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China's Solution and Experience in the Comprehensive Implementation of Supply-Side Structural Reform

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2023年第3期18卷 391-424页

作者： zhong ying Department of Economic History The Institute of Contemporary China StudiesChinese Academy of Social SciencesBeijing 100009China

Comprehensively implementing supply-side structuralreform isa major adjustment of ideas and focus of China's economic development,made by the Communist Party of China(CPC)Central Committee on the basis of a comprehensive analysis of the world's long-term economic cycle and the new normal of China's economic *** a major innovation to adapt to and lead the new normal of economic development,it has become a strategic deployment that concerns the overall long-term development of China's economy and *** the 19th CPC National Congress,the main tasks of supply-side structural reform were cutting overcapacity,destocking,deleveraging,reducing corporate costs and shoring up weak *** the 19th CPC National Congress,while continuing to do the tasks,the CPC Central Committee stuck to the main direction of improving the quality of the supply system,enriching the connotation of deepening supply-side structural *** 2016,China's supply-side structural reform has achieved remarkable results,and has been widely recognized and positively evaluated both internationally and *** reform provides not only a solidfoundationandvaluable experience for China's subsequent reforms,but also a useful reference fordeveloping countries.

关键词： supply-side reform demandside management supply-side structural reform China's solution China's experience

Long Time Behavior of the Fokker-Planck-Boltzmann Equation

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Acta Mathematicae Applicatae Sinica 2014年第2期30卷 533-554页

作者： Ming-ying zhong Hai-liang LI Department of Mathematical and Information Sciences Guangxi University Department of Mathematics Capital Normal University

This paper is devoted to the existence and long time behavior of the global classical solution to Fokker-Planck-Boltzmann equation with initial data near the absolute Maxwellian.

关键词： Fokker-Planck-Boltzmann equation global existence long time behavior

Design of new format for mass data compression

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The Journal of China Universities of Posts and Telecommunications 2011年第1期18卷 121-128页

作者： QIN Jian-cheng BAI zhong-ying School of Computer Science Beijing University of Posts and Telecommunications Beijing 100876 China

In the field of lossless compression, most kinds of traditional software have some shortages when they face the mass data. Their compressing abilities are limited by the data window size and the compressing format design. This paper presents a new design of compressing format named ＇CZ format＇ which supports the data window size up to 4 GB and has some advantages in the mass data compression. Using this format, a compressing shareware named ＇ComZip＇ is designed. The experiment results support that ComZip has better compression ratio than WinZip, Bzip2 and are compressed. And ComZip has the potential to beat 7-zip in WinRAR in most cases, especially when GBs or TBs of mass data future as the data window size exceeds 128 MB.

关键词： mass data coding tossless compression LZ77/LZSS algorithm arithmetic coding

Impact of nanoparticle-induced scattering of an azimuthally propagating mode on the resonance of whispering gallery microcavities

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Photonics Research 2017年第5期5卷 396-405页

作者： JUNDA ZHU ying zhong HAITAO LIU Key Laboratory of Optical Information Science and Technology Ministry of Education Institute of Modern Optics Nankai University State Key Laboratory of Precision Measuring Technology and Instruments Tianjin University

Optical whispering gallery microcavities with high-quality factors have shown great potential toward achieveing ultrahigh-sensitivity sensing up to a single molecule or nanoparticle, which raises a huge demand on a deep theoretical insight into the crucial phenomena such as the mode shift, mode splitting, and mode broadening in sensing experiments. Here we propose an intuitive model to analyze these phenomena from the viewpoint of the nanoparticle-induced multiple scattering of the azimuthally propagating mode(APM). The model unveils explicit relations between these phenomena and the phase change and energy loss of the APM when scattered at the nanoparticle; the model also explains the observed polarization-dependent preservation of one resonance and the particle-dependent redshift or blueshift. The model indicates that the particle-induced coupling between the pair of unperturbed degenerate whispering gallery modes(WGMs) and the coupling between the WGMs and the free-space radiation modes, which are widely adopted in current theoretical formalisms, are realized via the reflection and scattering-induced free-space radiation of the APM, respectively, and additionally exhibits the contribution of cross coupling between the unperturbed WGMs and other different WGMs to forming the splittingresonant modes, especially for large particles.

