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Traditional Medicine Research 2023年第10期8卷 56-68页

作者： Jing Jin yin-Yue xu Wen-Ping Liu Ke-Hua Hu Ning xue Zu-Guo Zheng State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Acupuncture Jurong Hospital Affiliated to Jiangsu UniversityZhenjiang 212499China

Background:The purpose of the study was to investigatethe active ingredients and potential biochemicalmechanisms of Simiao Wan(SMW)in obesity-associated insulin ***:An integrated network pharmacology method to screen the active compoundsand candidate targets,construct the protein-protein-interaction network,and ingredients-targets-pathways network was constructed for topological analysis to identify core targets and main *** find the possible signaling pathways,enrichment analysis was ***,a model of insulin resistance in HL-7702 cells was established to verify the impact of SMW and the regulatory ***:An overall of 63 active components and 151 candidate targets were obtained,in which flavonoids were the main *** analysis indicated that the PI3K-Akt signaling pathway was the potential pathway regulated by SMW in obesity-associated insulin resistance *** result showed that SMW could significantly ameliorate insulin sensitivity,increase glucose synthesis and glucose utilization and reduce intracellular lipids accumulation in ***,SMW inhibited diacylglycerols accumulation-induced PKCεactivity and decreased its translocation to the ***:SMW ameliorated obesity-associated insulin resistance through PKCε/IRS-1/PI3K/Akt signaling axis in hepatocytes,providing a new strategy for metabolic disease treatment.

关键词： Simiao Wan insulin resistance PKCε/IRS-1/PI3K/Akt signaling pathway network pharmacology DAG

The On-Vehicle Inspection System Based on Passive UHF RFID

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微计算机信息 2010年第32期26卷 133-134,198页

作者： HUANG yin-long xu xu TAN Guang-yun The Third Institute of Ministry of Public Security Shanghai200031 China

This article introduces a design theory of vehicle-related management in forms of system linkage in a certain close *** analyses the technology advantages,working principles,system structures and design solutions of the scene inspection system based on passive UHF RFID technology,which has functions of data capturing,image collection,wireless data transmission and provision of warning *** system enables scene disposal of vehicle-related management in a specific environment,people management in large-scale events and management of important *** system has the capability of rapid network connection and scene inspection especially in emergencies and public security affairs,in which advance deployment is normally *** system has been successfully applied in the vehicle safety monitoring system in the 2010 Shanghai World Expo Park.

关键词： mobile network on-vehicle system RFID image identification

The impact of female sex hormones on cardiovascular disease:from mechanisms to hormone therapy

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Journal of Geriatric Cardiology 2024年第6期21卷 669-681页

作者： Yi KAN Yu-Lu PENG Ze-Hao ZHAO Shu-Tong DONG yin-Xiao xu Xiao-Teng MA Xiao-Li LIU Yu-Yang LIU Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness from the *** pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex *** and progestogen impact cardiovascular system through genomic and non-genomic *** menopause,cardiovascular protective effects of estrogens have been well *** were often used in combination with estrogens in hormone *** in sex hormone levels,particularly estrogen deficiency,were considered the specific risk factor in women’s cardiovascular ***,considerable heterogeneity in the impact of hormone therapy was observed in clinical *** heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone *** review will delve into the pathogenesis and hormone therapy,summarizing the effect of female sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardiovascular risk factors specific to women.

关键词： impact dosage protective

因性别而异的多重阐释——当代藏族女作家汉语小说中男性形象塑造分析

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民族文学研究 2019年第5期37卷 50-56页

作者：徐寅天津财经大学人文学院

20世纪80年代以来,藏族汉语小说的发展呈现出了质的飞跃。结合部落文化、草原文化、都市文化以及寺院文化各自的特点,藏族女作家们在小说创作中对同族男性投以别样关注,这一方面显示出地域、族裔、宗教等多种文化综合的影响,另一方面又... 详细信息

20世纪80年代以来,藏族汉语小说的发展呈现出了质的飞跃。结合部落文化、草原文化、都市文化以及寺院文化各自的特点,藏族女作家们在小说创作中对同族男性投以别样关注,这一方面显示出地域、族裔、宗教等多种文化综合的影响,另一方面又具有女性性别视角下的独特观照。女作家通过笔下富有代表性的四类男性形象塑造体现出她们因性别而异的美学思考,对其进行解读,能够对藏族社会生活中男性地位有进一步的认识和了解。

关键词：藏族汉语小说女作家男性形象

Chiral symmetry restoration and properties of Goldstone bosons at finite temperature

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Chinese Physics C 2023年第3期47卷 84-92页

作者：徐胤禛秦思学宗红石 Department of physics Nanjing UniversityNanjing 210093China Department of Physics Chongqing UniversityChongqing 401331China Chongqing Key Laboratory for Strongly-Coupled Physics Chongqing 401331China Department of physics Anhui Normal UniversityWuhu 241000China Nanjing Proton Source Research and Design Center Nanjing 210093China Joint Center for Particle Nuclear Physics and CosmologyNanjing 210093China

We study chiral symmetry restoration by analyzing thermal properties of QCD's(pseudo-)Goldstone bo-sons,especially the *** meson properties are obtained from the spectral densities of mesonic imaginary-time correlation *** obtain the correlation functions,we solve the Dyson-Schwinger equations and the inhomo-geneous Bethe-Salpeter equations in the leading symmetry-preserving rainbow-ladder *** chiral limit,the pion and its partner sigma degenerate at the critical temperature T_(c).At T≥T_(c),it was found that the pion rapidly dissociates,which signals deconfinement phase *** the chiral limit,the pion dissociation temperature can be used to define the pseudo-critical temperature of the chiral phase crossover,which is consistent with that ob-tained by the maximum point of chiral susceptibility.A parallel analysis for kaon and pseudoscalar ss suggests that heavymesons maysurviveabove T_(c).

