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丁苯酞注射液联合胞磷胆碱片治疗急性脑梗死的效果

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中国临床实用医学 2024年第1期15卷 46-50页

作者：刘芳尹园园姚远刘博王夏红郑州市第二人民医院神经内科郑州450000

目的探讨丁苯酞注射液联合胞磷胆碱片对急性脑梗死(ACI)患者美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)评分及血清相关细胞因子水平的影响。方法本研究为病例对照研究,选取2022年1月至2023年6月郑州市第二人民医院神经内... 详细信息

目的探讨丁苯酞注射液联合胞磷胆碱片对急性脑梗死(ACI)患者美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)评分及血清相关细胞因子水平的影响。方法本研究为病例对照研究,选取2022年1月至2023年6月郑州市第二人民医院神经内科收治的80例ACI患者,男47例,女33例,年龄(60.90±4.70)岁,年龄范围为51~71岁,根据治疗方案不同将患者分为丁苯酞注射液组与联合组,每组40例。丁苯酞注射液组采用丁苯酞注射液治疗,联合组采用丁苯酞注射液联合胞磷胆碱片治疗。比较两组患者临床治疗效果、治疗前后的NIHSS、mRS评分、血脂水平[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇、甘油三酯]及血清相关细胞因子[C反应蛋白(CRP)、同型半胱氨酸(Hcy)、D-二聚体]水平。结果联合组患者临床治疗效果有效率[92.5%(37/40)]高于丁苯酞注射液组[75.0%(30/40)],差异有统计学意义(P<0.05)。治疗后,联合组患者NIHSS评分[(3.42±0.59)分]、mRS评分[(1.22±0.24)分]均低于丁苯酞注射液组[(5.88±1.24)分、(2.03±0.31)分];联合组患者HDL-C[(1.58±0.13)mmol/L]高于丁苯酞注射液组[(1.41±0.16)mmol/L],LDL-C[(2.09±0.33)mmol/L]、总胆固醇[(3.25±0.46)mmol/L]、甘油三酯[(1.01±0.27)mmol/L]均低于丁苯酞注射液组[(3.15±0.37)mmol/L、(4.82±0.51)mmol/L、(1.58±0.31)mmol/L];联合组患者CRP[(4.92±1.08)mg/L]、Hcy[(13.23±4.08)μmol/L]、D-二聚体[(131.95±12.18)μg/L]均低于丁苯酞注射液组[(7.11±1.63)mg/L、(19.79±5.24)μmol/L、(159.84±16.72)μg/L],差异均有统计学意义(P<0.05)。结论丁苯酞注射液联合胞磷胆碱片可显著提高临床治疗效果,降低ACI患者NIHSS、mRS评分,改善体内血脂水平及炎症反应。

关键词：丁苯酞注射液胞磷胆碱片急性脑梗死美国国立卫生研究院卒中量表改良Rankin量表血脂水平炎症反应

A game-theoretic approach for federated learning:A trade-off among privacy,accuracy and energy

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Digital Communications and Networks 2024年第2期10卷 389-403页

作者： Lihua yin Sixin Lin Zhe Sun Ran Li yuanyuan He Zhiqiang Hao Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China China Industrial Control Systems Cyber Emergency Response Team Beijing100040China

Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become *** devices not only provide adequate training data,but also cause privacy leakage and energy *** to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent *** this paper,we define the FL as a 3-layer architecture including users,agents and *** order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game *** use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated *** experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in *** the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.

关键词： Federated learning Privacy preservation Energy optimization Game theory Distributed communication systems

Heptamethine cyanines in bioorthogonal chemistry

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Chinese Chemical Letters 2024年第2期35卷 131-137页

作者： yuanyuan Liao Yuting Liang Yurou Huang Xiaoyan Zeng Tian He Jun yin National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological *** cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background *** reactions performed in living cells and tissues have developed by leaps and bounds in recent *** NIR fluorescent labeling technique involving cyanine has attracted widespread *** review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,*** expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.

