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Waveguide-integrated ultra-stable perovskite single-crystal photodetector

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Science China Technological Sciences 2025年

作者： zhenyu ZHANG Guoping wang State Key Laboratory of Radio Frequency Heterogeneous Integration Shenzhen University

Notwithstanding the exceptional photodetection capabilities of the laterally-structured perovskite single-crystal sheet(SCS), attributed to its notably lengthy carrier diffusion length and reduced defect density, operating the device within free space and exposing the SCS to the environment present obstacles in attaining on-chip integration and long-term *** overcome these challenges, this study proposes the introduction of a waveguide(WG) structure methodology, and selects the silicon WG(SWG) core and the polymer polymethyl methacrylate(PMMA) WG(PWG) fiber as materials. Furthermore, it integrates these two WG structures with the laterally-structured SCS photodetector into WG-SCS devices, enabling photodetection under near-field excitation of the WG. Significantly, the WG-SCS device encapsulated with silicone sealant demonstrates exceedingly high stability, with no degradation in performance after being exposed to light and water stimuli for1000 h. This study demonstrates the viability of on-chip integration of lateral-structured SCS photodetectors by means of introducing WG structures and investigates the technical facets of the device's long-term environmental stability. The results are expected to exert a crucial role in device integration in future applications such as optical communication, quantum photonics, and biochemical sensing.

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The Internet of Things under Federated Learning:A Review of the Latest Advances and Applications

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Computers, Materials & Continua 2025年第1期82卷 1-39页

作者： Jinlong wang zhenyu Liu Xingtao Yang Min Li Zhihan Lyu School of Information and Control Engineering Qingdao University of TechnologyQingdao260043China Anhui Province Key Laboratory of Intelligent Building&Building Energy Saving Anhui Jianzhu UniversityHefei230000China Department of Game Design Uppsala UniversityUppsala75310Sweden

With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application *** the IoT environment,many sensors and devices generatemassive data,but data security and privacy protection have become a serious *** learning(FL)can achieve many intelligent IoT applications by training models on local devices and allowing AI training on distributed IoT devices without data *** review aims to deeply explore the combination of FL and the IoT,and analyze the application of federated learning in the IoT from the aspects of security and privacy *** this paper,we first describe the potential advantages of FL and the challenges faced by current IoT systems in the fields of network burden and privacy ***,we focus on exploring and analyzing the advantages of the combination of FL on the Internet,including privacy security,attack detection,efficient communication of the IoT,and enhanced learning *** also list various application scenarios of FL on the ***,we propose several open research challenges and possible solutions.

关键词： Federated learning Internet of Things sensors machine learning privacy security

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao zhenyu yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping wang Shijun Shen Jia Zhao Zhiyi Lin Jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing yin Hong wang Zhiyang Chen zhenyu Ju Cizhong Jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of Animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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Efficient Helicopter-Satellite Communication Scheme Based on Check-Hybrid LDPC Coding

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Tsinghua Science and Technology 2018年第3期23卷 323-332页

作者： Ping wang Liuguo yin jianhua Lu Department of Electronic Engineering Tsinghua University Beijing 100084 China EDA Laboratory Research Institute of Tsinghua Universityin Shenzhen Shenzhen 518057 China. School of Information Science andTechnology Tsinghua University Beijing 100084 China EDA Laboratory Research Institute ofTsinghua University in Shenzhen Shenzhen 518057 China Department of Electronic Engineering Tsinghua University Beijing 100084 China

When implementing helicopter-satellite communications, periodical interruption of the received signal is a challenging problem because the communication antenna is intermittently blocked by the rotating blades of the helicopter. The helicopter-satellite channel model and the Forward Error Control（FEC） coding countermeasure are presented in this paper. On the basis of this model, Check-Hybrid（CH） Low-Density Parity-Check（LDPC）codes are designed to mitigate the periodical blockage over the helicopter-satellite channels. The CH-LDPC code is derived by replacing part of single parity-check code constraints in a Quasi-Cyclic LDPC（QC-LDPC） code by using more powerful linear block code constraints. In particular, a method of optimizing the CH-LDPC code ensemble by searching the best matching component code among a variety of linear block codes using extrinsic information transfer charts is proposed. Simulation results show that, the CH-LDPC coding scheme designed for the helicopter-satellite channels in this paper achieves more than 25% bandwidth efficiency improvement, compared with the FEC scheme that uses QC-LDPC codes.

关键词： helicopter-satellite communications check-hybrid Low-Density Parity-Check(LDPC) codes Extrinsic Information Transfer(EXIT) iterative decoding

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Microstructures andmicrom anics of

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第4期24卷 299-302页

作者： zhenyu yin Pei wang Sheng DAI Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlanta 30332 GAUSA

1Introduction Geomaterials,such as soil,rock,and concrete,have a clearly defined microstructure at the level of individual grains(Sprunt and Brace,1974;Ichikawa et al.,2001).While difficult to observe directly,these microstructures,including their particle size distribution,particle shape,mineralogy,interaction,and bonding behavior,have a strong influence on both microand macroscopic behaviors of geomaterials(Gao and Zhao,2013);He et al.,2018;Alqam et al.,2019;Sun et al.,2020;yin et al.,2020;wang et al.,2022 .In recent years,various kinds of engineered geomaterials,such as fiber-reinforced and bio-reinforced soils,have been shown to have even more sophisticated microstructures(Uygunoglu,2008;Mujah et al.,2019).

