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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin yiming qian.jiashu lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu Zhao Zonglin Liu He Chen qian Yan Huanxin lian Yunxiang Chen Qingyu Peng Xiaodong He National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

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持续性视觉注意对视觉工作记忆项目优先加工的影响

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心理学报 2025年第2期57卷 191-206页

作者：连浩敏张倩谷雪敏李寿欣山东师范大学心理学院济南250358

采用行为实验、事件相关电位和事件相关光信号联合采集技术,通过操纵视觉工作记忆(VWM)项目的检测概率变化VWM项目加工的优先性,探讨持续性视觉注意对VWM项目优先加工的影响是否受到工作记忆资源的调节,以及VWM项目优先加工的神经基础... 详细信息

采用行为实验、事件相关电位和事件相关光信号联合采集技术,通过操纵视觉工作记忆(VWM)项目的检测概率变化VWM项目加工的优先性,探讨持续性视觉注意对VWM项目优先加工的影响是否受到工作记忆资源的调节,以及VWM项目优先加工的神经基础。行为结果显示,在VWM保持阶段插入消耗视觉注意的任务,当优先加工1个项目时,非优先项目受到干扰,而优先项目不受影响;当优先加工2个项目时,优先与非优先项目均受到干扰。事件相关电位和事件相关光信号结果显示,在VWM保持阶段,与无项目优先加工相比,存在项目优先加工时诱发更大的晚期正成分和负慢波,更高激活额叶和枕叶。这表明,持续性视觉注意对VWM项目优先加工的作用受到工作记忆资源的调节,VWM项目优先加工的潜在机制是在保持阶段激活额叶和枕叶,并投入更多的工作记忆资源,增强优先项目的表征稳定性。

关键词：视觉工作记忆视觉注意优先加工事件相关光信号联合采集

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带拼接板螺栓连接耗能梁段的可恢复功能钢框筒结构抗震性能研究

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工程力学 2025年第1期42卷 83-102页

作者：连鸣戴子琳程倩倩西安建筑科技大学土木工程学院西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室西安710055 中国建筑西北设计研究院有限公司西安710018

为了提升传统钢框筒结构的延性和耗能能力,提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL),该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件进... 详细信息

为了提升传统钢框筒结构的延性和耗能能力,提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL),该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件进行了往复加载试验,试验结果表明,FTS-SRSL子结构试件具有良好的抗震性能,结构损伤集中于耗能梁段,且耗能梁段可实现更换。在试验的基础上,以耗能梁段长度比、耗能梁段腹板加劲肋间距、螺栓直径、翼缘拼接板和腹板拼接板厚度为参数,利用ABAQUS建立了15个足尺的单层单跨FTS-SRSL有限元模型,探究各模型的抗震性能,包括承载力、刚度、耗能以及塑性变形能力。有限元分析结果表明:改变拼接板螺栓连接的剪切型耗能梁段长度比会显著影响结构的承载力、刚度及耗能,建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段长度比取0.73~1.09;改变耗能梁段腹板加劲肋间距对结构的承载力、刚度和耗能影响较小,基于该文的分析结果,建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段腹板加劲肋间距取e/4~e/3(e为耗能梁段长度),且间距应满足我国抗规的规定;改变翼缘拼接板和腹板拼接板厚度对结构的承载力、刚度及耗能基本无影响;改变螺栓直径对结构承载力、刚度及耗能影响较小。

关键词：可更换耗能梁段拼接板螺栓连接钢框筒结构抗震性能参数分析

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生成式人工智能实践中的主体遭遇与教育应对

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当代教研论丛 2025年第1期11卷 12-19页

作者：闫欠欠王连照天津师范大学教育学部天津300387

生成式人工智能的教育应用深化了个体对自我的认知定位,同时对与他者的关系建构有了新的审视。人与技术关系的发展主要经历了人与技术的二元对立、人作为技术的主人以及技术对人的僭越等阶段;在此过程中,人的主体性异化引发了面对自我... 详细信息

