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Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2022年第4期11卷 29-42页

作者： yiguo Zhou Wan-Xue zhang Eljah Tembo Ming-Zhu Xie Shan-Shan zhang Xin-Rui Wang Ting-Ting Wei Xin Feng Yi-Lin zhang Juan Du Ya-Qiong Liu Xuan zhang Fuqiang Cui Qing-Bin Lu Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing 100191People's Republic of China Department of Public Health Emergency Management School of Public HealthPeking UniversityBejing 100191People's Republic of China institute for Hospital Management Research Chinese PLA General HospitalBeijing 100039People's Republic of China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191People's Republic of China

Background:Indoor residual spraying(IRS)is one of the key interventions recommended by World Health Organization in preventing malaria *** aimed to conduct a systematic review and meta-analysis of global studies about the impact of IRS on malaria ***:We searched PubMed,Web of Science,Embase,and Scopus for relevant studies published from database establishment to 31 December ***-effects models were used to perform meta-analysis and subgroup analysis to pool the odds ratio(OR)and 95%confidence interval(CI).Meta-regression was used to investigate potential factors of heterogeneity across ***:Thirty-eight articles including 81 reports and 1,174,970 individuals were included in the *** was associated with lower rates of malaria infection(OR=0.35,95%CI:0.27-0.44).The significantly higher effectiveness was observed in IRS coverage≥80%than in IRS coverage<80%.Pyrethroids was identified to show the greatest performance in malaria *** addition,higher effectiveness was associated with a lower gross domestic product as well as a higher coverage of IRS and bed net ***:IRS could induce a positive effect on malaria infection *** high IRS coverage and the use of pyrethroids are key measures to reduce malaria *** efforts should focus on increasing IRS coverage,developing more effective new insecticides against malaria,and using multiple interventions comprehensively to achieve malaria control goals.

关键词： Indoor residual spraying Malaria Meta-analysis Effectiveness evaluation

Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening

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Science China(Life Sciences) 2018年第2期61卷 244-252页

作者： Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng zhang Silin Zhong Paul Hunter Mahmut Tor yiguo Hong Research Centre for Plant RNA Signaling College of Life and Environmental Sciences Hangzhou Normal University Hangzhou 310036 China State Key Laboratory of Agrobiotechnology School of Life Sciences The Chinese University of Hong Kong Hong Kong China Warwick-Hangzhou Joint RNA Signaling Laboratory School of Life Sciences University of Warwick Warwick CV4 7AL UK Worcester-Hangzhou Joint Molecular Plant Health Laboratory Institute of Science and the Environment University of Worcester WR2 6A J UK

Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and *** technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and ***,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to *** tomato,fruit development and ripening are a complex process that involves epigenetic *** have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr *** compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 *** methylated regions were found for some of these ***-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr *** results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant.

关键词： tomato Cnr SlCMT3 SlDET1 SlPDS DNA methylation WGBS VIGS

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轨道交通封站条件下应急疏散车辆路径优化

山东科学 2023年第4期36卷 80-88页

作者：张仪果屈云超尹浩东吴建军北京交通大学轨道交通控制与安全国家重点实验室北京100044

针对轨道交通封站条件下站外滞留乘客需要应急疏散的现实需求,设计了一种疏散服务模式,在保证滞留旅客有效疏散的前提下,允许线路沿途旅客搭乘以提高车辆的利用效率。以车辆运营成本和乘客时间成本之和最小为优化目标,建立应急疏散车辆... 详细信息

针对轨道交通封站条件下站外滞留乘客需要应急疏散的现实需求,设计了一种疏散服务模式,在保证滞留旅客有效疏散的前提下,允许线路沿途旅客搭乘以提高车辆的利用效率。以车辆运营成本和乘客时间成本之和最小为优化目标,建立应急疏散车辆路径优化模型,根据问题特点改进自适应大邻域搜索算法进行模型求解。最后,结合北京市城市交通数据,对应急疏散车辆进行路线设计并进行灵敏度分析,用算例验证了模型与算法的有效性。结果表明,相较于最短路径疏散方案,模型的优化结果节省了15.02%的乘客乘车时间,能够在保证乘客出行体验的前提下实现对站点滞留乘客的快速疏散,提升封站事件下轨道交通应急管理的精细化水平。

