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Development of hyaluronic acid-based edible film for alleviating dry mouth

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Food Science and Human Wellness 2023年第2期12卷 371-377页

作者： Dong-Keon Kweon Jung-ah Han Jinwoo Bio Co. Ltd.Yongin 17111Korea Department of Food and Nutrition Sangmyung UniversitySeoul 03016Korea

For alleviating dry mouth symptoms,edible films based on hyaluronic acid(HA)with 3 different m(800,1200 and 2300 kDa)were prepared(800 F,1200 F and 2300 F,respectively),and the properties as well as effectiveness were *** concentration of each HA dispersion for film forming was set as 3.0%,1.5%or 1.0%,for the m800,1200 and 2300 kDa,respectively,based on the *** 800 F showed the highest thickness,tensile strength,and water vapor transparency,whereas obtained the lowest transparency and elongation at break among *** of the HA films showed safety against microorganism during 28 storage day at 40℃with 60%*** optimum site for film attachment in mouth was the palate,and800 F was the most effective for stimulating saliva secretion,eliciting a 38%increase compared to control(without film),tested by the elderly over 65 years *** the sensory test,800 F was also the most *** on above results,the edible films effectively stimulating saliva secretion could be produced with HA,and the physical,sensory characteristics as well as disintegration times of the film could be controlled by mand the dissolution concentration of HA.

关键词： Edible film Hyaluronic acid Saliva stimulating Tensile strength Thickness

Digital exchange attributes and the risk of closure

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Blockchain(Research and Applications) 2023年第2期4卷 136-145页

作者： Seung ah Lee George Milunovich Department of Actuarial Studies and Business Analytics Macquarie UniversitySydneyNSW2109Australia

Presently,there are over 500 cryptocurrency exchanges worldwide and more than 19,700 different *** the fact that cryptocurrency trading is possible via private peer-to-peer transactions,more than 90%of trading occurs on organised exchanges,which provide convenience and ***,centralised cryptocurrency exchanges are regarded as high-value targets by criminals and are often victims of *** this paper,we investigate the risk of cryptocurrency exchange closures and develop predictive models to forecast which markets will close down and which ones will remain active using publicly available *** models perform well and reach a high level of classification *** trading volume,the availability of public information on exchange staff,exchange lifetime,and several cybersecurity features are identified as key attributes in predicting exchange ***,our models do not account for all sources of risk,e.g.,potential fraud and mismanagement of client funds committed by the exchanges themselves,and market participants are encouraged to carefully consider where and how they store their digital assets.

关键词： Cryptocurrency markets Digital exchange Closure Classification Predictive models

碳限额及碳交易机制下低碳供应链合作促销与减排研究

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物流科技 2024年第7期47卷 1-7页

作者：邵灵芝尹丽安徽工业大学管理科学与工程学院安徽马鞍山243032

构建Stackelberg博弈模型,在碳限额及碳交易机制下,考虑由单一制造商和零售商组成的两级供应链,通过制造商和供应链成员之间的合作,来探讨减排与促销策略问题。分析了零售商制造商独自承担各自费用、合作促销和合作减排等情形下供应链... 详细信息

构建Stackelberg博弈模型,在碳限额及碳交易机制下,考虑由单一制造商和零售商组成的两级供应链,通过制造商和供应链成员之间的合作,来探讨减排与促销策略问题。分析了零售商制造商独自承担各自费用、合作促销和合作减排等情形下供应链成员最优决策。并通过算例分析研究发现:合作促销与合作减排成本分担比例在满足一定条件时都优于独自促销和减排,因此,碳排放依赖较大的行业可以选取合作减排模式,依赖销售努力较大的行业可以选取合作促销模式。

关键词：碳限额与碳交易低碳供应链 Stackelberg博弈合作减排合作促销

Mechanism and characterization of nanosecond laser rust-removal on ah36 steel

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Optoelectronics Letters 2023年第4期19卷 227-234页

作者： TAO Qing KUANG Wenxiang WEI Liangpeng yin Yegang CHENG Jian LIU Dun Laser Group School of Mechanical EngineeringHubei University of TechnologyWuhan 430068China Hubei Key Laboratory of Modern Manufacturing Quantity Engineering School of Mechanical EngineeringHubei University of TechnologyWuhan 430068China

In this paper,the effects of different laser powers,repetition rates,and spot overlaps on the surface roughness,micromorphology,and Vickers hardness of rusted ah36 steel were researched in the rust removal experiment of fiber pulse laser on the marine steel ***,the mechanical properties,corrosion resistance,and metallographic microstructure of the surface of samples after laser cleaning were *** experimental results show that when the processing parameters were the laser power of 40 W,the repetition rate of 110 k Hz,and the spot overlap of 50%,the rust removal effect on ah36 steel was the best,and it met the cleanliness standard of marine steel ***,its Vickers hardness,mechanical properties,corrosion resistance,and repainting properties were superior to those of the original substrate.