生成式人工智能的教育应用深化了个体对自我的认知定位,同时对与他者的关系建构有了新的审视。人与技术关系的发展主要经历了人与技术的二元对立、人作为技术的主人以及技术对人的僭越等阶段;在此过程中,人的主体性异化引发了面对自我时的主体性认同危机和面对他者时的主体性交流危机。为应对生成式人工智能实践中的主体遭遇,需要通过教育提升数字素养,建构人与技术的共生关系;重视关系建构,推进人类命运共同存续。

关键词：生成式人工智能主体性危机人与技术教育应对

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Multi-Objective Optimization for an Industrial Grinding and Classification Process Based on PBM and RSM

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IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2124-2135页

作者： Xiaoli Wang Luming Liu lian Duan qian Liao School of Automation Central South universityChangsha 410083China Changsha Research Institute of Mining and Metallurgy Changsha 410012China

The grinding and classification process is one of the key sub-processes in mineral processing, which influences the final process indexes significantly and determines energy and ball consumption of the whole plant. Therefore, optimal control of the process has been very important in practice. In order to stabilize the grinding index and improve grinding capacity in the process,a process model based on population balance model(PBM) is calibrated in this study. The correlation between the mill power and the operating variables in the grinding process is modelled by using the response surface method(RSM), which solves the problem where the traditional power modeling method relies on some unobservable mechanism-related parameters. On this basis, a multi-objective optimization model is established to maximize the useful power of the grinding circuit to improve the throughput of the grinding operation and improve the fraction of –0.074 mm particles in the hydrocyclone overflow to smooth the subsequent flotation operation. The elite non-dominated sorting genetic algorithm-II(NSGA-II) is then employed to solve the multi-objective optimization problem. Finally, subjective and objective weighting methods and integrated multi-attribute decision-making methods are used to select the optimal solution on the Pareto optimal solution set. The results demonstrate that the throughput of the mill and the fraction of –0.074 mm particles in the overflow of the cyclone are increased by 3.83 t/h and 2.53%, respectively.

关键词： Decision-making technique grinding process multiobjective optimization response surface method(RSM)

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Arietellus　unisetosus─a　new　species　of　calanoid　copepod　from　the　tropical　waters　of　the　central　Paci

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Acta Oceanologica Sinica 1997年第3期16卷 395-401页

作者： lian, Guangshan qian, Honglin Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China South China Sea Branch State Oceanic Administration Guangzhou 510300 China

Ａｒｉｅｔｅｌｌｕｓｕｎｉｓｅｔｏｓｕｓ─ａｎｅｗｓｐｅｃｉｅｓｏｆｃａｌａｎｏｉｄｃｏｐｅｐｏｄｆｒｏｍｔｈｅｔｒｏｐｉｃａｌｗａｔｅｒｓｏｆｔｈｅｃｅｎｔｒａｌＰａｃｉｆｉｃＯｃｅａｎＬｉａｎＧｕａｎｇｓｈａｎａ... 详细信息

Ａｒｉｅｔｅｌｌｕｓｕｎｉｓｅｔｏｓｕｓ─ａｎｅｗｓｐｅｃｉｅｓｏｆｃａｌａｎｏｉｄｃｏｐｅｐｏｄｆｒｏｍｔｈｅｔｒｏｐｉｃａｌｗａｔｅｒｓｏｆｔｈｅｃｅｎｔｒａｌＰａｃｉｆｉｃＯｃｅａｎＬｉａｎＧｕａｎｇｓｈａｎａｎｄＱｉａｎＨｏｎｇｌｉｎ（Ｒｅｃ...

关键词： calanoid species Arietellus

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A novel method to synthesize polyaluminum chloride with a membrane reactor

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Journal of Environmental Sciences 2004年第3期16卷 482-486页

作者： HEFei JIAZhi-qian PENGYue-lian WANGPei-jing LIUZhong-zhou ResearchCenterforEco-EnvironmentalSciences ChineseAcademyofSciencesBeijing100085China

Al 13 or Alb is usually regarded as the most efficient species of polyaluminum chloride(PAC), the performance flocculant for water treatment. This paper was intended to report a new method to synthesize PAC with high content Al b, by using the membrane reactor. NaOH solutions were managed to permeate slowly through the micropores of ultrafiltration membrane into AlCl 3 solutions under the suitable transmembrane pressure(TMP). Meanwhile NaOH drops size was limited to nano scale, resulting in dramatical reduction of the characteristic diffusion time and great increment of contact interface between the strong base and Al ions in solution to favor the formation of Al(OH) - 4, the precursor of Al 13 , so few precipitates and much Al b are produced. When the initial concentration of AlCl 3/NaOH is 0 40/2 0 (mol/L), MWCO =10000, TMP =0 0085 MPa, T =305 K and B (molar ratio of OH -/Al 3+ )=2 25, the quantity of Al b attains about 80%. The results of 27 Al NMR determination showed that the Al 13 content is equal to Al b content. And our PAC product has shown better flocculation effects than the commercial product.

