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Factors influencing clinical outcomes of acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator

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Chinese Medical Journal 2013年第24期126卷 4685-4690页

作者： HUANG yin-hui zhuO Shi-tu CHEN Ya-fang LI Ming-mei LIN You-yu YANG Mei-li CHEN Zhen-jie CAI Ruo-wei Department of Neurology Hospital of Jinjiang City Jinjiang Fujian 362000 China Department of Neurology Second Affiliated Hospital of Fujian Medical University Quanzhou Fujian 362000 China Department of Neurology Mingxuan Hospital of Anxi County AnxiFujian 362000 China

Background Thrombolysis with recombinant tissue plasminogen activator （rt-PA） has gained international recognition, clinical outcomes following this thrombolytic therapy varied from patient to patient. Factors affecting clinical outcomes have not been well understood yet, so this retrospective case-control study aimed to investigate factors that may influence clinical outcomes of acute ischemic stroke treated with intravenous rt-PA. Methods One hundred and one patients with acute ischemic stroke who received intravenous rt-PA thrombolysis within 4.5 hours from disease onset were included. Patients were divided into good or poor outcome group according to modified Rankin Scale （mRS） score, good outcome group： mRS score of 0-1; poor outcome group： mRS of 2-6. Stroke characteristics were compared between the two groups. Factors for stroke outcomes were analyzed via univariate analysis and Logistic regression. Results Of the 101 patients studied, patients in good outcome group （n=55） were significantly younger than patients in poor outcome group （n=46, （62.82±14.25） vs. （68.81±9.85） years, P=0.029）. Good outcome group had fewer patients with diabetic history （9.09% vs. 28.26%, P=0.012）, fewer patients with leukoaraiosis （7.27% vs. 28.26%, P=-0.005） and presented with lower blood glucose level （（5.72±1.76） vs. （6.72±1.32） mmol/L, P=0.012）, lower systolic blood pressure level （（135.45±19.36） vs. （148.78±19.39） mmHg, P=0.003）, lower baseline NIHSS score （12.02±5.26 vs. 15.78±4.98, P=0.002） and shorter onset-to-treatment time （OTT）（（2.38±1.21） vs. （2.57±1.03） hours, P=0.044） than poor outcome group. Logistic regression analysis showed that absence of diabetic history （odds ratio （OR） 0.968 （95% CI 0.941-0.996））, absence of leukoaraiosis （OR 0.835 （95% C/0.712-0.980））, lower baseline NIHSS score （OR 0.885 （95% Cl 0.793- 0.989））, lower pre-thrombolysis systolic blood pressure （OR 0.962 （95% CI 0.929-0.997））, and lower blood glucose level （OR 0.699 （95% Cl 0.491-0.994）） befor

关键词： recombinant tissue plasminogen activator, introvenous thrombolysis acute ischemic stroke, outcome

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Mulberry Diels-Alder-type adducts:isolation,structure,bioactivity,and synthesis

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Natural Products and Bioprospecting 2022年第1期12卷 442-504页

作者： Si-Yuan Luo Jun-Yu zhu Ming-Feng Zou Sheng yin Gui-Hua Tang School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

Mulberry Diels-Alder-type adducts(MDAAs)are unique phenolic natural products biosynthetically derived from the intermolecular[4+2]-cycloaddition of dienophiles(mainly chalcones)and dehydroprenylphenol dienes,which are exclusively distributed in moraceous plants.A total of 166 MDAAs with diverse skeletons have been isolated and identified since ***,the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups(Types A−H),while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs(Type I).These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures,remarkable biological activities,and synthetic *** present review provides a comprehensive summary of the structural properties,bioactivities,and syntheses of *** references were collected between 1980 and 2021 from the SciFinder,Web of Science,and China National Knowledge Internet(CNKI).

关键词： Mulberry Diels-Alder-type adducts MDAAs Natural products Bioactivity Synthesis

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Tunable superconductivity in parent cuprate Pr_2CuO_(4±δ) thin films

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Chinese Physics B 2019年第5期28卷 276-281页

作者： Xinjian Wei Ge He Wei Hu Xu Zhang Mingyang Qin jie Yuan Beiyi zhu Yuan Lin Kui Jin Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Songshan Lake Materials Laboratory State Key Laboratory of Electronic Thin Films and Integrated Devices & Center for Information in Medicine University of Electronic Science and Technology of China Collaborative Innovation Center of Quantum Matter

We studied the role of oxygen in Pr2 CuO_(4±δ) thin films fabricated by the polymer assisted deposition method. The magnetoresistance and Hall resistivity of Pr2 CuO_(4±δ) samples were systematically investigated. It was found that with decreasing oxygen content, the low-temperature Hall coefficient(RH) and magnetoresistance changed from negative to positive, similar to those with the increase of Ce-doped concentration in R_(2-x)Ce_x CuO_4 (R = La, Nd, Pr, Sm, Eu). In addition, we observed that the dependence of the superconducting critical temperature Tc with RH for the Pr_(2-x) Ce_x CuO_4 perfectly overlapped with that of Pr_2 CuO_(4±δ) . These findings point to the fact that the doped electrons induced by the oxygen removal are responsible for the superconductivity of the T-phase parent compounds.

