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General anesthetic agents induce neurotoxicity through astrocytes

Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li dandan Yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong Hu Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Anesthesiology Ningbo Women and Children’s HospitalNingboZhejiang ProvinceChina Department of Anesthesiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouZhejiang ProvinceChina Cell Biology Department Yale UniversityNew HavenCTUSA Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPAUSA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial *** studies,however,have focused on the effects of general anesthetic agents on neuroglia or *** can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive ***,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of *** would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular *** this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous *** hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

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成都冬季相对湿度概率分布及其污染效应研究

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环境科学与技术 2019年第S2期42卷 232-237页

作者：尹单丹倪长健石荞语朱育雷邓佩云成都信息工程大学大气科学学院四川成都610225 高原大气与环境四川省重点实验室四川成都610225

为研究城市空气湿度变化特征以及其对颗粒物浓度的影响,文章以成都为例,利用相对湿度和PM2.5浓度数据,对成都2014-2017年冬季12-2月相对湿度的概率分布特征及其污染效应进行分析,结果表明:(1)Lorentz概率密度函数拟合效果最佳,并通过a=0... 详细信息

为研究城市空气湿度变化特征以及其对颗粒物浓度的影响,文章以成都为例,利用相对湿度和PM2.5浓度数据,对成都2014-2017年冬季12-2月相对湿度的概率分布特征及其污染效应进行分析,结果表明:(1)Lorentz概率密度函数拟合效果最佳,并通过a=0.01显著性检验,因此该函数是表征成都冬季相对湿度概率分布特征的最优函数;(2)空气质量较好时,相对湿度在各区间分布较为均匀,而空气质量较差时,呈现低相对湿度状态缓慢增长、高相对湿度状态爆发性增长的趋势,且伴随污染等级的加重,高相对湿度状态对应的爆发性增长愈加明显;(3)轻度污染、中度污染和重度污染等级的样本量较多,而优、良和严重污染等级较少,说明成都冬季整体空气质量较差,污染较为严重。

关键词：成都冬季相对湿度概率密度函数污染效应

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A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 102-114页

作者： Cuixia Zheng Lingling Sun Hongjuan Zhao Mengya Niu dandan Zhang Xinxin Liu Qingling Song Weijie Zhong Baojin Wang Yun Zhang Lei Wang School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Huaihe Hospital of Henan University Translational medicine CenterKaifeng 475000China Pingyuan Lab Henan Normal UniversityXinxiang 453007China Gynecology the Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Weihai Municipal Hospital Cheeloo College of MedicineShandong UniversityWeihai 264200China

Bacterial-based antitumor immunity has become a promising strategy to activate the immune system for fighting ***,the potential application of bacterial therapy is hindered by the presence of instability and susceptibility to infections within bacterial ***,monotherapy is ineffective in completely eliminating complex cancer with multiple contributing *** this study,based on our discovery that spore shell(SS)of Bacillus coagulans exhibits excellent tumor-targeting ability and adjuvant activity,we develop a biomimetic spore nanoplatform to boost bacteria-mediated antitumor therapy,chemodynamic therapy and antitumor immunity for synergistic cancer *** detail,SS is separated from probiotic spores and then attached to the surface of liposome(Lipo)that was loaded with hemoglobin(Hb),glucose oxidase(GOx)and JQ1to construct SS@Lipo/Hb/GOx/*** tumor tissue,highly toxic hydroxyl radicals(·OH)are generated via sequential catalytic reactions:GOx catalyzing glucose into H_(2)O_(2)and Fe^(2+)in Hb decomposing H_(2)O_(2)into·*** combination of·OH and SS adjuvant can improve tumor immunogenicity and activate immune ***,JQ1-mediated down-regulation of PD-L1 and Hb-induced hypoxia alleviation synergistically reshape immunosuppressive tumor microenvironment and potentiate immune *** this manner,SS@Lipo/Hb/GOx/JQ1 significantly suppresses tumor growth and *** summarize,the nanoplatform represents an optimum strategy to potentiate bacteria-based cancer immunotherapy.

