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Effects of surface cracks on the rhizospheric microhabitat of Artemisia ordosica in subsidence area caused by coal mining

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 231-236页

作者： Tao DU yin-li bi Fei GAO Wei-ling LV School of Geoscience and Surveying Engineering China University of Mining and Technology (Beijing) Beijing 100083China

The effects of surface cracks caused by underground coal mining on microhabitat in the rhizosphere of Artem＆ia ordosias were studied based on field investigation and sample analysis. The results show that the amounts of microorganisms, enzyme activity and water content in soil vary with the biomass ofA. ordosias, and that the account exhibits in an order of large A. ordosias〉medium A. ordosias〉small A. ordosias. Surface cracks apparently decrease microbial quantities and enzymatic ac- tivities, and change the composition and structure of microbial community in the rhizosphere of A. ordosias. Surface cracks reduce water content and electrical conductivity, enhance the R/S （ratio of root and soil） of water content, electrical conductivity and pH value, and raise the content of Na and Pb in rhizosphere soil ofA. ordosicas, It can be concluded that the disturbance of underground coal mining on the microhabitat in the rhizosphere ofA. ordosica is obvious in the early days.

关键词： rhizosphere microhabitat mining crack microbial quantity enzymatic activity Artemisia ordosica

Machine learning for membrane design and discovery

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Green Energy & Environment 2024年第1期9卷 54-70页

作者： Haoyu yin Muzi Xu Zhiyao Luo Xiaotian bi Jiali li Sui Zhang Xiaonan Wang Department of Chemical Engineering Tsinghua University100084BeijingChina School of Materials Science&Engineering Tsinghua University100084BeijingChina Department of Chemical and biomolecular Engineering National University of SingaporeSingapore117576Singapore

Membrane technologies are becoming increasingly versatile and helpful today for sustainable *** Learning(ML),an essential branch of artiﬁcial intelligence(AI),has substantially impacted the research and development norm of new materials for energy and *** review provides an overview and perspectives on ML methodologies and their applications in membrane design and dis-covery.A brief overview of membrane technologies isﬁrst provided with the current bottlenecks and potential *** an appli-cations-based perspective of AI-aided membrane design and discovery,we further show how ML strategies are applied to the membrane discovery cycle(including membrane material design,membrane application,membrane process design,and knowledge extraction),in various membrane systems,ranging from gas,liquid,and fuel cell separation ***,the best practices of integrating ML methods and speciﬁc application targets in membrane design and discovery are presented with an ideal paradigm *** challenges to be addressed and prospects of AI applications in membrane discovery are also highlighted in the end.

关键词： Machine learning Membranes AI for Membrane Data-driven Design

Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： Huanhuan yin Qiulin Tang Hongwei Xia Feng bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

Identifying Carbon stars from the LAMOST pilot survey with the efficient manifold ranking algorithm

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Research in Astronomy and Astrophysics 2015年第10期15卷 1671-1694页

作者： Jian-Min Si yin-bi li A-li Luo liang-Ping Tu Zhi-Xin Shi Jian-Nan Zhang Peng Wei Gang Zhao Yi-Hong Wu Fu-Chao Wu Yong-Heng Zhao Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences National Key Laboratory of Pattern Recognition Institute of AutomationChinese Academy of Sciences University of Chinese Academy of Sciences School of Science Liaoning University of Science and Technology

Carbon stars are excellent kinematic tracers of galaxies and can serve as a viable standard candle, so it is worthwhile to automatically search for them in a large amount of spectra. In this paper, we apply the efficient manifold ranking algorithm to search for carbon stars from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） pilot survey, whose performance and robustness are verified comprehensively with four test experiments. Using this algorithm, we find a total of 183 carbon stars, and 158 of them are new findings. According to different spectral features, our carbon stars are classified as 58 C-H stars, 11 C-H star candidates, 56 C-R stars, ten C-R star candidates, 30 C-N stars, three C-N star candidates, and four C-J stars. There are also ten objects which have no spectral type because of low spec- tral quality, and a composite spectrum consisting of a white dwarf and a carbon star. Applying the support vector machine algorithm, we obtain the linear optimum clas- sification plane in the J - H versus/-/- Ks color diagram which can be used to distinguish C-H from C-N stars with their J - H and H - Ks colors. In addition, we identify 18 dwarf carbon stars with their relatively high proper motions, and find three carbon stars with FUV detections likely have optical invisible companions by cross matching with data from the Galaxy Evolution Explorer. In the end, we detect four variable carbon stars with the Northern Sky Variability Survey, the Catalina Sky Survey and the liNEAR variability databases. According to their periods and ampli- tudes derived by fitting light curves with a sinusoidal function, three of them are likely semiregular variable stars and one is likely a Mira variable star.

关键词： methods: data analysis -- methods: statistical -- stars: carbon -- binaries-- stars: variables

19 low mass hypervelocity star candidates from the first data release of the LAMOST survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1364-1377页

作者： yin-bi li A-li Luo Gang Zhao You-Jun Lu Peng Wei bing Du Xiang li Yong-Heng Zhao Zhan-Wen Han Bo Wang Yue Wu Yong Zhang Yong-Hui Hou Yue-Fei Wang Ming Yang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China State Key Laboratory of High-end Server & Storage Technology Jinan 250510 China Key Laboratory for the Structure and Evolution of Celestial Objects Yunnan Observatories Chinese Academy of Sciences Kunming 650216 China Nanjing Institute of Astronomical Optics & Technology National Astronomical Observatories Chinese Academy of Sciences Nanjing 210042 China

Hypervelocity stars are believed to be ejected out from the Galactic center through dynamical interactions between（binary） stars and the central supermassive black hole（s）. In this paper, we report 19 low mass F/G/K type hypervelocity star candidates from over one million stars found in the first data release of the LAMOST regular survey. We determine the unbound probability for each candidate using a MonteCarlo simulation by assuming a non-Gaussian proper-motion error distribution, and Gaussian heliocentric distance and radial velocity error distributions. The simulation results show that all the candidates have unbound possibilities over 50% as expected,and one of them may even exceed escape velocity with over 90% probability. In addition, we compare the metallicities of our candidates with the metallicity distribution functions of the Galactic bulge, disk, halo and globular clusters, and conclude that the Galactic bulge or disk is likely the birth place for our candidates.

