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Effect of movability of water on the low-velocity pre-Darcy flow in clay soil

Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3299-3310页

作者： Hui Cheng Fugang Wang Shengwei Li Xiaotong Guan Guohua Yang Zhongle Cheng Ceting Yu yilong Yuan Guanhong feng Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun130012China Jilin Provincial Key Laboratory of Water Resources and Water Environment Jilin UniversityChangchun130012China Chengdu Center China Geological SurveyChengdu610081China

Water seepage in soil is a fundamental problem involving various scientific and engineering *** to the literature,low-velocity water seepage in low-permeability porous media,such as clay,does not follow Darcy's law,also known as pre-Darcy *** formation of immovable water due to water adsorption on the pore wall is believed to be responsible for the formation of pre-Darcy ***,this view lacks direct solid *** investigate the pre-Darcy water flow in clay,head permeability experiments are conducted on six clay samples with different *** results indicate that water seepage in clay at low hydraulic gradients does not follow Darcy's law.A clear nonlinear relationship between flow velocity and hydraulic gradient is *** flow in clay can be divided into the pre-Darcy flow and Darcy flow regions by the critical hydraulic gradient,which is 10-12 for the Albic soil with dry density between 1.3 g/cm^(3)and 1.8 g/cm^(3).According to the disjoining pressure theory,immovable water due to water adsorption on the pore wall is the primary reason for water flow deviating from Darcy's law in *** results indicate that the percentage of movable water ranges from 39.7%to 59.3%for the six samples at a hydraulic gradient of *** the hydraulic gradient increases,the percentage of moveable water also ***,there is a strong correlation between the percentage of movable water and the variation in hydraulic conductivity with the hydraulic ***,a quantitative relationship between the percentage of movable water and the hydraulic conductivity has been *** results of this study suggest that water adsorption on the pore wall not only affects the water movability,but is also closely related to the pre-Darcy flow phenomenon in clay.

关键词： Pre-Darcy flow Clay Critical hydraulic gradient Water movability analysis

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A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement

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Molecular Plant 2023年第2期16卷 432-451页

作者： Xu Zhang Haiyan Wang Haojie Sun Yingbo Li yilong feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang State Key Laboratory of Crop Genetics and Germplasm Enhancement Cytogenetics InstituteNanjing Agricultural University/JCIC-MCPNanjingJiangsu 210095China Biotech Research Institute Shanghai Academy of Agricultural SciencesShanghai 201106China

Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease *** mining of favorable genes from *** is frustrated by the lack of a whole genome *** this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for *** assembly contains39727 high-confidence genes,and 85.31% of the sequences are *** reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in *** prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly *** sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum *** tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in *** than in Triticum *** hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene *** site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in ***,and MHS1.1 was more inducible in *** than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant *** summary,this study provides a valuable genome resource for functional genomics studies and *** introgression *** identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat.

关键词： D.villosum genome crop wild relative genome evolution disease resistance RNA-seq MNase hy-persensitivityassay

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Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 75-81,I0047-I0052页

作者： Xiaoling Liao Shuo feng Yicong Wang Yuesong Pan Weiqi Chen Hui Qu Xingquan Zhao Liping Liu Yongjun Wang yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing TiantanHospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background Perforating artery territorial infarction(PAI)caused by branch atheromatous disease(BAD)is prone to recurrence and early progression without an effective and well-documented antiplatelet treatment ***,an adjunctive antiplatelet agent,has shown great potential to treat acute ischaemic ***,whether the combination of tirofiban and aspirin can improve the prognosis of PAI remains *** To explore an effective and safe antiplatelet regimen for reducing the risk of recurrence and early neurological deterioration(END)in PAI caused by BAD by comparing the tirofiban and aspirin combination with placebo and aspirin *** Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction(STRATEGY)trial is an ongoing multicentre,randomised,placebo-controlled trial in *** patients shall be randomly assigned to receive standard aspirin with tirofiban or placebo on the first day and standard aspirin from days 2 to *** primary endpoint is a new stroke or END within 90 *** primary safety endpoint is severe or moderate bleeding within 90 *** The STRATEGY trial will assess whether tirofiban combined with aspirin is effective and safe in preventing recurrence and END in patients with *** registration number NCT05310968.

关键词： Aspirin regimen centre

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Randomised study of bailout intracranial angioplasty following thrombectomy for acute large vessel occlusion(ANGEL-REBOOT):protocol of a multicentre randomised controlled trial

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Stroke & Vascular Neurology 2024年第2期9卷 181-188页

作者： feng Gao Xu Tong Baixue Jia Ming Yang Yuesong Pan Zeguang Ren William Scott Burgin Liping Liu Xingquan Zhao yilong Wang Yongjun Wang Zhongrong Miao Interventional Neuroradiology Department of NeurologyBeijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Neurosurgery University of South FloridaTampaFloridaUSA Department of Neurology Morsani College of MedicineUniversity of South FloridaTampaFloridaUSA Comprehensive Stroke Center Tampa General HospitalTampaFloridaUSA Department of Neurology Beijing Tiantan HospitalBeijingChina