关键词： Biomimetic spore shell Bacteria-mediated antitumor therapy Chemodynamic therapy Immunotherapy Tumor microenvironment

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Diagnosis,Treatment,and Associated Factors Among Patients with HCV Infection—Jiangsu Province,China,2004–2020

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China CDC weekly 2024年第1期6卷 1-5,I0001-I0003页

作者： dandan Yang Jing Lu Zhi Zhang Chuanwu Sun Zhuping Xu Yao Qi XiaoXia Liu Huan Ding Feifei Chai Zhengdong Zhang Baoli Zhu Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of Jiangsu ProvinceNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of XuzhouXuzhou CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of WuxiWuxi CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of YanchengYancheng CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of ZhenjiangZhenjiang CityJiangsu ProvinceChina.

What is already known on this topic?The global efforts to address the hepatitis C virus(HCV)are progressing,but there are still significant gaps in the diagnosis and treatment of HCV,leading to an increasing number of deaths related to *** is added by this report?An extensive investigation was conducted to assess HCV RNA diagnosis,treatment uptake,and associated factors among individuals infected with HCV within Jiangsu *** study encompassed a large geographical area and utilized a substantial sample *** are the implications for public health practice?Implementing focused interventions to improve the timely diagnosis of HCV RNA and increase the uptake of HCV treatment could effectively reduce the future burden of HCV-related health problems,deaths,and healthcare *** is essential for achieving the global target of eliminating hepatitis C.

关键词： diagnosis utilized Jiangsu

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Salt-melt synthesis of poly(heptazine imide)in binary alkali metal bromides for enhanced visible-light photocatalytic hydrogen production

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Interdisciplinary Materials 2024年第3期3卷 389-399页

作者： Yaxuan Jin dandan Zheng Zhongpu Fang Zhiming Pan Sibo Wang Yidong Hou Oleksandr Savateev Yongfan Zhang Guigang Zhang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou UniversityFuzhouChina College of Environment and Safety Engineering Fuzhou UniversityFuzhouChina Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong KongChina

Poly(heptazine imide)(PHI),a semicrystalline version of carbon nitride photocatalyst based on heptazine units,has gained significant attention for solar H_(2)production benefiting from its advantages including molecular synthetic versatility,excellent physicochemical stability and suitable energy band structure to capture visible ***,PHI is obtained in saltmelt synthesis in the presence of alkali metal ***,we examined the role of binary alkali metal bromides(LiBr/NaBr)with diverse compositions and melting points to rationally modulate the polymerization process,structure,and properties of *** characterizations revealed that semicrystalline PHI with a condensedπ-conjugated system and rapid charge separation rates were obtained in the presence of LiBr/***,the apparent quantum yield of hydrogen using the optimized PHI reaches up to 62.3%at 420 *** density functional theory calculation shows that the dehydrogenation of the ethylene glycol has a lower energy barrier than the dehydrogenation of the other alcohols from the thermodynamic point of *** study holds great promise for rational modulation of the structure and properties of conjugated polymeric materials.

关键词： crystallinity hydrogen evolution photocatalysis poly(heptazine imide) salt-melt synthesis

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补体调节蛋白在糖尿病肾脏病发病机制中的研究进展

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中华糖尿病杂志 2024年第6期16卷 718-722页

作者：尹清风孙丹丹马海军新乡医学院第一附属医院健康管理中心卫辉453100 新乡医学院第一附属医院风湿免疫科卫辉453100

糖尿病肾脏病(DKD)是终末期肾病的主要病因之一,其确切发病机制至今尚未完全阐明。补体过度活化参与DKD的发病及进展,近来的研究提示,补体调节蛋白通过影响补体系统活化在DKD的发病中发挥重要作用。该文将对补体调节蛋白在DKD的发病及... 详细信息

糖尿病肾脏病(DKD)是终末期肾病的主要病因之一,其确切发病机制至今尚未完全阐明。补体过度活化参与DKD的发病及进展,近来的研究提示,补体调节蛋白通过影响补体系统活化在DKD的发病中发挥重要作用。该文将对补体调节蛋白在DKD的发病及进展中的作用进行综述。

关键词：糖尿病肾脏病补体系统补体调节蛋白

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The Relationship between Social Support and the Parenting Sense of Competence of Preschoolers’Fathers:The Mediator Role of Psychological Capital

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Frontiers of Education in China 2024年第1期19卷 61-82页

作者： YUAN Haojie YUE Yaping WU dandan Faculty of Education Henan UniversityKaifeng 475004China Faculty of Education and Human Development The Education University of Hong KongHong Kong 999077China

