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The Journal of Biomedical Research 2024年第1期38卷 66-75页

作者： Mingfeng He Chanjuan Gong yinan chen Rongting chen Yanning Qian Department of Anesthesiology and Perioperative Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly *** used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study *** measured when patients entered the operating room(T_(0)),when the induction was successful(T_(1)),and when before(T_(2))and 5 min after successful endotracheal intubation(T_(3)).We found that mean arterial pressure(MAP)was lower at T_(1–3),compared with T_(0) in both groups,but higher at T_(2) in the group R,whileΔMAP_(T0–T2) andΔMAP_(max) were smaller in the group R(ΔMAP_(T0–T2):the difference between MAP at time point T_(0) and T_(2),ΔMAP_(max):the difference between MAP at time point T_(0) and the lowest value from T_(0) to T_(3)).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T_(1–3) in the group *** findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels.

关键词： remimazolam propofol elderly patients hypotension left ventricular systolic function systematic vascular resistance

A case report of bilateral lateral ventricle calcified pseudoneoplasm of the neuraxins

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Chinese Neurosurgical Journal 2024年第1期10卷 67-72页

作者： Xiaolong Qiao yinan chen Ying Ji Chaoshi Niu Chuandong cheng Anhui University of Science and Technology HuainanAnhui 232001People’s Republic of China Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China1st Tianehu RoadHefeiAnhui 230031People’s Republic of China

Background Calcifying pseudoneoplasm of the neuraxis(CAPNON)is indeed a rare central nervous system lesion that can occur in central nervous system(CNS).Due to its infrequency and limited literature reports,it is challenging to diagnose and manage *** presentation In this intriguing study,we embarked on a quest to uncover the story of a 16-year-old girl who experienced bothersome *** advanced imaging techniques like computed tomography(CT)and magnetic resonance imaging(MRI),we glimpsed a delicate calcified growth within the lateral ventricles’posterior *** by our unwavering commitment to solving mysteries,we embarked on a surgical journey that not only freed the young patient from her ailment but also shed light on the true nature of her puzzling adversary—a remarkable *** For patients with CAPNON who have multiple or non-respectable lesions,the primary goal is to alleviate *** alleviating the symptoms with partial resection,close monitoring of any residual lesions is *** there is no evidence for disease progression,a strategy of continued close observation is appropriate.

关键词： CAPNON Imaging Pathology Operation

The Role of Personality in Second Language Learning: An Exploration of Influence of Students’ Personality Traits in Chinese foreign language schools

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Journal of Social Science Development Research

Journal of Social Science Development Research 2024年第2期2卷 34-40页

作者： yinan chen chengdu International Studies University ChengduSichuanChina

Individual differences(IDs)have an important influence on second language acquisition(SLA).Intelligence,learning styles,personality and motivation,*** included in the IDs and personality characteristics seem one of the significant influence factors of acquiring the second language *** article aims to explore some applications about the effects of personal characteristics in Chinese English *** extroverted students perform well in English language acquisition such as speaking tests and communication ***,there are some quiet learners or students who are unwilling to speak in the class could get good grades on pronunciation and listening as ***,these introverted students are likely to good at memorization and writing *** is different from stereotype of successful language learners who always are related to *** article aims to explore some applications about the effects of personal characteristics in Chinese English classrooms,and based on practice,research and explore how to create a class that suits most personality types and how to design the specific tasks to meet the needs of students with different characters to enhance language teaching efficiency.

关键词： Personality Chinese English as a Foreign Language(EFL)

Magnetic and electronic properties of La-doped hexagonal 4H-SrMnO3

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Chinese Physics B 2024年第1期33卷 725-729页

作者：李杰陈一楠宫诺黄欣杨志红翁亚奎 Grünberg Research Centre Nanjing University of Posts and Telecommunications School of Science Nanjing University of Posts and Telecommunications

As typical strongly correlated electronic materials, manganites show rich magnetic phase diagrams and electronic structures depending on the doped carrier density. Most previous relevant studies of doped manganites rely on the cubic/orthorhombic structures, while the hexagonal structure is much less studied. Here first-principles calculations are employed to investigate the magnetic and electronic structures of La-doped 4H-SrMnO3. By systematically analyzing the two kinds of La-doped positions, our calculations predict that the doped electron with lattice distortion would prefer to form polarons, which contribute to the local magnetic phase transition, nonzero net magnetization, and semiconducting behavior. In addition, the energy gap decreases gradually with increasing doping concentration, indicating a tendency of insulator–metal transition.