关键词： microstructure bonding macroscopic

Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 52-60页

作者： Yangyang Liu Zhiyu Qian jianhua yin Xiao wang Department of Biomedical Engineering Nanjing University of Aeronautics and Astronautics Nanjing P.R.China

Magnetic nanoparticle plays an important role in biomedical engineering,especially in tumor *** this paper,a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-fequency alternating magnetic field(LFAMF)to kill tumor *** LFAMF system which was used to drive magnetic nanoparticles(MNPs)was setup with the magnetic field frequency and power range at心10-100Hz and~10-200 mT,*** the experiment,the LFAMF was adjusted at different frequencies and power *** exper-imental results show that the liver tumnor cells(HepG2)mixed with MNPs(10 pug/mL)becamne partial fragments when exposed in the LFAMF with different frequencies(~10-100Hz)and power(~10200 mT),and the higher the frequency or the power,the more the tumor cells were killed at the same magnetic nanoparticle ***:Tumor oells were effectively damaged by MNPs under LFAMF,which suggests that they had great potential to be applied in tumor therapy.

关键词： Different frequency cells power cancer

Micromechanical modeling of hollow cylinder torsional shear test on sand using discrete element method

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JOURNAL OF ROCK MECHANICS AND GEOTECHNICAL ENGINEERING 2024年第12期16卷 5193-5208页

作者： Song, Shunxiang wang, Pei yin, zhenyu Cheng, Yi Pik East China Jiaotong Univ Inst Geotech Engn Sch Civil Engn & Architecture Nanchang Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hong Kong Peoples R China UCL Dept Civil Environm & Geomatic Engn London England

Previous studies on the hollow cylinder torsional shear test (HCTST) have mainly focused on the macroscopic behavior, while the micromechanical responses in soil specimens with shaped particles have rarely been investigated. This paper develops a numerical model of the HCTST using the discrete element method (DEM). The method of bonded spheres in a hexagonal arrangement is proposed to generate flexible boundaries that can achieve real-time adjustment of the internal and external cell pressures and capture the inhomogeneous deformation in the radial direction during shearing. Representative angular particles are selected from Toyoura sand and reproduced in this model to approximate real sand particles. The model is then validated by comparing numerical and experimental results of HCTSTs on Toyoura sand with different major principal stress directions. Next, a series of HCTSTs with different combinations of major principal stress direction (a) and intermediate principal stress ratio (b) is simulated to quantitatively characterize the sand behavior under different shear conditions. The results show that the shaped particles are horizontally distributed before shearing, and the initial anisotropic packing structure further results in different stress-strain curves in cases with different a and b values. The distribution of force chains is affected by both a and b during the shear process, together with the formation of the shear bands in different patterns. The contact normal anisotropy and contact force anisotropy show different evolution patterns when either a orb varies, resulting in the differences in the non-coaxiality and other macroscopic responses. This study improves the understanding of the macroscopic response of sand from a microscopic perspective and provides valuable insights for the constitutive modeling of sand. (c) 2024 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the

关键词： Sand Hollow cylinder torsional shear test (HCTST) Discrete element method (DEM) Principal stress rotation Micromechanics Anisotropy

A batch microfabrication of a self-cleaning,ultradurable electrochemical sensor employing a BDD film for the online monitoring of free chlorine in tap water

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Microsystems & Nanoengineering 2022年第2期8卷 85-96页

作者： Jiawen yin Wanlei Gao Weijian Yu Yihua Guan zhenyu wang Qinghui Jin Faculty of Electrical Engineering and Computer Science Ningbo University315211 NingboP.R.China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiP.R.China

Free chlorine is one of the key water quality parameters in tap ***,a free chlorine sensor with the characteristics of batch processing,durability,antibiofouling/antiorganic passivation and in situ monitoring of free chlorine in tap water continues to be a challenging *** this paper,a novel silicon-based electrochemical sensor for free chlorine that can self-clean and be mass produced via microfabrication technique/MEMS(Micro-Electro-Mechanical System)is proposed.A liquid-conjugated Ag/AgCI reference electrode is fabricated,and electrochemically stable BDD/Pt is employed as the working/counter electrode to verify the effectiveness of the as-fabricated sensor for free chlorine *** sensor demonstrates an acceptable limit of detection(0.056 mg/L)and desirable linearity(R^(2)=0.998).Particularly,at a potential of+2.5 V,hydroxyl radicals are generated on the BBD electrode by electrolyzing water,which then remove the organic matter attached to the surface of the sensor though an electrochemical digestion *** performance of the fouled sensor recovers from 50.2 to 94.1%compared with the initial state after self-cleaning for 30 *** addition,by employing the MEMS technique,favorable response consistency and high reproducibility(RSD<4.05%)are observed,offering the opportunity to mass produce the proposed sensor in the future.A desirable linear dependency between the pH,temperature,and flow rate and the detection of free chlorine is observed,ensuring the accuracy of the sensor with any hydrologic *** interesting sensing and selfcleaning behavior of the as-proposed sensor indicate that this study of the mass production of free chlorine sensors by MEMS is successful in developing a competitive device for the online monitoring of free chlorine in tap water.

关键词： chlorine batch electrode