Social support is an essential source of support for preschool children’s fathers to alleviate parenting anxiety,deal with parenting pressure,improve parenting methods,and enhance parenting sense of *** capital serves as a critical psychological resource for preschoolers’fathers,helping them cope with parenting stress and enhancing parenting *** explore the mediating mechanism of psychological capital between social support and the parenting sense of competence of preschoolers’fathers,this study employs stratified sampling to survey 678 fathers from three cities of Henan province in *** survey instruments mainly consist of the Social Support Rating Scale,Psychological Capital Questionnaire,and Parenting Sense of Competence *** findings show that social support,psychological capital,and fathers’parenting sense of competence are at the middle *** positive correlations exist among social support,psychological capital,and parenting sense of *** support can positively predict fathers’parenting sense of competence,while psychological capital partially mediates between social support and parenting sense of ***,it is possible to increase social support for preschool children’s fathers and improve their psychological capital to relieve their parenting pressure,enhance their parenting participation,and strengthen their parenting sense of competence.

关键词： fathers of preschoolers parenting sense of competence social support psychological capital

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Bioactive peptides alleviating oxidative stress-associated diseases by targeting the Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： dandan Qin Zuomin Hu Shuai Han Yi Luo Feiyan Yang Tiantian Xie Feijun Luo Hunan Key Laboratory of Grain-oil Deep Process and Quality Control， Hunan Key Laboratory of Forestry Edible Resources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Department of Gastroenterology， Xiangya Hospital， Central South University

Oxidative stress is caused by an imbalance of the antioxidant defense system and excessive production of free radicals， which can damage biological macromolecules such as proteins， lipids and nucleic acids， which can cause aging， ischemia-reperfusion injury， inflammatory injury， liver and kidney injury and other diseases. The nuclear factor erytheroid-2-related factor 2 (Nrf2) is a major regulator of redox balance. The Nrf2 pathway also exerts a central function in cell apoptosis， oxidative stress damage and metabolic diseases. Bioactive peptides are small molecular peptides composed of amino acid residues. They have many biological activities and play important physiological roles in human body. Antioxidant peptide is a kind of peptide which can reduce oxidative stress damage. They are safe， non-toxic and easily absorbed. In this review， we summarized the mechanism of bioactive peptides in regulating oxidative stress， especially antioxidant peptides， through regulating the Nrf2 signaling pathway and the expressions of oxidative stress-related genes， to alleviate oxidative stress-induced damage. The paper will provide valuable reference to investigators in the antioxidant peptide field and also promote the applications of antioxidant peptides in the oxidative stress-associated diseases.

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脓毒症骨骼肌萎缩机制的研究进展

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医学综述 2021年第6期27卷 1084-1089,1095页

作者：殷丹丹吴进蒋鹏江苏大学附属医院麻醉科江苏镇江212001 江苏大学医学院江苏镇江212001

骨骼肌萎缩是脓毒症严重的并发症之一,严重影响患者呼吸系统和外周运动系统,降低患者生活质量、危及生命安全。其中蛋白质降解水平增加是造成骨骼肌肉质量损伤的主要原因之一,另外,机体内环境激素水平、全身炎症反应、氧化应激、过氧化... 详细信息

骨骼肌萎缩是脓毒症严重的并发症之一,严重影响患者呼吸系统和外周运动系统,降低患者生活质量、危及生命安全。其中蛋白质降解水平增加是造成骨骼肌肉质量损伤的主要原因之一,另外,机体内环境激素水平、全身炎症反应、氧化应激、过氧化物酶体增殖物激活受体γ辅助活化因子1α等也均参与了机体蛋白质代谢的调节。因此,探索机体脓毒症骨骼肌萎缩相关分子机制及蛋白质代谢途径,可为临床治疗脓毒症肌病提供靶点,具有重要临床意义。

关键词：脓毒症骨骼肌萎缩蛋白质代谢

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Clinical Practice of Evidence-Based PDCA Cycle Management Model in Accelerated Recovery of Lung Cancer Patients

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Journal of Cancer Therapy 2024年第4期15卷 130-140页

作者： Lu Kang Juan Yuan dandan Liu Bo Deng Sun Yat-sen University Cancer Center Guangzhou China

Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.

关键词： Evidence-Based PDCA Cycle Thoracoscopic Lung Cancer Radical Surgery Accelerated Rehabilitation

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