Rationale Unsuccessful thrombectomy of acute large vessel occlusions(LVOs)has been associated with unfavourable *** randomised controlled trials(RCTs)have reported a failure rate of 12%–41%for thrombectomy *** factors contribute to failed thrombectomy,including technical difficulties in accessing the occlusion,unsuccessful thrombus retrieval,thrombotic reocclusion and pre-existing intracranial atherosclerotic *** some studies have explored balloon dilation or permanent stenting as rescue intracranial angioplasty for failed thrombectomy in individual cases,there is currently no evidence from RCTs on this specific *** To evaluate the potential superiority of bailout angioplasty over standard treatment in cases of unsuccessful recanalisation(eTICI 0 to 2a)or residual severe stenosis(>70%)after thrombectomy in acute LVO patients within 24 hours of stroke *** This study is a multicentre,prospective,randomised,controlled clinical trial designed by *** compares bailout angioplasty with standard therapy and follows an open-label treatment approach while maintaining a blinded outcome assessment(PROBE design).Our objective is to allocate 348 patients in a 1:1 ratio to either receive bailout angioplasty as an intervention or standard therapy as a control,following unsuccessful *** The main measure of interest is the modified Rankin Scale(mRS)Score,which will be assessed in a blinded manner at 90(±14)days following *** primary effect size will be determined using ordered logistic regression to calculate the common OR,representing the shift on the six-category mRS Scale at the 90-day ***,the safety outcomes will be evaluated,including symptomatic intracranial haemorrhage within 18–36hours,severe procedure-related complications and mortality within 90(±14)days,among *** The ANGEL-REBOOT study aims to generate substantial evidence regarding the efficacy

关键词： angioplasty throm intracranial

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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu Ning Ma feng Gao Dapeng Mo Wengui Yu Yongjun Wang yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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单宁酸/两性离子改性油-水分离膜的制备及性能

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高等学校化学学报 2020年第6期41卷 1337-1344页

作者：彭新艳刘云鸿李嘉文冯乙胧王汉春泉州师范学院化工与材料学院九牧集团表面材料研究所

以不锈钢网为基材,利用单宁酸对不锈钢网进行表面预处理并功能化接枝两性离子基团,制备了新型亲水和水下超疏油的单宁酸/两性离子改性油-水分离膜(TA-ZW-SSM).利用X射线光电子能谱仪(XPS)、扫描电子显微镜(SEM)及接触角测量仪等表征了... 详细信息

以不锈钢网为基材,利用单宁酸对不锈钢网进行表面预处理并功能化接枝两性离子基团,制备了新型亲水和水下超疏油的单宁酸/两性离子改性油-水分离膜(TA-ZW-SSM).利用X射线光电子能谱仪(XPS)、扫描电子显微镜(SEM)及接触角测量仪等表征了其化学结构、形态和润湿性.研究结果表明,两性离子基团通过化学键接枝在单宁酸预处理的不锈钢网表面.油-水分离实验结果表明,对于不同类型的油-水混合物,本文制备的超亲水和水下超疏油特性的TA-ZW-SSM可实现重力驱动的高效油-水分离,并具有较好的化学稳定性及再循环性.

关键词：单宁酸两性离子超亲水/水下超疏油分离膜表面改性油-水分离

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重庆地区种植毯式墙面绿化构建技术及效果一例

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南方农业 2019年第10期13卷 8-11页

作者：吴昊冯义龙重庆市风景园林科学研究院/重庆市城市园林绿化工程技术研究中心重庆401329

简述种植毯式墙面绿化的技术特点、建设基本要求,分析其优缺点。以重庆市风景园林科学研究院苗木基地管理房墙面绿化示范项目为例,浅析种植毯式墙面绿化的技术要点;该项目建成后,对温度数据进行监测,发现种植毯式墙面绿化在白天平均可... 详细信息

简述种植毯式墙面绿化的技术特点、建设基本要求,分析其优缺点。以重庆市风景园林科学研究院苗木基地管理房墙面绿化示范项目为例,浅析种植毯式墙面绿化的技术要点;该项目建成后,对温度数据进行监测,发现种植毯式墙面绿化在白天平均可以降低室内空气温度-0.2～1.4℃,降低室内墙面温度0.7～2.6℃。

关键词：城市立体绿化种植毯式墙面绿化技术要点实例效果

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微波电路用共面电极TaNx薄膜片式电阻器

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电子元件与材料 2009年第8期28卷 55-58页

作者：程超赵海飞冯毅龙杨俊锋广州翔宇微电子有限公司广东广州510288

采用反应溅射方法制作TaNx电阻薄膜,并通过溅射Ni、Au形成双层共面电极。研究了溅射条件对电阻薄膜组分的影响以及此类电阻器的微波特性。结果显示,溅射工作真空度小于0.5Pa,氮气体积分数大于5%时,可以得到阻值稳定的六方晶体结构TaNx... 详细信息