关键词： Pr2CuO4±δ thin film superconductivity polymer assisted deposition

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Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 262-266页

作者： Rui Wang Chang-zheng zhu Ping Qiao Jian Liu Qiang Zhao Kui-jie Wang Ting-bao Zhao Department of Spinal Cord Repairing Jinan Miliary General Hospital Department of Neurology People's Hospital of Zhangqiu Department of Orthopedics People's Hospital of Zhangqiu

Objective:To evaluate of the curative effect of human umbilical cord mesenchymal stem cells(hUC-MSCs)on rat acute radiation ***:Fourty rats were randomly divided into control group,radiation group,stem cell prevention group,stem cell treatment group and prednisone treatment *** rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage *** hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein(1×10~6 cells/kg BW)24 h before the radiation,while the same administration was performed in the rats of the treatment group 24 h after the *** 24 h post the radiation,the rats in tbe radiation group were given 0.4 mL physiological saline,and those in the prednisone group were given 1 mg/kg *** rats were,observed and executed 72 h after the radiation to defect lung histological ***:After the administration of hUC-MSCs,the survival status of the rats in the prevention group and treatment group was obviously better than that in the control *** shown by the histological staining,the morphology,proliferation activity aad bronchial state of lung tissues were better in the prevention group and treatment group than in the control ***:The hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats.

关键词： Human umbilical cord mesenchymal stem cell Radiation pneumonitis Rat

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武汉地埋管地源热泵系统能效测试分析

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煤气与热力 2024年第3期44卷 I0001-I0005页

作者：胡志高胡平放王彦芳康杰朱娜雷飞湖北风神净化空调设备工程有限公司湖北武汉430060 华中科技大学环境科学与工程学院湖北武汉430074

对武汉部分公共建筑地埋管地源热泵系统运行参数进行测试,对系统能效水平进行评价。将传统供能系统(常规水冷冷水机组+天然气锅炉)作为比较对象,计算地埋管地源热泵系统节能率。部分项目的热泵系统制冷、制热性能未能达标,但差距不大。... 详细信息

对武汉部分公共建筑地埋管地源热泵系统运行参数进行测试,对系统能效水平进行评价。将传统供能系统(常规水冷冷水机组+天然气锅炉)作为比较对象,计算地埋管地源热泵系统节能率。部分项目的热泵系统制冷、制热性能未能达标,但差距不大。热泵机组供回水温差普遍偏小。项目水泵能耗水平优于全国实测水平,但少数项目水泵能耗偏高。各项目的节能率为17.0%~50.9%,平均节能率为31.0%,节能性比较好。

关键词：地埋管地源热泵能效水平节能率后评估

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Impact of Au Nanocrystal Size and Inter-Nanocrystal Distance on the Storage Characteristics of Memory Devices

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Chinese Physics Letters 2013年第12期30卷 161-164页

作者： LAN Xue-Xin OU Xin XU Bo GONG Chang-jie LI Run yin Qiao-Nan XIA Yi-Dong yin Jiang LIU Zhi-Guo LI Ai-Dong YAN Feng National Laboratory of Solid State Microstructures and Department of PhysicsNanjing UniversityNanjing 210093 National Laboratory of Solid State Microstructures and Department of Materials Science and EngineeringNanjing UniversityNanjing 210093 School of Electronics Science and Engineering Nanjing UniversityNanjing 210093

The charge-storage characteristics of charge trapping memory devices containing different sizes of Au nanocrystals(NCs)sandwiched by Al2O3 tunneling and blocking layers are studied.A strong impact of both Au NC size and inter-NC distance on the charge trapping capability of the devices is *** total surface area of Au NCs associated with Au NC size is supposed to be a key factor in the charge-storage capability,and the device with larger size of Au NCs and a suitable inter-NC distance will possess better charge trapping *** range hopping as the lateral charge loss mechanism is considered as the main reason for the decrease of the charge trapping capability when Au NCs grow and overlap neighbors.

关键词： trapping size charge

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The expression,function,and coding potential of circular RNA circEDC3 in chicken skeletal muscle development

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Journal of Integrative Agriculture 2022年第5期21卷 1444-1456页

作者： WEI Yuan-hang ZHAO Xi-yu SHEN Xiao-xu YE Lin ZHANG Yao WANG Yan LI Di-yan zhu Qing yin Hua-dong Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China

As an emerging class of non-coding transcripts,circular RNAs(circRNAs)are proved to participate in the complex process of myogenesis in diverse species.A previous study has identified circular RNA EDC3(circEDC3)as a typical covalently closed circular RNA abundant in chicken skeletal *** study found that circEDC3 is a conservative circular RNA and performed functional analysis to investigate the role of circEDC3 in chicken muscle *** results indicated that circEDC3 could inhibit(Pying that circEDC3 might be *** study revealed that circEDC3 might be a negative regulator in chicken muscle development and suggested it has protein-coding potential in different species.

