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同时固定Cd和As煤气化渣基复合材料的制备及性能研究

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Journal of Central South University 2024年第4期31卷 1331-1343页

作者：周长志王谦朱芳孙在金尹宏亮侯红王俊欢 College of Water Sciences Beijing Normal UniversityBeijing 100875China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Technical Centre for Soil Agricultural and Rural Ecology and EnvironmentMinistry of Ecology and EnvironmentBeijing 100012China

本研究开发了一种铁改性煤气化渣材料(FGS),可以修复镉(Cd)和砷(As)复合污染的土壤。通过水相吸附实验和土壤修复模拟实验评估了FGS的钝化性能。FGS对水中Cd和As的最大吸附量分别为5.82和9.69 mg/g,而煤气化渣材料(CGS)的最大吸附量只有... 详细信息

本研究开发了一种铁改性煤气化渣材料(FGS),可以修复镉(Cd)和砷(As)复合污染的土壤。通过水相吸附实验和土壤修复模拟实验评估了FGS的钝化性能。FGS对水中Cd和As的最大吸附量分别为5.82和9.69 mg/g,而煤气化渣材料(CGS)的最大吸附量只有0.99和0.92 mg/g。X射线衍射图显示,铁氧化物被成功地负载到FGS上,Cd和As能够与Fe_(2)O_(3)和FeOOH发生络合从而显著提高FGS的吸附能力。在土壤中施用FGS后,DTPA提取Cd浓度从0.70 mg/kg降低到0.58 mg/kg,这与土壤pH从6.46升高到7.03以及Cd与含氧官能团或FeOOH的络合作用有关。由于FeOOH的络合作用,土壤中溶解As的浓度从15.33 mg/kg下降到13.72 mg/kg。本研究通过展示FGS作为土壤修复剂的应用潜力,揭示Cd和As的固定机理,为利用气化渣制备土壤Cd、As修复材料提供了理论依据。

关键词：镉砷铁改性煤气化渣

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陕西省动物疫病防控和信息化建设

动物医学进展 2024年第5期45卷 114-117页

作者：逄国梁郭倩陕西省畜牧技术推广总站陕西西安710016 陕西省动物卫生与屠宰管理站陕西西安710016

针对目前动物疫病防控现状和非洲猪瘟等重大疫病、布鲁氏菌病等人畜共患病防控中暴露出的主要问题,结合陕西省动物防疫和检疫工作的实际,提出了动物疫病防控信息化建设的对策,以《动物防疫法》中的动物疫病防控制度要求为主线,依托“陕... 详细信息

针对目前动物疫病防控现状和非洲猪瘟等重大疫病、布鲁氏菌病等人畜共患病防控中暴露出的主要问题,结合陕西省动物防疫和检疫工作的实际,提出了动物疫病防控信息化建设的对策,以《动物防疫法》中的动物疫病防控制度要求为主线,依托“陕西动物卫生监督管理平台”“陕西智慧动监微信公众号”和“陕西动物检疫证明出证系统”,以“检疫出证”为抓手,建设管理相对人和畜禽运输车辆备案、动物追溯、动物检疫流程、指定通道和落地监管等5个管理系统,建立动物防疫与检疫相关联的工作机制,在一定程度上解决目前动物疫病防控中管理相对人责任落实不到位、动物疫病工作人员力量不足的问题,以期实现对动物养殖、运输和屠宰全链条信息化监管,并逐步转向数据化、智慧化监管,为动物疫病防控提供参考。

关键词：动物疫病防控信息化监管

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

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World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： Yang-Zhou Jiang Lan-Yue Hu Mao-Shan Chen Xiao-Jie Wang Cheng-Ning Tan Pei-Pei Xue Teng Yu Xiao-Yan He Li-Xin Xiang Yan-Ni Xiao Xiao-liang Li qian Ran Zhong-Jun Li Li Chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ***,the positive regulators of ANKRD26 are still *** To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 *** Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family *** to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activi

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

Chen Nianzu,pioneer of medical popularization

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 1-2页

作者： Yongxuan liang yinghua Huang Beijing University of Chinese Medicine Beijing 100029China

Chen Nianzu,also known as Chen Xiuyuan and Chen Shengxiu(1573—1823)was from the Mei Village,Changle Xi,Fujian *** was a distinguished traditional Chinese medicine(TCM)theorist,clinician and educator of the Qing Dynasty and the author of the Three-Character Primer of Medicine(Yi Xue San Zi Jing),Versified Currrent Formulas(Shi Fang Ge Kuo),Briefly Annotated Treatise on Cold-induced Diseases(Shang Han Lun qian Zhu),and Briefly Annotated Essentials fromthe Golden Cabinet(Jin Kui Yao Lue qian Zhu),etc.

