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Termitomenins F and G,Two New Lignan Glucosides from Terminalia chebula ***(Kurz)***

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Natural Products and Bioprospecting 2021年第5期11卷 565-572页

作者： Jun yin Hong‑Tao zhu Man Zhang Dong Wang Chong‑Ren Yang ying‑Jun Zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

The extensive chemical investigation on the branches and leaves of Terminalia chebula ***(Combretaceae)led to the isolation of two new lignan glucosides with a furofuran skeleton,termitomenins F(1)and G(2).In addition,19 known compounds including five lignan glucosides(3-7),six hydrolyzable tannins(8-13)and eight simple phenolics(14-21)were also *** structures were determined by comprehensive spectroscopic *** is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6,respectively,which were rarely found in *** known compounds,6-9,13,and 18-21,were procured from the titled plant for the first time,while 3-5,10-12 and 14-17 were also found in the ***,the known hydrolyzable tannins 8-13 exhibited strongerα-glucosidase inhibitory activities with IC_(50) values ranging from 0.10 to 3.12μM,than the positive control,quercetin(IC_(50)=9.38±0.33μM).

关键词： Terminalia chebula var.tomentella Lignan glucosides Hydrolyzable tannins α-Glucosidase inhibitory activity Calculated ECD

热-应力老化作用对电容器用BOPP薄膜绝缘性能的影响

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电力电容器与无功补偿 2024年第1期45卷 83-87,101页

作者：宋家乐张添胤朱光宇赵亮潘振尹星力陈向荣浙江大学电气工程学院杭州310027 国网辽宁省电力有限公司电力调度控制中心沈阳110002 宁波市江北九方和荣电气有限公司浙江宁波315033

为了研究热-应力老化作用对电容器用双向拉伸聚丙烯(biaxially oriented polypropylene,BOPP)薄膜绝缘性能的影响,本文对电容器用厚度为7.8μm的BOPP薄膜进行120℃下单向拉伸,在应力分别为0、10、20、40 N下进行168 h的老化处理,利用万... 详细信息

为了研究热-应力老化作用对电容器用双向拉伸聚丙烯(biaxially oriented polypropylene,BOPP)薄膜绝缘性能的影响,本文对电容器用厚度为7.8μm的BOPP薄膜进行120℃下单向拉伸,在应力分别为0、10、20、40 N下进行168 h的老化处理,利用万能材料试验机测试了其拉伸应力应变特性,在85℃条件下测试了试样的电导率、介电常数和直流击穿等电气特性,并通过热刺激去极化电流分析了热-应力老化作用对BOPP薄膜陷阱特性的影响。结果表明:热-应力的老化作用导致BOPP薄膜电导率明显上升,热的作用导致介电常数的下降,单向应力的作用导致介电常数的上升。此外,热刺激去极化电流测试结果表明,热-应力老化作用导致BOPP薄膜中能级较深陷阱密度显著上升。上述结果表明,热-应力老化作用导致电容器用BOPP薄膜电气性能下降,应增强对其重视和研究。

关键词： BOPP薄膜热老化单向应力绝缘性能陷阱特性

Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 550-554页

作者： Bo Jiang Zhang-You Wu Zi-Cheng zhu Gen-jie Ke Yue-Chun Wen Si-Qin Sun Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University

AIM：To study the expression of collagen I and transcription factor specificity protein 1（Sp1）,a transforming growth factor-β1（TGF-β1） downstream target,and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic ***：Seventy-five 1-week-old guinea pigs were randomly divided into normal control,form deprivation myopia（FDM）,and self-control *** was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment;then,changes in refractive power and axial length were *** and reverse transcription-polymerase chain reaction were used to evaluate dynamic changes in collagen I and Sp1 expression in the sclera of guinea pigs with emmetropia and experimental myopia,and the relationship between collagen I and Sp1 levels was ***：In the FDM group,the refractive power was gradually changed（from 2.09±0.30 D at week 0 to-1.23±0.69 D,-4.17±0.59 D,-7.07±0.56 D,and-4.30±0.58 D at weeks 2,4,6,and 1wk after 4wk,respectively;P〈0.05）,indicating deepening of *** axial length was increased（from 5.92±0.39 mm at week 0 to 6.62±0.36 mm,7.30±0.34 mm,7.99±0.32 mm,and 7.41±0.36 mm at weeks 2,4,6,and 1wk after 4wk;P〈0.05）.The m RNA and protein expression of Sp1 and collagen I in the sclera of the FDM group was lower than that of the control groups（P〈0.05）,and the reduction was eye-coverage ***,correlation between Sp1 and collagen I down-regulation in the myopic sclera was ***：Our data indicate that transcription factor Sp1 may be involved in the regulation of type I collagensynthesis/degradation during myopic sclera remodeling,suggesting that TGF-β1 signaling plays a role in the development and progression of myopia.