关键词： circEDC3 chicken SMSCs myogenesis coding potential

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Petroleum Science 2023年第1期20卷 362-369页

作者： Yu-Long Yang Yu Hu Ya-Ting zhu Ji-Gang Zhang Ping Song Ming Qin Hai-Rong Wu Zhao-jie Song Ji-Rui Hou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing 102249China College of Carbon Neutral Energy China University of Petroleum-BeijingBeijing 102249China Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing 102249China Research Institute of Petroleum Exploration and Development Xinjiang OilfieldKaramay 834000China

Tight conglomerate reservoirs are featured with extremely low permeability,strong heterogeneity and poor water ***_(2) huff-n-puff has been considered a promising candidate to enhance oil recovery in tight reservoirs,owing to its advantages in reducing oil viscosity,improving mobility ratio,quickly replenishing formation pressure,and potentially achieving a miscible ***,reliable inhouse laboratory evaluation of CO_(2) huff-n-puff in natural conglomerate cores is challenging due to the inherent high formation *** this study,we put forward an equivalent method based on the similarity of the miscibility index and Grashof number to acquire a lab-controllable pressure that features the flow characteristics of CO_(2) injection in a tight conglomerate *** impacts of depletion degree,pore volume injection of CO_(2) and soaking time on ultimate oil recovery in tight cores from the Mahu conglomerate reservoir were successfully tested at an equivalent *** results showed that oil recovery decreased with increased depletion degree while exhibiting a non-monotonic tendency(first increased and then decreased)with increased CO_(2) injection volume and soaking *** lower oil recoveries under excess CO_(2) injection and soaking time were attributed to limited CO_(2) dissolution and asphaltene *** work guides secure and reliable laboratory design of CO_(2) huff-n-puff in tight reservoirs with high formation pressure.

关键词： Tight conglomerate reservoir CO_(2)huff-n-puff Similarity-based equivalent pressure Enhanced oil recovery

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一种压力容器充放气接头的设计与分析

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液压气动与密封 2024年第8期44卷 67-72页

作者：朱鲲捷丁森李辉颜士肖郁佳敏吴丹上海航天精密机械研究所上海201600

开展了压力容器充放气接头的结构设计与分析,并对充气接头的密封性开展了试验验证,针对试验结果进行分析,提出后续开展充放气接头结构优化的方向。为后续同类型压力容器充放气接头的设计与分析提供了方法和思路。

关键词：充气接头放气接头设计与分析

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A Preliminary Study on Dynamics and Models of N,P,K Absorption for High-Yield Cotton

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Agricultural Sciences in China 2003年第7期2卷 752-759页

作者： WANGKe-ru LIShao-kun CAOLian-pu SONGGuang-jie CHENGang CAOSuan-zhu XinjiangBingtuanKeyLaboratoryofOasisEcologyAgriculture ResearchCenterofXinjiangCropHigh-YieldShiheziUniversityShihezi832000P.R.China KeyLaboratoryofCropGeneticandBreeding MinistryofAgriculture/InstituteofCropBreedingandCultivationChineseAcademyofAgricultureSciencesBeijing100081P.R.China AgriculturalBureau TheThirdAgriculturalDivisionXinjiangBingtuanKashi844000P.R.China TheForty-fifthRegiment TheThirdAgriculturalDivisionXinjiangBingtuanKashi844603P.R.China

The field experiments were carried out to investigate the dynamics and models of N, P and K absorption for the cotton plants with a lint of 3 000 kg ha-1 in Xinjiang. The main results were as follows: The contents of N, P2O5, K2O in cotton leaves, stems, squares and bolls decreased obviously with the time over the whole growth duration and the falling extent was greater in high-yield cotton than in CK. Contents of N in leaves, squares and bolls, in particular in the leaves of fruit-bearing shoot was higher in high-yield cotton than in CK. Contents of P2O5 in squares and bolls and that of K2O in stems were higher in high-yield cotton than in CK during the whole growing period. The accumulations of N, P2O5 and K2O in the cotton plants could be described with a logistic curve equation. There was the fastest nutrient uptake at about 90 d for N, 92 d for P2O5 and 85 d for K2O after emergence, respectively. Total nutrient accumulation of N, P2O5 and K2O was 385.8, 244. 7 and 340.3 kg ha-1, respectively. Approximately 12. 5 kg N, 8. 0 kg P2O5 and 11.1 kg K2O were needed for producing 100 kg lint with the leaves and stems under the super high yield condition of 3 000 kg ha-1 in Xinjiang.

关键词： Xinjiang Cultivation of high yield Cotton N,P,K Absorption dynamics Model

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