关键词： manganites polaron magnetic phase transition

肺癌恶性胸腔积液来源肿瘤细胞的小鼠PDX模型构建及实验验证

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上海交通大学学报（医学版） 2024年第4期44卷 435-443页

作者：王梦婷陈怡楠轩辕欣阳袁海花上海交通大学医学院附属第九人民医院肿瘤科上海201999

目的·构建肺癌患者恶性胸腔积液(malignant pleural effusion,MPE)肿瘤细胞来源的肿瘤异种移植(patientderived tumor xenograft,PDX)模型,并进行实验验证。方法·从基因表达综合数据集(Gene Expression Omnibus,GEO)下载人肺癌伴MPE单细胞转录组测序公共数据GSE131907和人肺癌实体瘤单细胞转录组测序公共数据GSE203360,对数据进行聚类、差异基因本体功能富集分析,明确应用MPE建模的可行性。同时收集肺癌患者的MPE样本,经离心、裂解红细胞等富集细胞操作后,将其植入非肥胖型糖尿病重症联合免疫缺陷(non-obese diabetic/severe combined immunodeficient,NOD/SCID)小鼠皮下,待移植瘤生长至1000 mm³时进行瘤体传代及保存。对稳定传代移植瘤进行组织病理学检测,通过苏木精-伊红染色(hematoxylin-eosin staining,H-E染色)观察细胞组织形态,免疫组织化学法(immunohistochemistry,IHC)检测肺癌标志物表达情况。结果·经单细胞数据分析发现MPE中肿瘤细胞的增殖功能更强,提示MPE中肿瘤细胞PDX建模或具备更佳成瘤效果;共收集35例肺癌MPE样本,成功构建13例PDX模型,成功率达37.14%;在组织病理学检测中,H-E染色可见移植瘤组织细胞异型性明显,IHC检测显示细胞角蛋白7(cytokeratin 7,CK7)、甲状腺转录因子1(thyroid transcription factor-1,TTF1)和天冬氨酸蛋白酶A(Napsin A)等肺癌标志物均呈阳性表达。结论·通过富集肺癌患者MPE中的肿瘤细胞,成功构建了更为简便高效、可实时动态建模的PDX模型。该模型保留了肺癌患者肿瘤细胞的恶性特征及蛋白表达特性,为肺癌伴MPE患者的基础研究和临床用药指导提供了重要的实验模型工具。

关键词：肺癌恶性胸腔积液原代细胞培养患者来源的肿瘤异种移植模型

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产前超声诊断胎儿肠旋转不良并中肠扭转1例

医学影像学杂志 2024年第6期34卷 170-170,172页

作者：熊微迪陈奕男上海交通大学医学院附属上海儿童医学中心海南医院医学遗传与产前诊断中心海南三亚572000 上海交通大学医学院附属上海儿童医学中心海南医院超声科海南三亚572000

孕妇,30岁。G1P0,早孕超声检查及无创筛查无异常,22+周产前超声检查显示:肠管回声增强,结肠宽7.8 mm(图1A),腹腔少量积液。超声诊断:胎儿宫内发育迟缓,肠梗阻。两周后复查:肠管回声增强,最宽13.0 mm,肠管与血流呈“漩涡征”,少量腹腔积... 详细信息

孕妇,30岁。G1P0,早孕超声检查及无创筛查无异常,22+周产前超声检查显示:肠管回声增强,结肠宽7.8 mm(图1A),腹腔少量积液。超声诊断:胎儿宫内发育迟缓,肠梗阻。两周后复查:肠管回声增强,最宽13.0 mm,肠管与血流呈“漩涡征”,少量腹腔积液,腹腔散在强回声点(图1B~1G),羊水指数65.0 mm。

关键词：产前肠旋转不良中肠扭转胎粪性腹膜炎超声检查

Porous polymeric ligand promoted copper-catalyzed C-N coupling of(hetero)aryl chlorides under visible-light irradiation

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Science China Chemistry 2021年第1期64卷 17-21页

作者： Erfei Wang Kaixuan chen yinan chen Jiawei Zhang Xinrong Lin Mao chen State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education and Yunnan ProvinceSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091China

A porous polymeric ligand(PPL)has been synthesized and complexed with copper to generate a heterogeneous catalyst(Cu@PPL)that has facilitated the efficient C-N coupling with various(hetero)aryl chlorides under mild conditions of visiblelight irradiation at 80°C(58 examples,up to 99%yields).This method could be applied to both aqueous ammonia and substituted amines,and is compatible to a variety of functional groups and heterocycles,as well as allows tandem C-N couplings with conjunctive ***,the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration,affording reaction mixtures containing less than 1 ppm of Cu residue.