关键词： form-deprivation myopia sclera remodeling transforming growth factor-β1 specificity protein 1 collagen I

CD14反向辅助设门法在淋巴细胞亚群检测中的应用

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检验医学 2024年第3期39卷 227-236页

作者：景蓝汀朱梦婷杨振坤罗园园邹健殷莹南京医科大学附属无锡人民医院医学检验科江苏无锡214023 江苏大学医学院江苏镇江212013

目的建立CD14反向辅助设门法(简称CD14反向法),并探讨其在淋巴细胞亚群检测中的应用。方法在常规6色流式细胞术检测方案(常规法)中加入CD14-BV421抗体,建立CD14反向法。采用常规法和CD14反向法分别检测质控品、不同放置时间(4、24、48、... 详细信息

目的建立CD14反向辅助设门法(简称CD14反向法),并探讨其在淋巴细胞亚群检测中的应用。方法在常规6色流式细胞术检测方案(常规法)中加入CD14-BV421抗体,建立CD14反向法。采用常规法和CD14反向法分别检测质控品、不同放置时间(4、24、48、72 h)的样本和不同疾病(系统性红斑狼疮、病毒性肺炎和肾移植术后)患者的淋巴细胞亚群,比较2种方法检测结果的差异和偏移情况。结果CD14反向法检测细胞低值质控品的淋巴细胞百分比(LYMPH%)和自然杀伤(NK)细胞百分比(NK%)低于常规法(P0.05)。与放置4 h比较,CD14^(+)单核细胞与淋巴细胞的区分度随样本放置时间的延长而变小。与全血样本室温放置4 h比较,放置24 h后CD14反向法和常规法各项目的相对偏移均0.05);放置48 h,CD14反向法各项指标相对偏移均5%;放置72 h,2种方法所有项目的相对偏移均>10%,为临床不可接受。采用CD14反向法检测系统性红斑狼疮、病毒性肺炎、肾移植术后患者外周血淋巴细胞亚群,可较好地区分淋巴细胞和单核细胞,同时减少非典型单核细胞对NK%和NK细胞绝对数的影响。结论CD14反向法可减少流式细胞术检测中淋巴细胞门的误圈,有助于提高检测结果的准确性。

关键词： CD14 反向辅助设门淋巴细胞亚群流式细胞术

Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients

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World Journal of Gastroenterology 2008年第22期14卷 3490-3496页

作者： yin-Ping Lu Tao Guo Bao-Ju Wang Ji-Hua Dong Jian-Fang zhu Zhao Liu Meng-Ji Lu Dong-Liang Yang Department of Virology Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China Division of Clinical Immunology Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Institute of Virology Duisburg-Essen University Essen 45122 Germany

AIM: To establish a cell model harboring replicative clinical hepatitis B virus (HBV) isolates and evaluate its application in individualized selection of anti-HBV agents for chronic hepatitis B (CHB) patients. METHODS: The full-length HBV genomic DNA from 8 CHB patients was amplified by polymerase chain reaction (PCR). All the patients were treated with lamivudine for at least seven months and finally became resistant to lamivudine. The amplified HBV DNA fragments were inserted into pHY106 vectors by Sap Ⅰ?digestion. The recombinant plasmids containing 1.1 copies of HBV genome were transiently transfected into Huh7 cell line, and the levels of HBsAg, HBeAg and intercellular HBV replicative intermediates were determined by ELISA and Southern blot analysis, respectively, with or without lamivudine and adefovir treatment. The antiviral treatment with adefovir was administered to the patients and analyzed in parallel. RESULTS: A total of 25 independent HBV isolateswere obtained from the sera of 8 patients, each patient had at least two isolates. One isolate from each individual was selected and subcloned into pHY106 vector, including 5 isolates with YVDD mutation and 3 isolates with YIDD mutation. All recombinant plasmids harboring HBV isolates were transfected into Huh7 cells. The results indicated that HBV genome carried in HBV replicons of clinical HBV isolates could effectively replicate and express in Huh7 cells. Adefovir, but not lamivudine, inhibited HBV replication both in vitro and in vivo, and in vitro inhibition was dose-dependent. CONCLUSION: The novel method described herein enables individualized selection of anti-HBV agents in clinic and is useful in future studies of antiviral therapy for CHB.

