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Diabetes mellitus in patients with type 1 autoimmune pancreatitis at diagnosis and after corticosteroid therapy

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 393-398页

作者： Mei-Zi Li Tao Guo Yun-Lu Feng Sheng-Yu Zhang xiao-yin Bai Xi Wu Kai Xu Ai-Ming Yang Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Radiology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Background:A high prevalence of diabetes mellitus(DM)coexisting with autoimmune pancreatitis(AIP)is ***,evidence on the circumstances under which corticosteroid therapy(CST)for AIP improves or worsens DM is *** study aimed to demonstrate and identify predictors of DM control under the influence of ***:Patients diagnosed with type 1 AIP were enrolled from a prospectively maintained cohort and were classified into three groups according to the chronology in which AIP and DM were diagnosed:pre-existing DM(pDM),concurrent DM(cDM),and non-DM(nDM).The responses of DM to CST were assessed when corticosteroid was ceased or tapered to a maintenance dose and classified as‘improvement’and‘non-improvement’(including‘no change’and‘exacerbation’).Results:Among 101 patients with type 1 AIP,52(51.5%)patients were complicated with DM at the time of AIP diagnosis,with 36 patients in the cDM group and 16 patients in the pDM *** incidences of diffuse pancreatic swelling(72.2%)and pancreatic body/tail involvement(91.7%)were significantly higher in the cDM group than in both the pDM and nDM *** the 52 patients with DM,CST was administered in 48 *** logistic analysis identified that elevated serum gamma-glutamyl transferase(GGT)level at AIP diagnosis[odds ratio(OR)=0.032,95%confidence interval(CI):0.003-0.412,P=0.008]and pancreatic atrophy after CST(OR=0.027,95%CI:0.003-0.295,P=0.003)were negatively associated with DM control ***:Patients with diffuse pancreatic swelling and pancreatic body/tail involvement in pancreatitis tended to be complicated with cDM at AIP *** exerted a beneficial effect on the clinical course of DM in nearly half of the AIP patients complicated with DM at diagnosis,particularly in those without elevated serum GGT levels at diagnosis and who did not experience pancreatic atrophy after CST.

关键词： Type 1 autoimmune pancreatitis Diabetes mellitus Corticosteroid therapy Predictive factor Pancreatic atrophy

Pluggable multitask diffractive neural networks based on cascaded metasurfaces

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Opto-Electronic Advances 2024年第2期7卷 23-31页

作者： Cong He Dan Zhao Fei Fan Hongqiang Zhou Xin Li Yao Li Junjie Li Fei Dong yin-xiao Miao Yongtian Wang Lingling Huang Beijing Engineering Research Center of Mixed Reality and Advanced Display Key Laboratory of Photoelectronic Imaging Technology and System of Ministry of Education of ChinaSchool of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China Institute of Modern Optics Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network TechnologyNankai UniversityTianjin 300350China Department of Physics and Optoelectronics Faculty of ScienceBeijing University of TechnologyBeijing 100124China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100191China Beijing Aerospace Institute for Metrology and Measurement Technology Beijing 100076China

Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering *** has been considered as one of the powerful tools in promoting the fields of imaging processing and object ***,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems *** push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal *** the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared ***,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems.

关键词： optical neural networks diffractive deep neural networks cascaded metasurfaces

Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

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World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-Xun Zhou xiao-Qing Li Sheng-Yu Zhang Yang Chen xiao-yin Bai Hong Yang Yu-Jie Zhang Peng-Yu Zhao Ji Li Jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis

国际贸易网络拓扑结构及经济增长效应研究——以半导体贸易为例

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数理统计与管理 2024年第3期43卷 493-511页

作者：尹潇潇石磊东北财经大学经济学院辽宁大连116025 云南财经大学统计与数学学院云南昆明650221

本文在数字经济发展背景下,选择作为数字经济建设基础的半导体为研究对象,使用2001-2020年联合国商品贸易数据库HS编码为8541的半导体贸易数据,基于复杂网络分析方法构建有向加权半导体国际贸易网络,并分析了其拓扑结构特征。通过面板... 详细信息