关键词： Fluorescent probes Heptamethine cyanines Bioorthogonal reaction Imaging Cell

清热养阴除湿汤对类风湿关节炎模型大鼠肠道菌群的影响

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中国中医药信息杂志 2024年第5期31卷 68-75页

作者：张净张阳利尹圆圆张林聪郭家彬刘密凤首都医科大学附属北京中医医院北京100010 解放军疾病预防控制中心北京100071

目的观察清热养阴除湿汤对类风湿关节炎(RA)模型大鼠炎症因子及肠道菌群的影响。方法采用胶原诱导建立RA大鼠模型,将成模大鼠随机分为模型组、阳性药组和中药组,另设正常组,每组6只。给药组分别予相应药物灌胃5周。HE染色观察大鼠踝关... 详细信息

目的观察清热养阴除湿汤对类风湿关节炎(RA)模型大鼠炎症因子及肠道菌群的影响。方法采用胶原诱导建立RA大鼠模型,将成模大鼠随机分为模型组、阳性药组和中药组,另设正常组,每组6只。给药组分别予相应药物灌胃5周。HE染色观察大鼠踝关节组织病理形态,ELISA测定大鼠血清炎症因子转化生长因子(TGF)-β、γ干扰素(IFN-γ)、白细胞介素(IL)-4、IL-17A含量,采用16SrRNA技术及Illumina高通量基因测序平台对大鼠肠道菌群进行测序分析。结果与正常组比较,模型组大鼠踝关节软骨局部消失,骨小梁变少、变细,滑膜明显增厚,伴有大量炎性细胞浸润,血清促炎因子IFN-γ、IL-17A含量升高(P<0.01),抑炎因子TGF-β、IL-4含量降低(P<0.01);与模型组比较,中药组大鼠踝关节炎性细胞浸润及软骨表面侵蚀减轻,血清IFN-γ和IL-17A含量降低(P<0.01),IL-4和TGF-β含量升高(P<0.01)。肠道菌群测序分析结果显示,清热养阴除湿汤可调节模型大鼠肠道菌群组成结构及丰度,包括降低杆菌属Odoribacter、克里斯滕森菌属Christensenella、Povalibacter属丰度(P<0.05),升高节杆菌属Arthrobacter、棒杆菌属Corynebacterium、劳尔氏菌属Ralstonia、肠杆菌属Enterorhabdus和细小杆菌属Parvibacter丰度(P<0.05)。结论清热养阴除湿汤可能通过调节炎症因子及与其相关的肠道菌群调节免疫系统,发挥抗炎及骨保护作用。

关键词：清热养阴除湿汤类风湿关节炎肠道菌群炎症因子

参苓白术散对克罗恩病大鼠肠道炎症及PI3K/Akt信号通路的影响

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中医药导报 2024年第4期30卷 30-34页

作者：程扬宾东华尹园缘邹巍莹刘颖黄静雯余炼湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

目的:探究参苓白术散缓解克罗恩病(CD)大鼠结肠炎症反应的作用机制及其对磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路的影响。方法:将54只SD大鼠随机分为空白组、模型组、美沙拉嗪组(0.21 g/kg)、参苓白术散低剂量组(5.88 g/kg)、参... 详细信息

目的:探究参苓白术散缓解克罗恩病(CD)大鼠结肠炎症反应的作用机制及其对磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路的影响。方法:将54只SD大鼠随机分为空白组、模型组、美沙拉嗪组(0.21 g/kg)、参苓白术散低剂量组(5.88 g/kg)、参苓白术散中剂量组(11.76 g/kg)、参苓白术散高剂量组(23.59 g/kg),每组9只。采用5%2,4,6-三硝基苯磺酸(TNBS)灌肠进行CD造模,造模成功后药物干预组给予相应的药物灌胃,空白组、模型组给予等剂量生理盐水灌胃。14 d后观察各组大鼠结肠表面的病理变化并进行结肠黏膜损伤指数(CMDI)评分;苏木精-伊红(HE)染色观察大鼠结肠组织病理学改变;蛋白质印迹法(Western blotting)检测肠黏膜组织中磷脂酰肌醇3-激酶(PI3K)、磷酸化PI3K(p-PI3K)、蛋白激酶B(Akt)、磷酸化Akt(p-Akt)蛋白表达水平。结果:模型组大鼠CMDI评分高于空白组(P<0.01);美沙拉嗪组及参苓白术散中、高剂量组大鼠CMDI评分均低于模型组(P<0.01)。空白组大鼠黏膜组织损伤情况不明显,结构组织完整,未见明显充血水肿现象;与空白组比较,模型组大鼠黏膜上皮细胞大量坏死脱落,杯状细胞明显减少,单管状的腺体被破坏且排序紊乱,各层出现大量炎症细胞与淋巴细胞浸润现象,同时出现淋巴组织增生及淋巴滤泡;美沙拉嗪组与参苓白术散低、中、高剂量组黏膜损伤恢复在不同程度上优于模型组,结肠组织黏膜上皮细胞脱落坏死现象不显著,炎症细胞浸润状况较少,腺体破坏情况较轻微,正常结构尚未完全丧失;参苓白术散低剂量组可见少量血管扩张出血,有少许炎症反应。模型组大鼠结肠组织中p-PI3K/PI3K、p-Akt/Akt高于空白组(P<0.01);美沙拉嗪组及参苓白术散低、中、高剂量组大鼠结肠组织中p-PI3K/PI3K、p-Akt/Akt均低于模型组(P<0.05或P<0.01)。结论:参苓白术散能缓解CD大鼠肠道炎症,其作用机制可能与抑制PI3K/Akt信号通路有关。

