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Chinese Medical Journal 2006年第24期119卷 2129-2133页

作者： Ngai-Shing Mok Ching-Wan Lam Nai-Chung Fong yim-wo hui Yuen-Choi Choi Kwok-Yin Chan Department of Medicine & Geriatrics Princess Margaret Hospital Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Paediatrics Princess Margaret Hospital Hong Kong China

Sudden cardiac death （SCD） in children and adolescents is uncommon and yet it is devastating for both victim＇s family and the society. Recently, it was increasingly recognized that SCD in young patients with structurally normal heart may be caused by inheritable primary electrical diseases due to the malfunction of cardiac ion channels, a disease entity known as the ion channelopathies. Catecholaminergic polymorphic ventricular tachycardia （CPVT） is a specific form of ion channelopathy which can cause cardiac syncope or SCD in young patients by producing catecholamine-induced bi-directional ventricular tachycardia （BiVT）, polymorphic VT and ventricular fibrillation （VF） during physical exertion or emotion. We reported here an index case of CPVT caused by cardiac ryanodine receptor gene （hRyR2） mutation which presented as cardiac syncope and sudden cardiac arrest in a Chinese adolescent female.

关键词： cardiac ryanodine receptor catecholaminergic polymorphic ventricular tachycardia Chinese sudden death

CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4059-4072页

作者： Xiaoyu Wu Zijun Bai hui Wang Hanqing Wang Dahai Hou Yunzhu Xu Guanqun wo Haibo Cheng Dongdong Sun Weiwei Tao Department of Surgical Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China School of Integrated Medicine Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Nanjing University of Chinese MedicineNanjing 210023China School of Pharmacology Ningxia Medical UniversityYinchuan 750004China

Copper-based nanomaterials demonstrate promising potential in cancer ***^(+) efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione,initiating chemical dynamic therapy(CDT)and ***,a newly identified cell death modality that represents a great prospect in cancer therapy,is ***,active homeostatic systems rigorously keep copper levels within cells exceptionally low,which hinders the application of cooper nanomaterials-based ***,a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is *** Cu_(2)O and organosilica shell would degrade under the high level of glutathione and weak acidic environment,further releasing RNP and Cu^(+).The liberated Cut triggered a Fenton-like reaction for CDT and partially transformed to Cu^(2+),consuming intracellular GSH and initiating cuproptosis and ferroptosis ***,the release of RNP effectively reduced the expression of copper transporter ATP7A,subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT,cuproptosis,and *** tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis.

关键词： GSH-and pH-responsive Effective copper delivery CRISPR-Cas9 ATP7A Cuproptosis Chemodynamic Ferroptosis Synergistic therapy

维普期刊数据库评论

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生物序列比对算法与图形硬件加速研究

中国生物医学工程学报 2011年第6期30卷 853-858页

作者：张林柴惠沃立科沃兴德浙江中医药大学生命科学学院杭州30053

探索准确、高效、低成本、通用性并存的生物序列比对方法。将点阵图算法、启发式算法等各种序列比对算法中准确性最高的动态规划算法在计算机中实现,并通过流模型将其映射到图形硬件上,以实现算法加速;通过数据库比对搜索实例,进行比对... 详细信息

探索准确、高效、低成本、通用性并存的生物序列比对方法。将点阵图算法、启发式算法等各种序列比对算法中准确性最高的动态规划算法在计算机中实现,并通过流模型将其映射到图形硬件上,以实现算法加速;通过数据库比对搜索实例,进行比对时间和每秒百万次格点更新(MCUPS)性能值评测。结果表明,该加速算法在保证比对准确性的同时,能较大地提高比对速度。与目前最快的启发式算法相比,比对平均加速为18倍,最高加速可达28倍。

关键词：生物分子序列比对动态规划算法图形硬件

ovel Mutations in SCN4A Gene Cause Myotonia Congenita with Scoliosis

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Chinese Medical Journal 2018年第4期131卷 477-479页

作者： Yang-Qi Xu Xiao-Li Liu Xiao-Jun Huang wo-Tu Tian hui-Dong Tang Li Cao Department of Neurology Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China Department of Neurology Shanghai Fengxian District Central Hospital Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus Shanghai 201499 China Department of Neurology Ruijin Hospital North Shanghai Jiao Tong University Shanghai 201800 China

Myotonia congenita （MC） is a group of genetically and clinically heterogeneous congenital neuromuscular channelopathies, typically characterized by the delayed relaxation of the muscles after voluntary contraction, ...