关键词： chiral symmetry restoration finite temperature meson properties Dyson-Schwinger equa-tions correlation functions

A PCR-based Rapid Neutralization Assay for GⅡ.4 Norovirus Infection in HIEC6 Cell Culture

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Biomedical and Environmental Sciences 2015年第3期28卷 219-221页

作者： FAN Yi Sun LIU Cheng ZHU Hui Juan DING Yi ZENG Wan Jie yin xu Fang DING Shuang Shuang ZHANG Jun Clinical Laboratory Suzhou Kowloon HospitalShanghai Jiao Tong University Medical School Suzhou Center for Disease Prevention and Control Department of Epidemiology School of Public HealthJiangsu Key Laboratory and Translational Medicine for Geriatric DiseaseMedical College of Soochow University Suzhou Industrial Park Centers for Disease Control and Prevention(Institute of Health Inspection and Supervision)

Because of limited viral replication and lack of cytopathic effect in cell culture,a new PCR-based rapid seroneutralization assay for detection of GII.4norovirus neutralized antibodies was developed with serum samples from acute-phase patients,convalescent-phase patients and healthy *** to this study,neutralizing antibodies were detected in 100% ofconvalescent-phase sera, and in 2.5% of healthy controls sera. However, all of the acute-phase serum samples could not neutralize virus efficiently. Compared to the results from ELISA （96.2% at sensitivity and 80% at specificity）, the present in vitro neutralization assay is more specific and more sensitive.

关键词： Infection replication diluted stored titer Jiangsu processed capture approval genomic

Small-current grounding fault location method based on transient main resonance frequency analysis

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Global Energy Interconnection 2020年第4期3卷 324-334页

作者： Yongjie Zhang Xiaojun Wang Junjuan Li yin xu Guohong Wu School of Electrical Engineering Beijing Jiaotong UniversityBeijing100044China State Grid Lanzhou Electric Power Company LanzhouGansu730070China Dept.Of Electrical&Electronics Eng. Tohoku Gakuin University1-13-1ChuoTagajoMiyagi Prefecture9858537Japan

The small-current grounding fault in distribution network is hard to be located because of its weak fault *** accurately locate the faults,the transient process is analyzed in this *** the study we take that the main resonant frequency and its corresponding component is related to the fault *** on this,a fault location method based on double-end wavelet energy ratio at the scale corresponding to the main resonant frequency is *** back propagation neural network(BPNN)is selected to fit the non-linear relationship between the wavelet energy ratio and fault *** performance of this proposed method has been verified in different scenarios of a simulation model in PSCAD/EMTDC.

关键词： Small-current grounding fault location Main resonant frequency Double-end wavelet energy ratio Backpropagation neural network(BPNN)

Practice of Teaching Reform of Information System Design and Implementation

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Practice of Teaching Reform of Information System Design and...

Transforming growth factor beta1 signaling modulates function of primary sensory neurons and contributes to pancreatic hyperalgesia in rats with chronic pancreatitis

2013教育技术与信息系统国际会议

作者： xu yin xueifei Liu Jingfan Hu Computer School Beijing Information Science & Technology University

Practice is one of the effective ways to develop innovate ability of students. In order to solve the gap between professional theoretical knowledge in the teaching process and ability of analyzing and solving practical problems, changing the traditional teaching mode, adopting case teaching method, highlighting a problem in the case of multiple solutions, and integrating multiple knowledge related can broaden the depth and breadth of knowledge of students and truly improve students’ thinking skills and the ability of innovation.

关键词： practice teaching case-driven engineering education information systems

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Transforming growth factor beta1 signaling modulates functio...

The Pig Lhx8 Gene:cDNA Cloning,Bioinformatic Analysis and Expression Level in Tissues and Preimplantation Embryos

中华医学会疼痛学分会第十一届学术年会

作者： Xiao-yu Zhang Guang-yin xu Institute of Neuroscience Soochow University

＜正＞Background:Transforming growth factor beta1（TGFβ1） is upregulated in chronic inflammation,where it plays a key role in wound healing and promoting ***,the role of TGFβ1 in nociceptive processing in primary sensory neurons remains *** aim of this study is to investigate whether TGFβ1 plays a role in hyperalgesia in chronic pancreatitis（CP） and the underlying mechanisms.

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Agricultural Sciences in China 2009年第12期8卷 1503-1510页

作者： FANG Wei,LI Gui-qiang,LI Mei-li,WANG Wei and xu yin-xue College of Animal Science & Technology,Nanjing Agricultural University,Nanjing 210095,P.R.China College of Animal Science & Technology Nanjing Agricultural University Nanjing 210095 P.R. China

Evidence has shown in mouse that Lhx8 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis. In the current paper, attempts were made to clone and characterize a gene encoding Lhx8 from pig. Rapid amplification of cDNA ends （RACE） gave rise to a full-length of Lhx8 which contained 1 681 bp nucleotides, with a complete open reading frame of 885 bp, encoding a 295 amino acid polypeptide. Homology search and sequence multialignment demonstrated that the deduced pig Lhx8 protein sequence shared a high identity with Lhx8 from other mammals, including several highly conservative motifs and amino acids. The phylogenetic tree of the LIM superfamily proteins has been constructed to reveal the evolutionary relationship of various species. RT-PCR analysis showed that the Lhx8 gene was expressed in gonad and immunity tissues. In preimplantation embryos, Lhx8 mRNA expression profiling using realtime PCR revealed that its mRNA levels were highest in 4-cell stage embryos and gradually decreased until the blastocyst stage.

关键词： pig LhxS molecular cloning mRNA expression qRT-PCR preimplantation embryos