本文在数字经济发展背景下,选择作为数字经济建设基础的半导体为研究对象,使用2001-2020年联合国商品贸易数据库HS编码为8541的半导体贸易数据,基于复杂网络分析方法构建有向加权半导体国际贸易网络,并分析了其拓扑结构特征。通过面板回归模型,探究网络拓扑结构对全球经济增长的影响及其作用机制。研究发现,半导体国际贸易网络呈现小世界网络特性,中国和美国拥有较高的入度、接近中心性和特征向量中心性,他们均居于网络的中心,中国的中心性地位持续上升,但是美国地位下降。半导体国际贸易网络个体中心性的提升显著促进经济增长,一个国家(地区)在网络中越活跃、越处于中心以及影响力越大,经济增长越快。机制分析结果表明,网络中心结构通过技术创新推动经济发展。此外,一国(地区)是否为“一带一路”沿线国家(地区)和OECD成员对网络中心性与经济增长之间的关系产生异质性影响。本文综合复杂网络和计量理论方法,从经济全球化视角为中国半导体产业发展和经济增长提供了政策建议,同时也为经济问题分析提供新的研究思路。

关键词：半导体国际贸易网络网络拓扑结构技术创新经济增长

Can yin-Chai-xiao-Du decoction be useful of COVID-19?the mechanism research based on network pharmacology

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Traditional Medicine Research 2020年第4期5卷 188-200页

作者： Lu Yang Ning Li Hai-Bo Hu Bin yin Guo-Jing Zhao Feng-Chan Wang Xu-Hui Wang Hong-Wu Wang Xue-Chao Lu Huan-Tian Cui Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China First Clinical Hospital Shandong University of Traditional Chinese MedicineJinan 250000China Department of Pulmonary Disease in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266700China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250000China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China

Background:In this study,we preliminarily investigated the mechanism of yin-Chai-xiao-Du decoction for the treatment of COVID-19 by the method of network ***:The potential targets and pathways of yin-Chai-xiao-Du decoction for the treatment of COVID-19 were examined using network pharmacology;the ingredient and active targets of yin-Chai-xiao-Du decoction were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper databases;the COVID-19-related targets were obtained from the online Mendelian inheritance in man,GeneCards,and GeneMANIA databases;the STRING database and Cytoscape were used to build a protein-protein interaction network,and a Network Analyzer tool was used to perform topology analysis to screen for the key ingredients and targets;the ClueGO and KOBAS 3.0 databases were for the enrichment analysis of gene function(Gene Oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes);the herb-ingredient-target-pathway network diagram was constructed by ***:The core herbs screened by the network pharmacological analysis were Jinyinhua(Lonicerae japonicae flos),Lianqiao(Forsythia suspensa),Chaihu(Bupleuri radix),Huangqin(Scutellariae radix),yinchen(Herba Artemisiae Scopariae),Guanghuoxiang(Pogostemonis herba),Roudoukou(Semen myristicae)and Qinghao(Artemisiae annuae herba).A total of 293 active ingredients were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the key ingredients were quercetin,kaempferol,isorhamnetin,stigmasterol,beta-sitosterol,and ***-Chai-xiao-Du decoction has 138 COVID-19-related targets,and the key targets were mitogen-activated protein kinase 3,interleukin-6,tumor necrosis factor,vascular endothelial growth factor A,and CC motif ligand *** Encyclopedia of Genes and Genomes analysis revealed 120 enriched gene pathways,and the key pathways were signaling by interleukins,immune system,c

关键词： Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6

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肝内胆管结石与肝内胆管癌相关性研究进展

中国实用外科杂志 2024年第3期44卷 287-291页

作者：殷晓煜石殷浩中山大学附属第一医院胆胰外科广东广州510080

肝内胆管结石是指发生于左、右肝管汇合部之上的结石,在我国是一种常见的胆道良性疾病。肝内胆管癌是第二常见的肝脏原发性恶性肿瘤,其发生可能与肝内胆管结石、原发性硬化性胆管炎、先天性胆管囊性扩张症、乙肝与丙肝病毒感染以及胆道... 详细信息

肝内胆管结石是指发生于左、右肝管汇合部之上的结石,在我国是一种常见的胆道良性疾病。肝内胆管癌是第二常见的肝脏原发性恶性肿瘤,其发生可能与肝内胆管结石、原发性硬化性胆管炎、先天性胆管囊性扩张症、乙肝与丙肝病毒感染以及胆道寄生虫病等有关。鉴于我国肝内胆管结石具有高发的特点,其在诱发肝内胆管癌中的作用及潜在机制应予高度重视。从病理解剖来看,与肝内胆管结石相关的肝内胆管癌包含了从胆管内乳头状肿瘤(IPNB)、胆管上皮内瘤变(BilIN)到胆管癌不同阶段的特征。从分子层面来看,肝内胆管癌组织中炎症因子的过表达及转录因子、生长因子的功能紊乱,诱导了正常胆管上皮细胞的癌变。同时,肿瘤微环境中免疫细胞分群的变化进一步加重了肿瘤的恶性行为。这些特点提示结石对所在胆管部位的慢性机械及炎症刺激是造成胆管上皮癌变的重要原因。针对肝内胆管癌恶性程度高、治疗效果差的特点,有关肝内胆管结石诱发胆管癌的具体机制需要更多、更深入的研究,以便在早期发现胆管细胞癌变的证据及潜在的药物靶点,做到早期干预,提高这类病人的治疗效果及远期预后。

