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基于符号互动理论的高职学生规则意识研究

云南开放大学学报 2024年第3期26卷 76-82页

作者：高宇赵银琴云南开放大学云南昆明650500

符号互动论阐释了人与人通过符号进行互动并形成深层次互动交流关系,对于高校师生互动具有重要的启示意义。高职学校作为培养技能型人才的重要场所,在教育中应该把学生规则意识的培养放在重要位置,并不断通过创新教育方式和内容来培养... 详细信息

符号互动论阐释了人与人通过符号进行互动并形成深层次互动交流关系,对于高校师生互动具有重要的启示意义。高职学校作为培养技能型人才的重要场所,在教育中应该把学生规则意识的培养放在重要位置,并不断通过创新教育方式和内容来培养学生的规则意识。而规则意识作为现代公民必备能力之一,是规范学生行为,助力建设安全有序校园的关键。探寻培养高职学生规则意识现状,通过寻找共同的网络互动文字符号、记录和解释符号互动内容、创设教育性的环境符号、激发学生自我管理、重视课程思政教育、拉近师生感情,将文化符号种进心里;多渠道因材施教,加深对规则的认知和理解,促进师生良性互动,增强高职学生规则意识。

关键词：符号互动理论高职学生规则意识

云南边疆民族地区Y校高职学前教育专业《学前儿童文学》课程思政现状研究

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潍坊工程职业学院学报 2024年第1期37卷 57-63页

作者：高宇赵银琴云南开放大学昆明650500

云南边疆民族地区具有特殊地域性和民族性,在课程思政方面同样呈现出独特性,从“三全育人”的角度落实思政教育,通过专业课程加强思想教育,引导学生树立正确的三观。通过对云南Y校学前教育专业166名学生进行问卷调查,结果显示:学生对《... 详细信息

云南边疆民族地区具有特殊地域性和民族性,在课程思政方面同样呈现出独特性,从“三全育人”的角度落实思政教育,通过专业课程加强思想教育,引导学生树立正确的三观。通过对云南Y校学前教育专业166名学生进行问卷调查,结果显示:学生对《学前儿童文学》课程思政观念认知程度较高、满意度一般、评教结果有待提高;从教学内容来看,思政内容融入不足、教学方式单一、教师认知不到位、讲授水平有限。据此,提出加强思政理论学习、优化课程思政内容、创新课程思政教学过程、落实课程思政目标、加强课程思政考核等建议,以期为云南边疆民族地区课程思政发展提供参考。

关键词：边疆民族地区思想政治教育学前儿童文学课程思政

EXPERIMENTAL STUDY ON THE FLOW FIELD CHARACTERISTICS IN THE MIXING REGION OF TWIN JETS

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Journal of Hydrodynamics 2007年第3期19卷 309-313页

作者： yin zhao-qin ZHANG Hong-jun LIN Jian-zhong State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027China China Jiliang University Hangzhou 310018 China China Jiliang University Hangzhou 310018 China

Twin jets flow, generated by two identical parallel axisymmetric nozzles, has been experimentally investigated. The dimensionless spacing （B） between two nozzles were set at 1.89, 1.75 and 1.5. Measurements have been carded out at several free-stream velocities ranging from 10 m/s to 25 m/s or Reynolds numbers （based on the nozzle diameter of 44 mm） ranging from 3.33×10^4 to 8.33×10^4. The results show that the twin jets attract each other. With the increasing Reynolds number, the turbulence energy grows, which indicates that the twin jets attract acutely. The jet flow field and the merging process of two jets vary with B. The width of the twin jets flow spreads linearly downstream and grows with B. The merging between two jets occurs at the location closer to the nozzle exit for the cases with smaller spacing between nozzles and higher Reynolds number.

