检索结果-南通市图书馆

Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu Zequn Lu yimin cai Bin Li Ying Zhu Xiangpan Li Yongchang Wei Shaokai Zhang Jianbo Tian Xiaoping Miao Department of Epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China Research Center of Public Health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

引用

Chinese Medical Journal 2024年第4期137卷 431-440页

作者： Danyi Zou yimin cai Meng Jin Ming Zhang Yizhuo Liu Shuoni Chen Shuhui Yang Heng Zhang Xu Zhu Chaoqun Huang Ying Zhu Xiaoping Miao Yongchang Wei Xiaojun Yang Jianbo Tian Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Epidemiology and Biostatistics School of Public HealthTaiKang Center for Life and Medical SciencesWuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211166China

Background:Findings on the association of genetic factors and colorectal cancer(CRC)survival are limited and inconsistent,and revealing the mechanism underlying their prognostic roles is of great *** study aimed to explore the relationship between functional genetic variations and the prognosis of CRC and further reveal the possible ***:We first systematically performed expression quantitative trait locus(eQTL)analysis using The Cancer Genome Atlas(TCGA)***,the Kaplan-Meier analysis was used to filter out the survival-related eQTL target genes of CRC patients in two public datasets(TCGA and GSE39582 dataset from the Gene Expression Omnibus database).The seven most potentially functional eQTL single nucleotide polymorphisms(SNPs)associated with six survival-related eQTL target genes were genotyped in 907 Chinese CRC patients with clinical prognosis *** regulatory mechanism of the survival-related SNP was further confirmed by functional ***:The rs71630754 regulating the expression of endoplasmic reticulum aminopeptidase 1(ERAP1)was significantly associated with the prognosis of CRC(additive model,hazard ratio[HR]:1.43,95%confidence interval[CI]:1.08-1.88,P=0.012).The results of dual-luciferase reporter assay and electrophoretic mobility shift assay showed that the A allele of the rs71630754 could increase the binding of transcription factor 3(TCF3)and subsequently reduce the expression of *** results of bioinformatic analysis showed that lower expression of ERAP1 could affect the tumor immune microenvironment and was significantly associated with severe survival ***:The rs71630754 could influence the prognosis of CRC patients by regulating the expression of the immune-related gene *** Registration:***00454519(https://***/)

关键词： Colorectal cancer Prognosis Genetic variation Quantitative trait loci TCF3 rs71630754 Single nucleotide polymorphisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk Assessment of Heavy Metal Pollution in Sediments of the Fenghe River by the Fuzzy Synthetic Evaluation Model and Multivariate Statistical Methods

引用

Pedosphere 2016年第3期26卷 326-334页

作者： YANG Yang ZHOU Zhengchao BAI Yanying cai yimin CHEN Weiping State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of Sciences College of Environment and Tourism Shaanxi Normal University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Concentrations of heavy metals in 74 sediment samples from the Fenghe River, which originates from the north of the Qinling Mountains and flows through Xi'an, Shaanxi Province, China, were characterized by employing geographic information system(GIS)mapping, fuzzy synthetic assessment, and multivariate statistical analysis to determine the enrichment characteristics of heavy metals as well as their potential risks of pollution to sediments. Al, Cd, and Co were the major pollutants, with a high enrichment factor(EF) value. Heavy metal concentrations from samples near the paper plant were maintained at a high level. Significant enrichment of Al, Ba, Cr, Ni, Pb, and Co was found in the midstream and downstream, while high concentration of Cu occurred in the headwater stream. Based on the cluster and principal component analyses, sediment metals mainly came from the paper plants, agronomic practices, natural sources, and tourism, with a contribution of 51.59%, 23.01%, 14.21%, and 9.88%, respectively. Sediment pollution assessment explored using fuzzy theory based on the entropy method and toxicity coefficient showed that 26, 32, and 11 sites fell into Class III(slightly polluted), Class IV(moderately polluted), and Class V(heavily polluted), respectively, and their scores of membership degree in the polluted level were on the rise, suggesting a relatively high degree of sediment metal pollution in the study area. Closely related to the excessive industrial and agricultural applications, metal pollution in sediment is necessary to be addressed in the Fenghe River.

