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Attributes of Specialized Households'Resilience and Its Impact on Rural Industrial Advancement:A Case Study of National Musical Instrument Production Specialized Households in Lankao County,Henan,China

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Chinese Geographical Science 2024年第3期34卷 383-400页

作者： WU Nalin WEI yike FAN Sizhe LI Li sun Yufan ZHANG Yan SHU Yan Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of Educa-tion/The College of Geography and Environmental ScienceHenan UniversityKaifeng 475001China College of Urban and Envir-onmental Science Central China Normal UniversityWuhan 430079China Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural economy.In this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in China.The musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience level.The influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future actions.However,heightened exposure to the external macroeconomic environment can lead to a higher rate of export reduction.To enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology and prioritizing the training of technical talen

关键词： resilience specialized households rural industry Lankao County,China

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Etching of quartz crystals in liquid phase environment:A review

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Nanotechnology and Precision Engineering 2024年第2期7卷 87-109页

作者： Yide Dong yike Zhou Haizhou Huang Bosong Zhang Xihan Li Kaiwen Chen Litao sun Guangbin Dou SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096People’s Republic of China Nanjing Jingxin Optoelectronics Research Institute Nanjing 210096People’s Republic of China

Quartz crystals are the most widely used material in resonant sensors,owing to their excellent piezoelectric and mechanical properties.With the development of portable and wearable devices,higher processing efﬁciency and geometrical precision are required.Wet etching has been proven to be the most efﬁcient etching method for large-scale production of quartz devices,and many wet etching approaches have been developed over the years.However,until now,there has been no systematic review of quartz crystal etching in liquid phase environments.Therefore,this article provides a comprehensive review of the development of wet etching processes and the achievements of the latest research in thisﬁeld,covering conventional wet etching,additive etching,laser-induced backside wet etching,electrochemical etching,and electrochemical discharge machining.For each technique,a brief overview of its characteristics is provided,associated problems are described,and possible solutions are discussed.This review should provide an essential reference and guidance for the future development of processing strategies for the manufacture of quartz crystal devices.

关键词： Quartz crystal Materials processing Wet etching Microfabrication Quartz MEMS

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Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

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Acta Pharmaceutica Sinica B 2022年第2期12卷 708-722页

作者： Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao yike sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai Pediatric Research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Cardiovascular Disease the First Hospital of Jilin UniversityChangchun 130021China Department of Burn Surgery First Hospital of Jilin UniversityJilin UniversityChangchun 130021China Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKY 40202USA Pediatric Heart Research Program Cardiovascular Innovation InstituteUniversity of Louisville School of MedicineLouisvilleKY 40202USA Cincinnati Children’s Heart Institute Greater Louisville and Western Kentucky PracticeLouisvilleKY 40202USA

Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM.

关键词： Advanced glycation end-products AMPK Cell death Diabetic cardiomyopathy Engineered cardiac tissue Ferroptosis Lipid peroxidation NRF2

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Effects of seasonal changes on T-helper 1/T-helper 2 immune balance and eczema onset in rats

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 64-72页

作者： Hairong Zhang Leilei Liu yike sun Wenna Li Ruochong Wang Xiao sun Guangqin Zhu Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Department of Acupuncture and Minimally Invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

Objective: To explore the impact of seasonal changes on the T-helper 1(Th1)/T-helper 2(Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal eczema.Methods: Eighty 4-week-old male Sprague-Dawley rats were divided into 5 season groups kept in corresponding season simulation environments, and subdivided into the model group and the control group. The Eczema Area and Severity Index(EASI) and scratching frequency were evaluated. The serum levels of immunoglobulin E(IgE), interleukin-2(IL-2), interleukin-12(IL-12), and interferon-gamma(IFN-γ), interleukin-4(IL-4), interleukin-25(IL-25), and interleukin-31(IL-31), and melatonin(MT), as well as the MT receptor(MTR) levels in the spleen, were detected by enzyme-linked immunosorbent assay analysis. The mRNA expression levels of T-bet and GATA3 were detected by quantitative real-time polymerase chain reaction.Results: EASI scores and the scratching frequency of the model group were higher in the long summer than in the other 4 seasons. Meanwhile, the serum levels of IgE and the Th2 cytokines IL-4, IL-25, and IL-31, as well as GATA3 mRNA expression levels, were high during the long summer in both groups. However, the serum levels of the Th1 cytokines IL-2, IL-12, and IFN-γ, as well as MT, MTR, and T-bet mRNA levels, were lower during the long summer. In all 5 seasonal groups(spring, summer, long summer, autumn, and winter), the levels of all immune factors, especially IL-4 and IL-31, were higher in the model group than those in the control group,while the concentrations of MT and MTR were lower.Conclusion: Under long light, hot, and humid conditions in the long summer, the body is more likely to suffer from Th2-dominated immune imbalance. This is the internal mechanism behind the high incidence and severity of eczema during the long summer. MT and MTR play a key role in the seasonal onset of eczema.