关键词： twin jets mixing region turbulent experiment

NUMERICAL SIMULATION OF THE FORMATION OF NANOPARTICLES IN AN IMPINGING TWIN-JET

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Journal of Hydrodynamics 2007年第5期19卷 533-541页

作者： yin zhao-qin LIN Jian-zhong Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China China Jiliang University Hangzhou 310018 China

The Large Eddy Simulation （LES） method has been used to solve the fluid momentum equations coupled with a convection,liffusion equation to study the formation of pollutant nanoparticles in a vehicular exhaust with impinging twin-jet. The functions of the space （S） between the two jets and the distance （H） from the exit of nozzle to the impingement plane are evaluated according to the distributions of pollutant nanoparticles. The results show that the nucleation produces a large number of nanoparticles, and gas-to-nanoparticle conversion mostly takes place in the interface region of the two jets, the circumambience of the jets, and region near the plane. The maximal particle size and maximal number concentration produced by both nucleation and coagulation appear around the region of free jet and the region near the plane, respectively. The significant differences for various spaces between the two jets are the number concentration and size distributions in the interface region of the two jets. For the case with larger space, more nanoparticles are produced by nucleation and coagulation The more the distance from the exit of nozzle to the impingement plane, the lower is the fewer the particles distribute distance from nozzle to plane is nanoparticle formation. the number concentration and near the plane. Increasing the beneficial to the reduction of

关键词： pollutant nanoparticles vehicular exhaust,impinging twin-jet nucleation coagulation simulation

KNOCKDOWN OF SURVIVIN EXPRESSION BY SMALL INTERFERING RNA SUPPRESSES PROLIFERATION OF TWO HUMAN CANCER CELL LINES

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Chinese Medical Sciences Journal 2006年第2期21卷 115-119页

作者： Hai-tao Guan Xing-huan Xue Xi-jing Wang Ang Li zhao-yin qin Department of Ontological Surgery the Second AffiliatextHospital Medical College of Xi＇an Jiaotong University Xi＇an 710004 Medical Research Center Affiliated Stomatological l-Iospital Medical College of Xi＇an Jiaotong University Xi＇an 710004 Department of General Surgery the Second Affiliat~iHospital Medical College of Xi＇an Jiaotong University Xi＇an 710004

Objective To construct an expression vector of small interfering RNA （siRNA） against survivin and observe its effects on survivin expression and proliferation of human pancreatic cancer cell line PC-2 and breast cancer cell line MCF-7. Methods Constructed an expression vector of siRNA against survivin and transfected it into PC-2 and MCF-7 cells using lipofectamine^TM 2000. The expression of survivin was detected by semi-quanfifive RT-PCR and immunohistochemistry, and its effects on proliferation of PC-2 and MCF-7 cells were detected by MTT assay. Results The introduction of sequence-specific siRNA could efficiently suppress survivin expression at both mRNA and protein levels in the two cancer cell lines. In PC-2 cells, the expression inhibition rates were 81.25% at mRNA level and 74.24% at protein level In MCF-7 cells, the expression inhibition rates were 64.91% at mRNA level and 79. 72% at protein level The proliferation of PC-2 and MCF-7 cells was also suppressed, and24 and 48 hours after the cells were reseeded, the proliferation inhibition rates of PC-2 cells were 28. 00% and 33. 38%, and that of MCF-7 cells were 31.58% and 33.02%, respectively. Conclusions The expression vector of siRNA against survivin can block survivin expression in PC-2 and MCF-7 cells efficiently and specifically. Down regulation of survivin expression can suppress proliferation of PC-2 and MCF-7 cells. Survivin RNAi may have potential value in gene therapy of human cancers.

关键词： RNA interference small interfering RNA survivin pancreatic cancer breast cancer

Towards data-efficient mechanical design of bicontinuous composites usinggenerative AI

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 57-64页

作者： Milad Masrouri zhao qin Department of Civil and Environmental Engineering Syracuse UniversitySyracuseNY 13244USA Laboratory for Multiscale Material Modelling Syracuse UniversitySyracuseNY 13244USA The BioInspired Institute Syracuse UniversitySyracuseNY 13244USA