关键词： Province. Golden pioneer

体素内不相干运动MRI预测脑胶质瘤异柠檬酸脱氢酶及1p/19q分子分型

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中国医学影像技术 2024年第6期40卷 805-809页

作者：李俊杰梁倩景辉山西医科大学医学影像学院山西太原030001 太原钢铁(集团)有限公司总医院磁共振室山西太原030008

目的观察体素内不相干运动(IVIM)MRI预测脑胶质瘤异柠檬酸脱氢酶(IDH)及其1p/19q分子分型的价值。方法回顾性纳入32例脑胶质瘤患者,根据IDH检测结果分为IDH突变组(n=18)及野生组(n=14),并根据染色体1p/19q检测结果将突变组分为1p/19q共... 详细信息

目的观察体素内不相干运动(IVIM)MRI预测脑胶质瘤异柠檬酸脱氢酶(IDH)及其1p/19q分子分型的价值。方法回顾性纳入32例脑胶质瘤患者,根据IDH检测结果分为IDH突变组(n=18)及野生组(n=14),并根据染色体1p/19q检测结果将突变组分为1p/19q共缺失亚组(n=5)与非共缺失亚组(n=13)。比较组间、亚组间一般资料和IVIM参数,包括表观弥散系数(ADC)、慢弥散系数(D)、快弥散系数(D^(*))、灌注分数(f)、相对ADC(rADC)、相对D(rD)、相对D^(*)(rD^(*))及相对f(rf)值,分析其预测脑胶质瘤分子分型的效能。结果突变组患者年龄小于野生组(t=-4.274,P=0.001)。突变组ADC、rADC及D值高于野生组,D^(*)及rf值低于野生组(P均<0.05)。以ADC、rADC、D、D^(*)及rf值预测脑胶质瘤IDH分型的曲线下面积(AUC)分别为0.80、0.76、0.74、0.78及0.72。共缺失亚组D^(*)值大于非共缺失亚组(P<0.05);以D^(*)值预测IDH突变型脑胶质瘤1p/19q分型的AUC为0.88。结论脑胶质瘤ADC、rADC、D、D^(*)及rf值均有助于预测IDH突变,D^(*)值还有助于预测染色体1p/19q共缺失。

关键词：胶质瘤异柠檬酸脱氢酶染色体体素内不相干运动

员工对企业数字化转型的反应研究:基于压力的理论视角

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心理科学进展 2024年第4期32卷 594-615页

作者：周琦玮李倩梁爽中国海洋大学管理学院中国海洋大学创新创业研究中心山东青岛266100 北京外国语大学国际商学院北京100089

在数字经济蓬勃发展的时代背景下,数字化转型已成为推动企业高质量发展的关键环节。然而,很多企业在数字化转型过程中都遇到缺乏员工支持、消极合作等来自企业内部的挑战。目前,有关企业数字化转型的研究主要集中在宏观战略层面,探讨数... 详细信息

在数字经济蓬勃发展的时代背景下,数字化转型已成为推动企业高质量发展的关键环节。然而,很多企业在数字化转型过程中都遇到缺乏员工支持、消极合作等来自企业内部的挑战。目前,有关企业数字化转型的研究主要集中在宏观战略层面,探讨数字化转型对企业内部员工影响的研究尚不充足。因此,本文从企业内部微观层面着手,采用工作压力动态过程模型,将数字化转型视作一种压力源。通过聚焦数字化转型给员工带来的工作压力,试图揭示员工对数字化转型产生的差异化反应及其内在机理。第一,探究压力源,基于扎根理论归纳员工对数字化转型中压力源的感知和识别。第二,追踪压力结果,基于变革分析框架,探索数字化转型对员工工作绩效的影响及其随时间的动态变化。第三,分析压力体验,分别从认知和情绪视角,探讨员工支持或抗拒数字化转型的作用机制、边界条件及后续结果。本文不仅丰富了企业数字化转型在人力资源管理领域的研究范畴和内容,还为企业科学推动数字化转型、提升员工对数字化转型的支持水平提供了实践启示。

关键词：数字化转型压力动态过程压力认知评估压力源-情绪模型

石墨烯基介孔锰铈氧化物催化剂:制备和低温催化还原NO

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无机材料学报 2024年第1期39卷 81-89,I0005页

作者：王艳莉钱心怡沈春银詹亮华东理工大学化工学院化学工程联合国家重点实验室上海200237

锰铈氧化物由于较强的氧化还原活性、优良的低温脱硝性能,已被广泛用于选择性催化还原(SCR)脱硝反应,但是锰铈氧化物存在活性组分易团聚、比表面积较低等问题,限制其催化剂活性的提高。本研究以介孔结构的石墨烯基SiO_(2)(G@SiO_(2))纳... 详细信息