关键词： Eczema Seasonality Long summer Immunization Th1/Th2 Melatonin Immunoglobulin E

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Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 143-152页

作者： Wenna Li Ting Li Leilei Liu Qi Han Hairong Zhang yike sun Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Community Health Service Center of Hailar East Road Office Hohhotthe Inner Mongolia Autonomous Region010015China School of Medicine Henan Polytechnic UniversityJiaozuo454000China

Background: Based on the effect of seasonal changes on human visceral function, this study investigated the impact of seasonal photoperiod of the pineal body on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in rats, aiming to reveal the mechanism by which pineal gland melatonin regulates the seasonal secretion of hippocampal neurotransmitters.Methods: Vernal equinox, summer solstice, autumn equinox, and winter solstice were selected as four experimental time points, and rats were randomly divided into normal control group, sham operation group, and pinealectomized group. The seasonal changes in corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH), corticosterone, hypothalamic melatonin receptor(MTR), and hippocampal corticosterone receptor(CORTR) were examined by enzyme-linked immunosorbent assay.Results: Comparing the same group between different seasons, we showed that in the normal control group, CRH, ACTH, corticosterone, and MTR were higher, while CORTR was lower in autumn and winter than in spring(all P <.05). Compared with the normal control group, the pinealectomized group showed higher levels of corticosterone(P =.01), MTR(P =.01), and CORTR(P =.03) during spring;reduced levels of MTR and CORTR(both P <.001) during summer;higher levels of ACTH(P =.001) and MTR(P <.001),and lower levels of CRH(P =.001), corticosterone(P <.001), and CORTR(P =.003) during autumn;and lower levels of CRH(P <.001) and MTR(P =.004), and higher level of ACTH(P <.001) in winter.Conclusions: Seasonal photoperiod acts on the pineal gland to secrete different levels of melatonin,resulting in seasonal changes in the hypothalamic-pituitary-adrenal axis-hippocampal-receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder.

关键词： Pineal gland Melatonin Hippocampus Seasonal photoperiod Hypothalamic-pituitary-adrenal axis Receptor

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Creation and annihilation of artificial magnetic skyrmions with the electric field

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Chinese Physics B 2024年第3期33卷 132-137页

作者：程军孙亮张一可吉同舟曹荣幸缪冰锋赵永刚丁海峰 National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Department of Physics State Key Laboratory of Low-Dimensional Quantum PhysicsTsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Tsinghua UniversityBeijing 100084China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou 225127China

Recent theory and experiments show that artificial magnetic skyrmions can be stabilized at room temperature without the need for the external magnetic field,casting strong potentials for the device applications.In this work,we study the electric field manipulation of artificial magnetic skyrmions imprinted by Co disks on CoPt multilayers utilizing the micromagnetic simulations.We find that the reversible annihilation and creation of skyrmions can be realized with the electric field via the strain mediated magnetoelastic coupling.In addition,we also demonstrate controllable manipulation of individual skyrmion,which opens a new platform for constructing magnetic field-free and low-energy dissipation skyrmion based media.

关键词： skyrmions magnetic anisotropy micromagnetic simulations

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UPLC-MS/MS法测定血液中极性农药草铵膦和草甘膦

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当代化工研究 2024年第12期 55-57页

作者：孙玉婷韩亦可安徽全诚司法鉴定中心安徽230000 皖南医学院药学院安徽241002

建立一种超高效液相色谱-三重四极杆串联质谱(UPLC-MS/MS)检验血液中极性农药草铵膦和草甘膦的方法。血液样品经纯水稀释后采用乙腈沉淀蛋白法提取,充分振荡后,离心5 min(10000 r/min),取上清液,过0.22μm有机滤膜上机分析。负离子工作... 详细信息

建立一种超高效液相色谱-三重四极杆串联质谱(UPLC-MS/MS)检验血液中极性农药草铵膦和草甘膦的方法。血液样品经纯水稀释后采用乙腈沉淀蛋白法提取,充分振荡后,离心5 min(10000 r/min),取上清液,过0.22μm有机滤膜上机分析。负离子工作模式(ESI-)下,多反应监测模式(MRM)检验,外标曲线法定量。结果表明,血液中草铵膦和草甘膦检出限均低于0.25 ng/mL,定量限均低于0.83 ng/mL;在1~100 ng/mL范围内线性关系良好,R^(2)均大于0.9986;在低、中、高(1 ng/mL、10 ng/mL、100 ng/mL)三种添加浓度中,基质效应在85.61%~110.81%之间,提取回收率在83.92%~93.22%之间,日内、日间精密度RSD均不大于7.59%。结论:本方法专属性好、灵敏度高、准确性好,可用于快速检验中毒血液草铵膦和草甘膦。

