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Friction 2024年第6期12卷 1165-1175页

作者： Yinhu XI Jinhui DENG yiling li School of Mechanical Engineering Anhui University of Science and TechnologyHuainan 232001China Ericsson AB Datalinjen 3Linköping 58330Sweden

In this work,a new method to solve the Reynolds equation including mass-conserving cavitation by using the physics informed neural networks(PINNs)is *** complementarity relationship between the pressure and the void fraction is *** are several difficulties in problem solving,and the solutions are ***,the difficulty for considering the pressure inequality constraint by PINNs is solved by transferring it into one equality constraint without introducing *** the void fraction inequality constraint is considered by using the hard constraint with the max-min ***,to avoid the fluctuation of the boundary value problems,the hard constraint method is also utilized to apply the boundary pressure values and the corresponding functions are ***,for avoiding the trivial solution the limitation for the mean value of the void fraction is *** results are validated against existing data,and both the incompressible and compressible lubricant are *** agreement can be found for both the domain and domain boundaries.

关键词： Reynolds equation mass-conserving cavitation physics informed neural networks hard constraints trivial solution

FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 325-328页

作者： yiling li Zekun Gao Xiuxiu Yue Minhuan Lan Xiuli Zheng Benhua Wang Shuang Zhao Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410083China

To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH_(2)),through a hexamethylene linker to build a two-photon photosensitizer,*** TQ-NBS,TQ served as an energy donor and NBS-NH_(2) acted as an energy acceptor;and TQ-NBS was a F?rster resonance energy transfer(FRET)cassette with a 92.8%*** large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900 nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT ***,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2was kept in TQ-NBS under a TPE mode via a FRET *** TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.

关键词： Photodynamic therapy Two-photon excitation FRET-based photosensitizer Singlet oxygen Near-infrared fluorescence

“21·7”河南特大暴雨成因分析及三维概念模型的构建

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气象科学 2024年第1期44卷 73-81页

作者：李哲魏璐王津宇王超李伊呤国网河南省电力公司电力科学研究院郑州450000 河南省气象服务中心郑州450000

通过对“21·7”河南特大暴雨在地形效应、不同高度的大气环流和水汽输送通道的分析,结论如下:(1)台风“烟花”与副高形成的东南气流在底层灌入河南喇叭口地形,在地形热力抬升和动力阻挡抬升的共同作用下,有利于山前降水的形成。(2)在50... 详细信息

通过对“21·7”河南特大暴雨在地形效应、不同高度的大气环流和水汽输送通道的分析,结论如下:(1)台风“烟花”与副高形成的东南气流在底层灌入河南喇叭口地形,在地形热力抬升和动力阻挡抬升的共同作用下,有利于山前降水的形成。(2)在500 hPa中层,郑州涡旋处于两个高压的“鞍型场”内,该环流配置导致台风“烟花”、“查帕卡”和热带低压相互作用形成三股气流直达河南;在200 hPa高层,河南暴雨区辐散气流向东下沉到同一纬度的东海高层冷涡内,其次级环流进一步加强了河南云团的强度。(3)台风“烟花”和“查帕卡”输送丰沛水汽至河南中西部,受太行山和伏牛山地形阻挡,在山前形成强烈水汽辐合。(4)构建的河南极端暴雨概念模型通过水汽输送通道和次级环流,将环流、台风、低压系统和喇叭口地形等降水成因有机联系,并放入同一个构架之中,从宏观上了解这些成因的运行机理及其相互作用,可加深对该特大暴雨成因的理解。

关键词：暴雨成因地形效应台风水汽输送通道概念模型

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数字化视域下地理标志农产品产业发展研究

中国商论 2024年第3期 142-145页

作者：谭小平李屹玲林梓涵广东财经大学财税学院广东广州510632

数字经济时代,产业数字化与数据产业化不断重塑人类社会生产和生活形态。地理标志农产品产业在数字化浪潮下,也在积极利用数字化手段,以更好适应时代发展。本文分析了地理标志农产品的特点,认为农产品地理标志为典型的农村知识产权,地... 详细信息

数字经济时代,产业数字化与数据产业化不断重塑人类社会生产和生活形态。地理标志农产品产业在数字化浪潮下,也在积极利用数字化手段,以更好适应时代发展。本文分析了地理标志农产品的特点,认为农产品地理标志为典型的农村知识产权,地理标志具有明显的“农业”特征。数字化视域下地理标志农产品产业发展的机制包括风险弱化机制、质量控制机制及产销互动机制。本文分析了当前我国地理标志农产品产业数字化存在的问题,并从人才发展、物流系统智能化、品牌建设等角度提出政策建议,仅供参考。

关键词：地理标志农产品数字化产业发展数字经济产业数字化知识产权

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The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease

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iliVER 2022年第1期1卷 65-71页

作者： Xinhe Zhang Haoyu Tian yiling li Gastroenterology Department The First Affiliated Hospital of China Medical UniversityNo.155 North Nanjing StreetHeping DistrictShenyang 110001LiaoningChina The 3rd Clinical Department of China Medical University No.77 Puhe RoadShenyang North New AreaShenyang 110122LiaoningChina

Nonalcoholic fatty liver disease(NAFLD)is a common chronic metabolic liver disease *** is closely related to diseases of the cardiovascular system and chronic kidney *** can also occur secondary to many other *** research shows that patients with hypopituitarism have a high risk of developing *** the adenohypophysis is dominated by hypothalamic hormones,hormones are secreted to act on the corresponding tissues or *** is characterized by a decrease in the thyroid hormone,cortisol,and growth hormone *** this review,we analyzed the mechanisms related to NAFLD through thyroid secretion,growth hormone secretion,sex hormone,and prolactin axes in patients with hypopituitarism,which will provide information and a theoretical basis for clinical diagnosis and treatment.