关键词：城市轨道交通应急疏散车辆路径问题轨道交通封站自适应大邻域搜索算法

微型燃气轮机分布式能源系统混合逻辑建模研究

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中国电机工程学报 2016年第12期36卷 3354-3365页

作者：张俊礼沈炯李益国能源热转换及其过程测控教育部重点实验室(东南大学) 江苏省南京市210096

针对具有多设备集成、多产点和多负荷耦合特征,且运行方式灵活多样的微型燃气轮机分布式能源系统(microturbine-based distributed energy system,MT-DES),提出新的运行优化模型。将MT-DES分解成CHP机组、热/冷辅助设备、购/售电等环节... 详细信息

针对具有多设备集成、多产点和多负荷耦合特征,且运行方式灵活多样的微型燃气轮机分布式能源系统(microturbine-based distributed energy system,MT-DES),提出新的运行优化模型。将MT-DES分解成CHP机组、热/冷辅助设备、购/售电等环节。在厘清各设备/环节间耦合关系以及其与主要运行策略之间联系的基础上,采用混合逻辑方法,合理描述了考虑启停逻辑和负荷限制等约束的各环节运行特性。并与经济、能效和环保等目标模型联立,通过线性变换和矩阵化,得到了适用于各主要运行策略研究的滚动优化模型。对文中思路的可行性和优越性通过优化算例进行了验证。

关键词：分布式能源系统微型燃气轮机运行优化混合逻辑线性矩阵

China starts the world’s hardest “Sky-High Road” project: Challenges and countermeasures for Sichuan-Tibet railway

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The Innovation 2021年第2期2卷 29-30页

作者： yiguo Xue Fanmeng Kong Shucai Li Qingsong zhang Daohong Qiu Maoxin Su Zhiqiang Li Geotechnical and Structural Engineering Research Center Shandong UniversityJinan 250061China

InChina,a new“epic project”named theSichuan-Tibet railway linkingChengdu and Lhasa is in the construction *** 1,592-km-long railway passes through the western Sichuan basin,subsequently climbing 5,000 m and running ... 详细信息

关键词： Figure railway Road

肠道微生物群及其代谢物在肠缺血再灌注损伤中的研究进展

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医学综述 2023年第16期29卷 3190-3196页

作者：潘锐景祎馨张贻帼丁可陈榕孟庆涛武汉大学人民医院麻醉科武汉430060

肠缺血再灌注(IIR)损伤是一类病死率较高的危重病症,目前临床尚缺乏预防和治疗IIR损伤的有效措施。肠道微生物群及其代谢物在IIR损伤的发生、发展、诊断和治疗过程中起关键作用。不同肠道细菌的丰度、组成及其主要代谢物(短链脂肪酸、... 详细信息

肠缺血再灌注(IIR)损伤是一类病死率较高的危重病症,目前临床尚缺乏预防和治疗IIR损伤的有效措施。肠道微生物群及其代谢物在IIR损伤的发生、发展、诊断和治疗过程中起关键作用。不同肠道细菌的丰度、组成及其主要代谢物(短链脂肪酸、次级胆汁酸和色氨酸代谢物等)水平变化可从不同角度阐述IIR损伤的致病机制,改变肠道微生物及其代谢产物水平可影响IIR的肠道损伤。因此,深入研究肠道微生物群及其代谢物在IIR中的作用机制,可以为IIR损伤的诊断、预防和治疗提供关键靶点。

