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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei Feng Zi-Huang Cao Man I Lam Ran Li Hao Tian Da-Yi yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan Yi-Qiao Dong Xin-Feng Li Wei Wang Long Li Hugh RAJones Yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

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Nurse-led cancer care:A scope review of the past years (2003-2016)

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International Journal of Nursing Sciences 2017年第2期4卷 184-195页

作者： Xiao Bin Lai Shirley Siu yin Ching Frances Kam Yuet wong School of Nursing Fudan UniversityShanghaiChina School of Nursing The Hong Kong Polytechnic UniversityHung HomHong Kong

Nursing practice has been expanded greatly with time passing *** innovative form of nursing practice is nurse-led *** term“nurse-led care/service”has been introduced in nursing discipline for years as early as in 1960s[1].Later,several nurse-led services were reported in 1980s and 1990s[2-7].The common characteristics in these units were that the nurses provided additional things to improve patients'care,and the standard of practice was extremely high[8].The accelerating development of nurse-led care was triggered by the health care system reform in United Kingdom(UK)around *** 1999,the UK government document‘Making a difference’was published[9],under the pressure of redesigning services to reduce waiting time and medical cost and to meet shortfalls in junior medical staffing[10].Since then,nurse-led care has been reported in increasing studies[11].

关键词： nurse services expanded

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Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5046-5058页

作者： Huangcan Li Xiong Wang Yiran Wang Yichen Li ying Chen yin-Ting wong Jufang He Ming-Liang He Department of Biomedical Sciences City University of Hong KongHong KongChina CityU Shenzhen Research Institute NanshanShenzhenChina Department of Neurosciences City University of Hong KongHong KongChina

variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for ***,the way by viruses target IFN-signaling extracellularly has not been *** by both coronavirus SARS-CoV-2 and enterovi... 详细信息

关键词： immunity diseases eliminating

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Acquisition repeatability of MRI radiomics features in the head and neck:a dual-3D-sequence multi-scan study

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 115-127页

作者： Cindy Xue Jing Yuan Yihang Zhou Oi Lei wong Kin yin Cheung Siu Ki Yu Research Department Hong Kong Sanatorium&HospitalHong KongChina Medical Physics Department Hong Kong Sanatorium&HospitalHong KongChina

Radiomics has increasingly been investigated as a potential biomarker in quantitative imaging to facilitate personalized diagnosis and treatment of head and neck cancer(HNC),a group of malignancies associated with high ***,the feature reliability of radiomics is a major obstacle to its broad validity and generality in application to the highly heterogeneous head and neck(HN)*** particular,feature repeatability of radiomics in magnetic resonance imaging(MRI)acquisition,which is considered a crucial confounding factor of radiomics feature reliability,is still sparsely *** study prospectively investigated the acquisition repeatability of 93 MRI radiomics features in ten HN tissues of 15 healthy volunteers,aiming for potential magnetic resonance-guided radiotherapy(MRgRT)treatment of *** subject underwent four MRI acquisitions with MRgRT treatment position and immobilization using two pulse sequences of 3D T1-weighed turbo spin-echo and 3D T2-weighed turbo spin-echo on a 1.5T MRI *** repeatability of radiomics feature acquisition was evaluated in terms of the intraclass correlation coefficient(ICC),whereas within-subject acquisition variability was evaluated in terms of the coefficient of variation(CV).The results showed that MRI radiomics features exhibited heterogeneous acquisition variability and uncertainty dependent on feature types,tissues,and pulse *** a small fraction of features showed excellent acquisition repeatability(ICC>0.9)and low within-subject *** MRI scans improved the accuracy and confidence of the identification of reliable features concerning MRI acquisition compared to simple test-retest repeated *** study contributes to the literature on the reliability of radiomics features with respect to MRI acquisition and the selection of reliable radiomics features for use in modeling in future HNC MRgRT applications.

关键词： Radiomics Magnetic resonance guided radiotherapy Head and neck Repeatability Intraclass correlation coefficient

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VR and AR in human performance research―An NUS experience

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Virtual Reality & Intelligent Hardware 2020年第5期2卷 381-393页

作者： Jun-Hao yin Chin-Boon CHNG Pooi-Mun wong Nicholas HO Matthew CHUA Chee-Kong CHUI Department of Mechanical Engineering National University of Singapore119077Singapore Institute of Systems Science National University of Singapore119077Singapore

With the mindset of constant improvement in efficiency and safety in the workspace and training in Singapore,there is a need to explore varying technologies and their capabilities to fulfil this *** ability of Virtual Reality(VR)and Augmented Reality(AR)to create an immersive experience of tying the virtual and physical environments coupled with information filtering capabilities brings a possibility of introducing this technology into the training process and *** paper surveys current research trends,findings and limitation of VR and AR in its effect on human performance,specifically in Singapore,and our experience in the National University of Singapore(NUS).