关键词： fuzzy theory risk analysis river ecosystem sediment pollution spatial analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of dc bias on amorphous carbon deposited by pulse laser ablation

引用

Rare Metals 2002年第4期21卷 294-298页

作者： YANG yimin, GUO Jian, cai Mengqiu, and YANG GuoweiDepartment of Physics, Xiangtan University, Xiangtan 411105, China Department of Physics Xiangtan University Xiangtan 411105

Amorphous carbon films were deposited on single-crystalline silicon and K9glass by pulse laser ablation using different negative substrate bias. Scanning electron microscope(SEM) was used to observe morphology of the surface. Thickness and refractive index of the filmdeposited on K9 glass were measured by ellipsometry. Micro-hardness of films was measured relativelyto single crystal silicon. All films deposited on silicon were analyzed by Raman spectra. Allspectra were deconvoluted to three peaks. Line-width ratios varied similarly with bias voltage whenthe laser energy was kept invariant.

关键词： negative substrate bias amorphous carbon laser ablation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multichannel thermal bubble-actuated impedance flow cytometer with on-chip TIA based on CMOS-MEMS

引用

Journal of Semiconductors 2024年第5期45卷 41-49页

作者： Shengxun cai Jianqing Nie Kun Wang yimin Guan Demeng Liu School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai AURE Technology Limited Company Shanghai 201800China

Electrochemical impedance spectroscopy(EIS)flow cytometry offers the advantages of speed,affordability,and portability in cell analysis and cytometry ***,the integration challenges of microfluidic and EIS read-out circuits hinder the downsizing of cytometry *** address this,we developed a thermal-bubble-driven impedance flow cytometric application-specific integrated circuit(ASIC).The thermal-bubble micropump avoids external piping and equipment,enabling high-throughput *** a total of 36 cell counting channels,each measuring 884×220μm^(2),the chip significantly enhances the throughput of flow *** cell counting channel incorporates a differential trans-impedance amplifier(TIA)to amplify weak biosensing *** eliminating the parasitic parameters created at the complementary metal-oxidesemiconductor transistor(CMOS)-micro-electromechanical systems(MEMS)interface,the counting accuracy can be *** on-chip TIA can adjust feedback resistance from 5 to 60 kΩto accommodate solutions with different *** chip effectively classifies particles of varying sizes,demonstrated by the average peak voltages of 0.0529 and 0.4510 mV for 7 and 14μm polystyrene beads,***,the counting accuracies of the chip for polystyrene beads and MSTO-211H cells are both greater than 97.6%.The chip exhibits potential for impedance flow cytometer at low cost,high-throughput,and miniaturization for the application of point-of-care diagnostics.

关键词： EIS flow cytometry CMOS-MEMS thermal bubble lab-on-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于干预分析模型的三级医院重点监控高值耗材影响因素研究

引用

齐齐哈尔医学院学报 2024年第17期45卷 1668-1673页

作者：周继光李咏梅蔡毅敏黄海芳曾佳智福建医科大学附属漳州市医院福建漳州363000

目的利用漳州市某三甲医院人均重点监控高值耗材收入数据建立干预分析ARIMAX模型,寻找影响人均重点监控高值耗材的影响因素及影响程度。方法收集2018年1月—2024年1月按月为单位的人均重点监控高值耗材数据和三四级手术占比数据,并分... 详细信息

目的利用漳州市某三甲医院人均重点监控高值耗材收入数据建立干预分析ARIMAX模型,寻找影响人均重点监控高值耗材的影响因素及影响程度。方法收集2018年1月—2024年1月按月为单位的人均重点监控高值耗材数据和三四级手术占比数据,并分别设为因变量y和自变量x_1,同时分别设定哑变量x_2和x_3,分别代表国家耗材集采政策变量和DIP支付改革政策变量,其中x_2以2021年1月为界,在此之前未执行国家耗材集采,赋值为0,在此之后实行了国家耗材集采,赋值为1,x_3变量以2022年10月为界,在此之前未实行医保支付政策改革,赋值为0,之后实行了医保政策改革,赋值为1。利用干预分析模型建立人均重点监控高值耗材数据分析模型,确定影响人均重点监控高值耗材的影响因素及影响程度。结果以BIC最低为原则确定的最佳模型为ARIMA(1,0,0)模型,国家集采可以为患者降低10.75%重点监控高值耗材,医院三四级手术占比每上升1个百分点,将会使人均重点监控高值耗材提高2.16个百分点,医保支付政策改变并没有降低重点监控高值耗材使用,该政策在模型中没有统计学意义。结论国家集采将是今后进行耗材管控的重要途径,三四级手术占比对人均重点监控高值耗材的影响显著。

关键词：干扰分析模型 ARIMAX模型重点监控高值耗材三四级手术占比 DIP支付方式改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

