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Phenolics-saponins rich fraction of defatted kenaf seed meal exhibits cytotoxicity towards cancer cell lines

Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 404-409页

作者： Latifah Saiful Yazan Napsiah Abd Rahman Kim Wei Chan Wan Nor Hafiza Wan Abd Ghani yin sim tor Jhi Biau Foo Laboratory of Molecular Biomedicine Institute of BioscienceUniversiti Putra Malaysia (UPM) Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia (UPM)

Objectives: To determine the cytotoxicity of crude ethanolic extract, n-butanol fraction and aqueous fraction on selected cancer cell lines, and to observe the morphological changes of the cancer cells treated with n-butanol ***: The cytotoxic effect of n-butanol fraction, crude ethanolic extract and aqueous fraction on breast cancer(MCF-7 and MDA-MB-231), colon cancer(HT29), lung cancer(A549), cervical cancer(He La) and normal mouse fibroblast(3T3) cell lines was determined using MTT assay. The morphological changes of the treated cells were observed under an inverted light ***: n-Butanol fraction was the most cytotoxic towards HT29 and MCF-7 cells in a dose-dependent manner compared to crude ethanolic extract and aqueous fraction(P < 0.05). The IC50 of n-butanol fraction for HT29 and MCF-7 was(780.00 ± 28.28)and(895.00 ± 7.07) mg/m L, respectively. Cell shrinkage, membrane blebbing and formation of apoptotic bodies were noted following treatment of HT29 cells with n-butanol ***: In conclusion, n-butanol fraction was more cytotoxic than crude ethanolic extract and aqueous fraction towards the selected cancerous cell lines and induced apoptosis in HT29 cells.

关键词： Defatted kenaf seed meal Phenolic-saponin rich fraction Cytotoxic Apoptosis

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Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1018-1026页

作者： Latifah Saiful Yazan Yong Sze Ong Nur Elena Zaaba Razana Mohd Ali Jhi Biau Foo yin sim tor Laboratory of Molecular Biomedicine Institute of Bioscience Universiti Putra Malaysia Department of Biomedical Science Faculty of Medicine and Health Sciences Universiti Putra Malaysia Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia

Objective:To determine the anti-breast cancer activities and the safety oral consumption of Dillenia suffruticosa root aqueous extract(DRAE)in BALB/c ***:In the anti-breast cancer study,female BALB/c mice were divided into five groups(n=12),which were(1)positive control(with breast cancer,untreated),(2)negative control(without breast cancer,untreated)and other three groups of mice with breast cancer treated with 1 000,500 and 250 mg/kg of DRAE,respectively,by oral gavage for 28 *** mice except from the negative control group were injected into the mammary fat pad with 4T1 cells(1×1054T1 cells/0.1 m L of phosphate buffer solution).DRAE was administered orally on Day 11 after the tumor has ***:The tumor volume of the 1 000 mg/kg of DRAE group reduced significantly compared to the positive control while treatment with 500 mg/kg of DRAE had significantly inhibited metastasis to the *** the acute toxicity study,treatment with up to5 000 mg/kg of DRAE was not toxic to the animals,indicating its safety when a large amount of this plant extract was *** on the sub-acute toxicity study,treatment of the highest dose of DRAE(1 000 mg/kg)had mild liver toxicity indicated by mild focal ***:DRAE possesses anti-breast cancer properties but at the same time it shows mild toxicity to the *** non observable adverse effect dose for DRAE is500 mg/kg.

关键词： Dillenia suffruticosa 4T1 Tumor-bearing mice Breas

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