关键词： Hepatitis B virus Chronic hepatitis B Hepatitis B virus isolate Antiviral agents

Clinical evaluation of endoscopic resection for treatment of large gastric stromal tumors

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World Journal of Clinical Cases 2019年第7期7卷 830-838页

作者： Yuan-Yuan Xiang Yuan-Yuan Li Ling Ye yin zhu Xiao-Jiang Zhou You-Xiang Chen Guo-Hua Li Department of Digestive Diseases The First Affiliated Hospital of Nanchang University

BACKGROUND Gastric stromal tumor is a digestive tract mesenchymal tumor with malignant potential, and endoscopic techniques have been widely used in the treatment of gastric stromal tumors, but there is still controversy over their use for large gastric stromal tumors(≥ 3 cm).AIM To evaluate the clinical long-term efficacy and safety of endoscopic resection for large(≥ 3 cm) gastric stromal *** All patients who underwent endoscopic resection or surgery at our hospital from 2012 to 2017 for pathologically confirmed gastric stromal tumor with a maximum diameter of ≥ 3 cm were collected. The clinical data, histopathologic characteristics of the tumors, and long-term outcomes were *** A total of 261 patients were included, including 37 patients in the endoscopy group and 224 patients in the surgical group. In the endoscopy group, the maximum tumor diameter was 3-8 cm; the male: Female ratio was 21/16; 34 cases had low-risk tumors, 3 had intermediate-risk, and 0 had high-risk; the mean follow-up time was 30.29 ± 19.67 mo, no patient was lost to follow-up, and no patient received chemotherapy after operation; two patients with recurrence had low-risk stromal tumors, and neither had complete resection under endoscopy. In the surgical group, the maximum tumor diameter was 3-22 cm; the male: Female ratio was 121/103; 103 cases had low-risk tumors, 75 had intermediate-risk, and 46 had high-risk; the average follow-up time was 38.83 ± 21.50 mo, 53 patients were lost to follow-up, and 8 patients had recurrence after operation(6 cases had high-risk tumors, 1 had intermediate-risk, and 1 had low-risk). The average tumor volume of the endoscopy group was 26.67 ± 26.22 cm^3(3.75-120), all of which were less than 125 cm^3. The average volume of the surgical group was 273.03 ± 609.74 cm^3(7-4114). Among all patients with a tumor volume < 125 cm^3,7 with high-risk stromal tumors in the surgical group(37.625 cm^3 to 115.2 cm^3)accounted for 3.8%(7/183); of those

关键词： Endoscopic resection Surgery Gastric stromal tumor Clinical evaluation

定量脑电图对大脑中动脉闭塞性脑梗死侧支循环及预后的评估价值

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中华全科医学 2024年第1期22卷 108-111页

作者：朱英标官常荣吕锦陈伟康李洁蓝丽康温州医科大学附属第六医院神经内科浙江丽水323000 温州医科大学附属第六医院内分泌科

目的分析脑梗死患者脑电图(EEG)指数的变化,探讨定量脑电图对大脑中动脉闭塞性脑梗死侧支循环及预后的评估价值。方法选择2020年6月—2022年12月在丽水市人民医院神经内科就诊,经影像证实为大脑中动脉闭塞性脑梗死患者78例。在发病72 ... 详细信息