关键词： polymeric catalyst heterogeneous catalysis photocatalysis C-N coupling

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我国健康村镇建设政策演变的文本分析与建议

中国农村卫生事业管理 2024年第5期44卷 333-339页

作者：陈熠楠王晓林张宁浙江大学医学院公共卫生学院浙江杭州310058 浙江省爱国卫生发展中心浙江杭州310006

目的分析我国健康村镇相关政策文本,剖析现有政策体系存在的问题、演变趋势与现状,以期为优化完善健康村镇发展政策提供参考。方法以我国2012年以来国家和省级(自治区、直辖市)层面出台的54份健康村镇相关政策为研究样本,基于ROST CM6... 详细信息

目的分析我国健康村镇相关政策文本,剖析现有政策体系存在的问题、演变趋势与现状,以期为优化完善健康村镇发展政策提供参考。方法以我国2012年以来国家和省级(自治区、直辖市)层面出台的54份健康村镇相关政策为研究样本,基于ROST CM6软件文本挖掘技术和政策工具理论,运用内容分析法对政策文本进行统计分析。结果从政策效力看,健康村镇政策文件中包含行政法规4份(7.41%),部门规章4份(7.41%),党内法规制度2份(3.7%),地方规范性文件17份(31.48%),地方工作文件27份(50%),法律、地方性法规及地方政府规章没有涉及;政策文本内容主要涵盖健康村镇的建设领域、建设内容、建设机制及建设主体,相关政策在内容主题、发布数量、政策形式上呈现循序渐进的演变趋势;政策工具使用情况中,环境型政策工具使用频率最高,占比60.70%;其次为供给型政策工具,占比31.38%;最后为需求型政策工具,占比7.92%。结论我国健康村镇建设工作体系不断完善,从单一主体向多元参与、从粗放式管理到精细化发展转变,但仍存在政策发布总量偏少、核心政策和可操作性层面政策颁布不足、政策权威性较低、政策执行力有待提高、政策工具使用不均衡等问题。建议进一步健全健康村镇政策体系、强化多方协同、优化调整政策工具结构,构建健康村镇建设新模式,助力“健康中国行动”的全面推进和深入落实.

关键词：健康村镇政策文本文本挖掘政策工具量化分析健康中国

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一种谐振微加速度计频率测量及稳定度分析

仪表技术与传感器 2024年第6期 13-18,44页

作者：宋金鑫刘恒吴嘉乐陈逸楠孙婉璐南京信息工程大学电子与信息工程学院澳门城市大学数据科学学院中国澳门

针对谐振式微加速度计的高精度频率测量和长时间频率稳定度的快速分析需求问题,文中在总结Allan方差和原始#1理论方差的基础上,介绍了一种快速#1理论方差。实验测试表明:在不同采样间隔下快速#1理论方差的精度和响应速度都优于Allan方... 详细信息

针对谐振式微加速度计的高精度频率测量和长时间频率稳定度的快速分析需求问题,文中在总结Allan方差和原始#1理论方差的基础上,介绍了一种快速#1理论方差。实验测试表明:在不同采样间隔下快速#1理论方差的精度和响应速度都优于Allan方差和原始#1理论方差,而且采样间隔越小,越能提升谐振频率的稳定度分析。针对研制的谐振式微加速度计选择采样间隔为1 s,快速#1理论方差分析方法能在1 s内完成1 h频率稳定度分析,有利于高精度微机械谐振加速度传感器研制。

关键词：谐振式微加速度计频率稳定度 Allan方差 #1理论方差

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基于InVEST模型的河南省农田氮素面源污染时空模拟

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河南农业大学学报 2024年第4期58卷 644-653页

作者：于滢陈伟强郭宇龙姬广兴陈轶楠盛思雨邓亚茹河南农业大学资源与环境学院河南郑州450046 河南省土地整治与生态重建工程技术研究中心河南郑州450046 华中师范大学公共管理学院湖北武汉430079

【目的】进行农田氮素面源污染模拟,分析其时空分布特征及影响因素,实现高效治理面源污染和农业生态保护。【方法】综合农业分区、地形、种植模式、熟制、土地覆被等因素,划分河南省土地利用类型单元,基于InVEST模型对2000、2010和2020... 详细信息

【目的】进行农田氮素面源污染模拟,分析其时空分布特征及影响因素,实现高效治理面源污染和农业生态保护。【方法】综合农业分区、地形、种植模式、熟制、土地覆被等因素,划分河南省土地利用类型单元,基于InVEST模型对2000、2010和2020年河南省农田氮素面源污染状况进行时空模拟,并对输出负荷和影响因素进行分析。【结果】河南省大部分地市的氮素输出负荷总量及氮素排放强度与总体变化趋势相同,都呈现“先增后减”的趋势。各地市间差异明显,高氮素排放强度地区为南阳、信阳和驻马店市。氮素输出强度与地均施氮肥量、数字地理高程模型(digital elevation model,DEM)、降雨量、农田比例和坡度5个因素间均存在显著相关关系。偏相关分析表明,氮素输出强度与地均施氮肥量和降雨量密切相关。氮素排放强度分级结果表明,南阳、信阳和驻马店市存在一定范围的中高强度的排放区。【结论】揭示了河南省农田面源污染高排放强度区及其重要影响因素,从而促进相关氮素面源污染防控和精确治理。

关键词：农田氮素面源污染 InVEST模型偏相关分析强度分级