关键词： APM Impact of nanoparticle-induced scattering of an azimuthally propagating mode on the resonance of whispering gallery microcavities

Continuous and Discrete Similarity Coefficient for Identifying Essential Proteins Using Gene Expression Data

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Big Data Mining and Analytics 2023年第2期6卷 185-200页

作者： Jiancheng zhong Zuohang Qu ying zhong Chao Tang Yi Pan College of Information Science and Engineering Hunan Normal UniversityChangsha 410081China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences ShenzhenGuangzhou 518055China

Essential proteins play a vital role in biological processes,and the combination of gene expression profiles with Protein-Protein Interaction(PPI)networks can improve the identification of essential ***,gene expression data are prone to significant fluctuations due to noise interference in topological *** this work,we discretized gene expression data and used the discrete similarities of the gene expression spectrum to eliminate noise *** then proposed the Pearson Jaccard coefficient(PJC)that consisted of continuous and discrete similarities in the gene expression *** the graph theory as the basis,we fused the newly proposed similarity coefficient with the existing network topology prediction algorithm at each protein node to recognize essential *** strategy exhibited a high recognition rate and good *** validated the new similarity coefficient PJC on PPI datasets of Krogan,Gavin,and DIP of yeast species and evaluated the results by receiver operating characteristic analysis,jackknife analysis,top analysis,and accuracy *** with that of node-based network topology centrality and fusion biological information centrality methods,the new similarity coefficient PJC showed a significantly improved prediction performance for essential proteins in DC,IC,Eigenvector centrality,subgraph centrality,betweenness centrality,closeness centrality,NC,PeC,and *** also compared the PJC coefficient with other methods using the NF-PIN algorithm,which predicts proteins by constructing active PPI networks through dynamic gene *** experimental results proved that our newly proposed similarity coefficient PJC has superior advantages in predicting essential proteins.

关键词： Protein-Protein Interaction(PPI)network continuous and discrete similarity coefficient essential proteins

The immunophilin CYCLOPHILIN28 affects PSII-LHCII supercomplex assembly and accumulation in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2022年第4期64卷 915-929页

作者： Weining Zhu Linqing Xu Xiaoxia Yu ying zhong Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology Key Laboratory of Biotechnology Shaanxi ProvinceCollege of Life SciencesNorthwest UniversityXi'an 710069China

In plant chloroplasts,photosystem II(PSII)complexes,together with light-harvesting complex II(LHCII),form various PSII-LHCII supercomplexes(SCs).This process likely involves immunophilins,but the underlying regulatory mechanisms are ***,by comparing Arabidopsis thaliana mutants lacking the chloroplast lumen-localized immunophilin CYCLOPHILIN28(CYP28)to wildtype and transgenic complemented lines,we determined that CYP28 regulates the assembly and accumulation of PSII-LHCII *** to the wild type,cyp28 plants showed accelerated leaf growth,earlier flowering time,and enhanced accumulation of high molecular weight PSII-LHCII SCs under normal light *** lack of CYP28 also significantly affected the electron transport *** native-polyacrylamide gel electrophoresis analysis revealed more Lhcb6 and less Lhcb4 in M-LHCII-Lhcb4-Lhcb6 complexes in cyp28 versus wild-type ***-prolyl cis/trans isomerase(PPIase)activity assays revealed that CYP28 exhibits weak PPIase activity and that its K113 and E187 residues are critical for this *** analysis suggested that CYP28 may regulate PSIILHCII SC accumulation by altering the configuration of Lhcb6 via its PPIase ***,the Lhcb6-P139 residue is critical for PSII-LHCII SC assembly and ***,our findings suggest that CYP28 likely regulates PSII-LHCII SC assembly and accumulation by altering the configuration of P139 of Lhcb6 via its PPIase activity.

关键词： cyclophilin28 immunophilin peptidyl-prolyl cis/trans isomerase activity photosynthesis PSII-LHCII supercomplexes thylakoid lumen

Gene therapy in pancreatic cancer

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World Journal of Gastroenterology 2014年第37期20卷 13343-13368页

作者： Si-Xue Liu zhong-Sheng Xia ying-Qiang zhong Department of Gastroenterology Sun Yat-sen Me-morial HospitalSun Yat-sen University Department of Gastro-enterology Sun Yat-sen Memorial HospitalSun Yat-sen Univer-sity

Pancreatic cancer(PC) is a highly lethal disease and notoriously difficult to treat. Only a small proportion of PC patients are eligible for surgical resection, whilst conventional chemoradiotherapy only has a modest effect with substantial toxicity. Gene therapy has become a new widely investigated therapeutic approach for *** article reviews the basic rationale, gene delivery methods, therapeutic targets and developments of laboratory research and clinical trials in gene therapy of PC by searching the literature published in English using the PubMed database and analyzing clinical trials registered on the Gene Therapy Clinical Trials Worldwide website(http://www. ***/genmed/ clinical). Viral vectors are main gene delivery tools in gene therapy of cancer, and especially, oncolytic virus shows brighter prospect due to its tumor-targeting *** therapeutic targets for gene therapy include tumor suppressor gene p53, mutant oncogene K-ras,anti-angiogenesis gene VEGFR, suicide gene HSK-TK,cytosine deaminase and cytochrome p450, multiple cytokine genes and so on. Combining different targets or combination strategies with traditional chemoradiother-apy may be a more effective approach to improve the efficacy of cancer gene therapy. Cancer gene therapy is not yet applied in clinical practice, but basic and clinical studies have demonstrated its safety and clinical benefits. Gene therapy will be a new and promising field for the treatment of PC.