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Synthesis,Spectroscopic Properties and Structural Characterization of Sodium Potassium Citrato Oxotungstate(VI)Dimer

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Chinese Journal of Structural Chemistry 2000年第3期19卷 181-186页

作者： WANG Geng ZHOU Zhao-hui ZHANG hui YE Jian-Liang WAN hui-Lin Department of Chemistry and State Key Laboratory for Physical Chemistry of Solid Surface Xiamen UniversityXiamen361005

The sodium potassium citrato oxotungstate(VI) dimer, Na 4K 2〔W 2O 5\|(cit) 2〕·11H 2O (H 4cit = citric acid) was obtained by the reaction of sodium tungstate(VI) and excess potassium citrate monobasic (KH 3cit) in neutral solution. The crystal data for the title compound: monoclinic, C 12 H 30 K 2Na 4W 2O 30 , M r =1192.21, space group P2 1/n, a=17.427(4), b=10.022(2), c=18.637(3) , β=92.62(1)°, V=3252(2)  3, Z=4, D c =2.435 g/cm 3, μ( Mo Kα )=76.38 cm -1 , F( 000)=2288. The structure was refined to R =0.0434 for 6327 independent observed reflections with I>3σ(I) . The complex anion contains a quasi centrosymmetric (O 2W)O b(wo 2) core with a bent bridging oxo group 〔W-O b-W 175.0(4)°〕. Each citrate as tridentate ligand coordinates to a tungsten atom through the alkoxy, α carboxyl, and one β carboxyl group, while the other β carboxyl group remains uncoordinated. Principal dimensions are: W-O b 1.883(6) , (W=O t)av 1.715(6) , W-O (alkoxy) 1.959(6) , W-O ( α carboxy) 2.176(6)  and W-O ( β carboxy) 2.231(6) . The tungsten atom is located in a distorted octahedron environment.

关键词： oxotungstate(VI) citrate citric acid citrate method crystal structure

Efficient piezo-assisted near-infrared-light-driven Cr(Ⅵ)reduction over Bi_(2)S_(3) nanowires transformed from ultrathin Bi_(2)wo_(6) nanosheets

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Rare Metals 2024年第9期43卷 4333-4343页

作者： Qiang Zhang Yuan-Hao Cheng Wei Liu hui-Nan Che Yan-hui Ao Key Laboratory of Integrated Regulation and Resource Development On Shallow Lakes Ministry of EducationCollege of EnvironmentHohai UniversityNanjing 210098China

The utilization of piezo-photocatalytic technol ogy for environmental remediation under full spectrum solar light is promising but still ***,one dimensional Bi_(2)S_(3)nanowires,which can utilize both mechanical energy and near-infrared(NIR)light to remov hexavalent chromium(Cr(Ⅵ))efficiently,were synthe sized by a restrained growth *** reaction rat constants of Cr(Ⅵ)reduction in piezo-photocatalyti process under NIR(800–2500 nm)reached 0.334 min^(-1)which were 3.2 and 12.4 times as that of single piezo and photocatalytic *** formation of polarized electri fields and one-dimensional structure allow ultrafast sepa ration of charge carriers,thereby promoting the catalyti ***,due to the strong penetrability o NIR light,the piezo-photocatalysis performance in turbid solutions under NIR light(0.188 min^(-1))was even com parable to that under visible light(0.186 min^(-1)).Thi study provides a new concept on the development of piezo photocatalytic technology for environmental remediation by utilization of NIR light and natural mechanical energy.

关键词： Piezo-photocatalysis NIR light Bi_(2)S_(3)nanowires Cr(Ⅵ)

Ultrafast photocatalytic degradation of nitenpyram by 2D ultrathin Bi2wo6:mechanism,pathways and environmental factors

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Rare Metals 2022年第7期41卷 2439-2452页

作者： Yuan-Hao Cheng Juan Chen hui-Nan Che Yan-hui Ao Bin Liu Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education College of EnvironmentHohai UniversityNanjing 210098China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore

As a common insecticide,nitenpyram(NTP)seriously threatens the human health and environmental *** this work,a visible-light-responsive photocata-lyst two-dimensional(2D)Bi_(2)wo_(6) was synthesized and applied to degrade *** with bulk Bi_(2)wo_(6),the 2D Bi_(2)wo_(6)exhibits better photocatalytic performance for NTP degradation under visible-light *** enhanced activity can be ascribed to the unique 2D struc-ture which would induce to higher efficiency of carrier ***,hole(h+)plays a major role(and·O^(2-))in the degradation of *** on the interme-diates detected by high-performance liquid chromatogra-phy-mass spectrometry(HPLC-MS),the degradation pathway of NTP was *** addition,the influence of typical environmental factors(pH,water matrix,inorganic cations and common anions)on the degradation of NTP was also *** work not only helps people to understand the degradation of pesticides in actual water bodies,but also provides reference for the subsequent treatment of agricultural wastewater.

关键词： Photocatalysis Two-dimensional(2D)Bi_(2)wo_(6) Nitenpyram Degradation pathway

A Concise Proof of the Relation between Poisson Process and Exponential Distribution

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Systems Science and Systems Engineering 1999年第4期9卷 40-43页

作者： TANG Ying\|hui,\ TANG Xiao\|wo Dept. of Appl. Math., Mgt.College, Univer. of Electronic Science and Technology of China, Chengdu 610054, China

Using the memoryless property of the exponential distribution, we have proved again that the relation between the Poisson process and the exponential distribution, that is, the stochastic process {N(t), t≥0} is said to be a Poisson process with arrival rate λ(>0) if and only if the sequence of interarrival times {τ n,n≥1} are independent and identically distributed according to an exponential distribution with parameter λ, where N(t) denotes the arrival number in (0,t\].. It′s noting that the proof provided in this paper is concise and intuitive.