采用反应溅射方法制作TaNx电阻薄膜,并通过溅射Ni、Au形成双层共面电极。研究了溅射条件对电阻薄膜组分的影响以及此类电阻器的微波特性。结果显示,溅射工作真空度小于0.5Pa,氮气体积分数大于5%时,可以得到阻值稳定的六方晶体结构TaNx电阻薄膜,其共面电极的电阻器使用频率上限大于20GHz。

关键词： TaNx 共面电极薄膜片式电阻器

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Vienna整流器输入电流畸变与中点电位振荡综合优化调制策略研究

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中国电机工程学报 2022年第15期42卷 5685-5696页

作者：赵志宏吴佳衡冯义龙吕广强赵剑锋蓝建宇南京理工大学自动化学院江苏省南京市210094 东南大学电气工程学院江苏省南京市210096 上海空间电源研究所上海市闵行区200245

Vienna整流器具有转换效率高、无桥臂直通等优势,在通信电源、电动汽车、风力发电等领域具有广阔的应用前景。然而,Vienna整流器空间矢量调制在扇区切换处由于非理想矢量序列的使用,导致交流侧电流在过零点附近发生畸变。并且当运行在... 详细信息

Vienna整流器具有转换效率高、无桥臂直通等优势,在通信电源、电动汽车、风力发电等领域具有广阔的应用前景。然而,Vienna整流器空间矢量调制在扇区切换处由于非理想矢量序列的使用,导致交流侧电流在过零点附近发生畸变。并且当运行在直流侧电压不平衡工况时,将进一步加剧输入电流的畸变。此外,直流侧中点平均电流的波动也将引起中点电位振荡。为了改善输入电流质量,抑制中点电位波动,文中分析电流过零点畸变的原因,通过在改进的钳位区域添加补偿分量,而在非钳位的连续区域添加优化零序分量,提出一种Vienna整流器载波调制优化算法,实现了对交流侧电流畸变与直流侧电压振荡的有效抑制。通过仿真与实验结果验证所提方法的有效性与实用性。

关键词： Vienna整流器电流过零点畸变载波调制电压波动

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不同脑区白质高信号负荷与帕金森病患者认知功能的相关性研究

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中华神经科杂志 2024年第2期57卷 157-163页

作者：陈慧敏苏闻张美美冯涛王伊龙北京医院神经内科、国家老年医学中心、中国医学科学院老年医学研究院北京100730 首都医科大学附属北京天坛医院神经病学中心、国家神经系统疾病临床医学研究中心北京100070

目的观察不同脑区白质高信号(WMH)体积与帕金森病患者认知障碍之间的相关性。方法回顾性分析2018年10月至2019年8月首都医科大学附属北京天坛医院运动障碍性疾病科连续收治的帕金森病患者,并采集其人口学、疾病信息及头颅三维磁共振影... 详细信息

目的观察不同脑区白质高信号(WMH)体积与帕金森病患者认知障碍之间的相关性。方法回顾性分析2018年10月至2019年8月首都医科大学附属北京天坛医院运动障碍性疾病科连续收治的帕金森病患者,并采集其人口学、疾病信息及头颅三维磁共振影像学资料。采用简易精神状态检查量表(MMSE)评估患者的认知功能;采用汉密尔顿焦虑量表、汉密尔顿抑郁量表(HAMD)评估患者的情绪,并根据MMSE评分结果将患者分为帕金森病伴痴呆组和不伴痴呆组。采用不明亮点探测器算法,基于解剖自动标记模板,自动化定量分析患者脑区的WMH体积。比较帕金森病伴痴呆与不伴痴呆患者的人口学特征、疾病特点、WMH总体积之间的差异。采用偏相关[错误发现率(FDR)校正]及主成分回归分析患者不同脑区的WMH体积与MMSE评分之间的相关性。结果帕金森病伴痴呆组患者的WMH总体积显著大于帕金森病不伴痴呆组患者[5125(2727,13718)mm^(3)比3214(1959,7205)mm^(3),Z=-2.256,P=0.024]。校正年龄、低密度脂蛋白、血清胆固醇、HAMD评分后,偏相关分析结果提示,帕金森病患者的MMSE评分与右侧距状回(r=-0.204,P_(FDR校正)=0.034)、右侧梭状回(r=-0.180,P_(FDR校正)=0.046)、右侧舌回(r=-0.146,P_(FDR校正)=0.047)、左侧颞中回(r=-0.168,P_(FDR校正)=0.047)、左侧顶下小叶(r=-0.145,P_(FDR校正)=0.047)和右侧顶下小叶(r=-0.148,P_(FDR校正)=0.047)的WMH体积显著相关。主成分回归分析结果显示,MMSE评分与主成分2(B=-0.632,95%CI-1.222~-0.041,P=0.036)、主成分13(B=-1.384,95%CI-2.155~-0.613,P=0.001)、主成分14(B=-0.913,95%CI-1.599~-0.227,P=0.009)显著相关;主成分2、主成分13、主成分14主要由脑后部颞-顶-枕叶WMH体积构成,可解释WMH变异率的9.668%。结论脑后部颞-顶-枕叶WMH体积与帕金森病患者的认知障碍显著相关,但其可能不是帕金森病患者认知障碍的主要因素。

关键词：帕金森病认知障碍脑白质高信号

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