关键词： Pancreatic cancer Gene therapy Tumor suppressor Suicide Anti-angiogenesis Immunotherapy Oncogene Multidrug resistance Clinical trial

Monte Carlo study of the neutron ambient dose equivalent at the heavy ion medical machine in Wuwei

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Nuclear Science and Techniques 2022年第9期33卷 111-125页

作者： Sheng-Cong Huang Hui Zhang Kai Bai ying Luo Hai-Jun Mao zhong-ying Dai University of Chinese Academy of Sciences Beijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

The use of carbon-ion radiotherapy(CIRT)is gradually *** to the generation of high-energy secondary neutrons during CIRT,its use presents new challenges in radiation ***,secondary neutron dose distributions must be explored and evaluated under clinical scenarios based on different treatment ***,neutron dose and energy spectrum measurements are often *** can be primarily attributed to the inherent limitations of most neutron detectors,such as their unsuitability for spectral measurements and inaccurate responses to neutrons with energies above 20 *** calculation methods based on probabilistic statistical theory are fast and convenient for neutron dose *** this study,external secondary neutron doses at the heavy ion medical machine in Wuwei,which is equipped with a passive beam delivery system,were calculated using the Monte Carlo *** dependence of neutron doses on various treatment parameters(incident carbon-ion beam energy,spatial location,field size,and spread-out Bragg peak(SOBP)width)was ***,the feasibility of applying an analytical model to predict the ambient dose equivalent was *** the combination involving an energy of 400 MeV=u and SOBP width of 6 cm,the ambient dose equivalent per therapeutic dose(H=D)at the isocenter was 79.87 mSv=Gy:The H=D value decreased rapidly with increasing spatial distance and slightly with increasing aperture size and SOBP *** H=D values derived from the Monte Carlo simulations were in good agreement with the results reported in the *** analytical model could be used to quickly predict the H=D value along the incidence direction of the beam with an error of less than 20%.Thus,our study contributes to the understanding of the relationship between neutron radiation and treatment configuration parameters,which establishes a basis for predicting non-therapeutic radiation doses in CIRT.

关键词： Carbon-ion radiotherapy Passive beam delivery Secondary neutrons Monte Carlo method

Assessment of the induced radioactivity in the treatment room of the heavy-ion medical machine in Wuwei using PHITS

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Nuclear Science and Techniques 2023年第2期34卷 153-166页

作者： ying Luo Sheng‑Cong Huang Hui Zhang Hai‑Jun Mao Qiang Li zhong‑ying Dai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Science Lanzhou 730000China Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Lanzhou 730000China Lanzhou University Lanzhou 730000China

Carbon-ion radiotherapy(CIRT)offers unique physical and biological advantages over photon ***,some materials and devices in the CIRT treatment room become radioactive under bombardment by therapeutic carbon-ion beams due to nuclear reactions,thereby leading to possible radiation hazards to medical staff and additional and unwanted doses to *** study assessed the level of induced radioactivity in the treatment room of the Heavy-Ion Medical Machine(HIMM)in *** Carlo simulations using PHITS were performed for a conservative case under the conditions of maximum beam energy and intensity provided by the HIMM *** geometry and configuration of Treatment Room 2 of the HIMM facility in Wuwei were *** evaluated the activation of air,the phantom,and the components of the beamline,such as the primary collimator(PC),ridge filter(RF),and multileaf collimator(MLC).For air activation,we calculated the medical staff immersion external exposure and inhalation internal exposure caused by the corresponding *** phantom activation,we estimated the additional dose to the patient’s family members owing to secondary photons after *** addition,the exemption or non-exemption of the component material activation was *** results showed that external radiation caused by air activation was the main source of the annual effective dose at approximately 0.5 mSv/*** induced radioactivity exposure to family members of a patient after CIRT was approximately 40μSv,sufficiently lower than the public dose limit of 1 mSv/*** induced radioactivity of the PC,RF,and MLC was all above the exempt levels after the devices were retired,whereas the induced radioactivity of the RS and compensator could reach the exempt levels after one patient *** study indicated that medical staff engaged in CIRT should stay away from the high-dose-rate area of induced radioactivity along the beam direction,shorten the residence time in

关键词： activation approximate thereby