关键词：克罗恩病参苓白术散 PI3K/Akt信号通路炎症反应大鼠

Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

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Neural Regeneration Research 2024年第11期19卷 2488-2498页

作者： yuanyuan Ding Yu Sun Hongyan Wang Hongqin Zhao Ruihua yin Meng Zhang Xudong Pan Xiaoyan Zhu Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Qingdao Cadre Health Care Service Center The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE^(-/-)***,little is known about the role of lnc_000048 in classically activated macrophage(M1)*** this study,we established THP-1-derived testing state macrophages(M0),M1 macrophages,and alternately activated macrophages(M2).Real-time fluorescence quantitative PCR was used to verify the expression of marker genes and the expression of lnc_000048 in *** cytometry was used to detect phenotypic proteins(CD11b,CD38,CD80).We generated cell lines with lentivirus-mediated upregulation or downregulation of lnc_*** cytometry,western blot,and real-time fluorescence quantitative PCR results showed that down-regulation of lnc_000048 reduced M1 macrophage polarization and the inflammation response,while over-expression of lnc_000048 led to the opposite *** blot results indicated that lnc_000048 enhanced the activation of the STAT1 pathway and mediated the M1 macrophage ***,catRAPID prediction,RNA-pull down,and mass spectrometry were used to identify and screen the protein kinase RNA-activated(PKR),then catRAPID and RPIseq were used to predict the binding ability of lnc_000048 to ***(IF)-RNA fluorescence in situ hybridization(FISH)double labeling was performed to verify the subcellular colocalization of lnc_000048 and PKR in the cytoplasm of M1 *** speculate that lnc_000048 may form stem-loop structure-specific binding and activate PKR by inducing its phosphorylation,leading to activation of STAT1 phosphorylation and thereby enhancing STAT1 pathway-mediated polarization of THP-1 macrophages to M1 and inflammatory factor *** together,these results reveal that the lnc_000048/PKR/STAT1 axis plays a crucial role in the polarization of M1 macrophages and may be a novel therapeutic target for atherosclerosis alleviation in stroke.

关键词： atherosclerosis inflammation lnc_000048 lncRNA macrophage polarization protein kinase RNA-activated(PKR) STAT1

Heat Storage Performance of PCM in a Novel Vertical Pointer-Shaped Finned Latent Heat Tank

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Journal of Thermal Science 2024年第2期33卷 422-434页

作者： MAO Qianjun ZHU yuanyuan LI Tao School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China

The heat storage performance of latent heat storage systems is not good due to the poor thermal conductivity of phase change *** this paper,a new type of pointer-shaped fins combining rectangular and triangular fins has been employed to numerically simulate the melting process in the heat storage tank,and the fin geometry parameter effects on heat storage performance have been *** results indicate that compared with the bare tube and the rectangular finned tank,the melting time of the phase change material in the pointer-shaped finned tank is reduced by 64.2%and 15.1%,*** closer the tip of the triangular fin is to the hot wall,the better the heat transfer *** optimal height of the triangular fin is about 8 *** the number of fins from 4 to 6 and from 6 to 8 reduces the melting time by 16.0%and 16.7%***,increasing the number of fins from 8 to 10 only reduces the melting time by 8.4%.When the fin dimensionless length is increased from 0.3 to 0.5 and from 0.5 to 0.7,the melting time is shortened by 17.5%and 13.0%.But the melting time is only reduced by 2.9%when the dimensionless fin length is increased from 0.7 to *** optimising the design of the thermal storage system,the results can provide a reference value.

