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Engineering W/O/W pickering emulsion for the enhanced antigen delivery and immune responses

Particuology 2024年第9期92卷 224-233页

作者： Sihua Wu Xiaonan Huang yin Ma Naoki Asakawa Yufei Xia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Sinovac Biotech Ltd. Beijing100085China School of Chemical Engineering Nanjing Tech UniversityNanjing211816China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Tumor immunotherapy,particularly cancer vaccines,holds promise for combating cancer by harnessing tailored immune responses against malignant ***,conventional approaches face challenges in efficiently delivering antigens for optimal immune *** adjuvants,like MF59,enhance cellular uptake but struggle to induce robust CD8^(+)T cell ***,we introduce a novel strategy employing a water-in-oil-in-water(W/O/W)multiple Pickering emulsion(mPE)for antigen *** mPE,utilizing biocompatible,pH-sensitive particles,encapsulates antigens within the inner water phase,ensuring enhanced intracellular processing and dictating the intracellular fate of antigens for improved *** vitro and in vivo studies demonstrated that mPEs induced robust dendritic cells activation and antigen cross-presentation,leading to a significantly enhanced immune ***,calcium phosphate-stabilized mPE(CaP-mPE)illustrated the more robust IFN-γ^(+)T cell *** comparison with traditional surfactant-stabilized multiple emulsions,CaP-mPE significantly inhibit tumor growth and effectively prolong the survival of tumor-bearing *** innovative approach offers a promising avenue for the development of effective cancer vaccines with potent cellular immune responses.

关键词： Cancer vaccine Multiple pickeringemulsion Adjuvant Antigen delivery Anti-tumor response

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Smart Gait:A Gait Optimization Framework for Hexapod Robots

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 146-159页

作者： Yunpeng yin Feng Gao Qiao Sun Yue Zhao Yuguang Xiao State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Lenovo Corporation ShanghaiChina AI Institute School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The current gait planning for legged robots is mostly based on human presets,which cannot match the flexible characteristics of natural *** paper proposes a gait optimization framework for hexapod robots called Smart *** Gait contains three modules:swing leg trajectory optimization,gait period&duty optimization,and gait sequence *** full dynamics of a single leg,and the centroid dynamics of the overall robot are considered in the respective *** Smart Gait not only helps the robot to decrease the energy consumption when in locomotion,mostly,it enables the hexapod robot to determine its gait pattern transitions based on its current state,instead of repeating the formalistic clock-set step *** Smart Gait framework allows the hexapod robot to behave nimbly as a living animal when in 3D movements for the first *** Smart Gait framework combines offline and online optimizations without any fussy data-driven training procedures,and it can run efficiently on board in real-time after *** experiments are carried out on the hexapod robot *** results show that the energy consumption is reduced by 15.9%when in *** gait patterns can be generated spontaneously both in regular and challenge environments,and when facing external interferences.

关键词： Gait optimization Swing trajectory optimization Legged robot Hexapod robot

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Laminar Flame Instability of n-Hexane,n-Octane,and n-Decane in Spherical Expanding Flames

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Journal of Thermal Science 2024年第3期33卷 1189-1199页

作者： yin Geyuan HU Erjiang LI Xiaotian LV Xin HUANG Zuohua State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China United Automotive Electronic Systems Co. LtdShanghai201206China Chongqing Changan Automobile Co. Ltd.Chongqing401120China

This paper focuses on the laminar flame instability of three high molecular weight n-alkanes,namely n-hexane,n-octane,and *** experiment was carried out in a constant volume combustion bomb to get the flame *** critical radius under different conditions was extracted using the image processing *** with the existing critical Peclet number theory,the dominant factors of flame instability under current conditions for three n-alkanes can be figured ***,the average cell size(equivalent cell radius,R_(cell))was extracted to provide quantitative analysis of the flame cellular structure,based on the method developed in this *** theoretical R_(cell)were also calculated and compared with the experimental results to validate the proposed method.

关键词： cellular instability equivalent cell radius critical Peclet number spherical flame

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Advanced development of grain boundaries in TMDs from fundamentals to hydrogen evolution application

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Chinese Chemical Letters 2024年第5期35卷 117-129页

作者： Ziyang yin Lingbin Xie Weinan yin Ting Zhi Kang Chen Junan Pan yingbo Zhang Jingwen Li Longlu Wang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China

Grain boundary(GB),as a kind of lattice defect,widely exists in two-dimensional transition metal dichalcogenides(2D TMDs),which has complex and diverse influences on the physical/chemical properties of 2D *** are universally considered to be a double-edged sword,although some electrical and mechanical properties of 2D TMDs would be adversely affected leading to the reduced overall quality,certain structure-oriented applications could be realized based on its unique *** this review,we first detailed the atomic structure characteristics of GBs and the corresponding techniques,then we systematically summarized the methods of introducing GBs into 2D ***,we expounded unique electrical,mechanical,and chemical properties of the GBs in 2D TMDs and clarified its internal relationship with the atomic ***,the application of GB structure in hydrogen evolution reaction(HER)is also *** the end,we make a conclusion and put forward outlooks,hoping to further promote the basic research of GB and boost the wide application of 2D TMDs.