关键词： Hypopituitarism NAFLD Pathophysiological mechanism

沈阳市小学生非酒精性脂肪肝流行病学与生活习惯调查

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健康体检与管理 2024年第2期5卷 125-132页

作者：张鑫赫田昊宇关琳李异玲中国医科大学附属第一医院消化内科辽宁沈阳110001 中国医科大学临床三系辽宁沈阳110122

目的:调查沈阳市小学生非酒精性脂肪肝的患病率及相关影响因素,并分析生活习惯及家庭因素与脂肪肝患病的相关性。方法:选取2019年11月至12月在沈阳市进行健康体检的小学生,根据FibroScan结果将纳入人群分为脂肪肝组和非脂肪肝组,比较年... 详细信息

目的:调查沈阳市小学生非酒精性脂肪肝的患病率及相关影响因素,并分析生活习惯及家庭因素与脂肪肝患病的相关性。方法:选取2019年11月至12月在沈阳市进行健康体检的小学生,根据FibroScan结果将纳入人群分为脂肪肝组和非脂肪肝组,比较年龄、性别、身高、体质量、体质量指数(BMI)、腰围、臀围、腰臀比对脂肪肝的影响,并选取纳入人群中的一部分进行问卷调查,探讨生活习惯对脂肪肝患病的影响。结果:沈阳市小学生非酒精性脂肪肝的总患病率为22.73%,男生的患病率明显高于女生,且超重的学生相比于非超重的学生患脂肪肝的比例明显增高。饮食因素和家庭因素均与小学生脂肪肝患病有关。结论:沈阳市小学生非酒精性脂肪肝十分流行,与肥胖因素密切相关,生活习惯及家庭因素对小学生NAFLD患病有一定的影响。

关键词：非酒精性脂肪肝小学生肥胖生活习惯

弥漫性肝窦状血管肉瘤并发急性上消化道出血1例并文献复习

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实用肝脏病杂志 2024年第2期27卷 314-316页

作者：黄蝶林旭勇李异玲王颖中国医科大学附属第一医院消化内科沈阳市110001 中国医科大学附属第一医院病理科沈阳市110001

肝血管肉瘤(hepatic angiosarcoma,HAS)是肝脏一种罕见但具有侵袭性的恶性肿瘤,仅占所有原发性肝脏恶性肿瘤的2%^([1,2])。常见于60岁或70岁的老年人,其中男性发生率是女性的3倍^([3])。虽然一些研究表明,HAS与长期暴露于化学药物,如二... 详细信息

肝血管肉瘤(hepatic angiosarcoma,HAS)是肝脏一种罕见但具有侵袭性的恶性肿瘤,仅占所有原发性肝脏恶性肿瘤的2%^([1,2])。常见于60岁或70岁的老年人,其中男性发生率是女性的3倍^([3])。虽然一些研究表明,HAS与长期暴露于化学药物,如二氧化钍、氯乙烯、砷、镭和可能的铜等有关,使用雄激素类固醇和慢性特发性血色素沉着病可能促进发病,但75%的肿瘤没有已知的病因,并且环境暴露引起的HAS具有10~40年的延长潜伏期^([2,4])。HAS通常表现为右上腹痛、体质量减轻、腹胀、黄疸和疲劳等非特异性症状,具有不同的影像学特征,放射学检查也较难诊断,肝组织病理学检查是诊断的关键。

关键词：肝血管肉瘤窦状上消道出血

Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 235-248页

作者： Miaoqin Chen Shiman Hu yiling li Ting Ting Jiang Hongchuan Jin lifeng Feng Laboratory of Cancer Biology Key lab of Biotherapy in Zhejiang ProvinceCancer Institute of Zhejiang UniversitySir Run Run Shaw hospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Radiation Oncology Sir Run Run Shaw HospitalMedical School of Zhejiang UniversityHangzhou 310016China

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer ***,there are many patients who failed to benefit from these therapies,highlighting the need for new combinations to increase the clinical efficacy of immune checkpoint *** this review,we summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer *** the critical role of nuclear acid-mediated immunity in maintaining the activation of T cell function,it seems that harnessing the nuclear acidmediated immunity opens up new strategies to enhance the effect of immune checkpoint inhibitors for tumor control.