目的分析脑梗死患者脑电图(EEG)指数的变化,探讨定量脑电图对大脑中动脉闭塞性脑梗死侧支循环及预后的评估价值。方法选择2020年6月—2022年12月在丽水市人民医院神经内科就诊,经影像证实为大脑中动脉闭塞性脑梗死患者78例。在发病72 h内完成EEG、多时相计算机体层血管成像(mCTA)和美国国立卫生院卒中量表(NIHSS)评分,在发病后3个月完成改良Barthel指数量表(MBI)评分。侧支循环评估采用mCTA ASITN/SIR侧支循环评估系统。通过Pearson法对EEG指数与mCTA ASITN/SIR评分、NIHSS评分及MBI评分进行相关性分析。结果 EEG指数δ/α功率比(DAR)、(θ+δ)/(α+β)功率比(DTABR)、配对衍生脑对称指数(pdBSI)与ASITN/SIR评分(r=-0.734、-0.747、-0.759,P0.87)。结论定量脑电图能有效评估大脑中动脉闭塞性脑梗死神经损伤严重程度和侧支循环,对于3个月神经功能预后也有较好的预测价值。

关键词：定量脑电图缺血性脑卒中侧支循环预后评估

Influence of comorbidity on the choice of treatment and survival of elderly patients with advanced non-small cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2008年第5期7卷 259-262页

作者： Aiwu Li Caicun Zhou Jianfang Xu Ren zhu jie Luo Shanhao Chen Department of Oncology Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China

Objective： To identify the influence of comorbidity on the choice of treatment and survival of elderly patients （≥70 years） with advanced non-small cell lung cancer （NSCLC）. Methods： The clinical characteristics and the choices of treatment of 177 elderly patients, who had a good performance status （PS≤1） were retrospectively analyzed in Oncology Department, Shanghai Pulmonary Hospital, between January 2005 to December 2005. Survival data were only analyzed in those whose had received chemotherapy. All patients were stratified by number of comorbidity as none （0）, mild （1-2） and severe （≥ 3） groups. Results： The proportion of patients, who received chemotherapy, with none, mild and severe comorbidity was significantly different （79.3%, 76.2% and 57.4%, P=0.038）, and there was also significantly different about palliative radiotherapy rate among the three groups （21.7%, 11.7% and 37.0%, P=0.014）. The median survival and 1-year survival rate in none, mild and severe comorbidity groups, were 13.6 vs. 10.2 vs. 7.6 months and 53.5% vs. 41.3% vs. 20.8% respectively （Log-rank, P=0.071）. In univariate and multivariate Cox models analysis, only severe comorbidity was a independent hazard factor of survival of elderly patients with NSCLC. Relative ratio （RR, 95% CI）：（2.09, 1.06-4.15）, P=0.034. Conclusion： Comorbidity may affect the choice of treatment of elderly patients with advanced NSCLC slightly, but only severe comorbidity is a independent prognostic factor of survival.

关键词： elderly non-small cell lung cancer comorbidity

Effects of grape seed extract on meat color and premature browning of meat patties in high-oxygen packaging

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Journal of Integrative Agriculture 2022年第8期21卷 2445-2455页

作者： YANG Xiao-yin XU Bao-chen LEI Hong-mei LUO Xin zhu Li-xian ZHANG Yi-min MAO Yan-wei LIANG Rong-rong Laboratory of Beef Processing and Quality Control College of Food Science and EngineeringShandong Agricultural UniversityTai’an 271018P.R.China National R&D Center for Beef Processing Technology Tai’an 271018P.R.China

This study investigated the effects of grape seed extract(GSE)on fresh and cooked meat color and premature browning(PMB)in ground meat patties(85% beef and 15% pork back fat)packaged under high-oxygen modified atmospheres(HiOx-MAP).The GSE was added to patties at concentrations of 0,0.10,0.25,0.50 and 0.75 g kg^(-1).This study evaluated the surface color,pH,lipid oxidation,and total viable counts(TVC)of raw patties,and the internal color and pH of patties cooked to a temperature of 66 or 71℃ over 10-day storage at 4℃.Compared with the control(0 g kg^(-1) GSE),GSE improved the color stability(P0.05)on *** containing 0.50 and 0.75 g kg^(-1) GSE cooked to 66℃ exhibited greater(P<0.05)interior redness than the control and reduced the PMB of cooked patties in the late storage *** results suggested that 0.50 and 0.75 g kg^(-1) GSE can improve fresh meat color and minimize PMB of HiOx-MAP patties.

关键词： ground meat patties grape seed extract meat color premature browning high oxygen packaging lipid oxidation