关键词： Human computer interaction Virtual environment Human performance

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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility

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Frontiers of Medicine 2015年第3期9卷 331-343页

作者： Felice Ho-Ching Tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-yin Fan Joyce Man-Fong Lee Carmen Chak-Lui wong Irene Oi-Lin Ng Chun-Ming wong State Key Laboratory for Liver Research and Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong HongKong SAR China

MicroRNAs （miRNAs）, an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level, miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantly downregulated in hepatocellular carcinoma （HCC） and their expression levels decreased as the disease progressed. The ectopic expression of miR-142 significantly reduced HCC cell migration and invasion. Overexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperatively regulate cell movement, miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3＇- and 5＇-strands of the precursor miR-142, target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in human HCC cells. Moreover, overexpression of miR-142 significantly abrogated stress fiber formation in HCC cells and led to cell shrinkage. This study shows that mature miR-142 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of HCC cells.

关键词： hepatocellular carcinoma microRNA metastasis cytoskeletal reorganization

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Effect of ryanodine on adrenergic stimulation in rat smooth muscle cells

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中国药理学与毒理学杂志 1991年第4期5卷 255-260页

作者： Jean P BOURREAU ZD ZHANG Chiu-yin kwan Department of Biomedical Sciences Division of Physiology and PharmacologySmooth Muscle Research ProgramMcMaster University1200 Main Street WestHamiltonOntarioCanada L8N 3Z5

Norepinephrine(NE)endogenously released following electrical field stimulation(prazosin and TTX sensitive responses),produced a biphasic contraction of the rat vas deferens(RVD).The initial transient contraction was decreased by 30μmol/L ryanodine andμmol/L nifedipine while the secondary component was abolished by 2μmol/L nifedipine but increased by 30μmol/L *** added NE produced biphasic contractions of the *** contractions were inhibited by 2μmol/L ***(30μmol/L)decreased both phases by about 50%.We conclude that ryanodine binding sites reside in RVD endoplasmic reticulum(ER).There was a lack of uniformity in the effect of ryanodine against different phases of alpha-adrenergic stimulation may be indicative of two modes of stimulation-contraction coupling process related to this stimulation.

关键词： ryanodine smooth muscle nor epinephrine rat vas deferens

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In vivo genome editing thrives with diversified CRISPR technologies

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Zoological Research 2018年第2期39卷 58-71页

作者： Xun Ma Avery Sum-Yu wong Hei-yin Tam Samuel Yung-Kin Tsui Dittman Lai-Shun Chung Bo Feng Key Laboratory for Regenerative Medicine in Ministry of Education School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences SBS Core Laboratory CUHK Shenzhen Research Institute

Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site- specific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies. These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research.

关键词： CRISPR/Cas9 Genome editing Animal models

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Fine-tune chiroptical activity in discrete chiral Au nanorods

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Nano Research 2022年第7期15卷 6574-6581页

作者： Guangchao Zheng Sulin Jiao Wei Zhang Shenli Wang Qinghua Zhang Lin Gu Weixiang Ye Junjun Li Xiaochen Ren Zhicheng Zhang Kwok-yin wong School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityKowloonHong KongChina Institute of Applied Physics and Computational Mathematics Beijing 100088China School of Food Science and Engineering Henan University of TechnologyZhengzhou 450001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Applied Physics School of ScienceHainan UniversityHaikou 570228China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin University&Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China

Accurate researches on the surface plasmon resonance(SPR)-based applications of chiral plasmonic metal nanoparticles(NPs)still remain a great ***,a series of chiral plasmonic metal NPs,e.g.,chiral Au nanorods(c-Au NRs),c-Au@Ag core–shell,and c-Au@TiO_(2) core–shell NRs,with different chiroptical activities have been *** circular dichroism(PCD)bands of c-Au NRs can be precisely tailored by tuning the longitudinal SPR(LSPR)and amount of Au NRs as ***,a shift of PCD bands within ultraviolet–visible–near infrared ray(UV–vis–NIR)region can also be achieved through the functionalization of a shell of another metal or ***,chirality transfer from c-Au core to Ag shell leads to new PCD bands at the near-UV *** tuning of PCD bands and chirality transfer are confirmed by our developed theoretical *** chiral Au NRs-based chiral plasmonic nanomaterials with tunable chiroptical activities will be helpful to understand the structure-direct PCD and to extend circularly polarized-based applications.

关键词： chiral Au nanorods(c-Au NRs) surface plasmon resonance optical activity chirality transfer

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Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China

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Chinese Science Bulletin 2008年第4期53卷 501-507页

作者： WANG Yuan YEUNG Leo Wai yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul kwan Sing Centre for Coastal Pollution and Conservation Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Tong HKSAR China National Institute of Advanced Industrial Science and Technology (AIST) 16-10nogawa Tsukuba Ibaraki 305-8569 Japan

The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much *** human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other *** objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg *** pooled egg samples from eight locations were analyzed for 11 *** results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/*** results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations.

关键词：中国鸡蛋人体健康风险评估污染物含氟化合物全氟辛烷磺酸

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