The distribution of material phases is crucial to determine the composite’s mechanical *** the full structure-mechanics relationship of highly ordered material distributions can be studied with finite number of cases,this relationship is difficult to be revealed for complex irregular distributions,preventing design of such material structures to meet certain mechanical *** noticeable developments of artificial intelligence(AI)algorithms in material design enables to detect the hidden structure-mechanics correlations which is essential for designing composite of complex *** is intriguing how these tools can assist composite ***,we focus on the rapid generation of bicontinuous composite structures together with the stress distribution in *** find that generative AI,enabled through fine-tuned Low Rank Adaptation models,can be trained with a few inputs to generate both synthetic composite structures and the corresponding von Mises stress *** results show that this technique is convenient in generating massive composites designs with useful mechanical information that dictate stiffness,fracture and robustness of the material with one model,and such has to be done by several different experimental or simulation *** research offers valuable insights for the improvement of composite design with the goal of expanding the design space and automatic screening of composite designs for improved mechanical functions.

关键词： Generative artificial intelligence Stable diffusion Composite design Phase field model Molecular dynamics simulation

Immunological Exploration of Helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chemistry 2024年第3期42卷 243-251页

作者： Ming zhao Guangzong Tian Chunjun qin Xiaopeng Zou Peter H. Seeberger Jing Hu Jian yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi School of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

Helicobacter pylori(***)infection is a threat to human *** lipopolysaccharide(LPS)O-antigen holds promise for developing *** is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragments is *** screening with *** O2 LPS sera and patients’sera by glycan microarray,the disaccharide HPO2G-2b and trisaccharide HPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-HPO2G-3a IgG antibodies possess a much stronger binding affinity with the LPS and bacteria of *** O2 than the anti-HPO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LPS and bacteria of *** O1,O6,and *** results demonstrate the trisaccharide HPO2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates Helicobacter pylori Immunology Microarrays O-antigen Oligosaccharides

The Strategic Analysis of Demand Forecast-Sharing in a Hybrid-Format Online Platform Supply Chain

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 281-310页

作者： Jing zhao Zijun yin Guobiao Zhou School of Mathematical Sciences Tiangong UniversityTianjin300387China

This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who possesses demand forecasts from two *** asymmetry and co-opetitive relationship arise between the platform retailer and the supplier,which affect their operational decisions and the supply chain’s *** improve supply chain efficiency,we compare different forecast-sharing strategies(i.e.,no forecast sharing,sharing a single forecast,and sharing two forecasts),and analyze the effects of co-opetitive parameters on the optimal forecast-sharing *** analysis shows that forecast sharing is always beneficial to the supplier,and sharing two forecasts is more beneficial than sharing a single *** for the platform retailer and the whole supply chain,forecast sharing is beneficial only under certain conditions,depending on the co-opetitive *** optimal forecast-sharing strategy is the result of a combination of the negative effect of double marginalization in reselling channel and the positive effect of responding pricing to demand uncertainty in agency *** illustrate the parameter regions of the platform retailer’s voluntary sharing,contract sharing,and no sharing,and also find that higher channel competition intensity,higher market share of agency channel,and higher commission rate can promote the platform retailer’s voluntary *** study extends the research scope of demand forecast-sharing and sheds light on the decision-making processes for managing a hybrid-format online platform supply chain.

关键词： Supply chain management hybrid-format online platform demand forecast-sharing co-opetitive relationship channel competition intensity

cKBET:assessing goodness of batch effect correction for single-cell RNA-seq

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Frontiers of Computer Science 2024年第1期18卷 215-228页

作者： Yameng zhao yin GUO Limin LI School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

Single-cell RNA sequencing reveals the gene structure and gene expression status of a single cell,which can reflect the heterogeneity between ***,batch effects caused by non-biological factors may hinder data integration and downstream *** the batch effect can be evaluated by visualizing the data,which actually is subjective and *** this work,we propose a quantitative method cKBET,which considers the batch and cell type information *** cKBET method accesses batch effects by comparing the global and local fraction of cells of different batches in different cell *** verify the performance of our cKBET method on simulated and real biological data *** experimental results show that our cKBET method is superior to existing methods in most *** general,our cKBET method can detect batch effect with either balanced or unbalanced cell types,and thus evaluate batch correction methods.

关键词： single-cell RNA-seq dataset b batch effect assessment cKBET method