关键词： exponential distribution memoryless property Poisson process

Synthesis and Crystal Structure of Ammonium cis-Dioxo Dibenzilato Tungstate (VI) Dihydrate

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Chinese Journal of Structural Chemistry 2004年第5期23卷 502-505页

作者： ZHAOHong JIANGYa-Qi ZHANGhui ZHOUZhao-hui DepartmentofChemistryandStateKeyLaboratoryforPhysicalChemistryofSolidSurface XiamenUniversityXiamen361005China

A mononuclear tungsten-benzilate, (NH4)2[wo2(Ph2COCOO)2]?H2O was ob- tained by the reaction of ammonium tungstate(VI) with excess benzilic acid in ethanol solution at pH 5~6. The title compound crystallizes in monoclinic system, space group P21/n with a = 8.1078(5), b = 25.797(2), c = 13.6815(8) ? b = 91.001(1)? V = 2861.1(3) 3, Dc = 1.719 g/cm3, F(000) = 1472, C28H32N2O10W, Mr = 740.41, m(MoKa) = 4.097 mm-1 and Z = 4. The full-matrix least-squares refinement resulted in R = 0.033 and Rw = 0.068 for 3974 observed reflections with I >2s(I). The tungsten atom is six-coordinated by two cis-oxo groups and two bidentate benzilate ligands through deprotonated a-alkoxyl and a-carboxyl groups, forming a stable five-membered chelate ring. The compound has a distorted octahedral geometry, which is mainly attributable to the bulky ligand-ligand repulsions.

关键词： oxotungstate(VI) tungstate benzilic acid benzilate crystal structure

活化T细胞核因子非编码基因对人脐静脉内皮细胞调节作用的实验研究

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中华心血管病杂志 2013年第3期41卷 245-250页

作者：唐羽叶沃立科柴惠浙江中医药大学生命科学学院杭州310053 第一临床医学院

目的探讨活化T细胞核因子非编码基因（noncodingrepressorofnuclearfactorofactivatedTcells，NRON）在人脐静脉内皮细胞内过表达和干扰后，对活化T细胞核因子（nuclearfactorofactivatedTcells，NFAT）基因表达的影响，并探讨其对人脐静脉内皮细胞生长、成管能力和迁移能力的影响。方法使NRON基因在人脐静脉内皮细胞中过表达，并使用短发夹RNA（shRNA）干扰培养成NRON过表达细胞系和shRNA干扰细胞系。各细胞系采用不同浓度的小牛血清（1％、2％、4％、8％和10％）处理48h，观察其细胞生长变化。以正常HUVEC细胞系作为对照，另设加入pBABE空载体细胞系和pSuper空载体细胞系作为对照。采用非放射性细胞增殖实验、内皮细胞成管实验、内皮细胞迁移实验这几种血管内皮细胞功能实验，检测血管内皮细胞基本特性的变化。结果非放射性细胞增殖实验结果显示，各细胞系采用不同浓度小牛血清处理48h，其细胞生长均与小牛血清浓度呈正相关（正常HUVEC细胞系r=0．91；pBABE空载体细胞系，r：0．88；NRON过表达细胞系，r=0．89；pSuper空载体细胞系，r=0．95；shRNA干扰细胞系，r=0．97）；与正常HUVEC细胞系和pBABE空载体细胞系比较，NRON过表达细胞系细胞增殖能力较低（各浓度P均〈0．05）；与正常HUVEC细胞系和pSuper空载体细胞系比较，shRNA干扰细胞系增殖能力较高（各浓度P均〈0．05）。细胞成管实验中，与正常HUVEC细胞系和pBABE空载体细胞系比较，NRON过表达细胞系细胞成管能力较低[分别为（23．33±3．01）条和（19．67±1．42）条比（8．33±0．12）条，P均〈0．05]；与正常HUVEC细胞系和pSuper空载体细胞系[（17．33±2．93）条]比较，shRNA干扰细胞系[（36．00±0．51）条]细胞成管能力则较高（P均〈0．05）。细胞迁移实验中，与正常HUVEC细胞系和pBABE空载体细胞系比较，NRON过表达细胞系细胞迁移数较少[分别为（5145±72）个和（441l±117）个比（1857±65）个，P均〈0．05]；与正常HUVEC细胞系和pSuper空载体细胞系[（3883±109）个]比较，shRNA干扰细胞系[（6987±50）个]细胞迁移数较多（P均〈0．05）。结论NRON基因过表达和shRNA干扰，分别使NFAT基因呈抑制或激活状态。NRON基因过表达可抑制人脐静脉内皮细胞生长，减弱其成管能力和细胞迁移能力。shRNA干扰NRON后可促进人脐静脉内皮细胞生长，增强其成管能力和细胞迁移能力。

关键词：内皮细胞 RNA,未翻译 NFATC转录因子类