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Severe community-acquired pneumonia caused by Leptospira interrogans:A case report and review of literature

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World Journal of Clinical Cases 2021年第8期9卷 1901-1908页

作者： Qiu-Hong Bao Li Yu Jian-jun Ding ying-jun chen jun-Wei Wang Jian-Ming Pang Qi Jin Department of Respiratory and Critical Medicine Tiantai Hospital of Hangzhou Medical CollegeTiantai 317200Zhejiang ProvinceChina Department of Infectious Disease Tiantai Hospital of Hangzhou Medical CollegeTiantai 317200Zhejiang ProvinceChina Department of Critical Care Medicine Tiantai Hospital of Hangzhou Medical CollegeTiantai 317200Zhejiang ProvinceChina ICU Administration Tiantai Hospital of Hangzhou Medical CollegeTaizhou 317200Zhejiang ProvinceChina

BACKGROUND Leptospira is an uncommon pathogen for adult severe community-acquired pneumonia and its nonspecific manifestations and limited diagnostic tests make it difficult to *** conventional penicillin remains efficacious to treat leptospirosis,failure in early diagnosis and treatment can lead to progression into a deadly syndrome with multiple organ *** generation sequencing is of great value to understand cases with infection of unknown cause,which could help in the diagnosis of uncertain Leptospira *** SUMMARY We recently managed a patient with fever,cough and dyspnea on admission that progressed into persistent adult respiratory distress syndrome,hemoptysis and hematuria after *** this case,the rare Leptospira infection was clouded by the positive influenza tests at admission,delaying early Leptospira-targeted antibiotics *** generation sequencing,a novel molecular diagnostic tool,provided a key hint to uncover the crucial pathogen,Leptospira interrogans,further supported by the possible occupational exposure *** conventional penicillin and mechanical respiratory support were administrated to cure the patient successfully without any *** Clinicians must pay attention to possible exposure history and keep uncommon Leptospira in mind when managing pneumonia with unknown causes.

关键词： Leptospira interrogans Pneumonia Next generation sequencing Influenza Diagnosis Case report

Laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 508-512页

作者： ying-jun chen Zuo-jun Zhen Huan-Wei chen Eric CH Lai Fei-Wen Deng Qing-Han Li Wan Yee Lau Department of Liver Surgery The First People's Hospital of Foshan Faculty of Medicine The Chinese University of Hong Kong

BACKGROUND： With advances in technology, laparoscopic liver resection is widely accepted. Laparoscopic liver resection under hemihepatic vascular inflow occlusion has advantages over the conventional total hepatic inflow occlusion using the Pringle＇s maneuver, especially in patients with ***： From November 2011 to August 2012, eight consecutive patients underwent laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach with biliary bougie ***： The types of liver resection included right hepatectomy（n1）, right posterior sectionectomy（n1）, left hepatectomy and common bile duct exploration（n1）, segment 4b resection（n1）, left lateral sectionectomy（n2）, and wedge resection（n2）. Four patients underwent right and 4 left hemihepatic vascular inflow occlusion. Four patients had cirrhosis. The mean operation time was 176.3 minutes. The mean time taken to achieve hemihepatic vascular inflow occlusion was 24.3minutes. The mean duration of vascular inflow occlusion was54.5 minutes. The mean intraoperative blood loss was 361 *** patient required blood transfusion. Postoperatively, one patient developed bile leak which healed with conservative treatment. No postoperative liver failure and mortality occurred. The mean hospital stay of the patients was 7 ***： Our technique of hemihepatic vascular inflow vascular occlusion using the lowering of hilar plate approachwas safe, and it improved laparoscopic liver resection by minimizing blood loss during liver parenchymal transection.

关键词： laparoscopic liver resection hepatectomy vascular control liver neoplasm hilar plate

Multi-stimuli-responsive aggregation-induced emission copper iodide cluster

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Science China Chemistry 2024年第4期67卷 1193-1197页

作者： Bo Li Yuan-Yuan Liu Peng Luo Ye-Ru Liu ying-jun chen Kai Li Shuang-Quan Zang College of Chemistry and Pharmacy Engineering Nanyang Normal UniversityNanyang 473061China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Stimuli-responsive luminescent materials have attracted significant attention in the development of smart photoactive materials for both fundamental research and technological *** this work,a new copper iodide cluster(1)with aggregationinduced emission(AIE)characteristic,was obtained combining Cu_(4)I_(4) core with rhodamine B derivative ligand.1 has reversible and distinct multi-stimuli-responsive luminescence for external temperature,volatile organic compound,and mechanical ***,1 exhibited unusual large blue shift(84 nm)after being ground,which originated from the change of intermolecular ***,1 exhibits high oxygen quenching efficiency for 82.2% at 1 *** studies showed that the multi-stimuli-responsive luminescence properties of 1 can be attributed to the regulation of cluster-centered luminescence process,metal-to-ligand charge transfer process,halide-to-metal charge transfer luminescence process and aggregationinduced barrier to oxygen *** work not only reports an AIE copper iodide cluster,but also provides a new strategy to develop multi-stimuli-responsive luminescence materials.