关键词： Grain boundary Transition metal dichalcogenides Two-dimensional materials Hydrogen evolution reaction Dislocation Molybdenum disulfide

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Alkylene-functionality in bridged and fused nitrogen-rich poly-cyclic energetic materials:Synthesis,structural diversity and energetic properties

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Defence Technology（防务技术） 2024年第5期35卷 18-46页

作者： Man Xu Nanxi Xiang Ping yin Qi Lai Siping Pang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open *** the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark *** methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich ***,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic *** this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.

关键词： Energetic materials Alkyl bridge strategy Nitrogen-rich azoles Fused heterocycles Azoles

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Atomically Substitutional Engineering of Transition Metal Dichalcogenide Layers for Enhancing Tailored Properties and Superior Applications

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Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu Liu Si yin Tee Guijian Guan Ming‑Yong Han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhanced applications

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Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： Xi Quan Jun Zhang Linlin yin Wei Zuo Yu Tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

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A general descriptor for guiding the electrolysis of CO_(2)in molten carbonate

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Green Energy & Environment 2024年第4期9卷 748-757页

作者： Zhengshan Yang Bowen Deng Kaifa Du Huayi yin Dihua Wang School of Resource and Environmental Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergyWuhan UniversityWuhan430072China

Molten carbonate is an excellent electrolyte for the electrochemical reduction of CO_(2)to carbonaceous ***,the electrolyte–electrode-reaction relationship has not been well ***,we propose a general descriptor,the CO_(2)activity,to reveal the electrolyte–electrode-reaction relationship by thermodynamic calculations and experimental *** studies agree well with theoretical predictions that both cations(Li^(+),Ca^(2+),Sr^(2+)and Ba^(2+))and anions(BO_(2)^(-),Ti_(5)O_(14)^(8-),SiO_(3)^(2-))can modulate the CO_(2)activity to control both cathode and anode reactions in a typical molten carbonate electrolyzer in terms of tuning reaction products and *** this regard,the reduction of CO_(3)^(2-)can be interpreted as the direct reduction of CO_(2)generated from the dissociated CO_(3)^(2-),and the CO_(2)activity can be used as a general descriptor to predict the electrode reaction in molten ***,the CO_(2)activity descriptor unlocks the electrolyte–electrode-reaction relationship,thereby providing fundamental insights into guiding molten carbonate CO_(2)electrolysis.

关键词： Molten carbonate CO_(2)activity CO_(2)RR Electrolyte engineering Carbon

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Low-Rank Optimal Transport for Robust Domain Adaptation

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1667-1680页

作者： Bingrong Xu Jianhua yin Cheng Lian Yixin Su Zhigang Zeng IEEE the School of Automation Wuhan University of TechnologyWuhan 430070China Intelligent Transportation Systems Research Center Wuhan University of TechnologyWuhan 430063 Chongqing Research Institute Wuhan University of TechnologyChongqingChina the School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 the Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

When encountering the distribution shift between the source(training) and target(test) domains, domain adaptation attempts to adjust the classifiers to be capable of dealing with different domains. Previous domain adaptation research has achieved a lot of success both in theory and practice under the assumption that all the examples in the source domain are welllabeled and of high quality. However, the methods consistently lose robustness in noisy settings where data from the source domain have corrupted labels or features which is common in reality. Therefore, robust domain adaptation has been introduced to deal with such problems. In this paper, we attempt to solve two interrelated problems with robust domain adaptation:distribution shift across domains and sample noises of the source domain. To disentangle these challenges, an optimal transport approach with low-rank constraints is applied to guide the domain adaptation model training process to avoid noisy information influence. For the domain shift problem, the optimal transport mechanism can learn the joint data representations between the source and target domains using a measurement of discrepancy and preserve the discriminative information. The rank constraint on the transport matrix can help recover the corrupted subspace structures and eliminate the noise to some extent when dealing with corrupted source data. The solution to this relaxed and regularized optimal transport framework is a convex optimization problem that can be solved using the Augmented Lagrange Multiplier method, whose convergence can be mathematically proved. The effectiveness of the proposed method is evaluated through extensive experiments on both synthetic and real-world datasets.

关键词： Domain adaptation low-rank constraint noise corruption optimal transport

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Scuffing failure analysis based on a multiphysics coupling model and experimental verification

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Friction 2024年第6期12卷 1214-1234页

作者： Bugao LYU Xianghui MENG Jiabao yin Yi CUI Chengen WANG School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

General reductions in lubricant viscosities and increasing loads in machine components highlight the role of tribofilms in providing surface protection against ***,the relationship between the scuffing process and the growth and removal of tribofilm is not well *** this study,a multiphysics coupling model,which includes hydrodynamic lubrication,asperity contact,thermal effect,tribochemistry reaction,friction,and surface wear,was developed to capture the initiation of surface *** and experiments for a piston ring and cylinder liner contact were conducted following a step-load sequence under different temperature *** results show that high temperature and extreme load could induce the lubricant film collapse,which in turn triggers the breakdown of the tribofilm due to the significantly increased removal *** failures of both lubricant film and tribofilm progress instantaneously in a coupling way,which finally leads to severe scuffing.

关键词： scuffing failure tribofilm boundary lubrication multiphysics coupling effects

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