关键词：草甘膦草铵膦血液超高效液相色谱-三重四极杆串联质谱(UPLC-MS/MS)

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基于表型性状和SSR标记的半夏遗传多样性分析及分子身份证构建

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中国实验方剂学杂志 2024年第5期30卷 134-142页

作者：许祎珂李爽寇佩雯刘长乐孙晓春黄文静陕西中医药大学陕西中药资源产业化省部共建协同创新中心秦药特色资源研究开发国家重点实验室(培育)陕西咸阳712083

目的:研究半夏种质间遗传多样性,解析种质间的亲缘关系,为半夏种质鉴定、品种选育及资源保护提供依据。方法:该研究以27份半夏作为实验材料,测定其株高、叶长、叶宽等7个表型性状,并基于半夏转录组数据开发设计简单重复序列(SSR)引物,... 详细信息

目的:研究半夏种质间遗传多样性,解析种质间的亲缘关系,为半夏种质鉴定、品种选育及资源保护提供依据。方法:该研究以27份半夏作为实验材料,测定其株高、叶长、叶宽等7个表型性状,并基于半夏转录组数据开发设计简单重复序列(SSR)引物,对27份半夏进行聚合酶链式反应(PCR)扩增,利用POPGENE32、PowerMarker V3.25和NTSYS-PC 2.10e软件对半夏种质进行遗传多样性分析。结果:共筛选出10对具有高度多态性的引物(PIC>0.5),4对中度多态性的引物(0.25

关键词：半夏简单重复序列(SSR)分子标记遗传多样性分子身份证

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论历史档案开放审核先行的必要性、实施条件与推进策略

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山西档案 2024年第1期 5-11页

作者：陈永生王沐晖詹逸珂中山大学信息管理学院广州510006

历史档案因形成年代久远而具有不同于现行档案的特征,使其开放审核的实施具备易于且可快于现行档案开放审核的基础,以此为突破口推动档案开放审核有望改变目前其整体进展不理想的局面。阐述历史档案开放审核先行的必要性,分析历史档案... 详细信息

历史档案因形成年代久远而具有不同于现行档案的特征,使其开放审核的实施具备易于且可快于现行档案开放审核的基础,以此为突破口推动档案开放审核有望改变目前其整体进展不理想的局面。阐述历史档案开放审核先行的必要性,分析历史档案与现行档案相比具有较少需要解密、较少涉及馆藏增量两大有利于推动开放审核先行的实施条件,并分别从实施主体、实施工具、实施组织三个角度,提出探索建立构成适度多元的开放审核咨询议事机构、以档案内容识读为切入点强化数字赋能、探索实行历史档案开放审核“压力试点”三项推进历史档案开放审核的针对性策略。

关键词：档案开放开放审核历史档案

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Molecular mechanisms of seasonal photoperiod effects of the pineal gland on the hippocampus in rats

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Journal of Traditional Chinese Medical Sciences 2021年第2期8卷 135-144页

作者： Qi Han Guowen Du Leilei Liu Lepeng Wang Wenna Li Hairong Zhang yike sun Pei Zhu Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Background:Based on the theory of“five Zang-organs corresponding to the seasons”in traditional Chinese medicine(TCM),physiological functions including emotions vary with the seasons.We aimed to investigate the seasonal photoperiod effects of melatonin(MT)released from the pineal gland on the MT receptor(MTR)-Gs/Gi-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element-binding protein(CREB)signaling pathway in the hippocampus.Methods:Rats were divided into three groups:control,operation(surgery with pineal gland removal),and pseudo-operation groups(same surgery as operation group but without removing pineal gland),and fed at specific time across the four seasons.The levels of MTR,adenylate cyclase(AC),cAMP,PKA,and CREB in the hippocampus were analyzed using ELISA.The concentrations of Gs and Gi were analyzed using Western blot.The expression of CREB mRNA was detected by PCR.Results:For intragroup comparisons,compared with spring,the levels of Gs/Gi in the control group were higher in summer,autumn,and winter(P=.009 in summer;P<.001 in autumn and winter);the levels of MTR,cAMP,PKA,and CREB in the control group were significantly higher in autumn and winter than in spring(all P<.001).The levels of MTR,cAMP,PKA,and CREB in each season were significantly lower in the operation group than in the control group(all P<.05).Significant differences were noted in Gs/Gi levels between the operation group and control group in spring,autumn,and winter(all P<.05).Conclusion:Our findings suggest that MTR-Gs/Gi-cAMP-PKA-CREB signaling pathway is involved in the seasonal photoperiod effects of the pineal gland on the hippocampus and may underpin seasonal changes in emotions.It can support the prevention and treatment of the seasonal onset of mental disorders,and enrich the theory of“five Zang-organs corresponding to the seasons”.

关键词： Pineal gland Melatonin Hippocampus Photoperiod Signaling pathway

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