检索结果-南通市图书馆

Identification of human microRNA-disease association via low-rank approximation-based link propagation and multiple kernel learning

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第2期18卷 217-229页

作者： Yizheng WANG Xin zhang ying JU Qing LIU Quan ZOU Yazhou zhang Yijie DING ying zhang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China Beidahuang Industry Group General Hospital Harbin 150088China School of Informatics Xiamen UniversityXiamen 361005China Department of Anesthesiology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Software Engineering College Zhengzhou University of Light IndustryZhengzhou 450002China

Numerous studies have demonstrated that human microRNAs(miRNAs)and diseases are associated and studies on the microRNA-disease association(MDA)have been *** developed a model using a low-rank approximation-based link propagation algorithm with Hilbert–Schmidt independence criterion-based multiple kernel learning(HSIC-MKL)to solve the problem of the large time commitment and cost of traditional biological experiments involving miRNAs and diseases,and improve the model *** constructed three kernels in miRNA and disease space and conducted kernel fusion using *** propagation uses matrix factorization and matrix approximation to effectively reduce computation and time *** results of the experiment show that the approach we proposed has a good effect,and,in some respects,exceeds what existing models can do.

关键词： human miRNA-disease association multiple kernel learning link propagation miRNA similarity disease similarity

Microscale spherical TiO_(2)powder prepared by hydrolysis of TiCl_(4)solution:Synthesis and kinetics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第1期84卷 60-71页

作者： Peiyi Yan ying zhang Shili Zheng School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua617000China

Hydrolysis of TiCl_(4)solution is capable of preparing microscale TiO_(2)*** research studied the synthesis of microscale spherical TiO_(2)powders and the hydrolysis *** effects of the flow field generated by different agitators and baffles in the crystallizer,the initial free acid concentration,the initial equivalent TiO_(2)concentration,and the temperature on the hydrolysis progress and powder morphology were systematically *** results show that the flow field in a crystallizer can significantly affect the morphology and particle size of the powders,and the axial flow can improve the sphericity of the *** increased free HCl and equivalent TiO_(2)concentrations in the pregnant solution inhibit the forward hydrolysis reaction,prolong the time to reach equilibrium,and reduce the *** appropriate temperature matching the compositions of the pregnant solution is crucial for the powder morphology and *** with sizes ranging from around 5 um-40μm can be tuned under controlled flow field,solution compositions,and temperature *** addition,the Cheng and Wunderlich modified Avrami equation was used for the crystallization kinetic *** effects of the free HCl concentration,equivalent TiO_(2)concentration,and hydrolysis temperature are reflected in the reaction rate constant and active nuclei reduction *** the free HCl and equivalent TiO_(2)concentrations will reduce the reaction rate constant and accelerate the deactivation of the active nuclei,thus increasing the final powder size,while increasing the temperature will lead to the opposite results.

关键词： TiCl_(4) Hydrolysis Microscale TiO_(2) Spherical Kinetics

Feeding prehistoric coastal community:A study of marine faunal remains at the Jingtoushan site

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1574-1590页

作者： Endong WU Guoping SUN ying zhang School of Culture History and LanguageAustralian National UniversityCanberra 2600Australia Zhejiang Provincial Institute of Cultural Relics and Archaeology Hangzhou 310012China National Centre for Archaeology Beijing 100013China

This article examines the abundant marine mollusc,and fish remains at the Jingtoushan shell midden(8,300 to7,800 cal a BP)in Zhejiang Province,China,to investigate the fishing economy,community development,the palaeoenvironment,and their interactions among the prehistoric populations in the lower Yangtze River Basin and southeastern coastal *** also attempts to explore the prosperity and decline of coastal settlements in China during the Neolithic Age and the potential reasons for their rise and fall,*** on the ecological and biological principles of marine animals,standard zooarchaeological methods and radiocarbon dating analysis are used for sampling,identification,measurement,and *** show that at least 11 mollusc taxa and 14 fish taxa can be identified from the Jingtoushan faunal *** ancient Jingtoushan residents possibly lived in a settlement close to the coast and engaged in inshore and offshore fishing,hunting,and gathering as their primary subsistence strategies,with low-level rice cultivation as a supplementary means of ***,the changes in the coastal environment could be one of the reasons why the Jingtoushan residents abandoned their *** research contributes to Chinese Neolithic archaeology with new evidence of the exploitation of marine resources around 8000 a BP in the eastern coastal areas and the relationship between Neolithic community development and environmental changes.

关键词： Neolithic Age Marine faunal remains Fishing economy Palaeoenvironment Community development

How to implement a knowledge graph completeness assessment with the guidance of user requirements

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第3期35卷 679-688页

作者： zhang ying XIAO Gang Institute of Systems Engineering Academy of Military SciencesBeijing 100107China

In the context of big data, many large-scale knowledge graphs have emerged to effectively organize the explosive growth of web data on the Internet. To select suitable knowledge graphs for use from many knowledge graphs, quality assessment is particularly important. As an important thing of quality assessment, completeness assessment generally refers to the ratio of the current data volume to the total data *** evaluating the completeness of a knowledge graph, it is often necessary to refine the completeness dimension by setting different completeness metrics to produce more complete and understandable evaluation results for the knowledge ***, lack of awareness of requirements is the most problematic quality issue. In the actual evaluation process, the existing completeness metrics need to consider the actual application. Therefore, to accurately recommend suitable knowledge graphs to many users, it is particularly important to develop relevant measurement metrics and formulate measurement schemes for completeness. In this paper, we will first clarify the concept of completeness, establish each metric of completeness, and finally design a measurement proposal for the completeness of knowledge graphs.