关键词： immunity cancer therapies

A historical review of aggregation-induced emission from 2001 to 2020:A bibliometric analysis

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Aggregate

Aggregate 2022年第1期3卷 122-137页

作者： Qiming Xia Yiyin Zhang yiling li Yirun li Yixuan li Zhe Feng Xiaoxiao Fan Jun Qian Hui lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityZhejiang ProvinceHangzhouP.R.China State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhouP.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouP.R.China

Aggregation-induced emission(AIE)is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid *** year is the 20th anniversary since the AIE concept firstly proposed in *** advanced applications were gradually being explored,covering optics,electronics,energy,and bioscience and so *** present,bibliometrics can enlighten the researchers with comprehensive sights of the achievements and trends of a specific field,which is critical for academic ***,we presented a general bibliometric overview of AIE covering 20 years of *** the assistance of Web of Science Core Collection database and several bibliometric software tools,the annual publication and citation,most influential countries/regions,most contributing authors,journals and institutions,second near-infrared(NIR-Ⅱ)related hotspots,as well as the forecast of frontiers were demonstrated and systematically *** study summarizes the current research status in AIE research field and provides a reference for future research directions.

关键词： aggregation-induced emission(AIE) bibliometric analysis research trend second near-infrared(NIR-Ⅱ)

秸秆还田与灌溉方式对大豆玉米带状间作出苗及幼苗生长的影响

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中国农业科学 2024年第17期57卷 3366-3383页

作者：杨立达彭新月朱文雪赵静袁晓婷林萍罗凯李易玲罗春明李雨泽杨文钰雍太文四川农业大学农学院/农业农村部西南作物生理生态与耕作重点实验室/四川省作物带状复合种植工程技术研究中心山东省德州市禹城市农业农村局四川省遂宁市安居区农业农村局

【目的】大豆玉米带状间作是我国大豆产能提升工程的重要栽培模式。探究秸秆还田与灌溉方式对大豆玉米带状间作作物出苗及幼苗生长质量的影响，以期为带状间作解决出苗难题提供理论支撑。【方法】试验于2022和2023年在山东省德州市禹城... 详细信息

【目的】大豆玉米带状间作是我国大豆产能提升工程的重要栽培模式。探究秸秆还田与灌溉方式对大豆玉米带状间作作物出苗及幼苗生长质量的影响，以期为带状间作解决出苗难题提供理论支撑。【方法】试验于2022和2023年在山东省德州市禹城市和四川省遂宁市安居区进行，采用二因素裂区试验，设置3种秸秆还田方式（S1，秸秆不还田；S2，秸秆灭茬还田；S3，秸秆留茬还田）和3种灌溉方式（W1，抢墒播种；W2，畦灌造墒；W3，播后喷灌），研究其对带状间作作物出苗及幼苗生长的影响。【结果】灌溉可显著提高土壤含水量并缓解土壤紧实度，进而有效提高大豆、玉米出苗率，缩短出苗时间。禹城S2处理下W3、W2、W1的大豆出苗率分别为71.00%、45.70%、38.50%；安居S2处理下W3、W2、W1的大豆出苗率分别为90.17%、88.50%、61.67%,W2、W3的出苗时间较W1分别缩短3.29、2.92 d。不同灌溉方式下玉米出苗率均可达到90%以上，但出苗时间明显不同。禹城W2、W3的玉米出苗时间较W1分别缩短1.90、3.10 d；安居W2、W3较W1分别缩短0.96、0.60 d。秸秆还田显著提高了土壤含水量并降低土壤紧实度，两地效果均表现为S2>S3>S1。禹城秸秆还田在W1处理下可显著提高大豆出苗率，S2较S1提高45.08%。秸秆还田对两地玉米出苗率均无明显影响。秸秆还田与灌溉均显著提高了安居大豆脂肪酶（LPS）和玉米α-淀粉酶活性（α-AL）,W2、W3的LPS较W1分别高26.86%、37.77%,S2的LPS较S3、S1分别高14.14%、18.05%;W2的α-AL较W1平均高189.47%,S2的α-AL较S3、S1分别高61.52%、127.33%。2个灌溉处理均可促进两地大豆、玉米的生长发育，提高幼苗生长率和整齐度，W3、W2的大豆株高较W1分别平均高21.74%、15.70%，茎粗分别平均高12.52%、28.15%。叶面积分别平均高11.84%、38.78%;W3、W2的玉米株高较W1分别平均高21.80%、20.62%，茎粗分别平均高37.69%、26.39%,W3的叶面积较W2、W1分别平均高36.56%、73.33%。秸秆还田显著影响禹城玉米幼苗长势，表现为S3>S1>S2,S3的株高较S1、S2分别高19.92%、27.31%；茎粗分别高27.59%、59.80%；叶面积分别高42.76%、68.54%。【结论】顺利出苗和构建良好的幼苗群体是实现高产的基础，播后喷灌通过改善耕层物理结构进而促进带状间作出苗并缩短出苗时间，为后续作物生长提供了有利条件。秸秆留茬还田可提高禹城带状间作幼苗生长质量；秸秆灭茬还田具有蓄水和缓解土壤紧实的特点，有利于无灌溉下大豆出苗，对安居带状间作作物形成壮苗具有促进作用。

关键词：大豆玉米带状间作秸秆还田灌溉方式出苗率幼苗生长