关键词：肝内胆管结石肝内胆管癌危险因素机制

开挖作用下滑剪破坏下盘边坡扰动范围计算及稳定性评价方法

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Journal of Central South University 2024年第2期31卷 589-601页

作者：秦辉汤华尹小涛程谞 State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

滑剪破坏型下盘边坡是矿山工程中经常出现的一种顺层边坡,具有突发性强、破坏范围广的特点。如何快速、准确地确定开挖塑性扰动区并评估其稳定性对边坡安全控制至关重要。本文首先通过数值模拟揭示了该类边坡的破坏模式和特征。然后,根... 详细信息

滑剪破坏型下盘边坡是矿山工程中经常出现的一种顺层边坡,具有突发性强、破坏范围广的特点。如何快速、准确地确定开挖塑性扰动区并评估其稳定性对边坡安全控制至关重要。本文首先通过数值模拟揭示了该类边坡的破坏模式和特征。然后,根据其破坏模式,建立了描述开挖扰动区的数学方程。最后,提出了一种计算下盘边坡开挖扰动区和稳定性的力学截断新方法(MTM)。主要结果有,MTM方法考虑岩体单轴抗压强度,计算过程无需一般极限平衡方法需要的多次循环迭代,计算过程简便。MTM方法可以准确地表征扰动区,计算得到的极限边坡高度、扰动厚度和安全系数与数值模拟结果较吻合,且评价结果比数值模拟更安全。扰动区的最大厚度决定了锚索锚固端的深度,分区是为了指明加固的重点范围。该方法为下盘边坡的工程施工和监测提供指导。

关键词：下盘边坡滑剪破坏失效机制力学截断法扰动区稳定性分析

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平台数字劳动的伦理困境、根源及其纾解

河南社会科学 2024年第1期32卷 109-116页

作者：殷筱程嘉妮华中师范大学马克思主义学院湖北武汉430079

数字劳动是数字信息技术催生的新型劳动形态,成为与传统劳动共在的劳动范式。在数字劳动治理中,平台数字劳动是重点之一。平台数字劳动作为资本与技术相互融合的产物,由于受到资本逐利本性的驱动以及监管体系的相对滞后,在带来满足和愉... 详细信息

数字劳动是数字信息技术催生的新型劳动形态,成为与传统劳动共在的劳动范式。在数字劳动治理中,平台数字劳动是重点之一。平台数字劳动作为资本与技术相互融合的产物,由于受到资本逐利本性的驱动以及监管体系的相对滞后,在带来满足和愉悦的表象背后,消解了平台数字劳动者的主体性,隐含着资本对劳动自由、劳动公平等劳动伦理的侵蚀。为了有效纾解数字劳动的伦理困境,需要制定出科学的数字时代劳动法规,加强对平台算法自身的伦理构建,深化对算法平台的伦理审查和监管,提升平台数字劳动者的算法素养,进而最大化维护平台数字劳动者的合法权益。

关键词：平台数字劳动算法技术伦理困境劳动者权益伦理审查

经济规模与经济增长内生动力变动——来自国际经验的证据

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经济学家 2024年第3期 45-55页

作者：王强刘晓音上海海关学院工商管理与关务学院

本文通过引入经济规模变量构建了经济增长内生动力演变的理论分析框架,分析了经济增长动力的演变机制和路径,并利用国际面板数据实证检验了经济动能转换阶段经济增长的动力因素变动。研究发现,经济发展动能的转换存在一定的演变机制,随... 详细信息

本文通过引入经济规模变量构建了经济增长内生动力演变的理论分析框架,分析了经济增长动力的演变机制和路径,并利用国际面板数据实证检验了经济动能转换阶段经济增长的动力因素变动。研究发现,经济发展动能的转换存在一定的演变机制,随着经济规模的扩大,经济增长的动力逐渐由外循环动力向内循环动力转变。其中,出口、政府支出对经济增长的推动作用减弱,而居民消费、私人投资、技术创新、资源配置效率提升等因素对经济增长的拉动作用增强;通货膨胀、汇率变动、人口老龄化等因素对经济增长有明显的负向影响。本文研究结论表明,中等收入国家在经济发展动能转换的阶段应着眼于本国实际,适时调整经济政策保持经济增长内生动力的持续性和稳定性,这是成功跨入高收入国家的关键。

关键词：经济规模经济增长内生动力变动动态面板模型