关键词： knowledge graph completeness assessment relative completeness user requirement quality management

Gabapentinoids for the treatment of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1509-1516页

作者： ying zhang Chenyu zhang Xiaoli Yi Qi Wang Tiejun zhang Yuwen Li Department of Pharmacy West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Gabapentinoid drugs(pregabalin and gabapentin) have been successfully used in the treatment of neuro pathic pain and in focal seizure *** research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue,oxidative stress,and inflammation,which matches the mechanism of action via voltage-gated calcium *** this review,we briefly elaborate on the medicinal history and ligand-binding sites of *** systematically summarize the preclinical and clinical research on gabapentinoids in stroke,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,seizures after stro ke,cortical spreading depolarization after stroke,pain after stroke,and nerve regeneration after stro *** review also discusses the potential to rgets of gabapentinoids in stroke;however,the existing results are still unce rtain regarding the effect of gabapentinoids on stroke and related *** preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in ***,gabapentinoids have both opportunities and challenges in the treatment of stroke.

关键词： cortical spreading depolarization gabapentinoid intracerebral hemorrhage pain after stroke stroke subarachnoid hemorrhage

The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： Xiuxiu Liu ying zhang Yanming Zhao Qian zhang Feng Han Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

Structural characteristics and drivers of greenhouse gas emissions at county-level and long-time scales:A case study of the Anji County,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第6期140卷 319-330页

作者： Zhouxiang Cai Liting Hu Di Chen ying zhang Xuekun Fang College of Environmental&Resource Sciences Zhejiang UniversityHangzhou 310058China Center for Global Change Science Massachusetts Institute of TechnologyCambridgeMA 02139United States Anji Meteorological Bureau Anji 313300China

To achieve carbon neutrality,the Chinese government needs to gain a comprehensive understanding of the sources and drivers of greenhouse gas(GHG)emissions,particularly at the county *** County in eastern China is a typical example of an industrial transformation from quarrying to a low-carbon *** study analyzed the decoupling types and structural characteristics of GHG emissions and the driving factors of carbon dioxide(CO_(2))emissions in the Anji from 2006 to 2019,and explored the differences between countylevel and provincial-level or city-level *** was observed that energy-related activities are the main source of GHG emissions in Anji and that economic development is the driving factor behind the increasing CO_(2)***,industrial transformation and upgradation coupled with the alternative use of clean energy limit the growth of GHG *** study details the GHG emissions of county during the industrial transformation stage and provides corresponding policy recommendations for county governments.

关键词： County GHG emissions Decoupling Driving factors Policy recommendations

Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

在线全文

学校读者我要写书评

暂无评论

CHINESE JOURNAL OF POLYMER SCIENCE 2024年第8期42卷 1167-1176页

作者： Gong, Xiang-Jun Zhao, Zhi-Ping Sun, Chang-Mei zhang, ying Qu, Rong-Jun Wang, ying Ludong Univ Sch Chem & Mat Sci Yantai 264025 Peoples R China

In this work, aramid nanoparticles (ANPs) were prepared in dimethyl formamide (DMF) solution containing high impact polystyrene (HIPS) via a bottom-up approach. Transmission electron microscopy (TEM) images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any agglomeration. Chemical composition of the ANPs, i.e., poly(p-phenyl-p-phenylenediamine) (PPTA), was confirmed by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and X-ray diffractometer (XRD). The ANP/HIPS composites, obtained after ethanol precipitation, were added to neat HIPS as fillers to fabricate ANP/HIPS composite sheets. The surface roughness and the glass transition temperature (Tg) of the sheets were characterized by atomic force microscope (AFM) and differential scanning calorimetry (DSC), respectively. Compared with neat HIPS, the mechanical properties of the composite sheet were significantly improved, and the Young's modulus increased from 246.55 MPa to 2025.12 MPa, the tensile strength increased from 3.07 MPa to 29.76 MPa, and the toughness increased from 0.32 N/mm(2) to 3.92 N/mm(2), with an increase rate of 721%, 869% and 1125%, respectively. Moreover, the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property NANOFIBERS PERFORMANCE TOUGHNESS STRENGTH ADHESION FIBER

Efficient nitrite-to-ammonia electroreduction over Zr-Ni frustrated Lewis acid-base pairs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第5期67卷 1707-1714页

作者： ying zhang Zhuohang Li Wenyu Du Kai Chen Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Electrochemical NO_(2)~--to-NH_(3) conversion(NO_(2)RR) offers a green route to NH_(3) electrosynthesis, while developing efficient NO_(2)RR catalysis systems at high current densities remains a grand challenge. Herein, we report an efficient Zr-NiO catalyst with atomically dispersed Zr-dopants incorporated in NiO lattice, delivering the exceptional NO_(2)RR performance with industriallevel current density(>0.2 A cm^(-2)). In situ spectroscopic measurements and theoretical simulations reveal the construction of ZrNi frustrated Lewis acid-base pairs(FLPs) on Zr-Ni O, which can substantially increase the number of absorbed nitrite(NO_(2)~-),promote the activation and protonation of NO_(2)~- and concurrently hamper the H coverage, boosting the activity and selectivity of Zr-NiO towards the NO_(2)RR. Remarkably, Zr-NiO exhibits the exceptional performance in a flow cell with high Faradaic efficiency for NH_(3) of 94.0% and NH_(3)yield rate of 1,394.1 μmol h^(-1)cm^(-2) at an industrial-level current density of 228.2 m A cm^(-2),placing it among the best NO_(2)RR electrocatalysts for NH_(3) production.

关键词： electrochemical nitrite-to-ammonia conversion frustrated Lewis acid-base pairs(FLPs) in situ spectroscopy theoretical computations