关键词： steel corrosion microstructure

栀子苷抑制HSP70释放改善风湿热痹证胶原性关节炎大鼠血管新生的作用研究

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中国药理学通报 2024年第2期40卷 324-334页

作者：舒寅甘珮荣王言卜妍红吴虹安徽中医药大学药学院新安医学教育部重点实验室中药复方安徽省重点实验室安徽合肥230012

目的探讨栀子苷(geniposide,GE)改善风湿热痹证胶原性关节炎(collagen induced arthritis,CIA)大鼠血管新生的作用是否与调控热休克蛋白70(heat shock proteins 70,HSP70)的释放有关。方法在大鼠背部和尾根部多点皮内注射完全弗氏佐剂(c... 详细信息

目的探讨栀子苷(geniposide,GE)改善风湿热痹证胶原性关节炎(collagen induced arthritis,CIA)大鼠血管新生的作用是否与调控热休克蛋白70(heat shock proteins 70,HSP70)的释放有关。方法在大鼠背部和尾根部多点皮内注射完全弗氏佐剂(complete Freund’s adjuvant,CFA)与鸡Ⅱ型胶原蛋白(chicken type II collagen,CCII)等体积混合物,构建CIA模型,在此基础上,给予风湿热刺激,建立风湿热痹证CIA大鼠(CIA rats with moist heat arthralgia spasm syndrome,CIA-S)模型。造模成功后随机分组,给药组分别用GE(60、120 mg·kg^(-1)·d^(-1))、MTX(0.5 mg·kg^(-1)·3d^(-1))灌胃两周,取材。观察大鼠体质量、关节炎指数(arthritis index,AI)等评价模型情况,关节表面温度和血流变指标评价热痹模型热属性,HE染色观察大鼠滑膜病理,多普勒彩超检测血流信号,免疫组化和Westren blot法检测滑膜组织HSP70、CD31、VEGF含量,ELISA法检测大鼠血清HSP70含量。EdU染色、细胞划痕和Transwell迁移实验以及成管实验探究HSP70对人脐静脉血管内皮细胞(human umbilic vein endothelial cells,HUVECs)的增殖、迁移、成管能力的影响。结果与空白组相比,CIA-S组关节肿胀,热属性明显,血管新生强烈,滑膜组织异常增生,炎性细胞浸润,可见微血管形成;CIA-S组与CIA组比较,关节红肿程度加重,炎症峰值提前、持续时间延长,消退缓慢,血管新生与HSP70表达更为强烈。GE给药组呈剂量依赖性,有效改善关节炎症状,减少HSP70含量。细胞实验结果表明,GE抑制HSP70的表达和释放,进而抑制HSP70诱导的HUVECs增殖、迁移和成管能力增强。结论GE有可能通过抑制HSP70的释放改善风湿热痹证CIA大鼠血管新生,进而改善关节炎。

关键词：风湿热痹证CIA大鼠 HSP70 血管新生栀子苷人脐静脉血管内皮细胞热应激

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Nucleus-Encoded Thylakoid Protein,OsY3IP1,Confers Enhanced Tolerance to Saline and Alkaline Stresses in Rice

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Rice science 2022年第3期29卷 225-236页

作者： Hyeran MOON Young-ah KIM Ryoung SHIN Chang-Jin PARK Department of Molecular Biology Sejong University Department of Bioresources Engineering Sejong University RIKEN Center for Sustainable Resource Science Plant Engineering Research Institute Sejong University

Abiotic stress confers serious damage to the photosynthetic machinery,often resulting in plant growth *** chloroplast open reading frame 3(Ycf3)-interacting protein 1(Y3IP1)is a nucleus-encoded thylakoid protein and plays an essential role in the assembly of photosystem *** full-length cDNA over-expresser(FOX)gene-hunting system is an approach using systemically generated gain-of-function *** the FOX-rice lines,a line CE175 overexpressing rice Y3IP1gene(Os Y3IP1)displayed less inhibition of root growth under saline(NaCl)*** expression of Os Y3IP1 was up-regulated under saline and alkaline(Na2CO3)stresses in the rice variety *** saline and alkaline treatments,transgenic Kitaake overexpressing OsY3IP1-GFP(OsY3IP1-GFPox/Kit)displayed higher levels of chlorophyll content compared to *** the stress conditions,the maximum quantum yield of photosystem II photochemistry levels was higher in OsY3IP1-GFPox/Kit than in *** increased tolerance conferred by OsY3IP1 overexpression correlated with reduced reactive oxygen species *** data provide new insights into the possible role of OsY3IP1 in the pathway suppressing photooxidative damage under stress *** features can be further exploited to improve saline and alkaline tolerances of rice plants in future.