关键词：肠缺血再灌注损伤肠道微生物群肠道微生物代谢物

泊沙康唑肠溶片在中国健康受试者中的生物等效性研究

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中国医药科学 2024年第17期14卷 71-74页

作者：钱晓萍陈可心徐桥张悦翎曾琼侯晓璇郑俊红朱瑞芳江翊国黄立峰南京大学医学院附属苏州医院药学部江苏苏州215153 中国海洋大学医药学院山东青岛266100 江西山香药业有限公司江西赣州341000 上海健康医学院附属周浦医院药物临床试验机构办公室上海201318

目的研究泊沙康唑肠溶片在中国健康受试者体内的生物等效性。方法受试者空腹或餐后条件下口服受试或参比制剂100 mg后,用LC-MS/MS法检测泊沙康唑的血药浓度,用Phoenix WinNonlin 8.3计算药代动力学参数,并评价两制剂的生物等效性。结果... 详细信息

目的研究泊沙康唑肠溶片在中国健康受试者体内的生物等效性。方法受试者空腹或餐后条件下口服受试或参比制剂100 mg后,用LC-MS/MS法检测泊沙康唑的血药浓度,用Phoenix WinNonlin 8.3计算药代动力学参数,并评价两制剂的生物等效性。结果两制剂主要药代动力学参数C_(max)、AUC_(0-t)、AUC_(0-∞)几何均值比90%置信区间均落在80.00%~125.00%。在试验过程中,未发生严重不良事件和非预期可疑不良事件。结论在空腹和餐后条件下,两种泊沙康唑肠溶片在中国健康受试者中具有生物等效性,且两制剂的安全性相当。

关键词：泊沙康唑肠溶片空腹和餐后生物等效性安全性

Dynamic economic dispatch for CHP-MG system based on mixed logical dynamic model and MPC method

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Dynamic economic dispatch for CHP-MG system based on mixed l...

第三十九届中国控制会议

作者： Ke Chen yiguo Li Junli zhang Songlin Chen Honghai Niu Bing Li Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast University NR Electric Co. Ltd.

Common economic dispatches of combined heat and power-microgrid system（CHP-MG） are mainly conducted based on the static characteristics of the main equipment. However, when dispatching on a short time scale, the impact of their thermal dynamic characteristics should not be ignored. In this paper, logical variables are introduced to describe the start-stop status and working modes of the equipment. Moreover, an integrated mixed logical dynamic model（MLD） of the CHP-MG system considering the thermal dynamic characteristic of micro-turbine is established. A dynamic economic dispatch problem is then formulated in the framework of model predictive control（MPC）, and solved by using mixed-integer linear program algorithm. The effectiveness of the proposed dynamic economic dispatch method is verified in a CHP-MG system with typical equipment.

关键词： Combined heat and power-microgrid system(CHP-MG) Economic dispatch(ED) Mixed logical dynamic model (MLD) Model predictive control(MPC) Mixed-integer linear programming(MILP)

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基于在线支持向量机的锅炉动态建模方法研究

中国电机工程学报 2017年第S1期37卷 123-128页

作者：张晓宇付林沈炯李益国神华国华(北京)电力研究院有限公司北京市海淀区100025 东南大学能源信息与自动化系江苏省南京市210096

利用在线支持向量机的非线性映射特性,建立锅炉排放、锅炉效率与燃烧调整中诸多操作量(如:二次风门开度、燃烬风门开度、给煤量偏置等)的动态数学模型,并对动态模型进行仿真研究。现场数据仿真表明,所建的模型可以较好地体现锅炉燃烧系... 详细信息

利用在线支持向量机的非线性映射特性,建立锅炉排放、锅炉效率与燃烧调整中诸多操作量(如:二次风门开度、燃烬风门开度、给煤量偏置等)的动态数学模型,并对动态模型进行仿真研究。现场数据仿真表明,所建的模型可以较好地体现锅炉燃烧系统的动态特性。当过程中出现之前建模数据没有囊括的工况时,模型可以利用新数据实现在线更新,并补充新的支持向量,因而具备对煤质变化的适应能力。

关键词：在线支持向量机燃煤锅炉动态建模燃烧优化