关键词： thermal energy storage phase change material pointer-shaped fins heat storage performance

Developing a novel quantitative parameter for characterizing spatial distribution of fish following exposure to chemicals and wastewater:Behavioral Gini coefficient

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Journal of Environmental Sciences 2024年第7期141卷 129-138页

作者： Xuanyue Chen yuanyuan Li Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

While the spatial distribution pattern of fish is increasingly used for toxicological test o chemicals or wastewater,no ideal parameter is available for quantitative assessment of spa tial distribution,especially uneven distribution with multiple ***,to develop a quantitative assessment parameter for spatial distribution,the zebrafish were exposed to ethanol,pentylenetetrazole(PTZ),paraquat dichloride(paraquat)and wastewater,followed by a behavioral test in a narrow *** data was acquired and analyzed by id Tracker and *** comparing the effects of all treatments on behavior parameters we confirmed that the spatial distribution was more easily altered rather than general loco motor parameters,e.g.0.7-70 mg/L PTZ and 5-20 mg/L paraquat being effective for altering spatial distribution but having little effects on general locomotor *** on the heatmap,i.e.,the cumulative proportion of grids and that of frequency in grids,we calcu lated the behavioral Gini coefficient(G_(b))for quantitative assessment of fish spatial distri *** Gini coefficient ranged from zero to 1,with larger values meaning poorer even ness of spatial *** note,G_(b)showed smaller coefficient of variations(CV)with3%-19%between replicate tanks in all treatments than the highest frequency(4%-79%),dis playing well ***,G_(b)addressed the challenge of the complicated heatmap with multiple ***,the behavioral Gini coefficient we established is an idea parameter to quantitatively assess spatial distribution of fish shoal,which is expected to be applied in toxicity testing for chemicals and wastewater and automatic quality monitoring for surface water and aquaculture water.

关键词： Zebrafish Behavioral test Spatial distribution Behavioral Gini coefficient

Design Optimization and Operating Performance of S-CO_(2) Brayton Cycle under Fluctuating Ambient Temperature and Diverse Power Demand Scenarios

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Journal of Thermal Science 2024年第1期33卷 190-206页

作者： YANG Jingze YANG Zhen DUAN yuanyuan Key Laboratory for Thermal Science and Power Engineering of MOE Beijing Key Laboratory for CO_(2) Utilization and Reduction TechnologyTsinghua UniversityBeijing 100084China

The supercritical CO_(2)(S-CO_(2)) Brayton cycle is expected to replace steam cycle in the application of solar power tower system due to the attractive potential to improve efficiency and reduce *** the concentrated solar power plant with thermal energy storage is usually located in drought area and used to provide a dispatchable power output,the S-CO_(2) Brayton cycle has to operate under fluctuating ambient temperature and diverse power demand *** addition,the cycle design condition will directly affect the off-design *** this work,the combined effects of design condition,and distributions of ambient temperature and power demand on the cycle operating performance are analyzed,and the off-design performance maps are proposed for the first time.A cycle design method with feedback mechanism of operating performance under varied ambient temperature and power demand is introduced *** show that the low design value of compressor inlet temperature is not conductive to efficient operation under low loads and sufficient output under high ambient *** average yearly efficiency is most affected by the average power demand,while the load cover factor is significantly influenced by the average ambient *** multi-objective optimization,the optimal solution of designed compressor inlet temperature is close to the minimum value of35℃ in Delingha with low ambient temperature,while reaches 44.15℃ in Daggett under the scenario of high ambient temperature,low average power demand,long duration and large value of peak load during the peak temperature *** the cycle designed with compressor inlet temperature of 35℃ instead of 44.15℃ in Daggett under light industry power demand,the reduction of load cover factor will reach 0.027,but the average yearly efficiency can barely be improved.

关键词： supercritical CO_(2)Brayton cycle ambient temperature fluctuating power demand scenarios design optimization off-design performance