关键词： copper iodide cluster aggregation-induced emission multi-stimuli-response

Association of handgrip strength with semen characteristics:a study with repeated measurements among healthy Chinese men

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Asian Journal of Andrology 2022年第6期24卷 594-600页

作者： Bin Sun Heng-Gui chen Peng Duan Zhou-Zheng Tu ying-jun chen Tian-Qing Meng cheng-Liang Xiong Yi-Xin Wang An Pan Huazhong University of Science and Technology Wuhan 430000China Center for Reproductive Medicine Department of Obstetrics and GynaecologyXiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441100China Center for Reproductive Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Hubei Province Human Sperm Bank Wuhan 430000China Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health ***,the associations between handgrip strength and semen characteristics have not been *** recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month *** characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were ***-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen *** adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),*** positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous *** strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner.

关键词： epidemiology handgrip strength repeated measurements semen characteristics

A direct observation of aqueous humour flow in vivo after implantable collamer lens with a central hole implantation

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 160-162页

作者： Mei-Yan Li Feng Zhao Pei-jun Yao ying-jun chen Ruo-Yan Wei Xing-Tao Zhou Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityMyopia Key Laboratory of China Health MinistryShanghai 200031China

Dear Editor,We present the reported case of the aqueous humour flow observed in vivo after implantable collamer lens(ICL)with a central hole implantation ***,a phakic intraocular lens which is located in the posterior... 详细信息

关键词： implantation vivo flow

Establishment of a non-lethal model of antibody-dependent enhancement of infection in A129 mice based on a non-mouse-adapted dengue virus strain

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Zoological Research 2023年第5期44卷 943-946页

作者： Han Wang Ming-Wang Long Li Zhang Yue Pan jun-ying chen Kai Feng Qiang-Ming Sun Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeKunmingYunnan 650118China Yunnan Key Laboratory of Vaccine Research&Development on Severe Infectious Diseases KunmingYunnan 650118China Yunnan Key Laboratory of Vector-borne Infectious Disease KunmingYunnan 650118China Department of Clinical Laboratory Guizhou Provincial People's HospitalGuiyangGuizhou 550002China

DEAR EDITOR,Dengue fever(DF),caused by dengue virus(DENV)infection,is a highly prevalent mosquito-borne infectious *** development of antiviral drugs and vaccines relies on the clinical utility of dengue infection mod... 详细信息

关键词： infection drugs clinical

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao chen Xie Liu Changqing Xu Da-Jian Wu ying cheng Xiao-jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Preparation and Anti-Oxidation Properties of Ti(CN) Films Deposited by P CVD

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材料热处理学报 2004年第05B期25卷 851-853页

作者： PANying-jun chenShu-hua WUXin-jie LIPing-sheng ZHANGXi-ju DepartmentofMaterialandMetallurgy WuhanUniversityofScienceandTechnologyWuhanChina

Using metallo-organatic compound TPT as the source of Ti, H13 mould steels were coated with Ti(CN) films by plasma-assisted chemical vapor deposition (PCVD) and the properties of Ti(CN) films were studied. Under the appropriate temperature and pressure, Ti(CN) films on H13 mould steel surfaces had the highest micro-hardness of HV1760 at 500°C, and the films showed excellent anti-oxidation property below 500°C. The lifetime of Ti(CN)-coated augers and dies could be enhanced 7 and 4 times longer than those of untreated respectively.

关键词： PCVD 钛薄膜反氧化显微硬度

Genetic Analysis of the VP1 Region of Human Enterovirus 71 Strains Isolated in Fuyang,China,During 2008

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Virologica Sinica 2009年第3期24卷 162-170页

作者： Shao-hui MA Jian-sheng LIU Jing-jing WANG Hai-jing SHI Hui-juan YANG jun-ying chen Long-ding LIU Qi-han LI Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming 650118 China

Enterovirus 71 （EV71） is a common cause of Hand, foot, and mouth disease （HFMD） and may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity of EV71, we determined and analyzed the complete VP1 sequences （891 nueleotides） from nine EV71 strains isolated in Fuyang, China. We found that nine EV71 strains isolated were over 98% homologous at the nucleotide level and 93%-100% homologous tO members of the C4 subgenogroup. At the amino acid level, these Fuyang strains were 99% -100% homologous to one another, 97%-100% homologous to members of the C4 subgenogroup, and the histidine（H） at amino acid position 22 was conserved among the Fuyang strains. The results indicate that Fuyang isolates belong to genotype C4, and an H at position 22 appears to be a marker for the Fuyang strains.

关键词： VP1 gene Genotype C Enterovirus 71(EV71)