关键词： stars: low-mass—stars: kinematics and dynamics—Galaxy: abundances—stars: fundamental parameters—stars: distances

LASPM:the LAMOST stellar parameter pipeline for M-type stars and application to the sixth and seventh data release(DR6 and DR7)

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Research in Astronomy and Astrophysics 2021年第8期21卷 181-192页

作者： bing Du A-li Luo Shuo Zhang Xiao Kong Yan-Xin Guo yin-bi li Fang Zuo You-Fen Wang Jian-Jun Chen Yong-Heng Zhao CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

The molecular-rich atmospheres of M type stars complicate our understanding to their atmospheric ***,great progress has been made in atmospheric modeling of M-type stars,and we take advantage of the updated BT-Settl model grid to develop a pipeline LAS PM to measure atmospheric parameters(Teff,log g,[M/H]) of M-type stars from low-resolution *** pipeline was applied to the sixth and seventh data release(DR6 & DR7) of Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),which released atmospheric parameters for 610419 and 680 185 Mtype spectra,*** key algorithm is to find the best-matching for templates in the synthetic spectral library for an observed spectrum,and then minimizing χ^(2) through a linear combination of five best-matching *** intrinsic precisions of the parameters were estimated by using the multiple epoch observations for the same stars,which are 118 K,0.20 dex,0.29 dex for Teff,log g,and [M/H]*** Teff and log g are consistent with the spectral and luminosity classifications by LAMOST 1D pipeline,and the loci of giants and dwarfs both on spectral index and color-magnitude diagrams show the *** metallicities of LASPM are also checked with the selected members of four open clusters(NGC 2632,Melotte 22,ASCC16,and ASCC19),which are consistent without any *** the results between LASPM and the APOGEE Stellar Parameter and Chemical Abundance Pipeline(ASPCAP),there is a scatter of 73 K,0.22 dex,0.21 dex for Teff,log g,and [M/H],respectively.

关键词： atmospheric parameters data analysis spectrographs

lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

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Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： Yong-Yi Zeng Xin-Yi Xu Jin-Xuan Xie Wen-li Chen Lan liu Xin-Jian yin bi-Shuang Chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression lipase Photodecarboxylase

Observation of therapeutic effect of lamp irradiation combined with purple gromwell oil gauze on alleviating intestinal colic in patients

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1749-1755页

作者： bi-Zhi Cen yin-Song Chen li-Ping li Jing-Wen Wu Yan-Fen Xie Department of Tumor Center Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina

BACKGROUND Intestinal colic is a common complication in patients who have undergone radical surgery for colorectal *** Chinese medicine has advantages,including safety and stability,for the treatment of intestinal *** irra-diation for abdominal ironing has been applied in the treatment of many gas-trointestinal *** gromwell oil has the effects of clearing heat,cooling blood,reducing swelling,and relieving *** The general effective rate in the observation group was 95.00%,which was significantly higher than that in the control group(86.67%,P0.05).After 1,2,3,and 4 d of treatment,the duration of symptoms in both groups were decreased,and the duration in the observation group was significantly lower than that in the control group(96.54±9.57 vs 110.45±11.23,87.26±12.07 vs 104.44±11.68,80.45±16.21 vs 99.44±14.95,73.18±15.58 vs 92.17±14.20;P0.05).CONCLUSION The use of lamp irradiation combined with purple gromwell oil gauze in patients with intestinal colic after radical surgery for colorectal cancer can reduce symptom duration,alleviate intestinal colic,and improve treatment efficacy,and this approach is *** is worth promoting the use of this treatment in clinical practice.

关键词： Lamp irradiation Purple gromwell oil gauze Intestinal colic Radical surgery for colorectal cancer Therapeutic effect

Dynamic modeling and RBF neural network compensation control for space flexible manipulator with an underactuated hand

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Chinese Journal of Aeronautics 2024年第3期37卷 417-439页

作者： Dongyang SHANG Xiaopeng li Meng yin Fanjie li School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

In space operation,flexible manipulators and gripper mechanisms have been widely used because of light weight and ***,the vibration caused by slender structures in manipulators and the parameter perturbation caused by the uncertainty derived from grasping mass variation cannot be *** existence of vibration and parameter perturbation makes the rotation control of flexible manipulators difficult,which seriously affects the operation accuracy of ***’s more,the complex dynamic coupling brings great challenges to the dynamics modeling and vibration *** solve this problem,this paper takes the space flexible manipulator with an underactuated hand(SFMUH)as the research *** dynamics model considering flexibility,multiple nonlinear elements and disturbance torque is established by the assumed modal method(AMM)and Hamilton’s principle.A dynamic modeling simplification method is proposed by analyzing the nonlinear ***’s more,a sliding mode control(SMC)method combined with the radial basis function(RBF)neural network compensation is ***,the control law is designed using a saturation function in the control method to weaken the chatter *** the help of neural networks to identify the uncertainty composition in the SFMUH,the tracking accuracy is *** results of ground control experiments verify the advantages of the control method for vibration suppression of the SFMUH.

关键词： Space flexible manipulator RBF neural network Underactuated hand Dynamic models Model simplification