锰铈氧化物由于较强的氧化还原活性、优良的低温脱硝性能,已被广泛用于选择性催化还原(SCR)脱硝反应,但是锰铈氧化物存在活性组分易团聚、比表面积较低等问题,限制其催化剂活性的提高。本研究以介孔结构的石墨烯基SiO_(2)(G@SiO_(2))纳米材料为模板,采用水热法制备了系列石墨烯基介孔锰铈氧化物(G@MnO_(x)-CeO_(2))催化剂,并考察了该催化剂在低温下(100~300℃)的SCR脱硝性能。结果表明,与石墨烯基铈氧化物(G@CeO_(2))相比,G@MnO_(x)-CeO_(2)催化剂具有较高脱硝活性。当Mn、Ce与模板G@SiO_(2)质量比分别为0.35、0.90时,G@Mn(0.35)Ce(0.9)催化剂的脱硝活性最佳,220℃下NO转化率达到最高(80%)。添加适量MnO_(x),提高了G@MnO_(x)-CeO_(2)催化剂的比表面积、孔容,降低了催化剂的结晶度;并且MnO_(x)-CeO_(2)以纳米尺度(2~3 nm)较为均匀地分散于石墨烯片层表面。此外,由于MnO_(x)与CeO_(2)之间存在协同作用,Mn原子可以部分替代Ce原子掺杂于CeO_(2)的晶体结构中形成MnO_(x)-CeO_(2)固溶体,使G@Mn(0.35)Ce(0.9)催化剂表面存在较高含量的高价态Mn^(3+)和Mn^(4+)、Ce^(4+)以及较高的化学吸附氧浓度,从而展现出较高的脱硝性能。该工作为MnO_(x)-CeO_(2)基催化剂在低温NH3-SCR中的实际应用提供了基础数据。

关键词：石墨烯铈氧化物锰氧化物 NO 选择性催化还原

Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-Bang Liu Dong Wang Zi-Li Li Shu-Lin Liu qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan Hui Wang Ran Chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

Clinical evaluation of sintilimab in conjunction with bevacizumab for advanced colorectal cancer with microsatellite stable-type after failure of first-line therapy

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3277-3287页

作者： liang Wang Yong-Zhi Diao Xin-Fu Ma Yu-Shuang Luo Qi-Jing Guo Xiao-qian Chen Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastroenterology The First People’s Hospital of XiningXining 810000Qinghai ProvinceChina Department of Medical Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND At present,immune checkpoint inhibitors(ICIs)remain the 1st-line therapy me-thod for patients suffering from high microsatellite instability/deficient misma-tch repair metastatic colorectal cancer(mCRC).However,ICI treatments demon-strate minimal therapeutic efficacy against microsatellite stable(MSS)/proficient mismatch repair(pMMR)*** is mainly because this type of tumor is a“cold tumor”with almost no lymphocyte ***-angiogenic drugs have been found to improve the immune microenvironment by promoting many immune cells to enter the immune microenvironment,thereby exerting anti-tumor *** To investigate the effects of ICIs combined with bevacizumab monoclonal anti-body on tumor immune cells in MSS/pMMR advanced CRC patients with first-line treatment *** A total of 110 MSS/pMMR patients with advanced CRC after first-line treatment failure in the Affiliated Hospital of Qinghai University were enrolled for a ran-domized controlled *** short,patients in the experimental group(n=60)were given sintilimab plus bevacizumab for 4 cycles,and those in the control group(n=50)patients were treated with FOLFIRI combined with bevacizumab for 4 *** expression levels of cluster of differentiation(CD)8(+)T cells,tumor-associated macrophages(TAMs),and cancer-associated fibroblasts(CAFs)were comprehensively evaluated to assess the effects of sintilimab combined with bevacizumab on MSS/pMMR advanced CRC sufferers following failure of 1st-line *** The positive expression rates of CD8(+)T lymphocytes(30%vs 50%),TAMs(23.30%vs 60%),and CAFs(23.30%vs 50%)before and after treatment in both groups exhibited statistical significance(P<0.05).Additionally,the therapeutic effects of both groups(partial remission:26.67%vs 10%;objective response rate:26.70%vs 10%)were significantly different(P<0.05).Although the experimental group showed a higher progression-free survival,median progression-free survival,and disease control rate

关键词： Immune checkpoint inhibitors Bevacizumab Colorectal cancer Cytotoxic T lymphocytes Tumor-associated macrophages Cancer-associated fibroblasts