养老机构工作人员对于虐待老人行为的认知及相关经历质性研究的Meta整合

引用

中华现代护理杂志 2024年第16期30卷 2188-2194页

作者：张雨欣熊仪李爱群王洋阳蒋元源蔡益民湖南师范大学医学院护理系长沙410013 湖南师范大学附属第一医院(湖南省人民医院)护理教研室长沙410005

目的探讨养老机构工作人员对于虐待老人行为的认知及相关经历。方法检索中国知网、万方数据库、Web of Science、PubMed等数据库中关于养老机构工作人员虐待老人相关经历的质性研究,检索时限均为建库至2023年8月15日。采用Meta整合方法... 详细信息

目的探讨养老机构工作人员对于虐待老人行为的认知及相关经历。方法检索中国知网、万方数据库、Web of Science、PubMed等数据库中关于养老机构工作人员虐待老人相关经历的质性研究,检索时限均为建库至2023年8月15日。采用Meta整合方法对研究结果进行整合归类。结果共纳入14篇文献,提炼出93个主题,经反复阅读、分析和比较,将相似的结果归纳为12个新的类别,综合为3个整合结果(虐待老人的原因、虐待老人的形式及如何防治虐待老人)。结论工作人员应重视养老院中虐待老人的问题,建立机构、老人、家属三者之间的紧密联系,促进养老院中的老人实现健康老龄化。

关键词： Meta整合老年人虐待老人忽视养老院

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive Interval Type-2 Fuzzy Sliding Mode Control Based on Feedback Linearization

引用

控制工程期刊（中英文版） 2014年第5期4卷 138-149页

作者： Jing Hua Yang cai yimin Li Faculty of Science Jiangsu University Zhenjiang Jiangsu 212013 China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Cellulase and Lactic Acid Bacteria on Fermentation Quality and Chemical Composition of Wheat Straw Silage

引用

American Journal of Plant Sciences 2014年第13期5卷 1877-1884页

作者： Kuikui Ni Yanping Wang Huili Pang yimin cai Animal Physiology and Nutrition Division National Institute of Livestock and Grassland ScienceTsukuba Japan Henan Provincial Key Laboratory of Ion Beam Bio-Engineering Zhengzhou University Zhengzhou China

The object of this study was to determine the effect of cellulase and lactic acid bacteria (LAB) on fermentation quality and chemical composition of wheat straw silage. Silages were prepared using a small-scale fermentation system and the moisture level was adjusted to 60% of fresh matter (FM) with deionized water. Treatments were designed as: control silage without additives, LAB inoculant Lactobacillus casei Z3-1 (1.0 × 106 cfu·g-1 of FM), commercial inoculant L. plantarum FG 1 (1.0 × 106 cfu·g-1 of FM), Z3-1 + cellulase and FG 1 + cellulase. The neutral detergent fiber (NDF), acid detergent fiber (ADF) and crude protein (CP) contents of the wheat straw prior to ensiling were 76.93%, 48.52% and 4.63% of dry matter (DM), respectively. After 30 days of fermentation, the silages treated with LAB and LAB + cellulase had a lower (P < 0.05) pH and higher (P < 0.05) lactic acid content than the control, and the coliform bacteria, yeast and mold were inhibited at the early stage of fermentation. Besides, silages treated with cellulase had lower (P < 0.05) values of ADF and NDF than the control. The results confirmed that the addition of cellulase and LAB contributed to improving the fermentation quality of wheat straw silage.

关键词： Cellulase Chemical Composition Lactic Acid Bacteria Silage Fermentation Wheat Straw

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intense Photoluminescence and Movement of Optical Absorption Edge in Alumina Aerogels

引用

Journal of Materials Science & Technology 2000年第3期16卷 315-318页

作者： Xianting SUN, Lianzeng YAO, Chimei MO, Gang SHI, Weili cai and yimin ZHANG (Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China) Lide ZHANG (Institute of Solid State Physics, Chinese Academy Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Teacher's College of Ping Ding Shan China Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China

Alumina aerogels with high porosity of nanometer size were prepared from Al, n-butanol and ethyl acetoacetate by the sol-gel route and the N2 supercritical extraction drying technique. Optical experiment results showed that for alumina aerogels after annealing at 500℃ for 4 h one intense blue emission band appeared in the wavelength range of 400 to 800 nm, and the optical absorption edge moved from 8.0 eV of coarse grain Al203 to 3～eV and with increasing the annealing temperature, this luminescence band presented blue shifts. The reasons of these new optical properties are discussed in detail.

关键词： Aerogels

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：