关键词： membrane reactor polyaluminum chloride

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A new dynamic pushback control method for reducing fuel-burn costs: Using predicted taxi-out time

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Chinese Journal of Aeronautics 2019年第3期32卷 660-673页

作者： Guan lian Yaping ZHANG Zhiwei XING qian LUO Shaowu CHENG School of Transportation Science and Engineering Harbin Institute of Technology Ground Support Equipment Research Base Civil Aviation University of China The Second Research Institute of Civil Aviation Administration of China

Long departure-taxi-out time leads to significant airport surface congestion, fuel-burn costs, and excessive emissions of greenhouse gases. To reduce these undesirable effects, a Predicted taxi-out time-based Dynamic Pushback Control(PDPC) method is proposed. The implementation of this method requires two steps: first, the taxi-out times for aircraft are predicted by the leastsquares support-vector regression approach of which the parameters are optimized by an introduced improved Firefly algorithm. Then, a dynamic pushback control model equipped with a linear gate-hold penalty function is built, along with a proposed iterative taxiway queue-threshold optimization algorithm for solving the model. A case study with data obtained from Beijing International airport(PEK) is presented. The taxi-out time prediction model achieves predictive accuracy within 3 min and 5 min by 84.71% and 95.66%, respectively. The results of the proposed pushback method show that total operation cost and fuel-burn cost achieve a 14.0% and 21.1%reduction, respectively, as compared to the traditional K-control policy.(3) From the perspective of implementation, using PDPC policy can significantly reduce the queue length in taxiway and taxi-out time. The total operation cost and fuel-burn cost can be curtailed by 37.2% and 52.1%,respectively, as compared to the non-enforcement of any pushback control mechanism. These results show that the proposed pushback control model can reduce fuel-burn costs and airport surface congestion effectively.

关键词： Airport surface operation Fuel-burn cost Gate-hold time Pushback control Taxi-out time prediction Taxiway queue threshold

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Effect of Facet Displacement on Radiation Field and Its Application for Panel Adjustment of Large Reflector Antenna

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Chinese Journal of Mechanical Engineering 2017年第3期30卷 578-586页

作者： Wei WANG Peiyuan lian Shuxin ZHANG Binbin XIANG qian XU key laboratory of electronic equipment structure design of ministry of education xidian universityXi'an 710071China collaborative innovation center of information sensing and understanding xidian universityXi'an 710071China xinjiang astronomical observation chinese academy of sciencesUrumqi 830011China

Large reflector antennas are widely used in radars, satellite communication, radio astronomy, and so on. The rapid developments in these fields have created demands for development of better performance and higher surface accuracy. However, low accuracy and low effi- ciency are the common disadvantages for traditional panel alignment and adjustment. In order to improve the surface accuracy of large reflector antenna, a new method is pre- sented to determinate panel adjustment values from far field pattern. Based on the method of Physical Optics （PO）, the effect of panel facet displacement on radiation field value is derived. Then the linear system is constructed between panel adjustment vector and far field pattern. Using the method of Singular Value Decomposition （SVD）, the adjustment value for all panel adjustors are obtained by solving the linear equations. An experiment is conducted on a 3.7 m reflector antenna with 12 segmented panels. The results of simulation and test are similar, which shows that the presented method is feasible. Moreover, thediscussion about validation shows that the method can be used for many cases of reflector shape. The proposed research provides the instruction to adjust surface panels efficiently and accurately.

关键词： Reflector antennas Surface accuracy -Radiation field - Reflector antenna mechanical factors Electromechanical effects - Panel adjustment - Singularvalue decomposition (SVD)

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