng DOU zhong-ying Shaanxi Center of National Stem Cell Engineering ＆ Technology Research Center Northwest A＆F University Yangling 712100 P.R. China Biological Engineering College Henan Industrial University Zhengzhou 450052 P.R.China

To isolate and culture the porcine pancreatic stem cells and investigate their function, the fetal porcine pancreatic stem cells were isolated by the method of suspending plus adhering culture. The isolated cells were then identified by immunohistochemical staining, and their culture viability measured through the MTT method in vitro. This induced them to differentiate into endocrine cells and detect their function. The isolated IPSCS did not express nestin, but expressed CK-19, a marker of ductal epithelia cells and ct-actin, a smooth muscle marker, demonstrating the growth characteristics of ES-like cells, and strong proliferative ability, after 18 passages. They could excrete insulin, and showed ultrastructure changes after being induced. Porcine pancreatic stem cells can be isolated by this method, induced to form islet-like clusters, and can secret insulin.

关键词： fetal porcine islet pancreatic stem cells culture induced differentiation

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Semi-Supervised Learning Based on Manifold in BCI

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Journal of Electronic Science and Technology of China 2009年第1期7卷 22-26页

作者： Ji-ying zhong Xu Lei De-zhong Yao The authors are with the Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China

A Laplacian support vector machine （LapSVM） algorithm, a semi-supervised learning based on manifold, is introduced to brain-computer interface （BCI） to raise the classification precision and reduce the subjects＇ training complexity. The data are collected from three subjects in a three-task mental imagery experiment. LapSVM and transductive SVM （TSVM） are trained with a few labeled samples and a large number of unlabeled samples. The results confirm that LapSVM has a much better classification than TSVM.

关键词： Brain-computer interface manifold learning semi-supervised learning support vector machine.

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Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing

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Bioactive Materials 2023年第6期24卷 69-80页

作者： Nanbo Liu Shuoji Zhu Yuzhi Deng Ming Xie Mingyi Zhao Tucheng Sun Changjiang Yu ying zhong Rui Guo Keluo Cheng Dehua Chang Ping Zhu Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510100China University of Tokyo Hospital Department of Cell Therapy in Regenerative Medicine Tokyo113-8666Japan University of Tokyo Tokyo113-8666Japan Affiliated Hospital of Guangdong Medical University ZhanjiangGuangdong524001China Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier DevelopmentDepartment of Biomedical EngineeringJinan UniversityGuangzhou510632China Guangdong Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart DiseaseGuangzhou Key Laboratory of PathogenesisTargeted Prevention and Treatment of Heart DiseaseGuangzhouGuangdong510100China

Damaged skin cannot prevent harmful bacteria from invading tissues,causing infected wounds or even severe tissue *** this study,we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate(Cu-EGCG)*** prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli(***)and Staphylococcus aureus(***).It could also promote the proliferation and migration of L929 *** vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating *** collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated *** findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.

关键词： Metal polyphenol network Copper Epigallocatechin-3-gallate Infected wound healing

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ON THE 3-D PULSATING SOURCE OF MICHELL TYPE WITH FORWARD SPEED

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Journal of Hydrodynamics 1995年第2期7卷 84-95页

作者： Miao Guo-ping Liu ying-zhong Yang Qin-zheng Liu Zi-yuan(Shanghai Jiao Tong Univ., shanghai 200030 P. R. China) Shanghai Jiaotong Univ Shanghai China

An expression of the 3-D pulsating source of Michell type with forward speed for infinite water depth is derived in the present paper based on the Fourier transformation and contour integration technique. Emphases are laid on the discussion of the mechanical feature of the source and the radiation behavior far from the source. The relative importance of each components of the pulsating source is discussed in detail. Compared with the commonly used pulsating source of Haskind type, the present expression has the merits of simplicity for numerical treatment and being more meaningful in its physical explanation. The Michell type expression of the 3-D pulsating source with forward speed can be widely used for the estimation of motions and wave forces for ships and offshore structures in waves with forward speed. The radiative behavior of the source in the far field may also give a reasonabel description of the radiation condition or the open boundary condition for other numerical methods, such as the Rankine source method etc.

关键词： D pulsating source with forward speed radiative behavior of the source,Fourier transform

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Effects of Zn content on the microstructure and the mechanical and corrosion properties of as-cast low-alloyed Mg–Zn–Ca alloys

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 800-809页

作者： Hong-xiang Li Shi-kai Qin Hng-zhong Ma Jian WanE Yun-jin Liu Ji-shan Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

The effects of Zn content on the microstxucture and the mechanical and corrosion properties of as-cast low-alloyed Mg-xZn~.2Ca alloys （x = 0.6wt%, 2.0wt%, 2.5wt%, hereafter denoted as 0.6Zn, 2.0Zn, and 2.5Zn alloys, respectively） axe investigated. The results show that the Zn content not only influences grain refinement but also induces different phase precipitation behaviors. The as-cast microstxucture of the 0.6Zn alloy is composed of ct-Mg, Mg2Ca, and Ca2Mg6Zn3 phases, whereas 2.0Zn and 2.5Zn alloys only contain ct-Mg and Ca2Mg6Zn3 phases, as revealed by X-ray diffraction （XRD） and txonsmission electron microscopy （TEM） analyses. Moreover, with in- creasing Zn content, both the ultimate tensile strength （UTS） and the elongation to fracture first increase and then decrease. Among the three investigated alloys, the largest UTS （178 MPa） and the highest elongation to fracture （6.5%） are obtained for the 2.0Zn alloy. In addition, the corrosion rate increases with increasing Zn content. This paper provides on updated investigation of the alloy composi- tion-microstxucture-property relationships of different Zn-containing Mg-Zn-Ca alloys.

关键词： Mg-Zn-Ca alloy s as-cast micro stxucture mechanical properties corrosion properties

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