关键词： alkaline reactive oxygen species rice saline stress tolerance

基于生境组团化分析与景观廊道模拟的南京市白鹭生境网络构建与优化

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生态学报 2024年第8期44卷 3303-3316页

作者：沈舟尹海伟孔繁花苏杰孙辉李久林南京大学建筑与城市规划学院南京210093 南京大学地理与海洋科学学院南京210023 安徽建筑大学建筑与规划学院合肥230022 安徽省城镇化建设协同创新中心合肥230022

保持生境连通性是全球生物多样性保护面临的主要挑战之一。生境网络构建与优化是一种积极主动的景观策略,但其成效取决于异质性景观背景下生境分布格局与物种响应。以南京市为例、白鹭为目标物种,开展了基于生境组团化分析与景观廊道(LS... 详细信息

保持生境连通性是全球生物多样性保护面临的主要挑战之一。生境网络构建与优化是一种积极主动的景观策略,但其成效取决于异质性景观背景下生境分布格局与物种响应。以南京市为例、白鹭为目标物种,开展了基于生境组团化分析与景观廊道(LSCorridors)模拟的生境网络构建与优化研究。通过整合生境适宜性评价、干扰度评价、最大熵(MaxEnt)模型模拟,实现了物种生境源地综合识别;利用景观连通性指标与核密度分析,识别了物种生境分布的组团化格局;在最小成本路径(LCPs)的基础上,定义了优化新增型与提升型两类廊道,并从物种感知与适应性变化出发,应用LSCorridors软件模拟了这两类目标优化廊道的多重随机路径及其空间范围。结果表明,南京市白鹭生境斑块共计428个,总面积达31525.75 hm^(2),主要是林地与水域,具有较为明显的破碎化和局部集聚特征,九大生境组团以南京长江段水域斑块为轴,沿两侧分布,彼此联系比较薄弱;最佳距离阈值4.5 km内,识别LCPs共907条,总长度1548.59 km,平均较短、分布紧凑,主要位于各生境组团内部,但仅少数连接着不同生境组团;确定的8条优化新增型廊道和10条优化提升型廊道,其LSCorridors模拟结果与LCPs存在空间偏差,前者更符合现实进而有益于避免保护低效和促进多类型、差异化的优化措施制定。研究成果能为面向生物多样性保护的南京市生境网络保护以及重点生态廊道的规划实践提供决策参考。

关键词：生境网络最小成本路径连通性景观廊道(LSCorridors) 生物多样性

赤霉素对珍稀濒危植物银缕梅种子萌发及幼苗生长的影响

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生态学杂志 2024年第7期43卷 2026-2032页

作者：阳艳芳罗来开丁聪尹明月翟伟赵凯安庆师范大学生命科学学院皖西南生物多样性研究与生态保护重点实验室安徽安庆246133

银缕梅(Parrotia subaequalis)现为中国Ⅰ级保护植物,其自然条件下种子萌发率较低。为提高种子利用率,探究赤霉素对银缕梅种子萌发及幼苗生长的影响,本研究通过对野外采集的银缕梅种子进行不同浓度赤霉素(GA3)浸种实验。实验分别采用浓... 详细信息

银缕梅(Parrotia subaequalis)现为中国Ⅰ级保护植物,其自然条件下种子萌发率较低。为提高种子利用率,探究赤霉素对银缕梅种子萌发及幼苗生长的影响,本研究通过对野外采集的银缕梅种子进行不同浓度赤霉素(GA3)浸种实验。实验分别采用浓度为0、600、800、1000和1200 mg·L^(-1)的GA3浸泡48 h,而后测定种子的发芽率、发芽势、发芽指数、成苗率以及不同时期幼苗的茎长、胚根长、侧根数、叶片数、鲜重等指标。结果表明:适宜浓度GA3浸种后银缕梅种子发芽率、发芽势、发芽指数和成苗率均有提高;GA3浓度为800 mg·L^(-1)时,银缕梅种子萌发率最高,达81.1%,成苗率为92.67%,发芽势和发芽指数分别为36.67%、24.94;幼苗在GA3浓度为800 mg·L^(-1)的浸种条件下长势最佳,90 d后平均茎长为65.92 mm,胚根长44.84 mm,根数11.6,叶片数4.2片,鲜重0.444 g,与对照组相比差异显著(P<0.05);在银缕梅的人工繁育过程中,可以使用适宜浓度的GA3处理,提高种子的萌发率,缩短萌发时间。

关键词：濒危植物银缕梅种子萌发幼苗生长赤霉素

Valorising Ikseon-dong’s Hanok residence as a heritage place

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Frontiers of Architectural Research 2023年第5期12卷 947-965页

作者： Young-Jae Kim ah-Ra-Mi Yun Department of Heritage Conservation and Restoration Korea National University of Cultural HeritageBuyeo 33115Republic of Korea

This study aims to create a basis for sustainable conservation by identifying the heritage value of 166 *** on old land registers and cadastral maps of the 1920s and 1930s,it interpreted the construction procedure,social background,and urban architectural characteristics of the road and plot subdivision of the modern Hanok ***-dong Hanok produced four types of ground plans based on the grid-street *** study argues that these innovative experiments have already been attempted through Bak Young-hyo’s proposals in his Geonbaekseo and the architectural activities of Jeong Segwon,and that the idea of applying various housing types,layouts,and grid-street system planning was embodied through the development of the Hanok complex in ***,this attempt greatly influenced the design of other Hanok complexes built in colonial Gyeongseong after 1936,taking the Ikseon-dong Hanok as a role *** radiation of new perspectives will be a groundwork for the future sustainable conservation of heritage places.

关键词： ModernHanok residence Plot subdivision Ikseon-dong Construction background Heritage interpretation Sustainable conservation